An Exploratory Phase II, Randomized, Open-Label, Proof-of-Concept Trial Evaluating Add-on Polyunsaturated Fatty Acid Ethyl Esters on Pain and Minimal Disease Activity in Psoriatic Arthritis Patients Starting TNF-alpha Inhibitors

Psoriatic arthritis is a long-term condition where the body's immune system mistakenly attacks both the skin and the joints. This causes joint swelling, stiffness, and severe discomfort. One common and effective way doctors treat psoriatic arthritis is with biologic medicines known as TNF inhibitors. These drugs block a specific protein in the body that triggers inflammation. However, even when these medicines work, many people still live with lingering joint pain, fatigue, and poor sleep.

This study looks at whether adding a daily supplement of purified polyunsaturated fatty acids can help. These are healthy fats, much like the omega-3 oils found in oily fish, which are well known for having natural anti-inflammatory qualities. Scientists want to know whether pairing these healthy fats with standard biologic injections gives a better boost to pain relief than taking the biologic medicine alone.

Over the course of six months, researchers will measure whether participants experience lower pain levels and reach what rheumatologists call 'minimal disease activity.' This means having few or no tender joints, clear or nearly clear skin, and being able to carry on with daily life with minimal discomfort.

If successful, this trial could provide a simple, low-risk way to enhance standard arthritis care. It may help people manage their symptoms better, reduce the need for extra painkiller medications, and improve day-to-day quality of life.