- recruitingPHASE3
Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC
This study is looking at a new treatment called AAA817, combined with standard prostate cancer drugs, for men with advanced prostate cancer. It compares this new combination to existing treatments to see which works best at slowing the cancer's growth.
United States · Australia · Brazil - recruitingPHASE1
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
This early-stage study is testing a new drug, MOMA-313, for advanced solid tumours, including prostate, breast, and pancreatic cancers. It aims to find a safe dose and see how it works, either alone or with another drug called Olaparib, in patients whose tumours have a specific genetic weakness.
United States · Spain · United Kingdom - recruiting
The i4i PRODICT® Study: Evaluation of the i4i PRODICT® Test in Different Ethnic Groups (The i4i PRODICT® Study).
This study looks at a new saliva test, called i4i PRODICT®, to predict prostate cancer risk in men aged 40-55 from different ethnic backgrounds. It aims to see how well men accept and use this test.
United Kingdom - recruitingNA
Imperial Prostate 7 - Prostate Assessment Using Comparative Interventions - Fast Mri and Image-fusion for Cancer
This study looks at new ways to find prostate cancer using MRI scans and biopsies. Researchers want to see if a shorter, simpler MRI is as good as the usual one, and if guiding biopsies with a computer is better than relying on a doctor’s eye.
United Kingdom - recruiting
Precision Medicine in the Prostate Cancer Care Pathway
This study looks at a special genetic test for prostate cancer. It helps men understand their personal risk and how this information can guide decisions about screening and treatment. The aim is to use genetic insights for more tailored prostate cancer care.
United Kingdom - active not recruitingPHASE1
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer
This study is testing a new cancer medicine, botensilimab, sometimes with another drug, balstilimab. It's for people with advanced cancers that haven't responded to other treatments. Doctors want to see if it's safe, how it works, and find the best dose.
United States · United Kingdom - recruitingPHASE2
TherApeutics in Early ProState Cancer (TAPS02)
This study is looking at a new way to treat early prostate cancer. It tests a drug called apalutamide (Erleada) in men who are already under careful watch for their cancer. We want to see if this short-term treatment can help.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
PSMA PET For intermediate- or high-risk prostate cancer prior to RadioTherapY: A prospective interventional randomized clinical trial (P4RTY)
This study looks at a special scan called PSMA PET for men with prostate cancer before radiotherapy. It aims to see if this scan helps manage their cancer better and improves their health over time compared to standard care.
Germany - recruiting
International Registry for Men With Advanced Prostate Cancer (IRONMAN)
This study, called IRONMAN, is collecting information from men with advanced prostate cancer across many countries, including the UK. It aims to understand treatments, how they vary, and what helps men live longer and have a better quality of life.
United States · Australia · Barbados - recruiting
In Vivo Dosimetry for Brachytherapy Study
This study looks at using tiny devices to check radiation doses during brachytherapy for prostate or gynaecological cancer. The devices ensure patients receive the correct, planned amount of radiation inside their bodies, helping to make treatment safer and more effective.
United Kingdom - recruitingPHASE3
Evaluating Hormone Therapy to Achieve Optimal Doses in Metastatic Prostate Cancer
This study looks at treating advanced prostate cancer with hormone tablets. Researchers want to see if a lower dose works as well as the standard dose, with fewer side effects like tiredness. It aims to improve quality of life for patients.
United Kingdom - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - authorisedPhase I and Phase II (Integrated)- Other
Clinical Application of the Androgen Receptor Inhibitor Darolutamide to Upregulate the Prostate-Specific Membrane Antigen (PSMA) Protein Expression in Patients with Hormone Sensitive Prostate Cancer. - The DARO-flare Trial -
This study, called DARO-flare, explores if a drug for advanced prostate cancer, NUBEQA, can help doctors see the cancer more clearly on special scans. This might help find and treat the cancer more effectively in men with early-stage prostate cancer.
Netherlands - enrolling by invitation
Prophylactic Prostatectomy for Prostate Cancer (PPPC)
This study is gathering opinions about a possible operation called a prophylactic prostatectomy. This operation might reduce prostate cancer risk in men with high genetic risk. We want to understand if men would consider this surgery and what their concerns would be.
United Kingdom - active not recruitingNA
Evaluating the Effects of Frozen Section Technology on Oncological and Functional Outcomes at Radical Prostatectomy.
This study looks at a new surgical approach for prostate cancer called NeuroSAFE. It aims to see if this method can make surgery safer, more effective, and improve quality of life for men compared to standard robotic surgery, especially regarding issues like urine control and sexual function.
United Kingdom - active not recruitingPHASE3
Phase III Radium 223 mCRPC-PEACE III
This study is looking at whether using two treatments, Ra223 and enzalutamide, together works better than enzalutamide alone for men with prostate cancer that has spread to their bones. Doctors want to see if this combination can stop the cancer from growing for longer.
