Metastatic Castration-resistant Prostate Cancer research hub
50 indexed studies · 32 currently recruiting
- recruitingPHASE1, PHASE2
ACTinium in Castrate-RESistant Prostate Cancer After LUTEtium
This study is testing a new radioactive drug called Actinium (225Ac) rhPSMA-10.1 for men with advanced prostate cancer that has spread. It aims to find a safe dose and see how well it works, especially for those who've already had a similar treatment.
United Kingdom - recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium - active not recruitingPHASE3
Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC
This study is for men with a certain type of advanced prostate cancer (mCSPC) that has spread and has specific gene changes. It compares a new drug called talazoparib, given with standard treatment enzalutamide, against enzalutamide alone, to see if it's safe and effective.
United States · Argentina · Australia - active not recruitingPHASE3
Phase III Radium 223 mCRPC-PEACE III
This study is looking at whether using two treatments, Ra223 and enzalutamide, together works better than enzalutamide alone for men with prostate cancer that has spread to their bones. Doctors want to see if this combination can stop the cancer from growing for longer.
Belgium · Brazil · Canada - recruiting
In Vivo Dosimetry for Brachytherapy Study
This study looks at using tiny devices to check radiation doses during brachytherapy for prostate or gynaecological cancer. The devices ensure patients receive the correct, planned amount of radiation inside their bodies, helping to make treatment safer and more effective.
United Kingdom - recruitingNA
Hypofractionated Expedited Radiotherapy for Men With localisEd proState Cancer
This study compares different ways to treat prostate cancer with targeted X-ray therapy. We're looking at whether 2 treatments or 5 treatments work best using a special machine that helps us aim precisely. The goal is to find a shorter, equally safe treatment.
United Kingdom - active not recruitingPHASE2
Artificial Intelligence Supporting CAncer Patients Across Europe - the ASCAPE Project
This study uses AI to improve life quality for breast and prostate cancer patients across Europe. It aims to create personalised predictions about challenges patients might face and suggest ways doctors can help, using smart technology and data.
Greece · Spain · Sweden - recruiting
The Active Surveillance Study
This study looks at men with prostate cancer on Active Surveillance to see how genetics and body markers might affect their cancer. It compares men with and without a higher genetic risk to understand how their cancer changes over time.
United Kingdom - recruiting
The PROFILE Study: Germline Genetic Profiling: Correlation With Targeted Prostate Cancer Screening and Treatment
This study, called PROFILE, explores prostate cancer risk in men. It looks at how family history, ethnicity, and genetics might increase the chance of getting prostate cancer, hoping to find better early detection methods.
United Kingdom - recruitingNA
Imperial Prostate 7 - Prostate Assessment Using Comparative Interventions - Fast Mri and Image-fusion for Cancer
This study looks at new ways to find prostate cancer using MRI scans and biopsies. Researchers want to see if a shorter, simpler MRI is as good as the usual one, and if guiding biopsies with a computer is better than relying on a doctor’s eye.
United Kingdom - recruitingNA
Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions
This study looks at a new, very short course of radiotherapy for prostate cancer, given in just two treatments. We want to see if different ways of targeting the dose can reduce side effects while still controlling the cancer.
Canada · United Kingdom - recruiting
The PROSECCA Study, Answering New Questions in Prostate Cancer
This study uses AI to look at health records of prostate cancer patients. We want to find out how to make radiotherapy better and reduce side effects by personalising treatment for each person, especially those at higher risk of problems.
United Kingdom - active not recruitingPHASE2
Additional Treatments to the Local Tumour for Metastatic Prostate Cancer: Assessment of Novel Treatment Algorithms
This study looks at new ways to treat prostate cancer that has spread. It compares adding treatments directly to the prostate and other affected areas with standard care, to see if it improves outcomes for men who have recently been diagnosed.
United Kingdom - active not recruiting
The BARCODE 1 Study (Full Study): The Use of Genetic Profiling to Guide Prostate Cancer Targeted Screening.
This study looks at using a genetic test to help decide who needs prostate cancer screening. It uses a saliva sample to check for genetic differences that might increase your risk. If your risk is high, you might be offered further tests like an MRI scan and a biopsy.
United Kingdom - active not recruitingNA
Prostate Imaging Using MRI +/- Contrast Enhancement
This study compares different MRI scans for prostate cancer. We want to see if a shorter, simpler MRI without a special dye injection (biparametric MRI) works as well as the standard MRI with the dye (multiparametric MRI) in finding important prostate cancers.
United States · Argentina · Australia - recruitingNA
The Man Van Project
The Man Van project offers mobile health checks at workplaces and communities for men, especially those from ethnic minority groups, to find health problems like prostate cancer early. The goal is to make healthcare easier to access and improve men's health outcomes.
