Not yet recruitingOBSERVATIONAL

Endoscopic Sleeve Gastroplasty (ESG) Prospective Trial for Obesity (EGO-Trial)

The EGO-Trial is the first major study in France to investigate a treatment called Endoscopic Sleeve Gastroplasty (ESG) for obesity. Unlike traditional weight-loss surgery, ESG is a less invasive procedure that reduces the size of the stomach without needing surgery. This study will gather important information from different hospitals across France to understand how effective and safe ESG is, and how it's being used in everyday medical practice. Obesity is a significant health concern in France, and while surgery is an option for many, not everyone can have it. ESG offers a promising alternative for those seeking weight management, and this trial aims to provide strong evidence about its benefits and potential risks.

At a glance

Status

Not yet recruiting

Sponsor

IHU Strasbourg

Enrolment target

300

Start

01 Mar 2026

Estimated completion

01 Mar 2030

Obesity

What is this study about?

Obesity is a major health concern for many people, and it can increase the risk of developing other health problems like diabetes, heart disease, and high blood pressure. While there are treatments like weight-loss surgery, these can be quite involved and aren't suitable or wanted by everyone.

This study, called the EGO-Trial, is exploring a newer procedure known as Endoscopic Sleeve Gastroplasty (ESG). Think of it as a way to make your stomach smaller without needing major surgery. Instead, doctors use a special camera with tools at the end (an endoscope) that goes down your throat to reshape your stomach. This procedure has shown promising results in helping people lose weight and improve their health conditions.

The main goal of the EGO-Trial in France is to see exactly how well ESG works in real-world settings – meaning how it helps patients in different hospitals and clinics, how safe it is, and if it leads to lasting weight loss. This is important because it will give doctors and patients in France a clearer picture of ESG as a treatment option for obesity.

Key takeaways

The EGO-Trial explores a new, non-surgical weight-loss procedure called Endoscopic Sleeve Gastroplasty (ESG).
It aims to understand how effective and safe ESG is for people with obesity in France.
ESG makes the stomach smaller without traditional surgery, using an endoscope.
This study could offer a less invasive option for weight management.
Participants must have tried other weight-loss methods and be between 18-75 years old.

Who may be eligible?

To be considered for this study, you would generally need to be between 18 and 75 years old and have a Body Mass Index (BMI) of 30 or higher. You should also have tried other ways to lose weight, like diet and exercise, without success. This study might be an option if you're not suitable for traditional weight-loss surgery or if you prefer not to have it.

There are also some important things that would mean you couldn't join the study. For example, if you've had major stomach or gullet surgery before, or if you have certain existing stomach problems like ulcers. If you're pregnant, breastfeeding, or trying to get pregnant and not using reliable birth control, you also wouldn't be able to participate. They also need to make sure you're healthy enough for a general anaesthetic and don't have certain untreated eating disorders or psychiatric conditions.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 75 years old?
Do you have a Body Mass Index (BMI) of 30 or higher?
Have you already tried diet, exercise, or other non-surgical weight loss methods without success?
Are you either unable to have traditional weight-loss surgery or prefer not to have it?
Are you generally well enough to have a general anaesthetic?
Are you able to agree to follow all study instructions and attend appointments?

Answer every question to see your result.

What does participation involve?

The information provided does not detail the specific schedule of visits, assessments, or the total duration of the study. However, generally, if you were to take part in a study like this, it would involve regular check-ups with the study team. These visits would likely include monitoring your weight, general health, and any changes in your existing health conditions. You would also need to attend appointments related to the ESG procedure itself. It's important to be able to follow all study instructions and attend scheduled appointments for the entire duration of the study, which would be explained to you in full before you agree to participate.

Potential risks and benefits

Participating in this study could offer several potential benefits, including the chance to lose a significant amount of weight and see improvements in related health conditions like diabetes or high blood pressure, using a less invasive method than traditional surgery. However, like any medical procedure, ESG carries potential risks, which your doctor would discuss with you in detail. These risks can include complications from the general anaesthetic or the procedure itself. You have the right to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (10)

Hôpital Privé de Provence
Verified postcode
Aix-en-Provence, France
Polyclinique de Franche-Comté
Verified postcode
Besançon, France
Clnique des Cèdres
Verified postcode
Échirolles, France
Hôpital HURIEZ
Verified postcode
Lille, France
Hospices Civils de Lyon - Hôpital Edourard HERRIOT
Verified postcode
Lyon, France
Clinique Clémentville
Verified postcode
Montpellier, France
Centre Mutualiste de l'Obésité
Verified postcode
Saint-Etienne, France
Polyclinique Sainte Thérèse
Verified postcode
Sète, France
Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil
Verified postcode
Strasbourg, France
Clinique les Eaux Claires
Verified postcode
Baie-Mahault, Guadeloupe

Common questions

What is Endoscopic Sleeve Gastroplasty (ESG)?

ESG is a less invasive procedure that uses a special camera and tools to reduce the size of your stomach without needing surgery.

Who is this study for?

This study is for adults with obesity who have tried other weight loss methods without success, and who may not be able to or want to have traditional weight-loss surgery.

Is ESG a surgical procedure?

No, it's considered a non-surgical procedure because it's performed using an endoscope that goes down your throat, rather than through incisions in your abdomen.

What are the main goals of the EGO-Trial?

The trial aims to understand how well ESG helps with weight loss, how safe it is, and how it improves other health conditions in people with obesity in France.

Will I have to pay to be in the study?

The information states that participants must be part of the French social security system, suggesting the study costs likely fall under that system, but you should always confirm this directly with the study team.

How to find out more

Armelle TAKEDA

armelle.takeda@ihu-strasbourg.eu 0033 390 413608 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.