- authorisedPhase III and phase IV (Integrated)
BETARGET : Randomized trial of individualizing BETA-lactam taRGET combining therapeutic drug monitoring, minimal inhibitory concentration and model-based dose adjustment, in Intensive Care Units patients with gram negative bacilli infection
This study looks at whether personalised antibiotic doses help critically ill patients in intensive care recover faster from severe infections like sepsis. Doctors will test blood levels and use computer models to tailor standard antibiotic amounts to each person, aiming to clear infections sooner and reduce time spent in the ICU.
France - recruitingTherapeutic exploratory (Phase II)
EMAPALUMAB TREATMENT FOR ANTICIPATED CLINICAL BENEFIT IN SEPSIS DRIVEN BY THE INTERFERON-GAMMA ENDOTYPE (THE EMBRACE TRIAL)
This clinical trial is testing a medicine called emapalumab for people with severe sepsis. Sepsis happens when the body overreacts to an infection. Researchers want to see if this medicine helps vital organs recover better and faster compared to standard care with a simple salt-water drip.
Greece - recruitingTherapeutic use (Phase IV)
SePkLin Study: Pragmatic, Multicenter, Randomized, Controlled Clinical Trial in Patients with Sepsis to Evaluate the Safety and Efficacy of Personalized Pk/Pd Dosing Versus Standard Dosing of LINezolid.
This study looks at treating sepsis (a serious infection) with antibiotics. It compares giving a standard dose of the antibiotic linezolid with giving a personalised dose to see which is safer and works better, especially in preventing low platelet counts.
Spain - recruitingPhase III and phase IV (Integrated)
Adjunctive DobutAmine in sePtic cardiomyopathy with Tissue hypoperfusion: a randomized controlled multi-center trial
This study looks at treating severe blood poisoning (sepsis) that affects the heart. It tests a drug called Dobutamine to see if it helps improve organ function in people whose hearts aren't pumping enough blood, leading to tissue damage.
France - recruitingPhase IV
SepTiC: Sepsis Trials in Critical Care
The SepTiC trial is looking at better ways to treat sepsis in UK intensive care units. It tests tailored antibiotics, careful fluid control, and an immune-boosting drug. The goal is to discover which treatments give critically ill patients the best chance of recovery and survival.
United Kingdom · England - recruitingNot Applicable
A trial comparing short course antibiotics and standard course antibiotics for the treatment of sepsis
The SHORTER trial looks at whether a shorter five-day course of antibiotics is just as safe and effective as the standard seven- to nine-day course for adults treated for sepsis in intensive care. The aim is to clear infections quickly while reducing medication side effects and superbug risks.
United Kingdom · England · Northern Ireland - not yet recruitingNot Applicable
Investigating the effects of intravenous fluids and imatinib in human volunteers with a sepsis-like state
Sepsis is a serious reaction to infection that causes leaky blood vessels. Doctors often give intravenous fluids, but these might sometimes cause extra swelling. This study looks at how fluids and a medicine called imatinib affect healthy volunteers during a short, mild flu-like response that mimics early sepsis.
United Kingdom - recruitingPhase IV
A hospital study testing whether more tailored antibiotic treatment for patients with sepsis can improve recovery while also helping reduce antibiotic resistance
Sepsis is a serious, life-threatening reaction to an infection that needs urgent treatment. The PATH Sepsis study tests which standard NHS antibiotics work best as a first choice. The goal is to help patients recover quickly while preventing harmful bacteria from becoming resistant to vital medicines.
United Kingdom · England - recruitingTherapeutic use (Phase IV)
A randomized trial investigating the superiority of TDM-optimized teicoplanin dosing versus standard of care
This study is looking at whether a new way of giving a medicine called teicoplanin works better for people with a serious infection called sepsis. We want to see if adjusting the dose based on individual patient needs helps the medicine work more effectively.
