- completed
The SENSE-Cog Randomised Controlled Trial (RCT): Comparing individualised sensory intervention to standard care to improve quality of life in people with dementia and their companions
This trial looks at whether personalised support for hearing and sight loss improves daily life for people with dementia and their carers. Half of participants receive free hearing aids or glasses with home visits from a therapist, while the other half receive standard care and advice.
United Kingdom · England · Cyprus - completed
How does community group singing affect the wellbeing of people with dementia and their carers?
This study explores whether weekly community singing groups can boost wellbeing and memory for people living with mild to moderate dementia and their carers. Researchers want to see if singing together improves mood, strengthens relationships, and whether running a larger nationwide study in the future is practical and helpful.
United Kingdom · England - recruitingHuman Pharmacology (Phase I)- First administration to humans
A clinical trial of MK-4605 in healthy participants (MK-4605-001)
This early-stage clinical trial tests a new medicine called MK-4605 for the first time in humans. The medicine is being developed to treat dementia. Researchers want to check its safety and see how it behaves in the human body by testing it in healthy adult men.
Belgium - active not recruitingPHASE3
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
This study is testing a new medication called donanemab for people in the early stages of Alzheimer's disease. Researchers want to see if it's safe and helps improve or slow memory and thinking problems. It's a key step in understanding potential new treatments for this condition.
Argentina · Australia · China - recruitingNot Applicable
MinderCare: translational research and digitally enabled care
MinderCare is a UK research study testing whether simple home sensors can help people aged 50 and older living with dementia. The sensors track daily routines and sleep to spot signs of illness early. The goal is to provide timely care and help people stay safe and well at home.
United Kingdom · England - recruiting
Biomarkers and rapid imaging in dementia diagnosis
Brain scans like MRIs help doctors diagnose dementia, but usually take 30 minutes. Researchers in London are testing a new ultra-fast scan that takes just 7 minutes. This study checks if the quicker scan gives clear, reliable pictures, alongside a routine blood sample and brief memory questions.
United Kingdom · England - recruiting
Acceptability and feasibility of Jelly Drops™ in people with dementia
Dehydration is a common problem for people living with dementia. This NHS study looks at whether Jelly Drops™—water-filled sweets designed to boost fluid intake—are practical and helpful for hospital inpatients. Researchers are also gathering feedback from patients, their family carers, and the hospital staff caring for them.
United Kingdom · England - recruiting
Good Life with Dementia Feasibility Study
This study looks at a course called 'Good Life' for people newly diagnosed with dementia. It checks if the course can be run well in different places and helps people feel supported. The study aims to make future research on this course better.
United Kingdom · England - recruiting
Lived Experience Narratives in Dementia (LEND) Work Packages 1-3
This study aims to improve understanding and support for people with dementia by collecting real-life stories. It will create an online tool to share these experiences and help others learn, testing how well it works to improve care for people with dementia and their families.
United Kingdom · England - recruiting
A study of using the Living Well with Dementia for Couples and Families approach in the NHS
This study looks at a new way for people with dementia and their families to get support. Called LivDem-Families, it involves meeting a trained helper to talk about how dementia affects them. We want to see if it helps families and if it could be offered through the NHS.
United Kingdom · England - completed
Impact on patient anxiety and quality of life of a training package for evaluation of dementia symptoms in primary care using test bundles - the Ensemble feasibility study
This study looks at whether training healthcare assistants to use special tests can help GPs diagnose dementia quicker. It's for people aged 75 or older with memory problems who haven't been diagnosed yet. The aim is to make diagnosis less stressful and more local.
United Kingdom · England - recruiting
A blended app and coach support programme to improve brain health
This study looks at a special app and coach support to help people manage things that can increase their risk of dementia, like blood pressure or lifestyle habits. It's for people aged 60-80 with several of these risk factors, especially those from ethnic minority or lower-income backgrounds.
United Kingdom · England - recruitingNA
CONSTELLATIONS Living Lab: Improving the Care Transitions of Older Adults Living with Neurocognitive Disorders
This study aims to improve how older people with memory problems, like Alzheimer's, move between different healthcare services in Quebec, Canada. It's testing a special program to make care smoother and better for patients and their families.
Canada - active not recruitingNA
A Virtual Reality at Home Intervention for People Living With Dementia
This study looks at how virtual reality (VR) and tablets can help people with dementia and their family carers communicate better at home. It checks if VR, or just a tablet, improves their conversations and lives together.
Canada - not yet recruitingNA
Dyadic, App-supported Collaborative Care Intervention Trial for Family Caregivers of People Living With Dementia
This study looks at a new way to support families caring for loved ones with dementia at home. It uses expert nurses and a phone app to help caregivers and aims to ease their stress and improve life for people with dementia.
Germany - recruiting
Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness
This study aims to create a large database of genetic and health information from people with serious mental illnesses and dementia. The goal is to better understand these conditions, improve diagnosis, and help develop new, more personalised treatments.
