A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs

To join this study, you need to be at least 18 years old and have prostate cancer that has been confirmed by tests and has spread to other parts of your body. Also, your current prostate cancer must have shown signs of getting worse, for example, your PSA levels are rising, or scans show that the cancer has grown.

You would also need to be generally in good health, with certain blood and organ tests coming back within healthy ranges. Importantly, you would need to have had specific previous treatments for your prostate cancer, such as certain hormone therapies and possibly chemotherapy, depending on which part of the study you might join.

However, some things would mean you can't join. For example, if your cancer has spread to your brain or spinal cord, or if you have certain other serious medical conditions, especially heart problems. You also cannot have a type of prostate cancer that is mainly small cell or neuroendocrine carcinoma.

If you decide to take part, you'll visit the study centre regularly. At these visits, doctors will monitor your health, check for any side effects, and see how the medicine is affecting your cancer. This will involve physical examinations, blood tests, pee tests, and scans (like bone scans or CT scans) to check your cancer. You will receive the study medicine (AZD9750, possibly with saruparib). The full duration of your participation could vary, as you will continue with the study treatment until your cancer gets worse, you experience side effects that are too uncomfortable, or you choose to stop.