- ongoing, recruitingHuman Pharmacology (Phase I)- Other
A PHASE 1 STUDY TO ASSESS THE EXCRETION BALANCE, PHARMACOKINETICS, AND METABOLISM OF 14CDC806 IN HEALTHY VOLUNTEERS
This study is looking at how a new drug, DC-806, moves through the body in healthy men. It aims to understand how much of the drug gets absorbed, how it's processed, and how it leaves the body, primarily through urine and faeces.
Netherlands - recruitingNA
Sex Hormones as Regulators of the Age- and Sex-dependent Benefits of Caloric Restriction
This study looks at how hormones, age, and sex affect weight loss from dieting. We want to understand why some people find it harder to lose weight and how diet affects women's health to help fight obesity.
United Kingdom - recruitingPHASE1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
This study is looking at how two different forms of a new medicine, survodutide, are taken up by the body in healthy people who are overweight or have obesity. It aims to see if both forms work in a similar way.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Physiologically based pharmacokinetic modelling of oral and intranasal formulations of zolmitriptan in healthy volunteers
This study is looking at how a specific migraine medicine, zolmitriptan, works in the body when taken as a tablet or a nose spray. It involves healthy adult volunteers to understand how the medicine is absorbed and processed.
Spain - recruitingNA
The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease.
This study looks at how a natural supplement, 7-keto lithocholic acid (7-KLCA), might improve your gut health. We want to see if it helps good bacteria in your gut grow and if this could lead to better overall health.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to test how well different doses of BI 1815368 are tolerated by healthy men
This study is looking for healthy men aged 18 and over to test a new medicine chiamato BI 1815368. The main goal is to see how different doses are handled by the body and if they are safe. It's a very early stage of testing new medicines.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A phase I, open-label trial in two parallel parts to investigate mass balance, metabolism, and basic pharmacokinetics of BI 1810631 (C-14) administered as oral solution (part A) and to investigate absolute bioavailability of BI 1810631 administered as film-coated tablet together with an intravenous microtracer dose of BI 1810631 (C-14) (part B) in healthy male volunteers
This study looks at how a new medicine, BI 1810631, travels through the body and how much reaches the bloodstream. It helps us understand how the body processes the medicine when taken as a liquid or a tablet.
Netherlands - recruitingNA
Investigating the Clinical Utility of the Oxford Virtual Autism Assessment Tool (OVAAT)
This study is testing a new online tool, the Oxford Virtual Autism Assessment Tool (OVAAT), to see how well it can spot signs of autism in young people aged 13-18. Researchers want to know if it's as good as or better than existing assessments.
United Kingdom - recruiting
A Study Measuring Markers of Airway Inflammation in Breath Samples From People With Respiratory Diseases and Healthy Volunteers.
This study looks for early signs of lung cancer and other lung problems by testing breath. We're trying to find a simple, quick way to help doctors decide who needs more tests, especially for people with ongoing breathing issues.
United Kingdom - recruitingNA
Mapping the Impact of Gut Microbiota on Brain and Behavior Through the Lens of GABA
This study explores how gut bacteria, specifically those making GABA, might affect our brains and behavior. We're looking to see if taking a special probiotic can change GABA levels in the brain and improve how people perform on certain tasks.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A phase I, open-label, two-arm, non-randomised trial to investigate the metabolism and pharmacokinetics of a single dose of BI 764198 (C-14) administered as oral solution using two different approaches in healthy male volunteers.
This early-stage study looks at how a new medicine, BI 764198, moves through and leaves the body. Healthy men will take a single dose, allowing researchers to track where it goes and how much leaves in their urine and faeces.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study in healthy people to test how well repeated doses of BI 3032950 are tolerated
This study is looking for healthy men aged 18 and over to test a new medicine called BI 3032950. The main goal is to see how well people tolerate repeated doses of the medicine and if it causes any unwanted side effects when given over time. It's a very early stage of testing.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to investigate the pharmacokinetics of remibrutinib in CSF in healthy participants.