United Kingdom - active not recruiting
Predictors Of Cognitive Decline Using Digital Devices
This study looks at whether people with memory problems or healthy volunteers will use digital devices like smartwatches and sleep headbands. Researchers want to see if this technology can help predict dementia early by collecting data from the devices and combining it with health information.
United Kingdom - recruitingNA
VR&R: Providing Caregiver Respite by Managing BPSDs and Improving QoL in People with Dementia Using Immersive VR-Therapy
This study looks at how virtual reality (VR) can help people with dementia feel better and give their carers a break. It explores different types of VR and how they affect mood, behaviour, and quality of life for those with dementia.
Canada - recruitingPHASE2, PHASE3
A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
This study looks into new treatments for a rare, inherited form of Alzheimer's disease. Researchers want to see if these drugs can stop or slow down the disease in people who are at high risk or in the very early stages, based on their family history and genes.
United States · Argentina · Australia - not yet recruitingNA
Enhancing Mobility and Mental Health in Dementia Patients
This study looks at how a special walking group and activities, led by different health experts, might help people with dementia. It aims to see if it improves their walking, reduces anxiety, and boosts their memory and daily independence.
United Kingdom - recruitingNA
rTMS for Apathy Clinical Trial
This study looks at a brain stimulation treatment called rTMS for people with memory problems and a lack of interest, known as apathy. It aims to see if rTMS can help improve apathy, especially for those already taking medication or not.
Canada - active not recruitingNA
Cognitive Health Awareness Program in Surgical Patients
This study looks at how a short online course can help older patients understand more about keeping their brains healthy before surgery. It aims to help them make informed choices and prepare better for after their operation.
Canada - enrolling by invitation
Alzheimer's Disease Neuroimaging Initiative 4
ADNI4 is a research study building on previous work to better understand Alzheimer's disease. It involves looking at memory, brain scans, and blood tests in people with normal memory, mild memory problems, and dementia, to find better ways to detect and treat these conditions.
United States · Canada - recruitingNA
Lived Experience Narratives in Dementia
This study is called LEND and looks into how sharing personal stories can help people with dementia and their carers. It aims to create an online tool using these stories to improve well-being. Researchers are talking to people and developing an app to see if it helps, with the goal of making it widely available.
United Kingdom - active not recruitingPHASE3
Escitalopram for Agitation in Alzheimer's Disease
This study looks at whether a medicine called escitalopram can help with agitation in people with Alzheimer's disease. Some people will get the medicine, others a dummy pill, after a talking therapy didn't help. We want to see if it's safe and effective.
United States · Canada - recruitingNA
Investigating Different Frequencies of Transcranial Electrical Stimulations in Dementia Population
This study looks at using gentle electrical brain stimulation with brain exercises to help people with dementia. Researchers want to find the best way to do this to improve memory and thinking skills. They will also use special tests to see how the brain changes.
Canada - active not recruiting
Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer's Disease
This study investigates a new imaging technique, Cortical Disarray Measurement (CDM), to improve the early diagnosis of Alzheimer's disease in people with memory problems. It aims to see if CDM can identify early changes and how these relate to memory over two years, helping us better understand and diagnose Alzheimer’s.
United Kingdom - not yet recruitingNA
Support in Sound: Music Therapy for People Living With Dementia and Companions in Rural Communities
This study looks at whether group music therapy helps people with dementia and their companions in rural areas. It checks if it's practical to run and if it improves well-being, social connections, and mood over 10 weeks of sessions.
United Kingdom - enrolling by invitation
REAl World Dementia OUTcomes: Observational Study
This study looks at new blood tests for dementia. It will follow 3,165 people aged 45 and over with memory problems across the UK for three years. The goal is to see how accurate and reliable these blood tests are in real life, and if they can help diagnose dementia earlier.
United Kingdom - recruiting
Family Interventions iN Dementia Mental Health Environments
This study aims to improve support for families of people with dementia in mental health wards. It will explore their experiences and needs, then create practical ways for wards to work better with families across the UK.
United Kingdom - active not recruiting
Implementing Dementia Care Management Into Routine Care in the Region Siegen-Wittgenstein
This study in Germany is looking at how to make a special type of care, called Dementia Care Management, available to more people with memory problems and their families. It will follow 60 people to see if this care helps them and if it can be easily used in everyday healthcare.
Germany - recruiting
Biobank and Brain Health in Bordeaux.
This study, called "B cube," looks at how our brains change as we get older, especially from age 55. Researchers want to understand why some people's memories and thinking skills decline and how to prevent it. They are studying 2000 people in Bordeaux, France, focusing on things like diet and overall health.
France - recruiting
Trial-Ready Cohort-Down Syndrome (TRC-DS)
This study looks at adults with Down syndrome to understand how Alzheimer's disease develops. It aims to find better ways to measure changes in the brain for future drug trials, helping to speed up the search for effective treatments.
