- recruitingTherapeutic confirmatory (Phase III)
A Phase I/III Randomized, Double-blind Study to Evaluate the Safety, Efficacy, and Neutralizing Activity of AZD5156/AZD3152 for Pre-exposure Prophylaxis of COVID-19 in Participants with Conditions Causing Immune Impairment
This study is testing a new medicine, Sipavibart (also called AZD5156/AZD3152), to see if it can prevent COVID-19 in people with weaker immune systems. It compares the new medicine to an existing one called Evusheld or a dummy treatment, focusing on how safe and effective it is.
Spain · France · Germany - recruitingTherapeutic use (Phase IV)
A phase 4, open-label study to evaluate the short-term innate immune response after administration of a COVID-19 mRNA vaccine (Comirnaty JN.1®) in healthy adults aged 18 to 40 years.
This study looks at how a new COVID-19 vaccine (Comirnaty JN.1) affects the body's immediate protections. Researchers want to see changes in immune markers shortly after vaccination in healthy adults aged 18 to 40.
Belgium - recruitingTherapeutic use (Phase IV)
A Phase IV, open label, single arm trial to assess the safety and immunogenicity of BIMERVAX® LP.8.1 against SARS-CoV-2 variants.
This study is looking at a new COVID-19 vaccine, BIMERVAX LP.8.1, to see how safe it is and how well it helps your body fight off different types of the virus, especially Omicron. It's for people who've already had the vaccine (Phase IV).
Spain - completed
SARS-CoV-2 Delta variant dose finding infection study
This UK study looks at how vaccinated young adults respond to the Delta variant of COVID-19. Healthy volunteers aged 18 to 30 will receive a low, controlled dose of the virus in a hospital quarantine unit. This helps scientists understand immunity and safely test future treatments and vaccines.
United Kingdom · England - recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Adaptive, Randomized, Controlled Trial Platform to Evaluate Safety and Efficacy of Strategies and Treatments for Hospitalized Patients with Respiratory Infections: Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE) - Shionogi Protease Inhibitor (S-217622)
This study is looking into a new medication called S-217622 for people in hospital with COVID-19. It aims to see if the medication is safe and helps people recover faster. They will compare it to a dummy treatment.
Spain · Germany · Greece - recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Adaptive, Randomized, Controlled Trial Platform to Evaluate Safety and Efficacy of Strategies and Treatments for Hospitalized Patients with Respiratory Infections: Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE) - Immune Modulation Strategy Trial
This study is looking at new ways to treat adults in hospital with COVID-19. We're testing a medicine called Orencia against a dummy treatment to see if it helps people recover faster and has fewer side effects. It's a big study to find the best care.
Denmark · France · Sweden - recruitingPhase II and Phase III (Integrated)
A Phase 2/3 Single-Arm, Open-label Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Obeldesivir in Pediatric Participants With COVID-19
This study is looking at a new medicine called Obeldesivir for children with COVID-19. Researchers want to see if it's safe, how the body uses it, and if it helps children recover. They are testing two different dose strengths.
Poland · Spain · Italy - recruitingTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Bemnifosbuvir in High-Risk Outpatients with COVID-19
This study is testing new treatments for COVID-19 in people who are at higher risk of becoming very unwell. It compares a new medicine called Bemnifosbuvir with usual care and Paxlovid to see if it helps prevent serious illness or hospital stays.
Latvia · Netherlands · Sweden - recruitingTherapeutic exploratory (Phase II)
A 4-week double-blind, randomized, placebo-controlled, phase II study evaluating the effects of oral pamapimod 150 mg with pioglitazone 10 mg daily on COVID-19 evolution and recovery in non-hospitalized patients infected with SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2)
This study looks at how two medicines, pamapimod and pioglitazone, might help people with COVID-19 who don't need to be in hospital. It aims to see if they can help people get better faster and reduce their symptoms. Participants will take one of the study medicines or a dummy pill for 4 weeks.
Germany - active not recruitingPHASE2
Treatment of COVID-19 by Nebulization of Inteferon Beta 1b Efficiency and Safety Study
This study is looking into a new way to treat COVID-19 in hospital. We're testing if breathing in a medicine called Interferon Beta 1b through a nebuliser can help patients who need oxygen. This might reduce the need for oxygen and help people recover faster.
France - recruiting
COVID Infection in Pediatric Surgical Patient
This study looks at how common COVID-19 is in children having surgery. It uses a quick test to see if they have the virus. Most children with COVID-19 don't show many symptoms, but understanding how it spreads is important for everyone's safety.
Canada - active not recruiting
Immunogenicity of COVID-19 Vaccination in Immunocompromised Patients (Auto-COVID-VACC)
This study looks at how well COVID-19 vaccines work in people with weakened immune systems. Researchers are checking blood samples to see the body's response, using samples already taken during routine check-ups. It helps us understand vaccine protection for vulnerable groups.
Germany - recruiting
Immune Modulation by Exosomes in COVID-19
This study looks at how tiny messengers, called exosomes, from special cells might help reduce severe inflammation and organ damage in very sick COVID-19 patients. We're testing if these exosomes can calm the immune system in blood samples.
Germany - active not recruitingNA
Safety & Effectiveness Evaluation of Seraph 100 in Treatment of Pts With COVID-19
This study is looking at a new device called Seraph 100 to see if it's safe and helps people with COVID-19. It compares using the device with standard care to just standard care alone in hospitals in Germany and Spain.
