AuthorisedTherapeutic exploratory (Phase II)Interventional

MitOxyVit: Mitochondrial network modulation approach using hyperbaric oxygen (HBO) therapy and NNbUVB for treating vitiligo

This research, called MitOxyVit, is exploring new ways to treat vitiligo, a condition where people develop white patches on their skin. The study combines two treatments: hyperbaric oxygen therapy, where you breathe pure oxygen in a special chamber, and NNbUVB, which is a type of light treatment. The main goal is to see how much the white patches improve after 24 weeks of treatment, specifically by measuring how much skin colour returns. Researchers will also look at how effective the treatment is at 12 weeks and monitor if participants experience any side effects. This is a Phase II study, meaning it's an early-stage trial trying to find out if the treatment is promising and safe before larger studies are done.

At a glance

Status

Authorised

Phase

Therapeutic exploratory (Phase II)

Sponsor

Centre Hospitalier Universitaire De Nice

Enrolment target

Start

24 Mar 2026

Vitiligo

What is this study about?

This clinical trial is investigating a new approach for treating vitiligo, a condition that causes pale or white patches to appear on the skin. It happens when the cells that produce skin pigment stop working. The study is called MitOxyVit and combines two different treatments: hyperbaric oxygen therapy and a specific type of light treatment called NNbUVB.

Hyperbaric oxygen therapy involves breathing pure oxygen in a pressurised room. This increases the amount of oxygen in your blood and is thought to help repair damaged tissues. The light treatment, NNbUVB, uses a specific wavelength of ultraviolet light, which is already a known treatment for vitiligo, to help stimulate pigment cells. Researchers believe that using these two treatments together might be more effective than using them separately.

The main aim of this study is to see how much the white patches on the skin improve after 24 weeks of treatment. They will use a special scoring system to measure how much colour returns to the skin. They will also check how well the treatment is working after 12 weeks and keep a close eye on any side effects that might occur, ensuring the treatment is safe for patients.

Key takeaways

This study explores a new combination treatment for vitiligo: oxygen therapy and light treatment.
It aims to see how much skin colour can be restored over 24 weeks.
The study also monitors for any side effects to ensure safety.
It's an early-stage study, meaning researchers are testing if the treatment is promising.
Participants must be 18 years or older, with no upper age limit.
You can withdraw from the study at any time.

Who may be eligible?

To be considered for this study, you need to be an adult, aged 18 years or older. There is no upper age limit, so people of all adult ages can potentially take part. Both men and women are welcome to participate in this research.

While the basic requirements are straightforward, there will be other specific medical conditions or previous treatments that might mean you can't join the study. These are put in place to ensure the safety of participants and the accuracy of the study results.

A doctor involved with the study will carefully go through your medical history and current health to determine if this trial is suitable and safe for you.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you been diagnosed with vitiligo?
Are you willing and able to attend regular clinic appointments?
Are you comfortable with the idea of receiving hyperbaric oxygen therapy and light treatment?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you will receive a combination of hyperbaric oxygen therapy and light treatment (NNbUVB). The study will run for a total of 24 weeks, during which you will have regular visits to the clinic.

During these visits, healthcare professionals will assess your skin, usually by measuring the amount of colour that has returned to your vitiligo patches. They will also ask you about how you are feeling and if you have experienced any new symptoms or side effects. Your medical team will explain the exact schedule of treatments and assessments you'll need to attend.

After the initial 24 weeks of treatment, there might be follow-up appointments to see how your skin is doing over a longer period. Everything will be clearly explained to you before you agree to join the study.

Potential risks and benefits

Taking part in this study could potentially help your vitiligo patches regain some colour, possibly with an improved treatment approach. However, there are potential risks, as with any medical treatment, including side effects from the oxygen therapy or light treatment. These will be thoroughly explained to you, so you can make an informed decision. Remember, you can choose to leave the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
France

Common questions

What is vitiligo?

Vitiligo is a long-term skin condition where patches of skin lose their pigment, causing them to turn white.

What is hyperbaric oxygen therapy?

It's a treatment where you breathe pure oxygen in a special room with higher air pressure than usual. This helps more oxygen get into your body.

What is NNbUVB?

NNbUVB is a type of light treatment using specific ultraviolet light wavelengths, often used to help stimulate pigment production in vitiligo.

How long will the treatment last?

The main treatment period in this study is planned for 24 weeks.

Will I have to pay to participate?

No, you will not have to pay for the treatments or assessments directly related to the study.