United States · France · Ireland - recruitingNA
Aerobic Exercise for Older Adults at Increased Risk of Alzheimer's Disease and Related Dementias
This study looks at whether regular exercise can help prevent memory decline and Alzheimer's disease in older adults. We want to see if being more active can keep your brain healthier.
Canada - active not recruitingPHASE3
A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)
This study is looking at different ways of giving a medicine called donanemab for early Alzheimer's disease. Researchers want to see how different doses affect side effects and which patients might be more likely to experience them. It's for adults aged 60-85.
United States · United Kingdom - active not recruitingNA
You, Me and Nature Pilot Study
This study looks at how nature activities led by a helper might benefit people with memory problems like dementia. It's a small trial to see if a bigger study should be done. Participants include people with memory issues and their caregivers.
United Kingdom - recruiting
Digital App for Speech & Health Monitoring
This study is using a smartphone app to record and analyse speech from people with conditions like dementia, MND, MS, and Parkinson's. The goal is to see if speech changes can help diagnose and monitor these conditions, comparing them to healthy individuals, using simple digital technology.
United Kingdom - active not recruitingPHASE2, PHASE3
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001
This study is for people at risk for, or with, a specific early-onset Alzheimer's disease caused by a faulty gene. It tests if new medications can slow down memory and thinking problems, or improve markers of the disease, checking their safety and how well people tolerate them.
United States · Argentina · Australia - recruitingPHASE2, PHASE3
A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
This study is looking into a new treatment called remternetug for people who are at risk of developing a specific type of early-onset Alzheimer's disease due to their genes. It aims to see if the treatment can slow down or stop the disease before symptoms appear.
United States · Argentina · Australia - active not recruiting
Exploring How Health Care Support Workers Respond to Distressed Behaviour in People With Dementia
This study looks at how healthcare support workers in hospitals help people with dementia who are upset or distressed. We want to understand their experiences to improve training and care for patients with dementia.
United Kingdom - active not recruitingPHASE2, PHASE3
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)
This study is for people with a genetic form of early-onset Alzheimer's to test new medicines (E2814, Lecanemab) to see if they can slow down the disease. Researchers will check if these treatments improve brain markers and thinking skills.
United States · Argentina · Australia - recruiting
Benefits of Personalised Music in Dementia - a Feasibility Study
This study explores how personal music helps people with dementia. It aims to create easy ways to make and deliver custom music playlists, especially in care homes, and see how they affect well-being. It also includes a study on how music affects the brain.
United Kingdom - recruiting
Neurofrailty: A Study of Late-onset Epilepsy and Its Associations
This study looks at adults who have their first seizure later in life. We want to see if there's a link between these seizures and conditions like stroke or memory problems (dementia) that might happen years later. We'll observe people's health over time to learn more.
United Kingdom - active not recruitingPHASE2
METformin and FINGER Intervention to Prevent Cognitive Impairment and Disability in Older Adults at Risk for Dementia
This study looks at whether changing your lifestyle and taking a diabetes drug called metformin can help older adults at risk of memory problems stay healthy and independent, and reduce their risk of developing dementia.
Finland · Sweden · United Kingdom - recruitingNA
BELIDE: Better Living With Non-memory-led Dementia
This study looks at a new online program for unpaid carers of people with less common types of dementia, like those affecting language or vision more than memory. It aims to see if the program helps carers feel better and how it works.
United Kingdom - active not recruitingPHASE3
DIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease
This study looks at a new drug, lecanemab, to see if it can fully remove amyloid plaques in people with a rare, inherited form of Alzheimer's. It also checks if removing these plaques can slow down how quickly the disease progresses.
United States · Australia · United Kingdom - recruiting
Large Language Model for Understanding and Monitoring Elderly Neurocognition
This study is testing a new AI tool called LUMEN to help families describe dementia symptoms to doctors more easily. It aims to make dementia diagnosis quicker and more accurate, reducing stress for caregivers and improving support for patients.
United Kingdom - recruiting
Developing a New EEG Method for the Early Diagnosis of Dementia
This study is looking at a new way to use a common brain scan, called an EEG, to help diagnose dementia, especially Alzheimer's disease, at an early stage. It's a simple, non-invasive test and involves comparing results from people with early Alzheimer's with healthy volunteers to see if the EEG can spot differences.
United Kingdom - recruiting
Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project
This study, called VESPAR, looks at how blood flow in the brain affects thinking problems like dementia, depression, and stroke. Researchers want to find better ways to measure brain blood flow and understand how it changes in different conditions to help plan future research.
United Kingdom - recruiting
IONA Longitudinal Cohort Study
The IONA study in Scotland is looking at how memory and thinking decline. Researchers are collecting health, lifestyle, and genetic information from people over 50. The goal is to better understand dementia and eventually help develop new treatments for conditions like Alzheimer's disease.
United Kingdom