Netherlands - recruiting
Microvascular Monitoring in Circulatory Shock and Sepsis (MiMICSS)
This study looks at a new way to monitor critically ill patients in intensive care. It uses a device that shines a light on muscles and the brain to understand how blood flows in tiny vessels, hoping to improve care for conditions like sepsis.
Canada - recruitingNA
Hemodynamic Evaluation Using Microcirculation for Early Treatment of Septic Patients
This study looks at how nurses measuring tiny blood flow changes in sepsis patients could help them get treatment faster. Sepsis is a serious condition, and we want to see if quick treatment based on these measurements can improve patient outcomes.
France - recruiting
ARTICE® Real Data Collection & Observational Trial, Phase 4 Study
This study is gathering real-life health information about a treatment called ARTICE® for people with sepsis or septic shock in hospital. It aims to see how well ARTICE® works, if it helps reduce illness severity, and to understand who benefits most from it.
Germany - enrolling by invitation
Impact of the Introduction of a Performance Improvement Program on the Initial Management of Sepsis and Septic Shock in Adults in the Emergency Department: a Before-and-after Study (IPA-SOS)
This study looks at how a special improvement programme at Brest University Hospital affects the care of adults with serious infections called sepsis or septic shock. Researchers want to see if the programme helps staff follow treatment guidelines better and improves how patients recover.
France - recruiting
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
This study looks at how serious illness and strong antibiotics affect the helpful germs in your gut. Researchers want to see if changes in these germs are linked to brain problems and infections in people in intensive care. They will collect samples and check brain function over time.
Germany - not yet recruiting
Transcriptional Analysis of Mechanisms in Liver Failure and Sepsis
This study looks at how the body's immune system reacts to severe liver failure and serious infections (sepsis). We want to understand what makes inflammation spread and find new ways to treat these conditions, hopefully reducing the need for liver transplants.
United Kingdom - not yet recruitingNA
Safety, Tolerability and Performance of the NucleoCapture Device in the Reduction of Circulating CfDNA/NETs in Subjects with Sepsis
This study is testing a new device, NucleoCapture, for people with sepsis and breathing problems in intensive care. It aims to see if removing certain substances from the blood can improve treatment alongside standard care. Researchers are checking its safety and how well it works.
Germany · Switzerland · United Kingdom - recruitingPHASE3
Early Vasopressors in Sepsis
This study compares two ways to treat severe infection (sepsis) in hospital. One uses a salty fluid first, then medicine to raise blood pressure. The other uses blood pressure medicine first, then salty fluid. We want to see which helps patients recover better.
United Kingdom - recruiting
Evaluation of Parameters Collected From Routine Data for the Diagnosis of Sepsis and Septic Shock and Their Influence on Time to Diagnosis and Patient Outcome
This study looks back at hospital records to create a computer program to help spot health problems like sepsis earlier. It aims to improve how doctors diagnose and treat these serious conditions, potentially leading to better patient care and outcomes.
Germany - authorisedHuman Pharmacology (Phase I)- Other
Pharmacokinetics of Aztreonam-Avibactam in Critically Ill Patients with Sepsis Receiving ECMO Support: A Prospective PK Study
This study is looking at how a new medicine, Aztreonam-Avibactam, works in very sick adults with a serious infection called sepsis. We want to understand how the body uses and gets rid of this medicine when patients are also on a special life support machine called ECMO.
Austria - recruiting
Early Detection of At-risk Septic Patients
This study looks for better ways to spot serious infection (sepsis) in A&E. Researchers will test new tools like special monitors and blood tests to see if they can identify very sick patients faster than current methods. The aim is to help patients get life-saving treatment sooner.
United Kingdom - recruiting
Fosfomycin I.v. for Treatment of Severely Infected Patients
This study looks at how well the antibiotic fosfomycin works for serious infections like bone infections, meningitis, and severe pneumonia. It's for adults already being treated with fosfomycin and aims to see if it's safe and effective in real-world use.
