- active not recruitingPHASE3
Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma.
This study looks at how well a new asthma medicine, tezepelumab, works to control severe asthma while patients try to reduce their regular asthma inhaler use. It aims to see if patients can stay well on less medicine.
United States · Argentina · Belgium - active not recruitingPHASE2
A Long-Term Safety and Efficacy Study of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALOUR)
This study looks at the long-term safety and effectiveness of a new medicine called verekitug (UPB-101) for adults with severe asthma. It's for people who have already finished a related study called VALIANT.
United States · Argentina · Bulgaria - recruiting
Experience of Biologic Treatments for Severe Asthma: a Survey
This survey aims to understand the real-life experiences of people with severe asthma using biologic treatments. We want to know how these treatments affect daily life, beyond just medical improvements, by asking about both positive changes and challenges like side effects.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-blind, Placebo-controlled, Multi-center, Dose-ranging Study to Evaluate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants with Severe Asthma (VALIANT)
This study is testing a new medicine, Verekitug, for adults with severe asthma. We want to see if it can reduce severe asthma attacks and improve breathing over 60 weeks. Some people will get the medicine, others a dummy treatment, to see how well it works and if it's safe.
Czechia · Poland · Italy - not yet recruiting
The Inflammatory Profile of Exacerbations in Patients With Severe Asthma Receiving Tezepelumab: The TezEx Study
This study looks into why some people with severe asthma still get flare-ups even when taking a new medicine called tezepelumab. Researchers want to understand the body's natural reactions better to help improve treatments for severe asthma.
United Kingdom - recruiting
Exploring the Lived Experience of Young Adults With Severe Asthma
This study explores the daily experiences of young adults (16-25) with severe or uncontrolled asthma in Manchester and Liverpool. We aim to understand their challenges and needs to improve future care and support for this group, which is often overlooked.
United Kingdom