- recruitingNA
Detection of ISUP≥2 Prostate Cancers Using Multiparametric MRI: Prospective Multicenter Comparison of the PI-RADS Score and an Artificial Intelligence System
This study is testing a new artificial intelligence (AI) system to better detect important prostate cancers using MRI scans. It aims to see if this AI helps doctors find these cancers more reliably and consistently than current methods, especially in real-world settings across different hospitals.
France - recruitingNA
Using Rectal Hydrogel Spacer for Salvage SABR in Prostate Cancer
This study is looking at a gel spacer to protect the bowel during a new type of strong radiation (SABR) for prostate cancer that has come back. It aims to reduce side effects and improve comfort for patients.
Canada - recruitingNA
Evaluating the Effectiveness of the Nurse Ned Clinic
This study looks at a new way to help men who have had prostate cancer. It compares usual care with a new 'Nurse Ned Clinic' run by specialist nurses. The aim is to see if this new clinic can improve how we look after prostate cancer survivors.
Canada - recruitingNA
Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing
This study looks at a new digital tool called GA-Mainstream. It helps people with certain cancers like breast, ovarian, and colon cancer understand genetic testing better. The goal is to make sure patients feel informed and supported while getting tested for genes that can affect their cancer treatment.
Canada - recruitingNA
Needle Localization During Prostate Brachytherapy Using Power Doppler Ultrasound
This study is looking at a new way to guide needles during prostate brachytherapy for prostate cancer. Researchers will use a special ultrasound to see if a vibrating needle can make it easier to place treatment accurately, aiming to improve how this therapy is given.
Canada - active not recruiting
Validation of ClarityDX Prostate as a Reflex Test to Refine the Prediction of Clinically-significant Prostate Cancer
This study is looking at a new blood test called ClarityDX Prostate. It aims to see how well this test can predict serious prostate cancer in men who are having a prostate biopsy because of raised PSA levels.
United States · Canada - recruitingPHASE1
Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer
This study is looking at a new drug, xaluritamig, for men with prostate cancer that hasn't spread. We want to see if it's safe to give before surgery, either alone or with another common prostate cancer medicine, and how well surgery goes afterwards.
United States · Germany - active not recruitingPHASE2, PHASE3
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy
This study, called STAMPEDE, looks for better ways to treat prostate cancer that is spreading or has a high chance of spreading. It tests new treatments against standard ones to help men live longer and have a better quality of life.
Switzerland · United Kingdom - recruitingNA
Imperial Prostate 9 - ATLAS (Approaches To Long-Term Active Surveillance)
This study compares regular MRI scans with the usual care for men with early prostate cancer who are on 'active surveillance'. It aims to see if MRI is better at spotting cancer changes, potentially reducing the need for biopsies and clinic visits, improving monitoring.
United Kingdom - recruitingPHASE4
Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer
This study is looking into the long-term safety of a treatment called AAA617 for prostate cancer. It follows people who've already received AAA617 in previous research studies to see how they're doing over time and to learn more about any potential delayed side effects.
United States · Austria · Belgium - not yet recruitingPHASE2
Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
This study looks at using heat treatment (hyperthermia) with repeat radiation therapy for certain cancers that have come back after earlier radiation. It checks if this combined approach works as well as the first treatment for preventing the cancer from returning locally.
Germany - enrolling by invitation
Long-Term Follow-Up of AvenCell Sponsored CAR-T Cell Clinical Trials
This study looks at the long-term effects of AvenCell's CAR-T cell treatments for blood cancers like lymphoma and leukemia, and also prostate cancer. It checks how safe and effective these treatments are over time for people who've already had them in past AvenCell trials.
Germany - recruiting
Liquid Biopsy Under PSMA Radioligand Therapy
This study looks at prostate cancer that has spread and no longer responds to hormone therapy. We're using 'liquid biopsies' (blood tests) during a special treatment called PSMA-RLT to understand why the treatment sometimes stops working and to find better ways to check how well it's performing.