Austria · Germany · Greece - not yet recruiting
Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2
This study looks at how your body changes after surgery to spot problems like heart injury or infections early. It uses a small device to continuously monitor your vital signs, helping doctors learn more about how to keep patients safe.
Canada - recruitingNA
Precision Exercise to Improve Outcomes in Sepsis
This study looks at a special 12-week exercise programme for people who have recovered from sepsis. We want to see if this programme can help them exercise better and improve their overall health after sepsis.
Canada - recruitingPHASE1
Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI)
This study is looking at a new treatment called DNase I for people very sick with sepsis in intensive care. We want to see if it's safe, how much to give, and what effects it has on the body. This is an early-stage study to gather important information.
Canada - recruiting
Early Severe Illness TrAnslational BioLogy InformaticS in Humans
This study, called ESTABLISH, looks at how the body reacts to severe illnesses like sepsis in the Intensive Care Unit (ICU). Researchers want to find better ways to diagnose these conditions early and discover new treatments to help patients recover.
Canada - recruitingNA
Remote Ischemic Preconditioning in Septic Patients
This study looks at a simple method called Remote Ischemic Preconditioning (RIPC) in very ill patients with sepsis. It aims to see if this method, which involves briefly restricting blood flow to an arm, can help prevent or reduce kidney damage, a common problem in these patients.
Germany - authorisedTherapeutic exploratory (Phase II)
Early optimization of ceftazidine dosing regimen in critical care : FORTOPTIM_1
Researchers are looking at how to give ceftazidime, an antibiotic, to people with serious infections called sepsis. They want to find the best dose to make sure the medicine works well without causing side effects. This study aims to make treatment safer and more effective for very unwell patients.
France - not yet recruiting
Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples
This study is looking at a new test called InfectID-BSI. It uses a small amount of your blood to quickly check for serious infections caused by bacteria or yeast. We want to see if it works as well as, or better than, the current standard tests.
United States · Australia · United Kingdom - active not recruiting
Overview of Botriomycoma in Children with a Central Line: Epidemiology, Risk Factors, Treatments
This study looks at skin growths called botriomycomas near central lines in children needing special nutrition at home. It aims to understand why these growths appear and how best to treat them, as they can sometimes lead to infections and other problems.
France - not yet recruitingPHASE3
Venous Excess Ultrasound for Personalized Resuscitation in Septic Shock
This study looks at using a special ultrasound (VEXUS) to manage fluids in patients with septic shock, a severe infection. It aims to see if this method is safe and can prevent kidney problems, preparing for a larger study.
Canada - authorisedTherapeutic exploratory (Phase II)
PALETTE - Adaptive platform trial for personalisation of sepsis treatment in children and adults: a multi-national, treatable traits-guided, adaptive, exploratory, bayesian basket trial
This study is looking for better ways to treat sepsis in adults. It's testing several existing medicines to see if any work well for different types of sepsis. The main goals are to improve survival and help patients recover without needing machines to support their bodies.
France - not yet recruiting
Investigating the Impact of Sepsis Phenotypes on Antibiotic Treatment in Patients With Severe Pneumonia and Sepsis
This study looks at how antibiotics work differently in people with severe pneumonia and sepsis. We want to understand if different immune system reactions affect antibiotic levels, aiming to improve treatment and fight antibiotic resistance.
United Kingdom - recruiting
Characterisation of Endothelial Cells in Different Inflammatory Pathologies
This study looks at tiny cells lining blood vessels to understand why some people get very sick from inflammation, like in sepsis. Researchers want to find out how these cells change at a genetic level when the body is fighting severe illness, hoping to find new ways to help patients.
United Kingdom - recruitingPHASE2
A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.
This study looks at a new medicine called AZD4144 for people who have kidney damage from a serious infection (sepsis). We want to see if it's safe and helps their kidneys work better than a dummy medicine.
United States · Argentina · Belgium