RecruitingNAINTERVENTIONAL

Physical Activity Promotion and Clinical Remission in Severe Asthma

This study wants to find out if combining a guided physical activity programme with a modern asthma treatment called tezepelumab can help more adults with severe asthma get their condition under control. While new medicines have improved severe asthma for many, some people still struggle with being active and have ongoing symptoms. The research will compare two groups: one receiving standard care with tezepelumab, and another getting the same standard care plus a 12-week programme to help them become more active. This programme includes personal advice, group support, and tools to track activity. The study will follow participants for 12 months to see if the activity programme makes a difference in achieving asthma remission and improving overall well-being.

At a glance

Status

Recruiting

Phase

Sponsor

University of Leeds

Enrolment target

140

Start

31 Jul 2026

Estimated completion

01 Dec 2029

Severe Asthma

What is this study about?

Severe asthma can be very challenging, often leading to ongoing symptoms and making it hard to be as active as you'd like. Even with new and effective treatments, like a type of medicine called biologics (such as tezepelumab), some people still find their daily lives are affected. This study aims to see if we can improve things further by adding a structured physical activity programme to existing treatments.

The main idea is to understand if helping people with severe asthma become more active can lead to better health outcomes, specifically a state called 'clinical remission' – where asthma symptoms are much reduced or gone, and their asthma is well-controlled. Physical activity is known to be good for overall health, and researchers believe it might play an important role in managing severe asthma too. This research could help us find new ways to offer the best possible care for people living with severe asthma.

Participants will be split into two groups by chance: one group will receive their usual severe asthma care, including tezepelumab. The other group will receive the same usual care *plus* a 12-week physical activity programme. This programme is designed to give you personalised support, help you set goals, and use a smartphone app to track your progress. The study will then check on everyone for 12 months to compare how well each group is doing, looking at their asthma control, quality of life, and how active they are.

Key takeaways

This study explores how physical activity can help severe asthma.
It combines a new asthma drug (tezepelumab) with an exercise programme.
Participants will be in one of two groups for comparison.
The physical activity support lasts 12 weeks, with 12 months of follow-up.
Aims to see if more activity leads to better asthma control (remission).

Who may be eligible?

This study is looking for adults aged between 18 and 70 years old who have been diagnosed with severe asthma by a doctor. To be considered, your asthma should be severe enough that your specialist team has decided you would benefit from starting a new treatment called tezepelumab as part of your regular care.

You would also need to have had several asthma attacks that required steroid tablets in the past year, or be regularly taking steroid tablets for your asthma. Your doctor will also need to confirm your asthma diagnosis through specific tests.

However, you wouldn't be able to join if you are pregnant, or if you have other serious lung conditions that aren't asthma (like severe sleep apnoea). Also, if you have other health issues that would make it difficult or unsafe to be physically active, or if you couldn't complete the study safely, you might not be able to take part.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you aged between 18 and 70?
Do you have a doctor's diagnosis of severe asthma?
Has your asthma specialist decided you need to start tezepelumab?
Have you had several asthma attacks or take daily steroid tablets for asthma?
Are you able and willing to follow study instructions and use a smartphone app?
Are you *not* pregnant, and do you *not* have other serious health issues that would stop you from exercising?

Answer every question to see your result.

What does participation involve?

If you choose to take part, you'll first discuss the study with the team and give your consent. Then, you'll be randomly put into one of two groups. Both groups will receive tezepelumab as prescribed by your doctor. One group will also take part in a 12-week physical activity programme. This programme involves an individual meeting, group support sessions (which might be online), help with setting personal activity goals, and using a smartphone app to monitor your activity levels.

Throughout the study, you'll have regular check-ups and assessments, similar to what you might have for your usual asthma care, to see how your asthma is doing and to measure your activity levels. These assessments will help the researchers understand if the physical activity programme makes a difference. The study will follow you for a total of 12 months from when you start.

Potential risks and benefits

Taking part in this study may offer some potential benefits, such as receiving additional support to increase your physical activity, which could improve your asthma control and overall well-being. However, there's no guarantee that you will personally benefit. The main potential risks are those associated with increasing physical activity, which the programme is designed to introduce safely and gradually. You might also find the extra appointments or using the smartphone app time-consuming. You are free to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

Leeds Teaching Hospitals NHS Trust
Verified postcode
Leeds, United Kingdom· Recruiting

Common questions

What is 'clinical remission' in asthma?

It means your asthma symptoms are very well controlled, you're not having asthma attacks, and your lung function is good, almost like your asthma isn't there.

What is tezepelumab?

It's a modern medicine called a biologic, used to treat severe asthma when other treatments haven't worked well enough.

Will I have to do vigorous exercise?

The physical activity programme is designed to be personalised and introduced gradually. It will support you in finding ways to be more active that suit you and your abilities.

How long will I be involved in the study?

You'll be followed for a total of 12 months. The physical activity programme, if you're in that group, lasts for 12 weeks of that time.

Can I still take my usual asthma medicines?

Yes, you will continue your standard asthma treatment, including tezepelumab, as part of the study.

How to find out more

Oliver J Price, PhD

o.price1@leeds.ac.uk +44(0)113 343 2909 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.