Germany - active not recruitingPHASE2, PHASE3
A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer
This study is looking at a new combination of medicines, abemaciclib, abiraterone acetate, and prednisone, for men with advanced prostate cancer that has spread. It aims to see if adding abemaciclib is safe and effective in treating their cancer.
United States · Australia · China - active not recruitingPHASE3
A Study of Apalutamide (JNJ-56021927, ARN-509) Plus Androgen Deprivation Therapy (ADT) Versus ADT in Participants With mHSPC
This study looks at adding a new drug, Apalutamide, to standard hormone therapy for men with prostate cancer that has spread. We want to see if this combination helps patients live longer or keeps their cancer from getting worse.
United States · Argentina · Australia - recruitingPHASE3
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
This study is testing a new medicine, ifinatamab deruxtecan (I-DXd), for men with advanced prostate cancer that has spread and isn't responding to hormone therapy. We want to see if I-DXd helps men live longer and keeps their cancer from growing compared to standard chemotherapy.
United States · Argentina · Australia - active not recruitingNA
Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer
This study looks at how well a product called SpaceOAR Vue helps men with prostate cancer. It aims to reduce gut problems when they have a type of radiation treatment called SBRT, by putting a special gel between the prostate and bowel.
United States · Australia · France - recruiting
Microbiome Molecular Charaterisation
This study looks at how tiny germs in our gut might affect prostate cancer and its treatments. Researchers want to understand if these germs can help predict how well treatments work or cause side effects, hoping to find new ways to improve care.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
CYPENZA - A prospective cohort trial on antiandrogens influences on the pharmacokinetics of corticosteroids.
This study looks at how medicines for prostate cancer (antiandrogens like enzalutamide or apalutamide) might change how a steroid medicine (dexamethasone) works in the body. We want to see if these cancer drugs affect the amount of dexamethasone in your blood.
Sweden - active not recruiting
The BARCODE 1 Pilot Study
This study looks at whether checking genes can help find men at higher risk of prostate cancer, so they can be offered special screening. It starts with 300 men to see if this genetic test works well for guiding check-ups.
United Kingdom - recruitingPHASE1, PHASE2
Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection
This study is testing a new treatment for advanced prostate cancer that has spread and isn't responding to usual hormone therapy. It's called 177Lu-rhPSMA-10.1 and uses radiation to target cancer cells. We want to see how safe and effective it is.
United States · Belgium · Germany - recruitingNA
Clinical Utility of ClarityDX Prostate
This study looks at a new tool called ClarityDX Prostate. It helps doctors decide if men with prostate cancer concerns might need more tests like scans or biopsies. The goal is to avoid unnecessary procedures while finding serious cancers quickly.
Canada - active not recruiting
UK Genetic Prostate Cancer Study: Epidemiology and Molecular Genetics Studies
This study looks for genetic changes linked to prostate cancer. We're especially interested in men diagnosed young or with family history, but also include older men. We want to understand why some men get prostate cancer, hoping to improve future detection and treatment.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
Diagnostic Performance of Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) Imaging for Pre-operative Lymph Node Assessment in Intermediate and High-risk Nonmetastasic Prostate Cancer
This study looks at a special type of scan called a PET-PSMA scan to see how well it finds cancer in lymph nodes for men with prostate cancer. It helps doctors decide the best treatment, especially before surgery.
France - active not recruitingNA
Impact of Radical Prostatectomy as Primary Treatment in Patients With Prostate Cancer With Limited Bone Metastases
This study looks at whether surgery (radical prostatectomy) for prostate cancer, even when it has spread a little to the bones, can help men live longer, stop the cancer from getting worse, and improve their quality of life compared to standard drug treatments alone.
Germany - recruiting
The GENPET Study - An Imaging Study of FCH-PET-CT in Men With Prostate Cancer and a DNA Repair Gene Mutation.
This study looks at new ways to scan for prostate cancer in men with specific gene changes. We compare standard scans with a special PET-CT scan to see which is better at finding if the cancer has spread beyond the prostate.
