Quantifying 18kDa TSPO Expression in the Lung in Pulmonary Artery Hypertension (PAH)
We want to find out if there's a difference in how a specific protein (called TSPO) shows up in the lungs of people with Pulmonary Arterial Hypertension (PAH) compared to healthy people. We're using a special type of scan called a PET scan, which involves a tiny bit of a harmless, temporary radioactive substance. If we find this difference, it could mean that these PET scans could be a helpful, non-invasive way to see if new treatments for PAH are making a difference. The study involves two short scans to get a complete picture. Basically, we're trying to find a better way to monitor PAH and how well treatments are working without needing more invasive procedures.
At a glance
What is this study about?
This study is looking into a condition called Pulmonary Arterial Hypertension, or PAH. PAH is a serious condition where the blood vessels in the lungs become narrow, making it difficult for the heart to pump blood through them. We're trying to find a new way to understand what's happening in the lungs of people with PAH and, importantly, a better way to check if treatments are actually working.
We're using a special type of scan called a PET scan. This scan uses a small, safe amount of a temporary radioactive substance (called 11C-PBR28) that helps us see a specific protein, called TSPO, in the lungs. We believe that the amount of TSPO might be different in people with PAH compared to healthy people. If this is true, then tracking TSPO with these PET scans could become a useful tool for doctors.
To do this, each participant will have two PET scans. The first scan will show the overall amount of the substance in the lungs. The second scan, done after taking a different medication that blocks TSPO, will help us identify the specific TSPO signal. By comparing these two scans, we can accurately measure the amount of TSPO in the lungs. Ultimately, this research could lead to a less invasive and more effective way for doctors to monitor PAH and see if medicines are helping.
Key takeaways
- Researchers are using special scans to understand PAH.
- The study aims to find a new way to check if PAH treatments are working.
- Participation involves two PET scans on separate occasions.
- The scans use a safe, temporary radioactive substance.
- This research could lead to less invasive ways to monitor PAH.
- You can withdraw from the study at any time.
Who may be eligible?
We are looking for both men and women between the ages of 25 and 75. All participants must be able to understand the study and agree to take part in writing, and be able to lie comfortably on their back for about an hour and a half at a time.
For women who could become pregnant, you can take part if a pregnancy test is negative and you are using a very effective method of contraception (birth control), other than the contraceptive pill, until the study’s effects have worn off. Men who could father children must also agree to use contraception during the study.
You won't be able to join if you have certain medical conditions like serious kidney or liver problems, very low blood count (anaemia), sickle cell disease, thalassaemia, or uncontrolled high blood pressure. If you have an active infection, a long-term inflammatory illness like HIV, or if you've recently been part of another study involving radiation, you also won't be able to participate.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you between 25 and 75 years old?
- Can you comfortably lie on your back for 90 minutes?
- Do you have a clear understanding of the study and consent to participate?
- Do you have any serious kidney, liver problems, or anaemia?
- Are you pregnant or breastfeeding, or planning to be pregnant soon?
- Have you taken part in other radiation studies recently?
What does participation involve?
If you decide to take part, you will be invited to the research centre for a screening visit to check if you are suitable for the study. If you are eligible, you will then come for up to two study visits, where you will have the special PET scans. These visits will involve lying still on your back for around 90 minutes for each scan. In between the two scans, you will be given a small dose of a medication. There will be no long-term follow-up visits after the scans are complete. The total duration of your active involvement in the study will be focused around these two scan visits.
Potential risks and benefits
Locations (1)
- Imperial Clinical Research FacilityVerified postcodeLondon, United Kingdom· Recruiting
Common questions
What is Pulmonary Arterial Hypertension (PAH)?
PAH is a serious condition where blood vessels in the lungs become narrow, making it hard for the heart to pump blood, leading to breathlessness and tiredness.
What is a PET scan?
A PET scan is a special imaging test that uses a small amount of a temporary radioactive substance to create detailed pictures inside your body and show how your organs are working.
Will the radioactive substance be harmful?
No, the radioactive substance used is very small and temporary. It's carefully selected and handled to ensure your safety and quickly leaves your body.
How long will each scan take?
You will need to lie still on your back for up to 90 minutes for each of the two PET scans.
Can I eat or drink before the scan?
Specific instructions about eating and drinking before the scan will be provided to you by the study team.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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