- recruitingPHASE3
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
This study is looking at a new drug, Saruparib, for men with high-risk prostate cancer and a faulty BRCA gene. It aims to see if adding Saruparib to standard treatments can help prevent the cancer from spreading.
United States · Argentina · Australia - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - recruitingPHASE3
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
This study is testing a new medicine, ifinatamab deruxtecan (I-DXd), for men with advanced prostate cancer that has spread and isn't responding to hormone therapy. We want to see if I-DXd helps men live longer and keeps their cancer from growing compared to standard chemotherapy.
United States · Argentina · Australia - recruitingPHASE2
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
This study is for men with prostate cancer who are already taking enzalutamide as part of another research study. It aims to gather more information on the long-term safety of enzalutamide when it's helping them. Participants will continue their current treatment and have regular check-ups.
United States · Argentina · Australia - recruitingNA
Molecular Imaging Informed Radiation Dose Escalation to Sites of Recurrent Disease and De-escalation to Uninvolved Areas in Salvage Radiotherapy for Prostate Cancer
This study looks at a new way to give radiation treatment for prostate cancer that has come back after surgery. It uses special scans to guide the radiation, giving more to the cancer and less to healthy areas.
Canada - recruitingPHASE3
Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment
This study compares a new, shorter radiation treatment for prostate cancer with the usual treatment. It checks if the new method, using high-dose radiation in fewer sessions, works as well as the standard approach which combines external radiation with tiny radioactive seeds placed inside the prostate.
United States · Canada - active not recruitingPHASE2
177 LuPSMA-617 vs Docetaxel in Metastatic Castration Resistant and PSMA-Positive Prostate Cancer
This study compares a new treatment, 177Lu-PSMA-617, with standard chemotherapy (docetaxel) for men with advanced prostate cancer that has spread and no longer responds to hormone therapy. It aims to see if the new treatment can better slow cancer growth.
Canada - recruitingNA
Ultra Hypofractionnated Radiotherapy With HDR Brachytherapy Boost.
This study compares different ways of giving radiation therapy for prostate cancer. It looks at how well a faster, more focused type of radiation, called ultra-hypofractionated therapy, works compared to a slightly longer version, both combined with internal radiation (brachytherapy), focusing on side effects.
Canada - active not recruitingPHASE2, PHASE3
PSMA-PET Guided Radiotherapy
This study looks at whether using a special type of scan, called PSMA-PET, before radiotherapy for prostate cancer can improve treatment results. PSMA-PET is better at finding cancer spread than standard scans, and we want to see if using this information helps cure more patients.
Canada - not yet recruitingPHASE2
Focal Versus Whole Gland High Dose-Rate Brachytherapy (HDR-BT) Boost to External Beam Radiotherapy in Localized Prostate Cancer: A Phase 2 Randomized Trial
This study looks at a new way to treat prostate cancer using a targeted radiation boost. It compares focusing the radiation on just the cancer area versus treating the whole prostate, to see if the new method causes fewer urinary problems.
Canada - active not recruitingNA
Stereotactic Body Radiotherapy (SBRT) Post Prostatectomy
This study is looking at a new type of powerful, focused radiotherapy called SBRT for men who have had surgery for prostate cancer. We want to see if it's as safe and effective as standard radiotherapy, but with fewer treatment sessions.
Canada - recruitingEARLY_PHASE1
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
This study looks at whether apple cider vinegar can increase beneficial gut bacteria in men with prostate cancer starting hormone therapy. Researchers want to see if this helps reduce side effects like weight gain and diabetes, which can be linked to their treatment.
Canada - active not recruiting
PSMA PET/CT for Assessment of Recurrent Prostate Cancer
This study uses a special scan called PSMA PET/CT to find prostate cancer that has returned. It helps doctors see where the cancer is more clearly, especially when other scans aren't sure. This can help guide treatment decisions.