United Kingdom - recruitingNA
Diagnostic Performance of PSMA PET/CT for Pre-operative Lymph Node Assessment in Intermediate and High-risk Non-metastasic Prostate Cancer (PREOP-PSMA ).
This study is looking at a new type of scan called PSMA PET/CT for men with prostate cancer that hasn't spread far. It helps doctors see if the cancer has spread to nearby lymph nodes before surgery, aiming to improve treatment planning.
France - recruiting
Chronic Radiation Induced Bowel Toxicity Study
This study looks at how radiotherapy for prostate cancer affects the helpful germs in the gut. Researchers want to see if these germs change during treatment and if this is linked to gut problems. They will collect samples like poo and blood, and ask about diet.
United Kingdom - recruitingPHASE1
First-in-human Study of OVM-200 as a Therapeutic Cancer Vaccine
This study is testing a new cancer medicine, OVM-200, for the first time in people. It involves up to 52 patients with prostate, lung, or ovarian cancer to check if it's safe and how well it works. It's given as an injection under the skin.
United Kingdom - recruiting
ART-Pro: Clinical Trial Evaluating Biparametric MRI and Advanced, Quantitative Diffusion MRI for Detection of Prostate Cancer
This study is looking at new types of MRI scans for prostate cancer. We want to see if these new scans can find important cancers better and more easily than current methods, without needing injections or highly experienced doctors to read them.
United States · United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Open-label Study to Test the Diagnostic Performance of Copper Cu 64 PSMA I&T PET/CT in Staging of Men with Newly Diagnosed Unfavorable Intermediate-risk, High-risk or Very High-risk Prostate Cancer Electing to Undergo Radical Prostatectomy with Pelvic Lymph Node Dissection
This study is looking at a special scan called a PET/CT with copper-64 PSMA. It aims to see how well this scan can find prostate cancer that has spread to nearby lymph nodes in men about to have surgery. This could help doctors better understand the cancer's stage.
France · Spain · Italy - not yet recruiting
Identifying the Best Follow up Approach for People Who Have Had Treatment to Cure Newly Diagnosed Prostate Cancer
This study looks at the best way for men to have check-ups after prostate cancer treatment. It compares hospital, GP, shared care, and self-managed check-ups to find the safest and most cost-effective approach for the NHS and patients.
United Kingdom - active not recruitingNA
Stereotactic MRI-guided Radiation Therapy for Localized prostatE Cancer
This study looks at a new, faster way to treat prostate cancer using special MRI-guided radiation. Instead of many weeks, treatment might only take five sessions, making it quicker and potentially easier for patients.
Germany - active not recruitingNA
Improving Quality of Life After Prostate Brachytherapy: a Comparison of HDR and LDR Brachytherapy
This study compares two types of prostate cancer radiation therapy, HDR and LDR brachytherapy, to see which one works better to control cancer and improve quality of life. It aims to find out if one treatment causes fewer side effects and helps men feel better overall.
Canada - not yet recruitingNA
Prostate Cancer Early Detection Using Serial MRI Examinations
This study looks at a new way to detect prostate cancer early. Instead of just one MRI, doctors will check changes in MRI scans over time. The goal is to reduce unnecessary biopsies and avoid over-treating cancers that might not need it.
France - not yet recruitingPHASE2
Adaptive Versus Non-adaptive Radiotherapy and 2 Bladder Filling Instructions for Patients with Intermediate or High Risk Localized Prostate Cancer (ARP)
This study looks at two ways to give radiotherapy for prostate cancer: standard or daily adjusted. We're also testing different advice for bladder filling. The goal is to see which methods cause fewer side effects and work best for men with prostate cancer.
Canada - recruitingPhase I
A study of JNJ-78278343 in combination with JNJ-95298177 for treatment of prostate cancer
This study is testing two new medicines, JNJ-78278343 and JNJ-95298177, together for advanced prostate cancer. Researchers want to find the safest and most effective dose in men whose cancer has spread and is no longer responding well to standard hormone treatments.
