Renal impairment (mild research hub

A study to test how BI 456906 is taken up in the blood of people with and without kidney problems

This study is looking at how a new medicine, BI 456906, moves through the bodies of people with healthy kidneys and those with kidney problems. It's an early-stage study to understand the medicine better and make sure it's safe for different people.

A pivotal, randomized, open-label, two-treatment, two-sequence, four periods, crossover clinical trial to evaluate the bioequivalence of single doses of Test product Sacubitril/Valsartan, film-coated tablets 97 mg/103 mg (Manufacturer: JSC «Farmak», Ukraine) and Reference Entresto®, film-coated tablets 97 mg/103 mg (Novartis Europharm Limited, Ireland) in healthy subjects under fasted conditions

This study compares a new heart medicine from Ukraine with an existing one called Entresto. It aims to check if they work the same way in healthy people. Volunteers take both medicines, one after the other, to see how well their bodies absorb them when not eaten with food.

Enhancing Health Literacy Through AI-Powered Chatbot: a Randomized Controlled Trial

This study looks at whether an AI chatbot can help Japanese caregivers understand more about HPV vaccination. It compares the chatbot to a leaflet to see which is better at helping them make decisions for their daughters aged 12-18.

A TQT Study to Investigate the Effect of Enpatoran on Cardiac Repolarization in Healthy Participants

This study is looking at how a new medicine, called Enpatoran, affects the electrical activity of your heart. It's for healthy people aged 18 and over, and it's one of the first tests in humans to make sure the medicine is safe and doesn't cause heart problems.

A Bronchoscopy Study to Assess the Effects of Inhaled Corticosteroids on Adult Healthy Volunteers

This study looks at how a common asthma medicine (fluticasone propionate) affects healthy lung cells. We want to understand these effects better to help in developing new treatments for severe asthma. Healthy adults will either receive the medicine or no treatment, and their lungs will be checked.

Effect of Exercise on Appetite in Response to Meals

This study looks at how short or long bursts of exercise affect men's appetite and hormones that control hunger after eating. We want to see if exercise changes how much food they want to eat later.

De-stressing the Brain: Can Eating Grapes During Periods of Mental Stress Protect Brain and Vascular Health in Young Adults

This study looks at whether eating grapes before stressful tasks can protect your brain and blood vessels. Researchers want to see if special compounds in grapes called flavonoids help young adults handle stress better, improving mood and thinking abilities.

Who Fares Best With Mindfulness Meditation

Development of Novel MR Techniques Using Volunteer Participants

This study is developing new ways to use MRI scanners to get better and faster pictures of the body. We need healthy volunteers to help test these new scanning methods safely. It's about improving the technology, not about your health.

Investigating the Neuropsychological Effects of 5-HT2a Antagonism

This study looks at how a specific brain chemical, serotonin, affects memory, emotions, and decisions. Researchers are using a drug called pimavanserin to understand more about a particular 'lock' (receptor) for serotonin. This could help develop new treatments for depression.

Safety, PK/PD, and Immunogenicity Study of SC ALXN2030 in Healthy Participants

This study is looking into a new medication called ALXN2030. We want to check how safe it is and if it causes any side effects in healthy people. We're also seeing how the body handles the medicine. It's an early-stage study to gather important safety information.

Genetic Variants and Regulation of Specialized Pro-resolving Mediator

This study looks at how tiny changes in our genes might affect how our bodies handle inflammation. We're trying to understand why some people get long-term inflammatory diseases like arthritis and heart conditions, hoping to find new ways to treat them.

Development of a Non-invasive Screening Tool to Predict Metabolic Dysfunction-associated Steatotic Liver Disease

This study aims to develop a simple way to find liver disease commonly linked to weight and lifestyle, called MASLD (Fatty Liver Disease). We're looking at healthy volunteers and people with known MASLD to create a tool that can easily predict the condition without needing complicated tests.

The Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function.

This study looks at how beetroot juice and a special diet affect brain function and blood vessels in healthy older adults. Some will have a calorie-restricted diet, while others will maintain their weight. It's a pilot study to see if combining these approaches is helpful.

A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body

This study is looking at how two different forms of a new medicine, survodutide, are taken up by the body in healthy people who are overweight or have obesity. It aims to see if both forms work in a similar way.