United Kingdom - recruitingPHASE3
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
This study is testing a new medicine, ifinatamab deruxtecan (I-DXd), for men with advanced prostate cancer that has spread and isn't responding to hormone therapy. We want to see if I-DXd helps men live longer and keeps their cancer from growing compared to standard chemotherapy.
United States · Argentina · Australia - recruitingPHASE3
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
This study looks at a new drug, mevrometostat, combined with enzalutamide for men with prostate cancer that has spread. It compares this combination to enzalutamide alone, to see if it works better for those not yet treated with specific hormone therapies.
United States · Argentina · Australia - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - recruitingNA
Focal Therapy for Prostate Cancer Using HIFU
This study is looking at an advanced treatment called 'focal therapy' using HIFU for prostate cancer. It aims to see how well it controls cancer while reducing side effects like erection problems and bladder issues, which are common with other treatments.
United Kingdom - active not recruitingPHASE3
Prostate Advances in Comparative Evidence
This study looks at different ways to treat prostate cancer, comparing surgery with different types of radiotherapy. It aims to find out which treatments work best for different people, have fewer side effects, and improve quality of life.
Canada · Ireland · New Zealand - active not recruiting
The BARCODE 1 Pilot Study
This study looks at whether checking genes can help find men at higher risk of prostate cancer, so they can be offered special screening. It starts with 300 men to see if this genetic test works well for guiding check-ups.
United Kingdom - active not recruitingNA
SPCG17: Prostate Cancer Active Surveillance Trigger Trial
This study looks at how best to manage prostate cancer through 'active surveillance'. This means closely monitoring the cancer instead of immediate treatment. We want to find out if clear guidelines for monitoring can reduce unnecessary treatments while still keeping you safe.
Denmark · Finland · Norway - recruiting
The i4i PRODICT® Study: Evaluation of the i4i PRODICT® Test in Different Ethnic Groups (The i4i PRODICT® Study).
This study looks at a new saliva test, called i4i PRODICT®, to predict prostate cancer risk in men aged 40-55 from different ethnic backgrounds. It aims to see how well men accept and use this test.
United Kingdom - recruitingNA
Assessing a Digital Exercise Intervention for Health Outcomes and Engagement in Regular Exercise
This study looks at a digital exercise programme for men with prostate cancer on hormone therapy. It aims to see if online group exercise can help them stick to exercise and improve health, reducing side effects from their treatment.
United Kingdom - recruitingPHASE2
A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer
This study looks at a new injection, ASP5541, for advanced prostate cancer that has spread. It compares ASP5541 to a standard tablet treatment, abiraterone acetate, to see how safe and effective it is.
United States · China · France - recruiting
Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations
This study looks at how prostate cancer affects men with certain rare gene changes, like BRCA1 or BRCA2. Researchers compare their treatment results to men without these gene changes to understand how these genes impact the disease and find better ways to manage it.
United Kingdom - recruiting
The GENPET Study - An Imaging Study of FCH-PET-CT in Men With Prostate Cancer and a DNA Repair Gene Mutation.
This study looks at new ways to scan for prostate cancer in men with specific gene changes. We compare standard scans with a special PET-CT scan to see which is better at finding if the cancer has spread beyond the prostate.
United Kingdom - active not recruitingNA
Prostate Testing for Cancer and Treatment
This study, called 'Prostate Testing for Cancer and Treatment' (ProtecT), is looking at how different treatments for prostate cancer compare. It's for men aged 50-69 with early prostate cancer. Researchers want to see if surgery, radiation, or simply watching the cancer works best in the long run.
United Kingdom - active not recruiting
Exploiting Risk-Based Risk Stratification in Early Prostate Cancer to Discriminate Progressors From Non-Progressors
This study looks at men with early prostate cancer to understand why some cancers grow and others don't. Researchers will use MRI scans and samples over time to find differences between progressive and non-progressive cancers, aiming to improve future treatment decisions.
United Kingdom - active not recruitingPHASE3
A Study of Apalutamide (JNJ-56021927, ARN-509) Plus Androgen Deprivation Therapy (ADT) Versus ADT in Participants With mHSPC
This study looks at adding a new drug, Apalutamide, to standard hormone therapy for men with prostate cancer that has spread. We want to see if this combination helps patients live longer or keeps their cancer from getting worse.
United States · Argentina · Australia - recruitingNA
A Study to Evaluate the Performance of Confocal Microscopy to Detect Positive Margins During Radical Prostatectomy
This study tests a new method, LaserSAFE, to find cancer at the edge of the prostate during surgery. This helps surgeons decide if they can save important nerves, especially for men usually not offered this option. It aims to improve surgical decisions and help men recover better.
United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - active not recruitingPHASE1
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer
This study is testing a new cancer medicine, botensilimab, sometimes with another drug, balstilimab. It's for people with advanced cancers that haven't responded to other treatments. Doctors want to see if it's safe, how it works, and find the best dose.