United Kingdom · England · United States of America - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - recruiting
Trial of Randomised Approaches for National Screening FOR Men (TRANSFORM)
The TRANSFORM study is looking for the best way to screen men for prostate cancer. Since there's no national screening programme yet, this study aims to find a safe and effective way to detect prostate cancer early, improving treatment chances and saving lives across the UK.
United Kingdom · England - recruiting
A study to investigate using contrast-enhanced ultrasound during focal therapy for prostate cancer
This study looks at using a special ultrasound during prostate cancer treatment. It aims to help surgeons see and treat any remaining cancer straight away. This could improve how well focal therapy works for prostate cancer.
United Kingdom - active not recruitingPHASE2
ODM-201 vs Androgen Deprivation Therapy in Hormone naïve Prostate Cancer
This study compares a new drug, ODM-201, with standard hormone therapy (ADT) for men with prostate cancer. We want to see if ODM-201 can lower a specific blood marker (PSA) just as well as ADT, with potentially fewer side effects.
Belgium · France · Italy - recruitingPHASE1
A Study to Investigate the Biological Effects of Saruparib (AZD5305), Darolutamide, and in Combination in Men With Newly Diagnosed Prostate Cancer.
This study looks at new treatments, Saruparib and Darolutamide, for men recently diagnosed with prostate cancer before surgery. Researchers want to understand how these drugs affect the cancer, either alone or when used together.
United States · Australia · Canada - recruiting
LIVInG With chrONic Cancer TrEatments (LONGEVITI) Study
This study looks at how new cancer treatments affect daily life for people with long-term cancer. It aims to understand how to best support them while they are on these treatments, often for many months or years.
Canada - recruitingNA
Assessing a Digital Exercise Intervention for Health Outcomes and Engagement in Regular Exercise
This study looks at a digital exercise programme for men with prostate cancer on hormone therapy. It aims to see if online group exercise can help them stick to exercise and improve health, reducing side effects from their treatment.
United Kingdom - active not recruitingPHASE3
Androgen-Deprivation Therapy and Radiation Therapy in Treating Patients With Prostate Cancer
This study looks at different ways to treat prostate cancer using a combination of hormone therapy and radiation. Doctors want to see if a certain type of radiation, along with hormone therapy, helps patients live longer and better.
United States · Canada · Hong Kong - recruitingPHASE2
Postop Hypofractionated Radiation Therapy and LHRH in Patients With Prostate Cancer
This study looks at a new way to treat prostate cancer after surgery using a shorter course of radiotherapy and hormone therapy. It aims to see how safe and effective this combined treatment is for men whose cancer had a higher chance of coming back after their operation.
Canada - active not recruitingNA
Focal Salvage HDR Brachytherapy for the Treatment of Prostate Cancer
This study looks at a new way to treat prostate cancer that has come back only in the prostate after previous treatment. It uses targeted radiation seeds to treat just the affected area, hoping to reduce side effects compared to treating the whole prostate.
Canada - not yet recruitingPHASE2
Study of Radiation Therapy in Combination With Darolutamide + Degarelix in Intermediate Risk Prostate Cancer
This study looks at treating intermediate-risk prostate cancer with radiation and a new hormone therapy. It aims to see if adding the hormone therapy package (darolutamide + degarelix) works better than radiation alone, especially for certain men.
Canada - active not recruitingNA
A Comparison of TULSA Procedure vs. Radical Prostatectomy in Participants With Localized Prostate Cancer
This study compares two treatments for prostate cancer: standard surgery (radical prostatectomy) and a new, less invasive treatment called the TULSA procedure. It aims to see if TULSA is as good at treating cancer but causes fewer side effects, like problems with bladder control or sexual function.
United States · Canada · Finland - active not recruitingNA
Evaluation of Late Toxicity Following Intensity-Modulated Radiotherapy and Two Image-Guided Strategies With Corresponding Treatment Margins.
This study looks at a new way to give radiation therapy for prostate cancer using tiny implants. It aims to see if this method reduces side effects compared to standard treatment, by guiding the radiation more accurately.
France