Canada - active not recruitingPHASE2
Effects of EPA in Men With Biochemical Recurrence or Progression of Prostate Cancer.
This study looks at whether a special omega-3 supplement (MAG-EPA) can help men whose prostate cancer has started to come back after treatment. It aims to see if this supplement can delay the need for other treatments that might have side effects.
Canada - recruitingPHASE2
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
This study looks at a new injection, ASP5541, for advanced prostate cancer that has spread. It compares ASP5541 to a standard tablet treatment, abiraterone acetate, to see how safe and effective it is.
United States · China · France - active not recruitingPHASE1
[Ac-225]-PSMA-62 Trial in Oligometastatic Hormone Sensitive and Metastatic Castration Resistant Prostate Cancer
This study is testing a new treatment, [Ac-225]-PSMA-62, for advanced prostate cancer. It aims to find the safest and most effective dose, and see how well it works in men whose cancer has spread or returned.
Canada - not yet recruiting
Ultrahypofractionated, Adaptive Radiation Therapy of Prostate Cancer
This study looks at a new way to give radiation treatment for prostate cancer, called ultrahypofractionated radiotherapy. It uses a smart machine to adjust treatment daily, aiming to be gentler and improve quality of life.
Germany - active not recruitingPHASE2
Effects of EPA on Prostate Cancer Cells Proliferation and Quality of Life
This study is looking at how a fish oil supplement (EPA) might affect prostate cancer and a man's well-being. It aims to see if EPA can slow cancer cell growth and improve how people feel, especially their mood and quality of life.
Canada - recruiting
Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS)
This study is looking at a new way to give radiotherapy using a special machine called ETHOS. It aims to make radiotherapy more accurate by adjusting treatment daily for cancers like prostate or head and neck, potentially improving how well it works and reducing side effects.
Germany - recruitingNA
Prostate Cancer Patients Treated With Alternative Radiation Oncology Strategies
This study looks at different ways to give radiation therapy for prostate cancer after surgery. Researchers want to see if a shorter, more focused type of radiation, especially with protons, improves quality of life by reducing side effects.
Germany - recruitingNA
Detection of ISUP≥2 Prostate Cancers Using Multiparametric MRI: Prospective Multicenter Comparison of the PI-RADS Score and an Artificial Intelligence System
This study is testing a new artificial intelligence (AI) system to better detect important prostate cancers using MRI scans. It aims to see if this AI helps doctors find these cancers more reliably and consistently than current methods, especially in real-world settings across different hospitals.
France - recruitingNA
Using Rectal Hydrogel Spacer for Salvage SABR in Prostate Cancer
This study is looking at a gel spacer to protect the bowel during a new type of strong radiation (SABR) for prostate cancer that has come back. It aims to reduce side effects and improve comfort for patients.
Canada - recruitingNA
Evaluating the Effectiveness of the Nurse Ned Clinic
This study looks at a new way to help men who have had prostate cancer. It compares usual care with a new 'Nurse Ned Clinic' run by specialist nurses. The aim is to see if this new clinic can improve how we look after prostate cancer survivors.
Canada - recruitingNA
Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing
This study looks at a new digital tool called GA-Mainstream. It helps people with certain cancers like breast, ovarian, and colon cancer understand genetic testing better. The goal is to make sure patients feel informed and supported while getting tested for genes that can affect their cancer treatment.
Canada - recruitingNA
Needle Localization During Prostate Brachytherapy Using Power Doppler Ultrasound
This study is looking at a new way to guide needles during prostate brachytherapy for prostate cancer. Researchers will use a special ultrasound to see if a vibrating needle can make it easier to place treatment accurately, aiming to improve how this therapy is given.
Canada - active not recruiting
Validation of ClarityDX Prostate as a Reflex Test to Refine the Prediction of Clinically-significant Prostate Cancer
This study is looking at a new blood test called ClarityDX Prostate. It aims to see how well this test can predict serious prostate cancer in men who are having a prostate biopsy because of raised PSA levels.