This study is looking at how a new drug, remibrutinib, moves into the brain and spinal fluid in healthy people. We want to understand how it works in the body, which helps us learn about potential future treatments.
Netherlands - recruitingNA
Effect of Exercise on Appetite in Response to Meals
This study looks at how short or long bursts of exercise affect men's appetite and hormones that control hunger after eating. We want to see if exercise changes how much food they want to eat later.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Randomised Double-Blinded, Placebo-Controlled, Single and Multiple Ascending Dose, Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY3876602 in Healthy Participants.
This study is an early test of a new medicine called LY3876602 in healthy adults. We want to see if it's safe, how much the body can handle, and how it moves through the body. This is the first time it will be given to people.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study in healthy people to test whether iclepertin has an effect on cardiac safety
This study is looking at a new medicine called iclepertin. It's for healthy people and checks if the medicine affects the heart. Researchers want to make sure it's safe before it's given to people with illnesses. Your participation could help us understand this new medicine better.
Germany - recruitingPHASE1
Study to Evaluate Pharmacokinetics, Relative Bioavailability, Palatability of Obefazimod Minitablet Formulation
This study is looking at a new, smaller tablet form of a medicine called Obefazimod. It checks if the new tablet works in the body like the current capsule version and if people find it easy to take, especially with different foods.
United Kingdom - recruitingNA
Low-carbohydrate Diet and Low-Density Lipoprotein - Cholesterol (LDL-c) Interindividual Variability
This study looks at how a low-carbohydrate (keto) diet affects cholesterol levels differently in healthy people. We want to find out why some people might see their 'bad' cholesterol go up, to help offer personalised diet advice.
United Kingdom - recruitingPHASE1
Investigating the Effect of Itraconazole on the Pharmacokinetics of AZD4144 in Healthy Participants
This study is looking at how a new medicine, AZD4144, moves through the body of healthy volunteers. We want to see if another medicine, itraconazole, changes how AZD4144 works. This helps us understand how to use AZD4144 safely in the future.
United Kingdom - recruitingPHASE3
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
The BEATRIX study is looking at a vaccine for Group B Streptococcus (GBS) in pregnant women and their babies. It aims to understand if the vaccine is safe and how well it works to protect against GBS, a common bacteria that can sometimes cause serious infections.
United States · Argentina · Brazil - enrolling by invitation
Blood Testing at Entia
This study is looking for healthy volunteers to give small blood samples for a new blood testing device. Researchers want to make sure their device works well. You'll give finger-prick or nurse-taken blood samples. Your results won't be shared unless you ask for them, and you won't receive payment for taking part.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A phase I, open-label, single dose, mass balance trial to investigate metabolism and pharmacokinetics of BI 1291583(C-14) administered as oral solution in healthy male subjects
This study is looking at a new medicine called BI 1291583. It wants to understand how the body uses and gets rid of this medicine. Healthy men will take a single dose, and scientists will follow the medicine's journey through their bodies.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A Randomized, Open-label, Single Dose, 3-Period, 6-Sequence Cross-Over Trial to Investigate the Relative Bioavailability of Apraglutide Versus the Reference Formulation Following Subcutaneous Administrations.
This study is looking at a new medicine called apraglutide. We want to see how well the body takes in this medicine when given in two different ways. It's for healthy adults and helps us understand the best way to give apraglutide.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Effect of itraconazole on the pharmacokinetics of a single oral dose of BI 1815368 in healthy male subjects (an open-label, two-period fixed-sequence design study)
This study looks at how a drug called Sempera affects another medicine, BI 1815368, in healthy men. Researchers want to see if Sempera changes how much BI 1815368 gets into the body and how quickly it reaches its highest level.
Germany - recruitingNA
A Multidisciplinary Investigation of Cardiovascular Benefits of Wild Rice
This study looks at whether eating a small amount of wild rice daily for 28 days can improve heart health in healthy adults. Researchers will check health indicators at the start and end of the study.
