Diabetes Mellitus research hub

Understanding Beta Cell Disorders Through the Study of Rare Genotypes (ENDURE)

This study, called ENDURE, wants to understand how rare changes in our genes affect cells that control blood sugar. We're looking for people with and without these gene changes to help us learn more about diabetes and other sugar-related conditions, hoping to find new ways to help patients.

SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

This study looks at a treatment called renal denervation (RDN) for high blood pressure. It uses a device called Symplicity Spyral to see how well it works and if it's safe in the long term, especially for people whose blood pressure is hard to control.

EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV

The EuroSIDA study looks at how HIV affects people in Europe and how treatments work over time. It helps us understand health changes and the impact of new medicines for HIV and related conditions like hepatitis.

Automated Insulin Delivery in Adults With Advanced Kidney Disease

This study looks at a new system called automated insulin delivery (AID) for people with diabetes and advanced kidney disease. It checks if AID can improve blood sugar control and quality of life compared to usual care. It's a small study in London for people injecting insulin.

Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure

This study looks at a new way to find hidden heart failure in people with diabetes who are at higher risk. We're testing if checking a specific blood marker helps doctors discover heart problems earlier, so people can get the right care sooner.

Genetic Determinants of Kidney Disease in People of African Ancestry With HIV

This study looks at why kidney problems are more common in people of African heritage living with HIV in the UK. It found that certain genes can increase this risk. The research aims to better understand these factors to improve care.

RT-CGM in Young Adults at Risk of DKA

This study looks at how a special device called real-time continuous glucose monitoring (RT-CGM) helps young adults, aged 18-25, manage their type 1 diabetes. We want to see if it improves blood sugar control and reduces hospital visits for high blood sugar.

ASCEND: A Study of Cardiovascular Events iN Diabetes

The ASCEND study looked at whether daily aspirin or omega-3 tablets could prevent serious heart problems and strokes in people with diabetes who hadn't had them before. It found aspirin helped but also increased bleeding. Omega-3s didn't make a difference.

Is Community Based Monitoring of Diabetic Maculopathy and Pre-proliferative Diabetic Retinopathy Safe?

This study looks at whether opticians in your local area can help check for eye problems caused by diabetes, using special scans. It aims to make it easier to get checked and reduce hospital visits, while making sure it's safe and effective.

Convenient Home Access for Routine Monitoring in Diabetes (Charm-D Study)

This study looks at making diabetes monitoring easier. We're testing if people can accurately do their blood tests (for blood sugar, cholesterol, and thyroid) at home instead of going to a clinic. This could save time and make regular check-ups more convenient.

EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality

This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.

StartRight: Getting the Right Classification and Treatment From Diagnosis in Adults With Diabetes

This study, called StartRight, wants to better understand diabetes right from when it's first diagnosed in adults. Researchers hope to find ways to tell different types of diabetes apart earlier and predict who might need insulin treatment sooner. This could help people get the right care faster.

Reconfirming the Safety and Performance of the Glyconics-DS System in Known Populations With and Without Diabetes

This study is checking a new way to test for diabetes using your fingernails. It uses a special light to look for sugar levels in your nails. Researchers want to make sure it's safe and works well for people with and without diabetes, comparing it to a standard blood test.

Surveillance of Pancreatic Health After Diabetes Diagnosis

This study, called SAFE-D, is looking for a new blood test, Avantect, to find pancreatic cancer early in people newly diagnosed with type 2 diabetes. Early detection can lead to better treatment options. Participants will give blood samples and fill out a questionnaire over 12 months.

Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes

This study looks for early warning signs of kidney problems in people with diabetes undergoing heart procedures. We want to find new ways to predict and prevent kidney damage caused by the dye used in these important tests, aiming to make them safer for more patients.

Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension

This study looks at a procedure called renal denervation to treat high blood pressure. It aims to see if a simpler way of doing the procedure is just as good, and possibly quicker, than older methods. This could offer a new option for people whose blood pressure is hard to control.

Continuous Glucose Monitoring in People With Diabetes on Dialysis

This study looks at how blood sugar levels change in people with diabetes who are on dialysis, using a device called a continuous glucose monitor (CGM). It aims to see if these changes are linked to dialysis itself or to long-term health problems like hospital stays.

A randomised, double-blind, placebo controlled, parallel group, multi-centre trial in adult subjects with newly diagnosed type 1 diabetes mellitus investigating the effect of Verapamil SR on preservation of beta-cell function (VER-A-T1D)

This study looks at whether a drug called Verapamil can help people newly diagnosed with type 1 diabetes keep their bodies making some insulin. Researchers want to see if it preserves the 'beta cells' that produce insulin, which could be an important step for future treatments.

A study comparing the new drug PG413 produced by Celon Pharma SA with the drug Eliquis available on the market in healthy volunteers.

This study is testing a new medicine, PG413, to see how it compares to an existing medicine called Eliquis. Both medicines are used to prevent strokes and treat blood clots. This early study helps us understand how PG413 works in healthy people.

Changes in Coronary Plaque Composition By Semaglutide Use in Diabetic Patients With Acute Coronary Syndrome: A Randomized Optical Coherence Tomography Trial - ARMYDA - 10 study

This study looks at how a diabetes medicine, Rybelsus, affects the fatty build-up (plaque) in arteries of people with diabetes who have had heart problems. Researchers will use a special camera to see if the medicine changes this plaque over 24 weeks.

Sodium-glucose cotransporter-2 inhibitors to stABiLizE coronary atherosclerosis pro-gression after acute Myocardial Infarction in women and men with diabetes mellitus

This study looks at how certain diabetes medications, called SGLT2 inhibitors, might affect the build-up of fatty deposits (atherosclerosis) in the heart's arteries after a heart attack. It aims to see if these medicines can slow down or stop this build-up in people with diabetes.

Impact of Oral Semaglutide on Platelet Reactivity in Patients with Diabetes Mellitus or Overweight with High Risk or established Cardiovascular Disease: the SEMA-PLAT Study

This study looks at how new medicines for diabetes and weight management, called Rybelsus and Wegovy, might affect tiny cells in your blood called platelets. We want to see if these medicines change how sticky platelets are in people with diabetes, who are overweight, or who have heart disease, as sticky platelets can cause problems.

A study comparing exposure of semaglutide and dapagliflozin dosed orally as mono-components versus in a fixed-dose combination

A randomized, open-label, single dose, 2-way crossover bioequivalence study comparing apixaban 5 mg hard capsules (PG412 [Celon Pharma]) vs apixaban 5 mg film-coated tablets (Eliquis [Bristol-Myers Squibb]) under fasting conditions in healthy volunteers

Paraoxonase and HDL Qualities in Glycaemia and Inflammation

This study looks at how weight loss surgery and diabetes affect 'good' cholesterol (HDL), inflammation, and blood sugar. We want to understand how HDL works to protect your heart and how this changes with diabetes or after weight loss surgery to reduce heart disease risk.