A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Study Participants With Active Psoriatic Arthritis

To join this study, you generally need to be an adult diagnosed with psoriatic arthritis for at least six months. Your psoriatic arthritis should still be active, meaning you have tender and swollen joints, even if you've already tried some other arthritis medications. You also need to have at least one active psoriasis skin patch or a history of plaque psoriasis.

You might be able to join if you're currently taking certain arthritis medicines or if you've tried at least one of them (like methotrexate, leflunomide, or sulfasalazine) but it didn't work well enough or caused problems. If you've previously used a certain type of arthritis medicine called a TNF inhibitor, you might still be eligible, provided you only tried one, and it either didn't work or you had a bad reaction to it.

However, some things would prevent you from taking part. For example, if you have another significant medical or mental health condition that might interfere with the study, or if you have an active infection, you wouldn't be able to join. Also, women who are pregnant, breastfeeding, or planning to become pregnant during the study period cannot participate.

If you decide to take part in this study, you'll be assigned to one of three groups: receiving bimekizumab, risankizumab, or a placebo. You won't know which one you're getting, and neither will the study doctors, to keep the results fair. You'll have regular hospital visits for check-ups, where doctors will assess your joints and skin, take blood samples, and ask about your symptoms and how you're feeling. You'll receive the study medication, likely as injections, which will be given by a healthcare professional or you might be taught how to do them yourself.

The initial treatment phase where the main comparison happens lasts for 16 weeks. After that, there might be options to continue on the study medication for a longer period, and there will be follow-up appointments to monitor your health. The medical team will explain the full schedule of visits and procedures if you are interested in joining. The total time you'd be involved in the study would be discussed with you.