United States · Canada - recruitingPHASE1
Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer
This study is looking at a new drug, xaluritamig, for men with prostate cancer that hasn't spread. We want to see if it's safe to give before surgery, either alone or with another common prostate cancer medicine, and how well surgery goes afterwards.
United States · Germany - active not recruitingPHASE2, PHASE3
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy
This study, called STAMPEDE, looks for better ways to treat prostate cancer that is spreading or has a high chance of spreading. It tests new treatments against standard ones to help men live longer and have a better quality of life.
Switzerland · United Kingdom - recruitingNA
Imperial Prostate 9 - ATLAS (Approaches To Long-Term Active Surveillance)
This study compares regular MRI scans with the usual care for men with early prostate cancer who are on 'active surveillance'. It aims to see if MRI is better at spotting cancer changes, potentially reducing the need for biopsies and clinic visits, improving monitoring.
United Kingdom - recruitingPHASE4
Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer
This study is looking into the long-term safety of a treatment called AAA617 for prostate cancer. It follows people who've already received AAA617 in previous research studies to see how they're doing over time and to learn more about any potential delayed side effects.
United States · Austria · Belgium - not yet recruitingPHASE2
Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
This study looks at using heat treatment (hyperthermia) with repeat radiation therapy for certain cancers that have come back after earlier radiation. It checks if this combined approach works as well as the first treatment for preventing the cancer from returning locally.
Germany - enrolling by invitation
Long-Term Follow-Up of AvenCell Sponsored CAR-T Cell Clinical Trials
This study looks at the long-term effects of AvenCell's CAR-T cell treatments for blood cancers like lymphoma and leukemia, and also prostate cancer. It checks how safe and effective these treatments are over time for people who've already had them in past AvenCell trials.
Germany - recruiting
Liquid Biopsy Under PSMA Radioligand Therapy
This study looks at prostate cancer that has spread and no longer responds to hormone therapy. We're using 'liquid biopsies' (blood tests) during a special treatment called PSMA-RLT to understand why the treatment sometimes stops working and to find better ways to check how well it's performing.
Germany - active not recruitingPHASE2, PHASE3
A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer
This study is looking at a new combination of medicines, abemaciclib, abiraterone acetate, and prednisone, for men with advanced prostate cancer that has spread. It aims to see if adding abemaciclib is safe and effective in treating their cancer.
United States · Australia · China - active not recruitingPHASE3
A Study of Apalutamide (JNJ-56021927, ARN-509) Plus Androgen Deprivation Therapy (ADT) Versus ADT in Participants With mHSPC
This study looks at adding a new drug, Apalutamide, to standard hormone therapy for men with prostate cancer that has spread. We want to see if this combination helps patients live longer or keeps their cancer from getting worse.
United States · Argentina · Australia - active not recruitingNA
Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer
This study looks at how well a product called SpaceOAR Vue helps men with prostate cancer. It aims to reduce gut problems when they have a type of radiation treatment called SBRT, by putting a special gel between the prostate and bowel.
United States · Australia · France - recruiting
Microbiome Molecular Charaterisation
This study looks at how tiny germs in our gut might affect prostate cancer and its treatments. Researchers want to understand if these germs can help predict how well treatments work or cause side effects, hoping to find new ways to improve care.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
CYPENZA - A prospective cohort trial on antiandrogens influences on the pharmacokinetics of corticosteroids.
This study looks at how medicines for prostate cancer (antiandrogens like enzalutamide or apalutamide) might change how a steroid medicine (dexamethasone) works in the body. We want to see if these cancer drugs affect the amount of dexamethasone in your blood.
Sweden - active not recruiting
The BARCODE 1 Pilot Study
This study looks at whether checking genes can help find men at higher risk of prostate cancer, so they can be offered special screening. It starts with 300 men to see if this genetic test works well for guiding check-ups.
