RecruitingNAINTERVENTIONAL

Personalized Responses to Dietary Composition Trial 3

The PREDICT 3 study explores how our bodies react to different foods, with the goal of creating more personalised eating advice. It builds on previous research, using advanced computer models to predict individual responses. This study looks at specific meals in a controlled way, as well as tracking what people eat in their daily lives. Researchers also consider how everyday factors like exercise and sleep might affect these responses. For the first time, this study is working with a commercial product, allowing many more people to participate and contribute data from their digital health devices. The main idea is to help people with conditions like diabetes and heart problems make better food choices tailored just for them.

At a glance

Status

Recruiting

Phase

Sponsor

Zoe Global Limited

Enrolment target

250,000

Start

20 Jul 2020

Estimated completion

01 Jan 2030

Diabetes Heart Diseases Diet Habit Diet Modification Healthy Obesity Metabolism Microbial Colonization

What is this study about?

The PREDICT 3 study is all about understanding how different foods affect each of us in unique ways. You know how some people can eat certain things and feel great, while others might feel tired or unwell? This study aims to figure out why that happens. Researchers are using information from thousands of people to create special computer models that can predict how someone's body will react to various foods. The goal is to move away from 'one-size-fits-all' dietary advice and instead offer truly personalised eating guidance.

This research is really important because it could help many people, especially those dealing with health conditions like diabetes, heart problems, or obesity. By understanding how food affects things like blood sugar or metabolism, we can learn how to make better food choices that support our health. This study takes a look at both specially prepared meals in a controlled setting and what people eat during their regular daily lives, to get a clear picture of how food impacts our bodies.

Interestingly, this study is working with a commercial health program called ZOE. This means that people who are already using the ZOE program and collecting health data through their devices can contribute their information to science. This partnership allows the study to gather a lot more diverse data, which helps the researchers make their predictions even more accurate and useful for developing personalised nutrition advice.

Key takeaways

Aims to create personalized eating advice based on your body's response to food.
Contributes to research on diabetes, heart health, and obesity.
Involves tracking your food and wearing a glucose monitor for 6-14 days.
Requires you to be enrolled in the ZOE commercial program.
You'll eat two specific test meals, but mostly your normal diet.

Who may be eligible?

To join the PREDICT 3 study, you'll need to be at least 18 years old (or 19 in Alabama and Nebraska) and currently enrolled in the commercial ZOE testing program. You also need to have a Body Mass Index (BMI) of 16.5 or higher. The study is open to people living in the UK or most parts of the continental US (excluding New York State).

It's important that you are able to follow the study instructions and give your permission to take part. If you have ongoing health conditions like diabetes or eating disorders, you can still participate, but if you're in the US, you'll need to check with your doctor first to make sure it's safe for you. You also need to be able to read and write in English, as the app is in English.

However, you can't join if you're pregnant, or if you've had a heart attack, stroke, or major surgery in the last two months. Also, if you can't safely eat standard pre-made test meals, perhaps due to allergies or recent stomach surgery, or if you simply don't want to eat them, then this study isn't for you.

Quick self-check

Are you 18 years old or older (19 in Alabama/Nebraska)?
Are you already a participant in the ZOE commercial testing program?
Do you live in the UK or continental US (excluding New York)?
Is your Body Mass Index (BMI) 16.5 or higher?
Are you able to read and write in English?
Are you not pregnant, and haven't had a heart attack, stroke, or major surgery in the last two months?

This is a guide only — the research team will confirm whether you can take part.

What does participation involve?

If you decide to take part in the PREDICT 3 study, it will last between 6 and 14 days. On the first day, you'll be asked to put on a glucose monitor, which is a small device that tracks your blood sugar levels.

Over the next few days, you'll receive two specially prepared meals from the study team by post. You'll be asked to eat these exact meals as instructed. For all other meals, you can eat whatever you like. You'll use a special app to record any food you don't finish from the test meals, and later, to track everything you eat and drink during the 'free-living' part of the study. You'll also be asked to keep your usual physical activity levels throughout the study.

The study team will keep in touch with you regularly through your phone, the app, and text messages. They'll be there to answer any questions and help you stick to the plan. You'll also complete an online questionnaire at the beginning, share your height and weight, and you'll need to be using the ZOE testing program, as the study builds on that existing data.

Potential risks and benefits

Participating in this study means you'll be contributing to valuable research that could lead to better, more personalised health advice for many people, especially regarding conditions like diabetes or heart disease. As for risks, you'll be eating standard, commonly available foods, which should be safe for most people. However, if you have allergies or specific dietary needs, you should carefully consider if you can safely eat the provided meals. The study involves wearing a glucose monitor and tracking your food, which some people might find a minor inconvenience. Remember, your participation is completely voluntary, and you have the right to withdraw from the study at any time without giving a reason, and it won't affect any care you receive.

Locations (2)

Zoe US Inc.
Needham, United States· Recruiting
King's College London
London, United Kingdom· Recruiting

Common questions

What is the main goal of this study?

The main goal is to create more personalised eating advice by understanding how different foods affect each person differently.

Do I have to change my diet during the study?

You'll eat two specific test meals provided by the study, but for most of the study, you can eat what you normally would. You just need to track it.

How long will I need to be part of the study?

Each participant will be involved for a total of 6 to 14 days.

What kind of data will I be collecting?

You'll be asked to track your meals and drinks using a digital app, and you'll wear a glucose monitor to track your blood sugar.

Can I still participate if I have diabetes?

Yes, if you're in the US, you can, but you'll need to get your doctor's approval first to ensure it's safe for you to take part.

How to find out more

Meaghan Reardon

meaghan@joinzoe.com 866-771-7478 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.