Ongoing, recruitingHuman Pharmacology (Phase I)- OtherInterventional

A study to compare how the body absorbs different formulations of a new medicine, and how food affects drug absorption, in healthy participants

This research is a very early study focusing on how a new medicine works in the body. It's designed for healthy people, not those with psoriasis, to help us understand it safely. We want to see how the body absorbs this new medicine when given in different ways, and whether eating food around the time of taking the medicine changes how much of it gets into the bloodstream. This information is crucial for developing the medicine further and making sure it can help people with psoriasis effectively in the future. It's an important first step in understanding a new treatment.

At a glance

Status

Ongoing, recruiting

Phase

Human Pharmacology (Phase I)- Other

Sponsor

Janssen Cilag International

Enrolment target

Start

22 Dec 2025

Psoriasis

What is this study about?

Imagine you have a new key, but you're not sure which door it fits best or if it works differently when you try it in the morning versus after a meal. This study is a bit like that for a new medicine for psoriasis. Psoriasis is a skin condition that causes red, scaly patches, and scientists are always looking for better ways to treat it. Before a new medicine can be given to people who have psoriasis, we need to understand exactly how it behaves in the body.

This particular study is focusing on how the body takes in (or 'absorbs') this new medicine. We'll be looking at different forms of the medicine to see if one works better than another. We'll also be checking if eating food affects how much of the medicine gets into the bloodstream and how quickly. This is important because it helps us figure out the best way for people to take the medicine in the future – for example, with food, without food, or at a certain time of day.

By taking part, you would be helping researchers learn vital information about this new medicine. This isn't a study to treat psoriasis directly, but rather to gather important knowledge so that one day, this medicine might be a safe and effective option for people living with the condition.

Key takeaways

This is an early study for a new psoriasis medicine.
It's for healthy volunteers, not people with psoriasis.
Researchers want to see how the body absorbs the medicine.
They also want to know if food makes a difference.
Your health will be closely monitored if you take part.
You would be helping to advance medical science.

Who may be eligible?

To join this study, you need to be a healthy person, which means you don't have any major medical conditions, including psoriasis. We're looking for adults, so you must be at least 18 years old. There's no upper age limit, as long as you are generally healthy.

Both men and women are welcome to take part in this research. The main idea is to study how the medicine works in a typical healthy body before it's given to people who are unwell. This helps us get a clear picture of the medicine's basic behaviour without other health issues complicating the results.

Before you can join, a medical team will carefully check your health to make sure it's safe for you to take part. This will involve some health checks and tests to confirm you meet all the study's requirements.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you consider yourself generally healthy?
Do you NOT have psoriasis?
Are you willing to follow study rules, including clinic visits and blood tests?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would typically visit a research clinic a few times. During these visits, you might stay for several hours or even overnight, depending on the study design. You would be given the new medicine in different ways, and sometimes with or without food. Throughout these visits, the research team would regularly take small blood samples to measure how much of the medicine is in your body and how it's being processed. They might also check your vital signs like blood pressure and heart rate, and ask questions about how you are feeling. You would also have follow-up calls or visits to ensure you remain well after you finish taking the medicine. The total time you spend in the study will be explained in detail.

Potential risks and benefits

The main benefit of taking part in this study is contributing to medical science and helping to develop new treatments for psoriasis, which could eventually help many people. As with any medicine, there is always a chance of side effects, which the research team will explain fully. These studies are carefully designed to keep you safe, and your health will be closely monitored throughout. You are free to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Netherlands

Common questions

What is psoriasis?

Psoriasis is a common, long-lasting skin condition where cells build up rapidly on the skin's surface, creating red, scaly patches that can be itchy and sometimes painful.

Why do you need healthy people for this study?

We test new medicines on healthy people first to understand how they work in the body without other health problems affecting the results. This helps us ensure the medicine is safe before it's given to people who are unwell.

Will this study treat my psoriasis?

No, this study is not designed to treat psoriasis. It's for healthy volunteers to understand how a new medicine is absorbed by the body. If you have psoriasis, this study is not suitable for you.

Will I receive the new medicine regularly?

You will receive the medicine according to the study schedule during your visits. You won't be taking it continuously at home for treatment purposes, as this is an early-stage study.

Will I be paid for taking part?

While this information isn't provided, many early-phase studies offer compensation for your time and inconvenience. The research team will be able to tell you if this is the case.