- recruiting
Early Detection of At-risk Septic Patients
This study looks for better ways to spot serious infection (sepsis) in A&E. Researchers will test new tools like special monitors and blood tests to see if they can identify very sick patients faster than current methods. The aim is to help patients get life-saving treatment sooner.
United Kingdom - recruitingPHASE2
A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.
This study looks at a new medicine called AZD4144 for people who have kidney damage from a serious infection (sepsis). We want to see if it's safe and helps their kidneys work better than a dummy medicine.
United States · Argentina · Belgium - recruitingPHASE3
Early Vasopressors in Sepsis
This study compares two ways to treat severe infection (sepsis) in hospital. One uses a salty fluid first, then medicine to raise blood pressure. The other uses blood pressure medicine first, then salty fluid. We want to see which helps patients recover better.
United Kingdom - not yet recruitingNA
Safety, Tolerability and Performance of the NucleoCapture Device in the Reduction of Circulating CfDNA/NETs in Subjects with Sepsis
This study is testing a new device, NucleoCapture, for people with sepsis and breathing problems in intensive care. It aims to see if removing certain substances from the blood can improve treatment alongside standard care. Researchers are checking its safety and how well it works.
Germany · Switzerland · United Kingdom - recruiting
Fosfomycin I.v. for Treatment of Severely Infected Patients
This study looks at how well the antibiotic fosfomycin works for serious infections like bone infections, meningitis, and severe pneumonia. It's for adults already being treated with fosfomycin and aims to see if it's safe and effective in real-world use.
Austria · Germany · Greece - authorisedHuman Pharmacology (Phase I)- Other
Pharmacokinetics of Aztreonam-Avibactam in Critically Ill Patients with Sepsis Receiving ECMO Support: A Prospective PK Study
This study is looking at how a new medicine, Aztreonam-Avibactam, works in very sick adults with a serious infection called sepsis. We want to understand how the body uses and gets rid of this medicine when patients are also on a special life support machine called ECMO.
Austria - ongoing, recruitingTherapeutic use (Phase IV)
A randomized trial investigating the superiority of TDM-optimized teicoplanin dosing versus standard of care
This study is looking at whether a new way of giving a medicine called teicoplanin works better for people with a serious infection called sepsis. We want to see if adjusting the dose based on individual patient needs helps the medicine work more effectively.
Netherlands - ongoing, recruitingTherapeutic use (Phase IV)
SePkLin Study: Pragmatic, Multicenter, Randomized, Controlled Clinical Trial in Patients with Sepsis to Evaluate the Safety and Efficacy of Personalized Pk/Pd Dosing Versus Standard Dosing of LINezolid.
This study looks at treating sepsis (a serious infection) with antibiotics. It compares giving a standard dose of the antibiotic linezolid with giving a personalised dose to see which is safer and works better, especially in preventing low platelet counts.
Spain - ongoing, recruitingPhase III and phase IV (Integrated)
Adjunctive DobutAmine in sePtic cardiomyopathy with Tissue hypoperfusion: a randomized controlled multi-center trial
This study looks at treating severe blood poisoning (sepsis) that affects the heart. It tests a drug called Dobutamine to see if it helps improve organ function in people whose hearts aren't pumping enough blood, leading to tissue damage.
France - not yet recruiting
Transcriptional Analysis of Mechanisms in Liver Failure and Sepsis
This study looks at how the body's immune system reacts to severe liver failure and serious infections (sepsis). We want to understand what makes inflammation spread and find new ways to treat these conditions, hopefully reducing the need for liver transplants.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
C3601010: A Phase 2A, 2-Part, Open-Label, Non-Randomized, Multicenter, Single and Multiple Dose Trial to Evaluate Pharmacokinetics, Safety and Tolerability of Aztreonam and Avibactam ± Metronidazole in Neonates and Infants From Birth to Less Than 9 Months of Age With Suspected or Confirmed Infections Due to Gram-Negative Pathogens Requiring Intravenous Antibiotic Treatment
This study is testing a new combination antibiotic treatment (Aztreonam and Avibactam, sometimes with Metronidazole) for serious bacterial infections in babies up to 9 months old. It aims to see how the medicines work in their bodies and if they are safe.
Slovakia · Greece · Bulgaria - authorisedTherapeutic exploratory (Phase II)
Early optimization of ceftazidine dosing regimen in critical care : FORTOPTIM_1
Researchers are looking at how to give ceftazidime, an antibiotic, to people with serious infections called sepsis. They want to find the best dose to make sure the medicine works well without causing side effects. This study aims to make treatment safer and more effective for very unwell patients.
France - authorisedPhase III and phase IV (Integrated)
Vitamin D as add-on treatment option of pneumonia and sepsis in elderly subjects (TreatViD)
This study is looking at whether high-dose vitamin D can help older people admitted to hospital with severe infections like pneumonia or sepsis. Researchers want to see if it helps them recover faster or prevents serious problems like needing intensive care or even death.
Italy - authorisedTherapeutic exploratory (Phase II)
PALETTE - Adaptive platform trial for personalisation of sepsis treatment in children and adults: a multi-national, treatable traits-guided, adaptive, exploratory, bayesian basket trial
This study is looking for better ways to treat sepsis in adults. It's testing several existing medicines to see if any work well for different types of sepsis. The main goals are to improve survival and help patients recover without needing machines to support their bodies.
France - recruiting
Characterisation of Endothelial Cells in Different Inflammatory Pathologies
This study looks at tiny cells lining blood vessels to understand why some people get very sick from inflammation, like in sepsis. Researchers want to find out how these cells change at a genetic level when the body is fighting severe illness, hoping to find new ways to help patients.
United Kingdom - not yet recruiting
Investigating the Impact of Sepsis Phenotypes on Antibiotic Treatment in Patients With Severe Pneumonia and Sepsis
This study looks at how antibiotics work differently in people with severe pneumonia and sepsis. We want to understand if different immune system reactions affect antibiotic levels, aiming to improve treatment and fight antibiotic resistance.
United Kingdom - not yet recruiting
Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples
This study is looking at a new test called InfectID-BSI. It uses a small amount of your blood to quickly check for serious infections caused by bacteria or yeast. We want to see if it works as well as, or better than, the current standard tests.
United States · Australia · United Kingdom