- recruiting
Effectiveness and cost-effectiveness of hip implant types in patients younger than 70 years undergoing primary elective total hip replacement
Over 100,000 hip replacements happen in the UK each year. Surgeons can fix artificial hips with bone cement, without cement, or using a mix of both. This trial compares all three types in people under 70 with osteoarthritis to see which works best, lasts longest, and offers the best value.
United Kingdom · England · Wales - recruitingTherapeutic exploratory (Phase II)
Evaluation of intra articular Tranexamic acid for reduction of total blood loss in total hip arthroplasty
This study looks at whether injecting a medicine called tranexamic acid directly into the hip joint during hip replacement surgery reduces bleeding. Researchers want to see if this lowers total blood loss during the first two days after surgery for adults with severe hip osteoarthritis.
Denmark - recruitingTherapeutic exploratory (Phase II)
A 5- year randomized, double-blind, placebo-controlled, multi-center study assessing the efficacy, safety, and tolerability of intra-articular regimens of LNA043 versus placebo in patients with symptomatic knee osteoarthritis (ONWARDS)
This 5-year study is looking at a new medicine, LNA043, for knee osteoarthritis. It compares LNA043 to a dummy treatment (placebo) to see if it improves knee structure and reduces pain and stiffness for people aged 18 and over.
Spain · Poland · Denmark - recruitingHuman Pharmacology (Phase I)- First administration to humans
A first-in-human study to investigate safety and tolerability of SAR446959 in participants with osteoarthritis of the knee
This study is looking at a new medicine called SAR446959 for knee osteoarthritis. It's the first time this medicine is being given to people, so the main goal is to check if it's safe and how well people tolerate it. Anyone aged 18 and over can potentially take part.
Germany - recruitingPHASE3
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
This study is testing a new medication called Eloralintide for people with knee osteoarthritis pain who are also overweight or obese. It's a large study aiming to see how well and safely the medication works to help with pain.
United States · Argentina · Belgium - recruiting
The role of soluble epoxide hydrolase in osteoarthritis pain
This study looks into a protein called sEH, which might be key to treating osteoarthritis (OA) pain. We're hoping to understand how sEH levels relate to pain in knee OA, aiming to find better future treatments.
United Kingdom · England - active not recruitingNA
The Technology, Exercise Programming, and Activity Prescription for Enhanced Mobility (TEAM) Study
This study looks at new ways to help people with knee or hip osteoarthritis manage their pain and move better without surgery. We're testing if special advice on exercise from doctors and a free online resource can improve their quality of life.
Canada - active not recruiting
Assessing Central Aspects of Pain
This study looks at new ways to understand long-lasting pain in conditions like arthritis and fibromyalgia. Researchers are using questionnaires and simple tests to see how the brain and nerves contribute to pain, aiming for better diagnosis and personalised treatments.
United Kingdom - active not recruitingNA
14022 ATTUNE Cementless RP Clinical Performance Evaluation
This study looks at a new type of cementless knee replacement, called ATTUNE, for people with osteoarthritis. It checks how well two different versions of this knee replacement improve daily activities two years after surgery. Researchers will also look at pain levels, overall satisfaction, and track any issues.
United States · Austria · Canada - active not recruiting
Comprehensive Nano - Post Market Clinical Follow-Up Study
This study looks at how well a shoulder replacement system, called Comprehensive Nano, works for people with shoulder pain from conditions like arthritis. Doctors will check on patients who have had this surgery to see how they recover and how the new shoulder helps them.
Austria · Canada · South Korea - recruitingNA
The Effectiveness of a Herbal Supplement in Osteoarthritis.
This study looks at a plant-based supplement for adults with knee or hip osteoarthritis. We want to see if it helps reduce pain and improve movement, compared to a dummy pill. It involves taking the supplement and a placebo, and answering questions.
United Kingdom - active not recruitingNA
Persona Partial Knee Clinical Outcomes Study
This study looks at how well a new partial knee replacement, called the Persona Partial Knee, works. Researchers want to see if it helps people with knee pain from conditions like arthritis and how long it lasts. They'll follow patients for up to 10 years.
United States · Austria · Belgium - active not recruitingNA
Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System
This study looks at a new surgical plate, the A.L.P.S. Proximal Humerus Plating System, used for broken upper arm bones. It aims to confirm the plate is safe and works well after it's been made available for use.
United States · Australia · Canada - recruitingPHASE4
Kinematic and Mechanical Alignment Randomized Trial
This study compares two ways to do knee replacement surgery for arthritis: standard 'mechanical alignment' and a more personalised 'restricted kinematic alignment'. We want to see which method leads to better natural feel and movement using robotic help for precise surgery.