United States · United Kingdom - recruitingPHASE3
A Trial of 5 Fraction Prostate SBRT Versus 5 Fraction Prostate and Pelvic Nodal SBRT
This study compares two ways of giving radiotherapy in 5 sessions for prostate cancer. Half of men receive radiotherapy to the prostate, while the other half get it for both the prostate and surrounding lymph nodes, to see which is safer and more effective.
Ireland · New Zealand · United Kingdom - recruitingNA
Imperial Prostate 9 - ATLAS (Approaches To Long-Term Active Surveillance)
This study compares regular MRI scans with the usual care for men with early prostate cancer who are on 'active surveillance'. It aims to see if MRI is better at spotting cancer changes, potentially reducing the need for biopsies and clinic visits, improving monitoring.
United Kingdom - active not recruitingPHASE2, PHASE3
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy
This study, called STAMPEDE, looks for better ways to treat prostate cancer that is spreading or has a high chance of spreading. It tests new treatments against standard ones to help men live longer and have a better quality of life.
Switzerland · United Kingdom - recruiting
Precision Medicine in the Prostate Cancer Care Pathway
This study looks at a special genetic test for prostate cancer. It helps men understand their personal risk and how this information can guide decisions about screening and treatment. The aim is to use genetic insights for more tailored prostate cancer care.
United Kingdom - recruiting
Selecting Hypoxic Tumours for Treatment Modification
This study aims to find better ways to treat bladder and prostate cancers that are hard to cure with standard radiotherapy. We are testing a new method to identify these 'hard-to-treat' tumours so doctors can choose the best treatment for each patient.
United Kingdom - active not recruitingPHASE3
Trial Comparing Irradiation Plus Long Term Adjuvant Androgen Deprivation With GnRH Antagonist Versus GnRH Agonist Plus Flare Protection in Patients With Very High Risk Localized or Locally Advanced Prostate Cancer
This study looks at treating advanced prostate cancer with radiation and hormone therapy. It compares two types of hormone therapy to see which is better at stopping the cancer from growing, spreading, or coming back.
Belgium · Denmark · France - recruiting
ART-Pro: Clinical Trial Evaluating Biparametric MRI and Advanced, Quantitative Diffusion MRI for Detection of Prostate Cancer
This study is looking at new types of MRI scans for prostate cancer. We want to see if these new scans can find important cancers better and more easily than current methods, without needing injections or highly experienced doctors to read them.
United States · United Kingdom - active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
United States · United Kingdom - active not recruiting
UK Genetic Prostate Cancer Study: Epidemiology and Molecular Genetics Studies
This study looks for genetic changes linked to prostate cancer. We're especially interested in men diagnosed young or with family history, but also include older men. We want to understand why some men get prostate cancer, hoping to improve future detection and treatment.
United Kingdom - recruitingPHASE2
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
This study is for men with prostate cancer who are already taking enzalutamide as part of another research study. It aims to gather more information on the long-term safety of enzalutamide when it's helping them. Participants will continue their current treatment and have regular check-ups.
United States · Argentina · Australia - recruitingPHASE1, PHASE2
A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs
This study is looking at a new medicine called AZD9750 for men with prostate cancer that has spread. We want to find out if it's safe, how well it works alone, and how it works when given with another cancer drug.
United States · Australia · Canada - recruitingPHASE1, PHASE2
Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection
This study is testing a new treatment for advanced prostate cancer that has spread and isn't responding to usual hormone therapy. It's called 177Lu-rhPSMA-10.1 and uses radiation to target cancer cells. We want to see how safe and effective it is.
United States · Belgium · Germany - recruitingPHASE2
TherApeutics in Early ProState Cancer (TAPS02)
This study is looking at a new way to treat early prostate cancer. It tests a drug called apalutamide (Erleada) in men who are already under careful watch for their cancer. We want to see if this short-term treatment can help.
United Kingdom - active not recruitingPHASE3
Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours
This study looks at whether taking aspirin daily after cancer treatment can stop cancer coming back and help people live longer. It focuses on common cancers like breast, bowel, and prostate cancer.
Ireland · United Kingdom - recruitingPHASE1
First-in-human Study of OVM-200 as a Therapeutic Cancer Vaccine
This study is testing a new cancer medicine, OVM-200, for the first time in people. It involves up to 52 patients with prostate, lung, or ovarian cancer to check if it's safe and how well it works. It's given as an injection under the skin.
United Kingdom - not yet recruitingNA
Comparing pOrtable MRI and TRUS-Fusion Prostate Biopsy to Assess aCcuracy of Prostate Cancer Detection
This study compares a new, portable MRI-guided biopsy for prostate cancer with the current standard method. It aims to see if the portable MRI is just as good, or better, at finding cancer and if it can make the process simpler for patients.
United Kingdom