Precision Medicine in the Prostate Cancer Care Pathway
This study is exploring a new genetic test designed for men affected by or at high risk of prostate cancer. The test examines a person's DNA to identify specific genetic changes, both rare and common, that might increase their chance of developing prostate cancer. Researchers want to see how this genetic information can make a real difference in how doctors assess a man's risk and manage his care. This includes looking at how it could influence decisions about regular check-ups (screening) and potential treatments, helping to create more personalised care plans based on a man's unique genetic profile. The overall goal is to make prostate cancer care more precise and effective for each individual.
At a glance
What is this study about?
Imagine being able to understand your own body's blueprint a little better, especially when it comes to something like prostate cancer. This study is all about a special genetic test that does just that for men. It looks at tiny parts of your DNA to find specific changes that might mean you have a higher chance of getting prostate cancer, or an aggressive form of it.
The main idea behind this research is to see if having this detailed genetic information can help doctors make better decisions about your care. For example, if the test shows you have certain genetic changes, it might mean you need to start screening for prostate cancer earlier, or have check-ups more often. It could also help doctors choose the best treatment for you if you're diagnosed with the disease.
Ultimately, this study aims to explore whether using these genetic insights can lead to more personalised and effective ways to prevent, detect, and treat prostate cancer. It's about moving towards 'precision medicine,' where treatments and care plans are tailored to you as an individual, rather than a one-size-fits-all approach.
Key takeaways
- The study looks at how genetic tests can personalise prostate cancer care.
- It aims to identify genetic changes linked to prostate cancer risk.
- The goal is better-tailored screening and treatment plans.
- Participation involves providing a DNA sample and discussing results.
- It's about understanding individual risk, not predicting certain outcomes.
Who may be eligible?
To join this study, you need to be a man between 30 and 70 years old. There are two main groups of men the study is looking for.
One group is for men who have already been diagnosed with prostate cancer. This includes men who were diagnosed before age 60, or men who have a more advanced type of prostate cancer (called metastatic castration-resistant prostate cancer) at any age. It also covers men with a more aggressive prostate cancer diagnosed before age 70. Another part of this group is for men who have a strong family history, meaning three or more close relatives (like a father, brother, or son) have had prostate cancer.
The study previously looked for healthy men with a strong family history of prostate cancer, but that part of the study has finished recruiting. However, for everyone, you must be well enough to carry out most of your daily activities without much trouble.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you a man aged between 30 and 70?
- Do you currently have prostate cancer, or did you have it before age 60?
- Do you have advanced prostate cancer (mCRPC) at any age?
- Do you have aggressive prostate cancer diagnosed before age 70?
- Do you have 3 or more close male relatives (father, brother, son) who have had prostate cancer?
- Are you generally well enough to do most of your daily activities?
What does participation involve?
The study involves a genetic test, which means you'll provide a DNA sample, likely from a simple blood test or saliva sample. Researchers will then analyse this sample to look for specific genetic changes related to prostate cancer. You won't need to take any new medications as part of this study, and there aren't any specific treatments being tested on you. The main focus is on providing information to you and your doctor to guide existing care.
While the study doesn't specify how many visits or how long your follow-up will be, it will involve discussing the genetic test results with your healthcare team. This will help them understand how the information might affect your risk assessment and any future screening or treatment plans. You will also be asked to share how you felt about receiving this genetic information and how it influenced your decisions.
Potential risks and benefits
Locations (1)
- Royal Marsden Hosital,Verified postcodeSutton, United Kingdom· Recruiting
Common questions
What is 'precision medicine'?
Precision medicine means tailoring medical care, like treatments and screenings, specifically to you based on your individual characteristics, including your genetics.
Will this test tell me for sure if I will get prostate cancer?
No, this test aims to show your personal risk, not a certainty. It provides information that helps you and your doctor understand your chances better.
Is this genetic test available to everyone?
This study is evaluating the test. It's not yet a standard test widely available to everyone. Participating helps contribute to understanding its usefulness.
What happens if the test shows I have a high risk?
If the test shows a higher risk, your doctor can discuss personalised screening plans or other ways to manage that risk with you.
Who will see my genetic information?
Your genetic information will be used for research by the study team, and relevant results will be shared with you and your doctor to help with your care.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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