Investigating the Clinical Utility of the Oxford Virtual Autism Assessment Tool (OVAAT)

This study is testing a new online tool, the Oxford Virtual Autism Assessment Tool (OVAAT), to see how well it can spot signs of autism in young people aged 13-18. Researchers want to know if it's as good as or better than existing assessments.

Mapping the Impact of Gut Microbiota on Brain and Behavior Through the Lens of GABA

This study explores how gut bacteria, specifically those making GABA, might affect our brains and behavior. We're looking to see if taking a special probiotic can change GABA levels in the brain and improve how people perform on certain tasks.

The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease.

This study looks at how a natural supplement, 7-keto lithocholic acid (7-KLCA), might improve your gut health. We want to see if it helps good bacteria in your gut grow and if this could lead to better overall health.

The Effect of Ketone Esters on Forearm Glucose Metabolism

This study looks at how a special drink containing ketones might affect how our muscles use sugar. Ketones are natural substances in your body, and understanding them could help treatments for certain health conditions or aid recovery after exercise.

Personalized Responses to Dietary Composition Trial 3

This study, PREDICT 3, aims to understand how different foods affect individuals. By looking at how people respond to meals in their everyday life, it helps create more personalised eating advice to improve health for conditions like diabetes and heart problems.

Single and Multiple Dose Pharmacokinetics (PK) of Aramchol From an Aramchol Meglumine Tablet

This study looks at a new medicine called Aramchol, in tablet form, for healthy adults. We want to see how the body absorbs and uses different doses of Aramchol and how much stays in the body over time. This helps us find the best way to give the medicine.

Muscle Mass, Quality, and the Menopause: Sex-specific Strategies to Mitigate Sarcopenia in Ageing Populations

This study looks at how menopause affects muscle and why women lose muscle faster than men as they age. Researchers will use special scans to see fat in muscles and speak to women about how exercise can help improve muscle strength and quality.

A Single- and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY4066708 in Healthy Participants

This study looks at a new medicine called LY4066708 in healthy volunteers. We want to check it's safe, how well the body handles it, and how long it stays in the system. It's a first step to see if it could help with certain health conditions later on.

Do Daily Disposable Soft Contact Lenses Require Frequent Checks After the Initial Fitting is Complete in Adults Under 40 With No Contraindications

This study looks at whether adults under 40 who wear daily disposable contact lenses really need lots of check-up appointments after their first fitting. Researchers want to find out the best number of visits. We're interested in healthy people new to lenses or who already wear them.

Reconfirming the Safety and Performance of the Glyconics-DS System in Known Populations With and Without Diabetes

This study is checking a new way to test for diabetes using your fingernails. It uses a special light to look for sugar levels in your nails. Researchers want to make sure it's safe and works well for people with and without diabetes, comparing it to a standard blood test.

Clinical and Radiographic Outcomes of the JointMedica Custom-Made Resurfacing Device

This study looks at a special custom-made hip cap for people with hip pain. It checks how well it works and if it's safe, especially how long it lasts and if it helps people move better and feel less pain. It gathers information from everyday patient experiences.

Effects of Diet on Perinatal Mood and Cognition

This study looks at how eating foods rich in plant compounds called flavonoids might help new mothers with their mood, thinking skills, and blood pressure during and after pregnancy, aiming to reduce 'baby blues' and improve well-being.

Quantifying 18kDa TSPO Expression in the Lung in Pulmonary Artery Hypertension (PAH)

This study aims to see if a special scan can detect changes in the lungs of people with Pulmonary Arterial Hypertension (PAH). By comparing these scans to healthy people, we hope to find a new way to check if treatments for PAH are working.

Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs

This study looks at how digital programs can prepare healthy people for a single 25mg psilocybin session. It compares a meditation program with a music program, checking if they are practical and how they affect the experience and well-being.

Effect of Exercise on Appetite in Response to Meals During Energy Restriction

This study looks at how exercise affects appetite and hunger hormones when people eat much less than usual. Researchers want to see if a short workout can change how much food healthy men want to eat afterwards.

The Gut-Lung Axis and Respiratory Illness in Children

This study in Glasgow looks at how bugs in children's guts and lungs are linked, especially in kids with breathing or tummy problems. It wants to understand what a healthy link looks like and if these bugs change when children are unwell.