Canada - active not recruiting
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
This study looks at how well a new type of shoulder replacement, called the Trabecular Metal Reverse Shoulder System, works for people with severe shoulder problems. It aims to see how long it lasts, if it reduces pain, and improves movement.
United States · United Kingdom - active not recruiting
G7 BiSpherical Acetabular Shell PMCF Study
This study looks at how well a new part for hip replacements, called the G7 BiSpherical Acetabular Shell, works for people with certain hip problems like arthritis. It checks if it reduces pain and improves movement after surgery.
France · Germany · Netherlands - recruiting
Developing Allogeneic Musculoskeletal Therapies
This study looks at cells from donated body tissues, like those from children's surgeries or tissue banks. Scientists want to find the best cells to grow new cartilage and bone. This could help treat conditions like arthritis in the future.
United Kingdom - recruiting
OSTEOMICS: Identifying Regulators of Bone Homeostasis
This study, OSTEOMICS, is looking at bone diseases like osteoporosis and osteoarthritis. We're collecting bone samples from patients having orthopaedic surgery to understand bone health better and find new ways to treat these common conditions.
United Kingdom - active not recruiting
BC Study of G7 Cup and Compatible Femoral Stems
This study looks at how well a new hip replacement cup, called the G7 Acetabular System, works for people needing hip surgery due to joint problems like arthritis. It helps ensure new implants are safe and effective.
United Kingdom - enrolling by invitation
Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With Cruciate Sacrificing Insert
This study looks at a new type of knee replacement called EVOLUTION® NitrX™. It checks how well these knee parts work and if they are safe for people with joint problems like arthritis. The study follows patients who have already had or are planning to have this specific knee replacement.
United States · United Kingdom - active not recruitingNA
SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization
This study is looking at a new treatment called SakuraBead for knee pain caused by osteoarthritis. It compares SakuraBead with corticosteroid injections to see which works better and is safer for people aged 40-79.
United States · Georgia · United Kingdom - active not recruiting
Zimmer POLAR Persona - TKA (EMEA Study)
This study looks at how well the Zimmer Persona knee replacement works for people with severe knee pain and disability. It tracks how long the implant lasts, its safety, and how much it improves patients' daily lives over several years.
Austria · France · Germany - active not recruiting
A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
This study looks at a new type of knee replacement system, called Vanguard 360, for people with knee problems like arthritis. It aims to see if this new system helps people move better, reduces pain, and lasts a long time after surgery.
United States · Belgium · Denmark - recruitingNA
Manual Arthroplasty Versus VELYS Robotic-Assisted Solution Functional Alignment Arthroplasty for Knee Osteoarthritis
This study compares standard knee replacement surgery with a new robotic-assisted method for knee arthritis. It aims to see if the robotic approach leads to better pain relief, function, and patient satisfaction, and if it's safer and more efficient.
United Kingdom - active not recruiting
Sidus(TM) Post Market Clinical Follow-up (PMCF) Study
This study looks at how well a new shoulder replacement, called Sidus Stem-Free Shoulder, works in patients with shoulder pain due to conditions like arthritis. Doctors will check its safety and how long it lasts, as well as pain relief and shoulder movement, over a long period.
Austria · France · Germany - active not recruiting
Continuum Ceramic on Ceramic Bearing Post Market Clinical Follow-Up Study
This study looks at how well a specific type of ceramic hip replacement works. Doctors will check pain, movement, and how long the new hip lasts in people having a hip replacement for conditions like arthritis. The aim is to see if it's safe and effective.
Finland · Italy · United Kingdom - active not recruitingNA
AMIStem Primary Hip System Prospective Post-marketing Multi-centre Surveillance Study
This study looks at how well a new hip replacement, called the AMIStem Hip System, works after it's been used in real patients. Doctors are checking its performance and how patients recover over time. It's for people needing hip surgery due to conditions like arthritis.
Switzerland · United Kingdom - active not recruitingNA
Resistance Exercise Training to Improve Bone and Articular Cartilage Health in Women
This study looks at how different types of exercise can help strengthen bones and protect joints in women aged 50-70. It compares two exercise programs to see which is best for conditions like weak bones (osteoporosis) and joint wear (osteoarthritis).
United Kingdom - active not recruitingNA
Total Ankle Replacement Versus Arthrodesis Trial
This study compares two operations for severe ankle arthritis: total ankle replacement and ankle fusion. It aims to find out which surgery works better for people aged 50-85, offering less pain and better movement, and which is more cost-effective for the NHS.
United Kingdom - active not recruitingNA
Unicompartmental Versus Total Knee Replacement for Medial Compartment Knee Osteoarthritis
This study compares two types of knee replacement for arthritis in one part of the knee: a partial or a full replacement. We want to see which one helps patients move better, especially with tricky activities like stepping down, using special movement sensors.
United Kingdom