Belgium · Brazil · Canada - not yet recruitingNA
Comparing pOrtable MRI and TRUS-Fusion Prostate Biopsy to Assess aCcuracy of Prostate Cancer Detection
This study compares a new, portable MRI-guided biopsy for prostate cancer with the current standard method. It aims to see if the portable MRI is just as good, or better, at finding cancer and if it can make the process simpler for patients.
United Kingdom - recruitingNA
The Remote Study: Investigating the Effects or Online Exercise on Quality of Life in Men With Prostate Cancer
This study looks at how online exercise coaching can improve the well-being of men with prostate cancer who are on long-term hormone therapy. It's an 8-week programme using virtual sessions to see if this approach is helpful and can be offered more widely.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to assess how radium-223 moves through the patients with prostate cancer receiving radium-223 dichloride treatment.
This study looks at how a medicine called radium-223 moves through the bodies of men with prostate cancer who are receiving this treatment. It helps doctors understand how the drug works and is processed by the body.
Austria · Italy · Lithuania - active not recruitingPHASE2
Artificial Intelligence Supporting CAncer Patients Across Europe - the ASCAPE Project
This study uses AI to improve life quality for breast and prostate cancer patients across Europe. It aims to create personalised predictions about challenges patients might face and suggest ways doctors can help, using smart technology and data.
Greece · Spain · Sweden - recruitingPHASE1, PHASE2
Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer
This study looks at a new drug combination, Gedatolisib and Darolutamide, for men with prostate cancer that has spread and is no longer responding to standard hormone therapy. It helps work out the best dose and how well it works.
United States · France · Spain - recruitingPHASE1, PHASE2
A Study to Learn How Safe AZD6621 is, How Well it Works, and How it Moves Throughout the Body Over Time, in Adult Male Participants With Metastatic Prostate Cancer
This study is looking at a new treatment called AZD6621 for men with prostate cancer that has spread. It aims to find out how safe the treatment is, how well it works, and how it moves through the body.
United States · Belgium · Canada - recruitingPHASE3
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
This study is testing a new medicine, ifinatamab deruxtecan (I-DXd), for men with advanced prostate cancer that has spread and isn't responding to hormone therapy. We want to see if I-DXd helps men live longer and keeps their cancer from growing compared to standard chemotherapy.
United States · Argentina · Australia - recruitingPHASE2
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
This study looks at a new injection, ASP5541, for advanced prostate cancer that has spread. It compares ASP5541 to a standard tablet treatment, abiraterone acetate, to see how safe and effective it is.
United States · China · France - recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium - recruitingNA
A Study to Evaluate the Performance of Confocal Microscopy to Detect Positive Margins During Radical Prostatectomy
This study tests a new method, LaserSAFE, to find cancer at the edge of the prostate during surgery. This helps surgeons decide if they can save important nerves, especially for men usually not offered this option. It aims to improve surgical decisions and help men recover better.
United Kingdom - active not recruitingNA
Prostate Imaging Using MRI +/- Contrast Enhancement
This study compares different MRI scans for prostate cancer. We want to see if a shorter, simpler MRI without a special dye injection (biparametric MRI) works as well as the standard MRI with the dye (multiparametric MRI) in finding important prostate cancers.
United States · Argentina · Australia - recruitingNA
Hypofractionated Expedited Radiotherapy for Men With localisEd proState Cancer
This study compares different ways to treat prostate cancer with targeted X-ray therapy. We're looking at whether 2 treatments or 5 treatments work best using a special machine that helps us aim precisely. The goal is to find a shorter, equally safe treatment.
United Kingdom - active not recruitingPHASE3
Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)
This study compares two treatments for advanced prostate cancer that has spread and no longer responds to hormone therapy. It tests if adding a new drug, capivasertib, to standard chemotherapy (docetaxel) works better than chemotherapy alone to help patients live longer and keep the cancer from growing.
United States · Australia · Belgium - recruiting
The PROFILE Study: Germline Genetic Profiling: Correlation With Targeted Prostate Cancer Screening and Treatment
This study, called PROFILE, explores prostate cancer risk in men. It looks at how family history, ethnicity, and genetics might increase the chance of getting prostate cancer, hoping to find better early detection methods.
United Kingdom - active not recruitingPHASE3
Prostate Advances in Comparative Evidence
This study looks at different ways to treat prostate cancer, comparing surgery with different types of radiotherapy. It aims to find out which treatments work best for different people, have fewer side effects, and improve quality of life.
