Exploratory effect of long-term Verapamil therapy in adults with Type 1 diabetes mellitus (Ver-A-Long)

This study is specifically designed for adults who are already involved in another related study called "Ver-A-T1D." To join Ver-A-Long, you must have been taking either Verapamil or a dummy pill (placebo) in the Ver-A-T1D study for about 11 to 12 months, and be nearing the end of that part of the study.

You need to be 18 years old or older, and your body must still be making a small amount of insulin. This is checked by a blood test that measures something called C-peptide, which tells us your pancreas is still working a little.

There are also some health conditions that would mean you can't join. For example, if you are pregnant, breastfeeding, or planning to get pregnant, or if you have certain serious health problems like cancer (other than some skin cancers), or severe liver or kidney issues. You also can't be taking certain other medications or herbal remedies that might interfere with Verapamil.

If you decide to take part, you'll be given 360 mg of Verapamil daily. Initially, you'll start with a lower dose (120 mg) and gradually increase it over the first three weeks until you reach the full daily dose. This treatment will continue for two years.

During these two years, you'll need to visit the clinic about 6 or 7 times, depending on when you start. You'll also have 4 phone calls with the study team. These visits and calls are important for checking how you're doing, monitoring your health, and making sure the medication isn't causing any problems. They will track things like your blood sugar levels, how much insulin you need, and any episodes of very low blood sugar. Your heart health will be checked with an ECG, and blood tests will be done regularly.