United Kingdom - recruitingPHASE1, PHASE2
Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection
This study is testing a new treatment for advanced prostate cancer that has spread and isn't responding to usual hormone therapy. It's called 177Lu-rhPSMA-10.1 and uses radiation to target cancer cells. We want to see how safe and effective it is.
United States · Belgium · Germany - recruitingNA
Clinical Utility of ClarityDX Prostate
This study looks at a new tool called ClarityDX Prostate. It helps doctors decide if men with prostate cancer concerns might need more tests like scans or biopsies. The goal is to avoid unnecessary procedures while finding serious cancers quickly.
Canada - active not recruiting
UK Genetic Prostate Cancer Study: Epidemiology and Molecular Genetics Studies
This study looks for genetic changes linked to prostate cancer. We're especially interested in men diagnosed young or with family history, but also include older men. We want to understand why some men get prostate cancer, hoping to improve future detection and treatment.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
Diagnostic Performance of Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) Imaging for Pre-operative Lymph Node Assessment in Intermediate and High-risk Nonmetastasic Prostate Cancer
This study looks at a special type of scan called a PET-PSMA scan to see how well it finds cancer in lymph nodes for men with prostate cancer. It helps doctors decide the best treatment, especially before surgery.
France - active not recruitingNA
Impact of Radical Prostatectomy as Primary Treatment in Patients With Prostate Cancer With Limited Bone Metastases
This study looks at whether surgery (radical prostatectomy) for prostate cancer, even when it has spread a little to the bones, can help men live longer, stop the cancer from getting worse, and improve their quality of life compared to standard drug treatments alone.
Germany - recruiting
The GENPET Study - An Imaging Study of FCH-PET-CT in Men With Prostate Cancer and a DNA Repair Gene Mutation.
This study looks at new ways to scan for prostate cancer in men with specific gene changes. We compare standard scans with a special PET-CT scan to see which is better at finding if the cancer has spread beyond the prostate.
United Kingdom - recruitingNA
Diagnostic Performance of PSMA PET/CT for Pre-operative Lymph Node Assessment in Intermediate and High-risk Non-metastasic Prostate Cancer (PREOP-PSMA ).
This study is looking at a new type of scan called PSMA PET/CT for men with prostate cancer that hasn't spread far. It helps doctors see if the cancer has spread to nearby lymph nodes before surgery, aiming to improve treatment planning.
France - recruiting
Chronic Radiation Induced Bowel Toxicity Study
This study looks at how radiotherapy for prostate cancer affects the helpful germs in the gut. Researchers want to see if these germs change during treatment and if this is linked to gut problems. They will collect samples like poo and blood, and ask about diet.
United Kingdom - recruitingPHASE1
First-in-human Study of OVM-200 as a Therapeutic Cancer Vaccine
This study is testing a new cancer medicine, OVM-200, for the first time in people. It involves up to 52 patients with prostate, lung, or ovarian cancer to check if it's safe and how well it works. It's given as an injection under the skin.
United Kingdom - recruiting
ART-Pro: Clinical Trial Evaluating Biparametric MRI and Advanced, Quantitative Diffusion MRI for Detection of Prostate Cancer
This study is looking at new types of MRI scans for prostate cancer. We want to see if these new scans can find important cancers better and more easily than current methods, without needing injections or highly experienced doctors to read them.
United States · United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Open-label Study to Test the Diagnostic Performance of Copper Cu 64 PSMA I&T PET/CT in Staging of Men with Newly Diagnosed Unfavorable Intermediate-risk, High-risk or Very High-risk Prostate Cancer Electing to Undergo Radical Prostatectomy with Pelvic Lymph Node Dissection
This study is looking at a special scan called a PET/CT with copper-64 PSMA. It aims to see how well this scan can find prostate cancer that has spread to nearby lymph nodes in men about to have surgery. This could help doctors better understand the cancer's stage.
France · Spain · Italy