Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI
This study is for adults aged 18-80 who have recently had a specific type of heart attack (STEMI), whether they have diabetes, prediabetes, or normal blood sugar. We want to understand how different body processes, especially how your body uses sugar and fats (metabolism), affect heart recovery. Researchers will also look at how these processes affect the heart's ability to pump blood and how the disease might progress over time. By comparing people with and without diabetes, the study aims to find new ways to identify those at risk of complications and develop more personalised treatments, helping to improve care for heart attack survivors.
At a glance
What is this study about?
Imagine your heart is a house, and a heart attack is like a major structural problem. This study is trying to understand more about that house, specifically how the building materials and energy systems (your body's metabolism) affect the damage and how well the house can be repaired afterwards. We're especially interested in how this works in people who have diabetes, pre-diabetes, or normal blood sugar levels, because diabetes can affect how your body recovers.
Researchers will look closely at different aspects of your health, like how your body handles sugar and fats, details about your immune system, and your blood vessels. They want to see how these factors are connected to the recovery of your heart muscle and how the disease might change over time. By carefully studying these things in many people who have recently had a heart attack, they hope to find clear patterns.
The main goal is to figure out if understanding an individual's unique metabolism can help predict how well their heart will recover and if they might develop related problems. Ultimately, this research could lead to better ways to identify people at higher risk and then offer more specific treatments tailored just for them, helping improve long-term health after a heart attack. This is all about precision medicine – finding the right treatment for the right person.
Key takeaways
- A research study for people who have recently had a specific type of heart attack (STEMI).
- Looks at how your body uses energy (metabolism) and its link to heart recovery.
- Includes people with diabetes, pre-diabetes, and normal blood sugar levels.
- Aims to find better ways to predict risks and tailor treatments for future patients.
- Involves two detailed check-ups: one soon after your heart attack and one year later.
Who may be eligible?
This study is looking for adults between 18 and 80 years old who have recently had a specific type of heart attack called a STEMI. You could be considered for the study if you have diagnosed diabetes, or if you have pre-diabetes (which means your blood sugar levels are higher than normal but not yet at the level for diabetes), or if your blood sugar levels are completely normal. Your diabetes, if you have it, should be generally well-managed, with a specific blood test result (HbA1c) below 9.0%.
It's important that you are generally stable and able to give your consent to take part, and not taking certain medications that might interfere with the study. Researchers will need to be sure you don't have other serious health problems, such as severe kidney, liver, or heart disease, cancer, or serious ongoing infections. If you are pregnant or have gestational diabetes, you wouldn't be able to join. Also, if you're already in another research study that involves a treatment, this study wouldn't be for you.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- I am between 18 and 80 years old.
- I have recently had a STEMI heart attack.
- My diabetes, if I have it, is generally well-managed (HbA1c below 9.0%).
- I do not have other serious health problems like advanced kidney, liver, or heart disease, or cancer.
- I am not currently pregnant or participating in another treatment-based research study.
What does participation involve?
If you decide to take part, you would have a thorough health check-up when you first join the study, not long after your heart attack. This would involve various tests to understand your body's metabolism, immune system, and heart function. One year after your heart attack, you would have another detailed follow-up visit and similar tests. The study does not involve taking any new medications or changing your current treatment. It's about carefully observing and learning from what's happening with your health over this period.
Potential risks and benefits
Locations (1)
- German Diabetes CenterVerified postcodeDüsseldorf, Germany· Recruiting
Common questions
What is a STEMI?
STEMI stands for 'ST-segment Elevation Myocardial Infarction', which is a severe type of heart attack where a major artery supplying blood to the heart is blocked.
What does 'metabolism' mean?
Metabolism is the word for all the chemical processes in your body that turn food into energy and help your body function and grow.
What is 'prediabetes'?
Prediabetes means your blood sugar levels are higher than normal, but not high enough to be diagnosed as type 2 diabetes yet. It's a warning sign that you're at higher risk of developing diabetes.
Will I have to change my medicines if I join?
No, this study is about observing your health. You won't be asked to take new medicines or change your current treatment for your heart attack or diabetes.
How long will I be in the study?
You will have an initial visit shortly after your heart attack and then a follow-up visit one year later.
How to find out more
Michael Roden, Prof., MD
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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