Canada - enrolling by invitationPHASE2
Topical Menthol For Tear Secretion
This study is looking into whether applying a menthol solution to your cheek can help your eyes make more tears naturally. It aims to see if the menthol vapour can gently encourage your eyes to feel more comfortable, especially if they sometimes feel dry.
Canada - active not recruitingPHASE1
A Study in Healthy People to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
This study is looking at a new version of a medicine called survodutide, which may help people with obesity or liver conditions. We want to see how the new version is absorbed by the body in healthy people aged 18-65 with a BMI between 27 and 39.9.
Germany - recruitingPHASE1
A Study of LY3938577 in Healthy Participants and Participants With Type 1 Diabetes Mellitus (T1DM)
This study looks at a new medicine called LY3938577 for type 1 diabetes. We want to see how it works in the body and if it helps control blood sugar, comparing it to existing insulin treatments. Safety is also a key focus.
Germany - active not recruitingNA
The Effects of Protein Supplementation With or Without Urolithin A During Single-leg Immobilization
This study looks at how protein drinks, with or without a natural ingredient called Urolithin A, can help protect muscles when someone can't use their leg, like after an injury. Researchers want to see if these drinks can stop muscle weakening during this time.
Canada - active not recruitingPHASE1
A Study in Healthy People or Otherwise Healthy With Overweight or Obesity to Compare 2 Formulations of Survodutide Given in Different Ways, Either as a Pre-filled Syringe or a Pen-like Injector
This study looks at a new medicine called survodutide for people who are healthy or have overweight/obesity. We want to see if two different versions of the medicine, given with different types of injectors, work similarly in the body. It's an early-stage study.
Germany - recruitingPHASE1
A Study in Healthy Men to Test How Well Different Doses of BI 3821001 Are Tolerated
This study is looking at a new medicine called BI 3821001 in healthy men. Scientists want to see if it's safe, how well people tolerate different doses, and how the body handles the medicine.
Germany - recruitingNA
Effect of Smoking and Time of Day on Eosinophils
This study looks at how smoking and time of day affect immune cells called eosinophils in healthy smokers. Researchers will compare blood samples from smokers and non-smokers both with and without recent smoking.
Germany - recruitingPHASE1
A Study in Healthy People to Test How Vicadrostat Affects the Heart
This study is looking at how a new medicine, Vicadrostat, affects the heart in healthy adults. Researchers will compare Vicadrostat to a dummy medicine (placebo) to see if there are any differences. Moxifloxacin, another medicine, will also be used in some people.
Germany - recruitingNA
Personalized Responses to Dietary Composition Trial 3
This study, PREDICT 3, aims to understand how different foods affect individuals. By looking at how people respond to meals in their everyday life, it helps create more personalised eating advice to improve health for conditions like diabetes and heart problems.
United States · United Kingdom - recruitingPHASE1
A Study to Test How Well Different Doses of BI 3031185 Are Tolerated by Healthy Men and Women
This study is testing a new medicine, BI 3031185, to see how safe it is and how the body handles different doses. It involves healthy men and women.
Germany - not yet recruitingNA
Pre-analytical Processing of Human Samples for Microbiota Analysis Quality
This study aims to find the best ways to collect and store poo samples for studying the tiny living things (microbes) in your gut. It compares different collection methods to make sure the science is accurate.
France - enrolling by invitationNA
Effects of Reactive Hypoglycaemia on Cognition in Earlier or Later Chronotypes
This study looks at how certain breakfasts affect memory and attention in university students. We want to see if a quick drop in blood sugar after eating (called reactive hypoglycaemia) impacts thinking skills, especially for those who naturally prefer going to bed and waking up later.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
The effect of multiple doses of BI 425809 on the pharmacokinetics of multiple doses of a combination of ethinyl estradiol and levonorgestrel following oral administration in healthy premenopausal female subjects (an open-label, twoperiod, fixed sequence design trial with run-in period)
This study looks at how a new medicine, BI 425809, affects a common type of contraceptive pill (Microgynon) in healthy women. It helps us understand if the new medicine changes how the contraceptive pill works in the body.
