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Sleep and Motor Learning in Stroke

This study wants to understand if sleep problems after a stroke affect how well people get their movement back, especially in their arms. After a stroke, the brain needs to learn new ways to move. This learning process, called 'motor learning,' involves practice during the day and a special 'consolidation' process overnight, which depends on good sleep. Researchers know that many stroke survivors have disrupted sleep, and studies have shown that those with worse sleep recover more slowly. This research will investigate if poor sleep directly impacts the brain's ability to consolidate motor learning, therefore affecting how much movement is regained. It aims to see if better sleep could lead to better recovery.

At a glance

Status
Recruiting
Sponsor
University of Oxford
Enrolment target
150
Start
01 Mar 2023
Estimated completion
01 Mar 2027

What is this study about?

When someone has a stroke, their brain often needs to relearn how to control parts of their body, like an arm or a leg. This re-learning is called 'motor learning.' It's not just about practising movements during the day; a really important part of this learning happens while you sleep. Think of it like your brain sorting out and making sense of all the new things it learned that day. This sorting process, called 'consolidation,' helps strengthen those new skills.

After a stroke, many people find their sleep is disturbed. This study wants to find out if these sleep problems get in the way of that vital overnight consolidation process. If your brain can't properly consolidate what it's learned, it might mean slower or less complete recovery of movement. The researchers will look closely at people's sleep patterns shortly after a stroke and compare them to how well they recover movement in their arm over time. They want to see if there's a direct link: do people who sleep better recover more movement, and is this because their brain is better at consolidating what it's learned?

Understanding this link is really important because if sleep is a key factor, then finding ways to improve sleep after a stroke could potentially help people recover better. This study isn't about giving new treatments yet; it's about observing and understanding how sleep, brain learning, and recovery are connected in people who have recently had a stroke affecting their arm.

Key takeaways

  • This study explores the link between sleep quality after a stroke and arm movement recovery.
  • It aims to see if poor sleep stops the brain from 'learning' new movements overnight.
  • Participants will have their sleep patterns and arm movement recovery observed over time.
  • This is an observational study, meaning no new treatments will be given.
  • Findings could help improve support for stroke survivors in the future.

Who may be eligible?

To join this study, you need to be at least 18 years old and have had a stroke affecting your arm within the last month. It's important that you or a family member can understand and agree to take part.

There are some reasons why you might not be able to join. For example, if you have other brain conditions that affect movement, like Parkinson's disease or Multiple Sclerosis, then this study might not be suitable for you.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you 18 years old or older?
  2. Have you had a stroke that affected your arm within the last month?
  3. Are you able to provide consent, or can a family member provide it for you?
  4. Do you have any other brain or nerve conditions that affect movement (like Parkinson's)? (If yes, you might not be eligible)
Answer every question to see your result.

What does participation involve?

If you decide to take part, you'll join the study within one month of your stroke. Initially, the researchers will check how well your arm can move and might do a special test called Transcranial Magnetic Stimulation (TMS) to understand your brain's recovery potential. They'll also ask you questions about your general health, how severe your stroke was, and any medicines you're taking.

Around one month after your stroke, you'll start measuring your sleep with a special device called an actigraphy watch, which you wear on your wrist to track your sleep patterns without you having to do anything special. The study will just observe you over time to see how your sleep patterns relate to your arm movement recovery. You won't be given any new treatments or medications as part of this study.

Potential risks and benefits

Taking part in this study may not directly benefit you, but the information gathered could help doctors better understand how sleep affects recovery after a stroke, which could lead to better support for future patients. The risks are generally low, mainly involving the time commitment for assessments. The TMS test, if applicable, is a safe procedure. Remember, you can choose to stop participating in the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.
  • Wellcome Centre for Integrative Neuroimaging (WIN)
    Verified postcode
    Oxford, United Kingdom· Recruiting

Common questions

What is 'motor learning consolidation'?

It's your brain's way of strengthening and fixing new movement skills it learned during the day, mostly while you sleep.

Will I receive any new treatment?

No, this study is observational. It means the researchers will just be watching and collecting information; you won't be given any new treatments or medications.

What is an actigraphy watch?

It's a small device like a wristwatch that quietly tracks your sleep and wake patterns without you needing to press buttons or actively participate.

How long will I be in the study?

The study collects information about your sleep and recovery over a period, starting within a month of your stroke. The exact duration isn't specified, but it's an observational study over time.

What does 'sub-acute phase' mean?

This refers to the period shortly after a stroke has happened, typically within the first few weeks or months.

How to find out more

Melanie K Fleming, Dr

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "Sleep and Motor Learning in Stroke…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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