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PRospective phenotypIng and Multi-omic Endotyping of Progressive Pulmonary Fibrosis

This study focuses on people living with specific types of lung scarring (fibrosis) that are not idiopathic pulmonary fibrosis (IPF), such as those linked to connective tissue diseases or certain allergies. Researchers will observe participants over two years, collecting detailed health information, lung scans, and blood samples. The main goal is to improve how we classify and understand Progressive Pulmonary Fibrosis (PPF), which is when lung scarring worsens over time. It aims to find better ways to predict who might develop PPF and why, exploring different health markers and advanced imaging. The study doesn't involve new medicines but helps doctors understand these conditions better to guide future treatments.

At a glance

Status
Recruiting
Sponsor
University of Massachusetts, Worcester
Enrolment target
500
Start
01 May 2025
Estimated completion
01 Dec 2029

What is this study about?

This study is designed to learn more about a serious lung condition called Progressive Pulmonary Fibrosis (PPF). This happens when existing lung scarring, from conditions like certain autoimmune diseases or specific allergic reactions, gets worse over time. If you have one of these conditions, it can be very worrying to think it might progress.

Researchers want to closely follow people with these conditions for two years. They will gather a lot of information, including details about your health, special lung scans, and blood and other bodily fluid samples. By doing this, they hope to get a clearer picture of how PPF develops and how it affects different people. The main aims are to find better ways to identify when a person's lung scarring is progressing and to understand how common this progression is for different types of lung conditions. This will help doctors diagnose and help people earlier.

The study also explores new ways to predict who might be at risk of their lung scarring getting worse. They will look at whether special tests, including new markers in the blood or advanced details from lung scans, can help predict this. By understanding more about PPF, doctors can hopefully develop more effective ways to manage care and improve the lives of people living with these lung conditions in the future.

Key takeaways

  • Learning more about worsening lung scarring (Progressive Pulmonary Fibrosis).
  • Focuses on lung conditions *other than* Idiopathic Pulmonary Fibrosis (IPF).
  • No new medicines, just careful observation and data collection.
  • Participation involves ongoing health checks, scans, and blood tests over two years.
  • Aims to find better ways to identify and predict progression earlier.
  • Your contribution helps improve future care for people with these conditions.

Who may be eligible?

To be able to take part in this study, you generally need to be an adult between 18 and 80 years old. You must have a confirmed diagnosis of certain types of scarring lung disease that are *not* called Idiopathic Pulmonary Fibrosis (IPF). These specific types often include lung conditions linked to autoimmune diseases (like rheumatoid arthritis or lupus) or scar tissue related to certain environmental allergies.

There are also some important reasons why you might *not* be able to join. For example, if your initial diagnosis of lung scarring was more than five years ago, or if your lung condition is very mild with little scarring. You also couldn't take part if you have extensive emphysema (another type of lung damage), or if you've had certain types of cancer recently. You also can't be pregnant or planning to become pregnant, or be taking specific medications for lung fibrosis that are part of other clinical trials.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you between 18 and 80 years old?
  2. Do you have a diagnosis of lung scarring NOT called Idiopathic Pulmonary Fibrosis (IPF), such as one related to an autoimmune disease or specific allergy?
  3. Was your lung scarring diagnosed within the last 5 years?
  4. Are you able to attend regular appointments for health checks, scans and sample collections?
  5. Are you not currently pregnant or planning to become pregnant during the next two years?
  6. Are you not taking certain specific anti-fibrotic medications that are part of other clinical trials?
Answer every question to see your result.

What does participation involve?

If you decide to join this study, you would be followed for two years. This is an 'observational' study, meaning you wouldn't be given any new or experimental medicines as part of the research. Instead, the doctors will simply observe your condition and collect information as you go about your usual medical care.

Your participation would involve regular visits where doctors would collect detailed information about your health. This includes taking blood and other bodily fluid samples, and having special lung tests and scans. These assessments would happen at specific times throughout the two-year period. The study team would explain the exact schedule of visits and what happens at each one.

Potential risks and benefits

Taking part in a study like this can have potential benefits, such as receiving very careful monitoring of your lung condition and contributing to a better understanding of Progressive Pulmonary Fibrosis, which may help others in the future. The main risks involve the procedures for collecting blood samples and the occasional exposure to radiation from lung scans, similar to what you might have in your usual medical care. You always have the right to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (13)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.
  • University of Massachusetts Chan Medical School
    Verified postcode
    Worcester, United States· Recruiting
  • University of Michigan
    Verified postcode
    Ann Arbor, United States· Recruiting
  • University of Texas Southwestern
    Verified postcode
    Dallas, United States· Not yet recruiting
  • University of Virginia
    Verified postcode
    Charlottesville, United States· Not yet recruiting
  • University of Washington
    Verified postcode
    Seattle, United States· Not yet recruiting
  • Royal Prince Alfred Hospital
    Verified postcode
    Camperdown, Australia· Not yet recruiting
  • Prince Charles Hospital
    Verified postcode
    Brisbane, Australia· Not yet recruiting
  • Austin Health
    Verified postcode
    Melbourne, Australia· Not yet recruiting
  • University of Calgary
    Verified postcode
    Calgary, Canada· Not yet recruiting
  • University of British Columbia
    Verified postcode
    Vancouver, Canada· Not yet recruiting
  • University College Dublin
    Verified postcode
    Dublin, Ireland· Not yet recruiting
  • Royal Brompton
    Verified postcode
    London, United Kingdom· Not yet recruiting

Common questions

What is Progressive Pulmonary Fibrosis (PPF)?

PPF is when existing scarring in the lungs, from conditions like certain autoimmune diseases, gets worse over time.

Will I receive new medication in this study?

No, this study is observational. It does not involve giving new or experimental medications. You will continue to receive your usual medical care.

What kind of tests will I have?

You'll have regular medical check-ups, lung function tests, special lung scans, and blood or other fluid samples collected over two years.

How long will I be involved in the study?

If you join, you will be followed by the study team for a total of two years.

Who is running this study?

This study is being run by a group of medical researchers aiming to improve our understanding of lung scarring conditions.

How to find out more

Fernando J Martinez, MD, MS

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "PRospective phenotypIng and Multi-omic Endotyping of Progres…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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