Germany - recruitingPHASE1
Phase 1 Single Ascending Doses (SAD) of M5542 in Healthy Participants
This study is testing a new medicine called M5542 in healthy volunteers. It checks how safe it is, whether people can tolerate it, and how the body handles it after a single dose. This is an early stage of testing new medications.
Germany - recruitingNA
Investigating the Neuropsychological Effects of 5-HT2a Antagonism
This study looks at how a specific brain chemical, serotonin, affects memory, emotions, and decisions. Researchers are using a drug called pimavanserin to understand more about a particular 'lock' (receptor) for serotonin. This could help develop new treatments for depression.
United Kingdom - not yet recruitingNA
Light-Based Monitoring (SR-NIRS) for Suspected Testicular Torsion in Children
This study uses a special light to check blood flow in boys' testicles. It aims to find a quick, easy way to spot twisted testicles (testicular torsion) which need urgent treatment. It looks at healthy boys and boys with sudden pain to see if this new method works.
Canada - active not recruitingNA
The Effect of Ketone Esters on Forearm Glucose Metabolism
This study looks at how a special drink containing ketones might affect how our muscles use sugar. Ketones are natural substances in your body, and understanding them could help treatments for certain health conditions or aid recovery after exercise.
United Kingdom - recruitingNA
Effect of Exercise on Appetite in Response to Meals During Energy Restriction
This study looks at how exercise affects appetite and hunger hormones when people eat much less than usual. Researchers want to see if a short workout can change how much food healthy men want to eat afterwards.
United Kingdom - active not recruitingNA
Effects of Diet on Perinatal Mood and Cognition
This study looks at how eating foods rich in plant compounds called flavonoids might help new mothers with their mood, thinking skills, and blood pressure during and after pregnancy, aiming to reduce 'baby blues' and improve well-being.
United Kingdom - enrolling by invitation
GlyCoBrain Observational Study
This study looks at how your breakfast choices affect your memory and attention, especially for young adults. Researchers want to understand if different meal timing and food types, particularly those that cause quick sugar spikes, impact brain function in students.
Germany - recruitingPHASE1
A Phase 1 Single Dose and Multiple Ascending Dose Study to Assess the Relative Bioavailability, Food Effect, Safety, Tolerability and Pharmacokinetics of SYT-510 in Healthy Participants
This study is testing a new medicine, SYT-510, in healthy people to see how safe it is and how the body handles it. We're looking at different doses and how food affects it to help future studies.
United Kingdom - recruitingPHASE1
A Single- and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY4066708 in Healthy Participants
This study looks at a new medicine called LY4066708 in healthy volunteers. We want to check it's safe, how well the body handles it, and how long it stays in the system. It's a first step to see if it could help with certain health conditions later on.
United Kingdom - recruitingNA
Interaction Between White Potato Consumption and Meal Timing on Glycemic Response and Appetite in Adults
This study looks at how eating white potatoes at different times affects blood sugar and hunger. Researchers want to see if potatoes can help you feel full and eat less, especially if eaten for breakfast, compared to other foods.
Canada - active not recruitingNA
Clinical Study to Predict the Risk of Bone Fractures With the POROUS Ultrasound Device
This study looks at a new ultrasound scanner, called POROUS, to see if it can better predict bone breaks, especially in older adults. It compares POROUS with the usual X-ray scan (DXA) to help improve how we find and treat weak bones.
Austria · Germany · Netherlands - active not recruitingPHASE1
Safety, PK/PD, and Immunogenicity Study of SC ALXN2030 in Healthy Participants
This study is looking into a new medication called ALXN2030. We want to check how safe it is and if it causes any side effects in healthy people. We're also seeing how the body handles the medicine. It's an early-stage study to gather important safety information.
United Kingdom