Ongoing, recruitingTherapeutic use (Phase IV)Interventional

TURN-COVID Biobank: The Dutch cohort study tor the evaluation of the use of neutralizing monoclonal antibodies and other antiviral agents against SARS-CoV-2

This research study, called TURN-COVID Biobank, is looking closely at how well certain treatments for COVID-19 work in people. These treatments include medications like Ronapreve, Evusheld, Xevudy, and Paxlovid. Researchers want to understand how the amount of virus in the body changes during and after treatment, and if new forms of the virus appear. They are also studying how the body's immune system reacts to these treatments. Another important part of this study is creating a biobank – a collection of samples like blood – which will help scientists in the future compare these existing COVID-19 treatments with newer ones being developed. This study focuses on adults who have COVID-19.

At a glance

Status

Ongoing, recruiting

Phase

Therapeutic use (Phase IV)

Sponsor

Stichting Amsterdam UMC

Enrolment target

400

Start

22 Nov 2024

SARS-CoV-2 infection

What is this study about?

This study, called TURN-COVID Biobank, is designed to help us better understand some of the treatments currently used for COVID-19. You might have heard of some of these, like Ronapreve, Evusheld, Xevudy, and Paxlovid. These medications work in different ways to fight the SARS-CoV-2 virus, which causes COVID-19.

The main goals of this research are to see how these treatments affect the amount of virus in a person's body over time. Researchers also want to find out if new types of the virus develop during treatment, and how the body's natural defences (its immune system) respond. Understanding these things can help doctors decide when and how to best use these treatments. The 'Biobank' part means they are also collecting samples, like blood, to create a valuable resource for future research. This will help them compare these established treatments with new COVID-19 medicines that are still being developed.

Ultimately, this study aims to gather important information that will improve how we treat COVID-19, protect people from severe illness, and prepare for future challenges with the virus. It's a key step in making sure we have the most effective tools to fight COVID-19.

Key takeaways

This study helps understand how well existing COVID-19 treatments work.
It specifically looks at how the virus changes and how your body reacts to treatment.
A collection of samples is being built for future research on COVID-19.
Adults (18+) with COVID-19 can potentially join.
Participation involves regular check-ups and sample collection, like blood.

Who may be eligible?

To be part of this study, you need to be at least 18 years old. There is no upper age limit, so people of any adult age can potentially join.

All adults, regardless of whether they are male or female, are welcome to take part in this research.

The most important requirement is that you have a SARS-CoV-2 infection, meaning you have COVID-19. Beyond these basic points, a study doctor would check other details to make sure the study is a good fit for you and that it's safe for you to participate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you currently have a SARS-CoV-2 infection (COVID-19)?
Are you receiving one of the specified COVID-19 treatments?
Are you comfortable with providing samples for research?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, the specific details of your involvement will depend on which treatment you receive as part of your normal care for COVID-19. Generally, it will involve regular visits or check-ups with the study team. During these visits, the research team will monitor how you are responding to treatment.

This will likely include taking samples, such as blood or swabs, to measure the amount of virus in your body and see how your immune system is reacting. They will also keep track of any symptoms you have. The total length of your participation will depend on the treatment course and follow-up needed, but the team will explain this to you clearly from the start.

Potential risks and benefits

Taking part in this study may offer some benefits, as the treatments being studied are already used for COVID-19. By closely monitoring your health, the study team will be able to track your progress. While the treatments being studied are approved medications, there's always a chance of side effects, which the study team will discuss with you. You will be carefully monitored for these. It's important to remember that you are free to leave the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Netherlands

Common questions

What kind of treatments are being looked at?

The study is looking at several COVID-19 treatments like Ronapreve, Evusheld, Xevudy, and Paxlovid.

What does a 'biobank' mean?

A biobank is a collection of samples, like blood, that will be stored for future research to help understand COVID-19 treatments better.

Do I have to be sick with COVID-19 to join?

Yes, to be eligible for this study, you must currently have a SARS-CoV-2 infection (COVID-19).

Will I get a new medicine?

The study focuses on existing treatments for COVID-19 that are already in use, not entirely new, unapproved medications.

Can I stop participating if I change my mind?

Yes, you can choose to leave the study at any point without it affecting your medical care.