Trimethylamine N-oxide Effects of a Pomegranate Supplement Simultaneously With Carnitine (TESSA)

This study looks at whether pomegranate extract can lower a substance called TMAO in healthy adults. TMAO is made when your body processes certain foods like meat and dairy, and high levels might be linked to heart disease. Researchers want to see if adding pomegranate can help reduce it.

Study to Evaluate Pharmacokinetics, Relative Bioavailability, Palatability of Obefazimod Minitablet Formulation

This study is looking at a new, smaller tablet form of a medicine called Obefazimod. It checks if the new tablet works in the body like the current capsule version and if people find it easy to take, especially with different foods.

Sex Hormones as Regulators of the Age- and Sex-dependent Benefits of Caloric Restriction

This study looks at how hormones, age, and sex affect weight loss from dieting. We want to understand why some people find it harder to lose weight and how diet affects women's health to help fight obesity.

Cycle Nation Communities: Increasing Cycling in Glasgow

This study in Glasgow checks if a 9-week cycling programme helps adults cycle more and improves their health, compared to a single cycling session. We're looking for adults who don't cycle much to take part.

The Effect of Short-term Supplementation of OliPhenolia® on Fat Oxidation

This study looks at whether a natural olive extract drink (OliPhenolia®) can help your body burn more fat during exercise. We're also checking if adding a caffeinated drink beforehand makes a difference for healthy, active people.

BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies

The BEATRIX study is looking at a vaccine for Group B Streptococcus (GBS) in pregnant women and their babies. It aims to understand if the vaccine is safe and how well it works to protect against GBS, a common bacteria that can sometimes cause serious infections.

A Phase 1 Single Dose and Multiple Ascending Dose Study to Assess the Relative Bioavailability, Food Effect, Safety, Tolerability and Pharmacokinetics of SYT-510 in Healthy Participants

This study is testing a new medicine, SYT-510, in healthy people to see how safe it is and how the body handles it. We're looking at different doses and how food affects it to help future studies.

A Study Measuring Markers of Airway Inflammation in Breath Samples From People With Respiratory Diseases and Healthy Volunteers.

This study looks for early signs of lung cancer and other lung problems by testing breath. We're trying to find a simple, quick way to help doctors decide who needs more tests, especially for people with ongoing breathing issues.

The effect of multiple doses of BI 425809 on the pharmacokinetics of multiple doses of a combination of ethinyl estradiol and levonorgestrel following oral administration in healthy premenopausal female subjects (an open-label, twoperiod, fixed sequence design trial with run-in period)

A phase I, open-label, single dose, mass balance trial to investigate metabolism and pharmacokinetics of BI 1291583(C-14) administered as oral solution in healthy male subjects

A phase I, open-label, two-arm, non-randomised trial to investigate the metabolism and pharmacokinetics of a single dose of BI 764198 (C-14) administered as oral solution using two different approaches in healthy male volunteers.

A Randomized, Open-label, Single Dose, 3-Period, 6-Sequence Cross-Over Trial to Investigate the Relative Bioavailability of Apraglutide Versus the Reference Formulation Following Subcutaneous Administrations.

A study to test how well different doses of BI 1815368 are tolerated by healthy men

A study in healthy people to test how well repeated doses of BI 3032950 are tolerated

A PHASE 1 STUDY TO ASSESS THE EXCRETION BALANCE, PHARMACOKINETICS, AND METABOLISM OF 14CDC806 IN HEALTHY VOLUNTEERS

A Randomised Double-Blinded, Placebo-Controlled, Single and Multiple Ascending Dose, Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY3876602 in Healthy Participants.

Physiologically based pharmacokinetic modelling of oral and intranasal formulations of zolmitriptan in healthy volunteers

Effect of itraconazole on the pharmacokinetics of a single oral dose of BI 1815368 in healthy male subjects (an open-label, two-period fixed-sequence design study)

A phase I, open-label trial in two parallel parts to investigate mass balance, metabolism, and basic pharmacokinetics of BI 1810631 (C-14) administered as oral solution (part A) and to investigate absolute bioavailability of BI 1810631 administered as film-coated tablet together with an intravenous microtracer dose of BI 1810631 (C-14) (part B) in healthy male volunteers