Diffuse Cutaneous Systemic Sclerosis research hub
20 indexed studies · 14 currently recruiting
- active not recruitingPHASE2
Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)
This study looks at a new drug, tulisokibart, for people with a lung condition called interstitial lung disease (ILD) linked to scleroderma. We want to see if it's safe and helps improve the condition.
United States · Argentina · Australia - active not recruitingNA
ILD: Health Outcomes in Remote Digital Monitoring Versus Usual Care
This study looks at whether checking your lung health at home with a smartphone or tablet app can help manage Interstitial Lung Disease (ILD). We'll compare this remote monitoring to usual care over 12 months to see how it affects your health.
United Kingdom - not yet recruiting
FIBRotic Interstitial Lung Disease With Nocturnal hypOXaemia and EXercise Induced desaTuRAtion
This study looks at how breathing during sleep or exercise affects people with lung fibrosis. We want to see if checking oxygen levels in these situations can help predict how their condition might change over time.
United Kingdom - recruiting
PRospective phenotypIng and Multi-omic Endotyping of Progressive Pulmonary Fibrosis
This study looks at people with certain types of lung scarring (fibrosis) that are getting worse. Researchers want to better understand why some lung conditions progress and how best to identify this progression early. It involves collecting health information, scans, and blood samples over two years.
United States · Australia · Canada - recruitingNA
Pilot Study of Nitrate-rich Beetroot Juice Supplementation in Patients With Idiopathic Pulmonary Fibrosis (IPF)
This study looks at whether nitrate-rich beetroot juice can help people with a lung condition called Idiopathic Pulmonary Fibrosis (IPF) breathe and exercise more easily. We want to see if it boosts their exercise ability and changes certain substances in their blood.
United Kingdom - recruitingPHASE3
Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
This study looks at a new inhaled medicine, called TPIP, for people with high blood pressure in the lungs due to scarring (PH-ILD). It wants to see if the medicine helps them walk further over 24 weeks compared to a dummy medicine.
United States · Argentina · Australia - active not recruiting
Deciphering Rheumatoid Arthritis-associated Interstitial Lung Disease Pathogenesis 2
This study looks into why some people with rheumatoid arthritis (RA) also get a lung condition called interstitial lung disease (ILD). Researchers want to understand the causes and how ILD progresses in RA patients to improve care.
France - not yet recruitingNA
NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases
This study compares different breathing support methods for people with severe lung scarring causing sudden breathing problems. It looks at how two types of oxygen therapy – non-invasive ventilation and high-flow oxygen – affect breathing, effort, and blood pressure to see which is best.
France - enrolling by invitationPHASE3
Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease
This study looks at the long-term effects of an inhaled medicine called treprostinil for people with certain lung scarring conditions like Idiopathic Pulmonary Fibrosis. It follows people who've already been part of similar studies to see how safe and helpful the treatment is over time.
United States · Argentina · Australia - recruitingNA
Evaluation of the Reproducibility of the Automated Measurement of the Extent of ILD on Chest CT
This study looks at how consistently automated tools measure lung damage in people with Interstitial Lung Disease (ILD) using CT scans. We want to see if these measurements are reliable by repeating scans and using different software to analyse them. This helps ensure we get accurate information about your condition.
France - recruiting
Assessing Functional Capacity in Directly and Remotely Monitored Home-based Settings: A Protocol for a Multinational Validation Study in Individuals With Chronic Respiratory Diseases
This study looks at a new step test for lung conditions like COPD. It checks if the step test is accurate, if it works well at home with remote support, and if it's safe. It compares the step test to other common exercise tests.
Canada · France - recruitingPHASE2
Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung Disease
This study looks at new ways to help people with lung cancer and a lung condition called Interstitial Lung Disease (ILD) who are having radiotherapy. It tests if two medicines, NAC and a short course of steroids, can reduce breathing problems after treatment.
Canada - recruitingPHASE2
Mycophenolate Mofetil in Systemic Sclerosis With Subclinical Interstitial Lung Disease
This study looks into using mycophenolate mofetil for systemic sclerosis patients with early lung problems. It aims to see if an earlier treatment can help prevent the lung condition from getting worse and test if a larger study is possible.
Canada - recruiting
Evaluation of HRCT Patterns in Systemic Sclerosis-associated Interstitial Lung Disease
This study looks at lung scans (HRCT) of people with a condition called Systemic Sclerosis (SSc). Many people with SSc also get lung problems (Interstitial Lung Disease or ILD). Researchers want to see if patterns on these scans can help understand how severe or quickly their ILD might progress.
France - not yet recruitingNA
Interpretation of the Role of Eosinophils in Diffuse Interstitial Pneumopathies
This study looks into how certain white blood cells, called eosinophils, might play a part in a group of lung diseases known as Interstitial Lung Disease (ILD). Researchers want to understand if these cells contribute to inflammation and scarring in the lungs, aiming to find new ways to treat these conditions.
France - recruiting
Cough therapy for interstitial lung disease
This study looks at a special type of physiotherapy, called Cough Control Therapy (CCT), for people with Interstitial Lung Disease (ILD) who have a lasting cough. It aims to see if CCT can help reduce coughing and improve their quality of life. Participants attend group sessions over 7 weeks.
United Kingdom · England - recruitingPHASE3
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
This study looks at an inhaled medicine called treprostinil for people with progressive pulmonary fibrosis. It aims to see if it's safe and effective in slowing down this lung condition over 52 weeks. Half get the medicine, half get a dummy treatment.
United States · Argentina · Australia - active not recruitingNA
Assessment of Precision Irradiation in Early NSCLC and Interstitial Lung Disease
This study looks at a special type of radiation (SABR) for early-stage lung cancer in people who also have a lung scarring condition (ILD). The goal is to see how well it works and if it's safe for this group, especially if surgery isn't an option.
Canada · United Kingdom - recruitingNA
Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE)
This study looks at how a self-guided online tool called SELF-BREATHE helps adults with long-term breathlessness. It aims to see if using this website improves their breathing and quality of life, and if it could be used more widely in the NHS.
United Kingdom - active not recruitingPHASE2
A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis
This study is testing a new inhaled medicine (AP01) for people with progressive pulmonary fibrosis. It aims to see if it's safe and effective, compared to a dummy medicine, over one year, alongside usual care.
United States · Argentina · Australia