Not yet recruitingOBSERVATIONAL

Characterization of the Fungal Immunopeptidome Involved in the Immunopathological Mechanisms of Psoriasis

Psoriasis is a long-term skin condition that causes red, scaly patches and sometimes joint pain. While treatments help with symptoms, there's no cure yet. This study investigates the connection between fungi that naturally live on and inside our bodies (called "mycobiota") and psoriasis. We know that certain immune cells play a key role in psoriasis. Researchers believe that these fungi might be making the immune system overreact, leading to the skin inflammation. The aim is to understand which specific fungi are involved and how they interact with our immune system. This knowledge could help in developing brand new treatments for psoriasis.

At a glance

Status

Not yet recruiting

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrolment target

100

Start

01 Oct 2025

Estimated completion

01 Oct 2027

Psoriasis

What is this study about?

Psoriasis is a common and often uncomfortable skin condition that causes red, flaky patches, and sometimes affects the joints too. Many treatments are available to manage the symptoms, but unfortunately, there isn't a permanent cure. This study wants to get to the bottom of what makes psoriasis tick.

Our bodies are home to countless tiny living things, including bacteria and fungi, both on our skin and in our gut. Researchers suspect that some of these fungi might be playing a trick on our immune system, making it think there's a threat when there isn't. This overreaction could then lead to the inflammation and skin changes we see in psoriasis. Think of it like a faulty alarm system that keeps going off for no good reason.

The main goals of this research are to identify which specific fungi are present in people with psoriasis, both on their skin and in their gut, and to see how their immune system reacts to them. They also want to pinpoint the exact parts of these fungi that trigger the immune response. By understanding these interactions better, the hope is to pave the way for completely new and more effective treatments for psoriasis in the future.

Key takeaways

Psoriasis has no cure, but this study aims to understand its causes better.
Researchers are investigating if common fungi on our skin and in our gut play a role.
The study hopes to identify specific fungi that trigger the immune system in psoriasis.
Findings could help develop new treatment approaches for psoriasis.
It's a research study, not a treatment trial.

Who may be eligible?

To join this study, you need to be an adult, 18 years old or older. You must have psoriasis that hasn't gotten better with the usual local treatments, like creams or ointments.

They are also looking for some healthy adults who live in the same house as someone with psoriasis. These participants will help the researchers understand the normal gut fungi.

However, if you are pregnant or breastfeeding, or if you are under 18 years old, you cannot take part in this study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you have psoriasis that hasn't cleared up with local treatments?
Are you NOT pregnant or breastfeeding?
Are you NOT under 18 years old?

Answer every question to see your result.

What does participation involve?

The detailed involvement for participants isn't fully described, but based on the study aims, you would likely have some skin samples taken, perhaps from areas affected by psoriasis and healthy skin. You would also probably be asked to provide stool samples to check the fungi in your gut. Blood samples would also be needed to look at how your immune system is reacting. The study doesn't mention specific visits, medication, or follow-up schedules, or the total duration. These details would be explained fully by the study team if you express interest.

Potential risks and benefits

Participating in this study might not directly benefit you, but the information found could lead to new and better treatments for psoriasis in the future. The risks involve minor discomfort from skin and blood samples. It's important to remember that you have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Service de Parasitologie-Mycologie Hôpital St Antoine
Verified postcode
Paris, France

Common questions

What is psoriasis?

Psoriasis is a long-term skin condition that causes red, scaly, and sometimes itchy patches, occasionally affecting joints too.

What are 'fungi' in this study?

Fungi refers to the natural yeasts and moulds that live on our skin and in our gut, which are usually harmless.

Why are researchers looking at fungi?

Researchers believe certain fungi might be triggering the immune system in people with psoriasis, making the condition worse.

Will I get a new treatment in this study?

No, this study is about understanding psoriasis better, not testing new treatments directly. It aims to find information that could lead to new treatments later on.

Will taking part help me personally?

Direct personal benefits are not guaranteed, but your participation is vital in helping scientists learn more about psoriasis and creating better options for future patients.

How to find out more

Alicia MORENO, Doctor

alicia.moreno@aphp.fr +33 149282000 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.