Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

To be considered for this study, you would need to be an adult over 18 years old. A key requirement is that you have a Body Mass Index (BMI) of 27 or higher. You should also have knee osteoarthritis and experience pain from it. Additionally, you need to meet at least one of these criteria: be over 50 years old, experience morning knee stiffness lasting around 30 minutes, or hear/feel a crackling or grinding in your knee.

There are also some important reasons why you might not be able to join. For example, if you've had weight loss surgery, certain procedures, or are currently taking weight loss medications. People with certain health conditions like specific types of diabetes, an active knee infection, or a recent heart attack, stroke, or heart failure would also not be able to participate. The study team will review all your health information carefully to see if this study is suitable for you.

If you decide to take part, the study will last for approximately 75 weeks. This includes an initial screening period to check if you're a good fit for the study. During the study, you'll either receive the new medication, Eloralintide, or a placebo (a treatment that looks the same but contains no active medicine). You won't know which one you're receiving. You'll have regular visits to the clinic where the study team will monitor your health, assess your knee pain, and check for any side effects. These visits will involve various tests, such as physical examinations and blood tests, to ensure your safety and track the medication's effects. The study team will provide all the necessary medication.