Germany · Spain - recruitingNA
Understanding the Determinants of Mucosal Immunity and Optimizing the Diagnosis of Infection With SARS-CoV-2 Variants
This study aims to understand how our bodies fight off COVID-19, especially focusing on how different body parts like our nose and mouth protect us. We also want to find better ways to test for the virus and its newer versions.
France - recruiting
Longitudinal Population-based Observational Study of COVID-19 in the UK Population
COVIDENCE UK is a study looking at how COVID-19 affects people across the UK. Researchers want to understand who gets sick, how the illness progresses, and its long-term effects on physical and mental health. This helps us learn more about the virus.
United Kingdom - active not recruiting
COVID-19 Symptom Tracker
This study uses a free app to track COVID-19 symptoms and how the illness progresses. It also looks at how isolation impacts people's well-being. The goal is to learn more about the virus and help tell it apart from common colds.
United States · United Kingdom - recruiting
Post-intensive Care Syndromes in Pregnant Patients With Respiratory Failure and COVID-19 Compared to Non-pregnant Patients With Respiratory Failure and COVID-19
This study looks at how COVID-19 affects pregnant and non-pregnant patients who needed intensive care for breathing problems. It checks their health after leaving the hospital, focusing on long-term effects, by reviewing their medical records from 2020-2024.
Germany - recruitingNA
Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments
This study looks into using oxygen therapy in a special chamber to help people with ongoing symptoms after COVID-19, especially tiredness. It's a small study to see if a bigger one is possible, aiming to find new ways to improve well-being for those with long COVID.
Canada - recruitingPHASE1
A Study to Assess the Safety and Immunogenicity of a COVID-19 Vaccine Booster in Healthy Adults
This study is testing a new COVID-19 vaccine booster called Prime-2-CoV_Beta in healthy adults aged 18-55. Researchers want to see if it's safe and how well it boosts your immune system to fight the virus. It's an early-stage study to work out the best dose.
Germany - active not recruiting
Intestinal Microbiota of Patients Hospitalized With Sars-CoV-2
This study looks at how COVID-19 affects the germs in your gut. Researchers want to see if changes in these gut germs might be linked to how severe COVID-19 becomes and how it shows up in your body, by studying poo samples from hospitalised patients.
France - recruiting
COVID-19: Early Detection of Worsening by Voice and Respiratory Pattern Characteristics
This study looks at whether we can use a phone app to spot early signs of COVID-19 getting worse. It uses your voice and breathing sounds to predict if someone might need intensive care, helping hospitals prepare.
France - recruitingNA
Olfactory Training As a Treatment for Olfactory Dysfunction Post COVID-19
This study looks at how "smell training" can help people whose sense of smell changed after COVID-19. We're comparing two different sets of smells to see which works best to bring back normal smelling.
Canada - recruiting
REVIVe: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI
This study looks at how frailty affects adults and children who had severe COVID-19 or other serious lung infections. It wants to know if frail patients survive less often and have more problems afterwards. It also studies the types of rehabilitation that help these patients get better.
Canada - recruitingPHASE2
OPtimisation of Antiviral Therapy in Immunocompromised COVID-19 Patients: a Randomized Factorial Controlled Strategy Trial
This study is looking at better ways to treat COVID-19 in people with weakened immune systems. It compares a standard antiviral treatment (Paxlovid) with a longer course, and with a combination of Paxlovid and another medicine (Veklury).
France · Italy · Norway - active not recruiting
Burden for STaff Working in the NHS
This study looks at how the COVID-19 pandemic has affected the mental well-being of NHS staff. Researchers want to understand these effects to find better ways to support them now and in any future health crises. Participants will complete online surveys over time.
United Kingdom - recruiting
Hospitalised COVID-19 Patients Cohort Study in the EuCARE Project
This study looks at hospitalised COVID-19 patients across the world. Researchers want to understand how different types of the virus and vaccination affect how ill people get and how they recover. They're collecting patient information and some blood samples to learn more.
Germany · Italy · Kenya - recruitingNA
Impact of Aerosol Box Use During Cardiopulmonary Arrest: A Multicenter Study
This study looks at how a special box, called an aerosol box, helps protect healthcare workers during CPR for patients who might have COVID-19. It aims to see if the box stops tiny virus particles from spreading in the air, making it safer for staff.
United States · Canada - recruiting
Serological and PCR Testing for COVID-19
This study is looking at different ways to test for COVID-19, including current infections and past infections. By doing this, researchers hope to better understand how the virus spreads and how our bodies fight it, which can help in developing better ways to manage the pandemic.
United Kingdom - recruitingPHASE3
EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease
This study is looking at a medicine called nirmatrelvir/ritonavir for children and young people under 18 with COVID-19. It aims to see how safe and effective it is for those who aren't in hospital but are at higher risk of getting seriously ill.
United States · Bulgaria · Japan - recruiting
Brain Imaging in Babies Study
This study looks at how babies' brains develop from before birth until they are 3-4 years old. Researchers use safe brain scans and check children's behaviour to understand brain growth. They also want to see if they can predict conditions like autism and ADHD early on, and how COVID-19 might affect brain development.
United Kingdom - recruiting
Post COVID-19 Condition
This study looks at how many people get Long COVID and what might lead to it. It follows adults who have recovered from COVID-19 to understand the long-lasting health effects. The goal is to learn why some people continue to feel unwell months after having the virus.
Germany · Italy · Lithuania