Canada · Ireland · New Zealand - recruiting
The Active Surveillance Study
This study looks at men with prostate cancer on Active Surveillance to see how genetics and body markers might affect their cancer. It compares men with and without a higher genetic risk to understand how their cancer changes over time.
United Kingdom - recruiting
The PROSECCA Study, Answering New Questions in Prostate Cancer
This study uses AI to look at health records of prostate cancer patients. We want to find out how to make radiotherapy better and reduce side effects by personalising treatment for each person, especially those at higher risk of problems.
United Kingdom - recruiting
Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations
This study looks at how prostate cancer affects men with certain rare gene changes, like BRCA1 or BRCA2. Researchers compare their treatment results to men without these gene changes to understand how these genes impact the disease and find better ways to manage it.
United Kingdom - recruitingPHASE1, PHASE2
A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs
This study is looking at a new medicine called AZD9750 for men with prostate cancer that has spread. We want to find out if it's safe, how well it works alone, and how it works when given with another cancer drug.
United States · Australia · Canada - ongoing, recruitingTherapeutic exploratory (Phase II)
Lutetium-177-PSMA in Oligo-metastatic Hormone Sensitive Prostate Cancer.
This study is looking at a new treatment called Lutetium-177-PSMA for men with prostate cancer that hasn't spread widely and is sensitive to hormone therapy. It aims to see if this treatment can slow down the cancer's growth.
Cyprus · Netherlands - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - active not recruiting
The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer
The IMPACT study checks men with certain inherited gene changes (BRCA1, BRCA2, or Mismatch Repair genes) for prostate cancer. It also includes men without these changes. Researchers want to see if these gene changes increase prostate cancer risk and if screening helps.
United Kingdom - recruiting
Patient and Provider Perspectives on Genetic Risk Profiling
This study wants to understand what patients and doctors think about using genetic tests to check prostate cancer risk. It aims to see how useful these tests are in everyday healthcare and what benefits or concerns people have.
United Kingdom - active not recruitingPHASE3
Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC
This study is for men with a certain type of advanced prostate cancer (mCSPC) that has spread and has specific gene changes. It compares a new drug called talazoparib, given with standard treatment enzalutamide, against enzalutamide alone, to see if it's safe and effective.
United States · Argentina · Australia - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - active not recruitingPHASE3
A Study of Apalutamide (JNJ-56021927, ARN-509) Plus Androgen Deprivation Therapy (ADT) Versus ADT in Participants With mHSPC
This study looks at adding a new drug, Apalutamide, to standard hormone therapy for men with prostate cancer that has spread. We want to see if this combination helps patients live longer or keeps their cancer from getting worse.
United States · Argentina · Australia - recruitingPHASE3
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
This study looks at a new drug, mevrometostat, combined with enzalutamide for men with prostate cancer that has spread. It compares this combination to enzalutamide alone, to see if it works better for those not yet treated with specific hormone therapies.
United States · Argentina · Australia - active not recruitingPHASE2
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
This study is for men with prostate cancer who are already taking enzalutamide as part of another research study. It aims to gather more information on the long-term safety of enzalutamide when it's helping them. Participants will continue their current treatment and have regular check-ups.
United States · Argentina · Australia - recruitingPHASE4
Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer
This study is looking into the long-term safety of a treatment called AAA617 for prostate cancer. It follows people who've already received AAA617 in previous research studies to see how they're doing over time and to learn more about any potential delayed side effects.
United States · Austria · Belgium - active not recruitingPHASE2, PHASE3
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy
This study, called STAMPEDE, looks for better ways to treat prostate cancer that is spreading or has a high chance of spreading. It tests new treatments against standard ones to help men live longer and have a better quality of life.
Switzerland · United Kingdom - not yet recruitingNA
Resistance Exercise, IL-7 and Immune Phenotypes in Prostate Cancer
This study looks at whether strength training can help men with prostate cancer on hormone therapy. It investigates if exercise can prevent muscle loss, boost immune cells, and improve quality of life, which often suffer during treatment.
United Kingdom - active not recruitingPHASE2
Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
This study is testing a new drug, PF-07220060, for people with advanced cancers like breast, prostate, and lung cancer. Researchers want to see if it's safe and how it works, both by itself and with other cancer medicines.
United States · Argentina · China - recruitingPHASE3
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
This study is looking at a new drug, Saruparib, for men with high-risk prostate cancer and a faulty BRCA gene. It aims to see if adding Saruparib to standard treatments can help prevent the cancer from spreading.
United States · Argentina · Australia - active not recruitingPHASE2
Effects of EPA in Men With Biochemical Recurrence or Progression of Prostate Cancer.
This study looks at whether a special omega-3 supplement (MAG-EPA) can help men whose prostate cancer has started to come back after treatment. It aims to see if this supplement can delay the need for other treatments that might have side effects.
Canada