Dementia research hub

Digital App for Speech & Health Monitoring

This study is using a smartphone app to record and analyse speech from people with conditions like dementia, MND, MS, and Parkinson's. The goal is to see if speech changes can help diagnose and monitor these conditions, comparing them to healthy individuals, using simple digital technology.

Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness

This study aims to create a large database of genetic and health information from people with serious mental illnesses and dementia. The goal is to better understand these conditions, improve diagnosis, and help develop new, more personalised treatments.

A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

This study is looking into a new treatment called remternetug for people who are at risk of developing a specific type of early-onset Alzheimer's disease due to their genes. It aims to see if the treatment can slow down or stop the disease before symptoms appear.

Exploring How Health Care Support Workers Respond to Distressed Behaviour in People With Dementia

This study looks at how healthcare support workers in hospitals help people with dementia who are upset or distressed. We want to understand their experiences to improve training and care for patients with dementia.

Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project

This study, called VESPAR, looks at how blood flow in the brain affects thinking problems like dementia, depression, and stroke. Researchers want to find better ways to measure brain blood flow and understand how it changes in different conditions to help plan future research.

REAl World Dementia OUTcomes: Observational Study

This study looks at new blood tests for dementia. It will follow 3,165 people aged 45 and over with memory problems across the UK for three years. The goal is to see how accurate and reliable these blood tests are in real life, and if they can help diagnose dementia earlier.

DIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease

This study looks at a new drug, lecanemab, to see if it can fully remove amyloid plaques in people with a rare, inherited form of Alzheimer's. It also checks if removing these plaques can slow down how quickly the disease progresses.

A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

This study looks into new treatments for a rare, inherited form of Alzheimer's disease. Researchers want to see if these drugs can stop or slow down the disease in people who are at high risk or in the very early stages, based on their family history and genes.

Benefits of Personalised Music in Dementia - a Feasibility Study

This study explores how personal music helps people with dementia. It aims to create easy ways to make and deliver custom music playlists, especially in care homes, and see how they affect well-being. It also includes a study on how music affects the brain.

A Study to Evaluate the Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia (MK-1167-008)

This study is testing a new medicine called MK-1167 for people with Alzheimer's disease. Researchers want to see if it can improve memory and thinking when taken with standard treatment and if it's safe and well-tolerated.

Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer's Disease

This study investigates a new imaging technique, Cortical Disarray Measurement (CDM), to improve the early diagnosis of Alzheimer's disease in people with memory problems. It aims to see if CDM can identify early changes and how these relate to memory over two years, helping us better understand and diagnose Alzheimer’s.

Predictors Of Cognitive Decline Using Digital Devices

This study looks at whether people with memory problems or healthy volunteers will use digital devices like smartwatches and sleep headbands. Researchers want to see if this technology can help predict dementia early by collecting data from the devices and combining it with health information.

A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)

This study is looking at different ways of giving a medicine called donanemab for early Alzheimer's disease. Researchers want to see how different doses affect side effects and which patients might be more likely to experience them. It's for adults aged 60-85.

EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality

This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.

You, Me and Nature Pilot Study

This study looks at how nature activities led by a helper might benefit people with memory problems like dementia. It's a small trial to see if a bigger study should be done. Participants include people with memory issues and their caregivers.

A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)

This study is testing a new medication called donanemab for people in the early stages of Alzheimer's disease. Researchers want to see if it's safe and helps improve or slow memory and thinking problems. It's a key step in understanding potential new treatments for this condition.

Trial-Ready Cohort-Down Syndrome (TRC-DS)

This study looks at adults with Down syndrome to understand how Alzheimer's disease develops. It aims to find better ways to measure changes in the brain for future drug trials, helping to speed up the search for effective treatments.

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)

This study is for people with a genetic form of early-onset Alzheimer's to test new medicines (E2814, Lecanemab) to see if they can slow down the disease. Researchers will check if these treatments improve brain markers and thinking skills.

Family Interventions iN Dementia Mental Health Environments

This study aims to improve support for families of people with dementia in mental health wards. It will explore their experiences and needs, then create practical ways for wards to work better with families across the UK.

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

This study is for people at risk for, or with, a specific early-onset Alzheimer's disease caused by a faulty gene. It tests if new medications can slow down memory and thinking problems, or improve markers of the disease, checking their safety and how well people tolerate them.

Neurofrailty: A Study of Late-onset Epilepsy and Its Associations

This study looks at adults who have their first seizure later in life. We want to see if there's a link between these seizures and conditions like stroke or memory problems (dementia) that might happen years later. We'll observe people's health over time to learn more.

METformin and FINGER Intervention to Prevent Cognitive Impairment and Disability in Older Adults at Risk for Dementia

This study looks at whether changing your lifestyle and taking a diabetes drug called metformin can help older adults at risk of memory problems stay healthy and independent, and reduce their risk of developing dementia.

BELIDE: Better Living With Non-memory-led Dementia

This study looks at a new online program for unpaid carers of people with less common types of dementia, like those affecting language or vision more than memory. It aims to see if the program helps carers feel better and how it works.

IONA Longitudinal Cohort Study

The IONA study in Scotland is looking at how memory and thinking decline. Researchers are collecting health, lifestyle, and genetic information from people over 50. The goal is to better understand dementia and eventually help develop new treatments for conditions like Alzheimer's disease.

CHARACTERIZATION OF ASTROCYTE REACTIVITY WITH [18F]F-DED PET IN NEURODEGENERATIVE DISEASES

This study is looking at a new brain scan for people with certain brain conditions like dementia. It aims to see how brain cells called astrocytes behave in these conditions using a special tracer called [18F]DED. This could help us understand these diseases better.

I5T-MC-AACQ: Investigating the Effect of Different Donanemab Dosing Regimens on ARIA-E and Amyloid Lowering in Adults with Early Symptomatic Alzheimer’s Disease

Large Language Model for Understanding and Monitoring Elderly Neurocognition

This study is testing a new AI tool called LUMEN to help families describe dementia symptoms to doctors more easily. It aims to make dementia diagnosis quicker and more accurate, reducing stress for caregivers and improving support for patients.

Enhancing Mobility and Mental Health in Dementia Patients

This study looks at how a special walking group and activities, led by different health experts, might help people with dementia. It aims to see if it improves their walking, reduces anxiety, and boosts their memory and daily independence.