Oncology research hub

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.

A Pan-European Post-Authorisation Safety Study: Risk of Pancreatic Cancer Among Type 2 Diabetes Patients Who Initiated Exenatide as Compared With Those Who Initiated Other Non-Glucagon-Like Peptide 1 Receptor Agonists Based Glucose Lowering Drugs

This study looks at the possible link between a type 2 diabetes medicine called exenatide and pancreatic cancer. Researchers are comparing patients who started exenatide with those who started other diabetes medicines, using health records from several European countries.

Volatile Organic Compound Assessment in Pancreatic Ductal Adenocarcinoma

Researchers are developing a breath test for pancreatic cancer. This test looks for tiny chemicals in your breath that might change when pancreatic cancer is present. The goal is to help doctors find pancreatic cancer earlier, especially in people with unclear symptoms, so treatment can start sooner.

Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

This study is for people who have had surgery for pancreatic cancer. We are testing a new drug, daraxonrasib, to see if it can stop the cancer from coming back, compared to just being watched. It's to help see if this new treatment works better.

Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.

This study looks at whether we can find signs of non-bowel cancers, like lung or pancreatic cancer, in a small sample of mucus taken from a person's bottom. We're testing a new, simple device to see if it can help detect these cancers earlier.

A Randomised Trial of ATRA in a Novel Drug Combination for Pancreatic Cancer

This study looks at a new combination of medicines for pancreatic cancer. It tests if adding a drug called ATRA to standard treatment (gemcitabine and nab-paclitaxel) helps patients with locally advanced pancreatic cancer not yet treated with other drugs. It's a randomised trial, meaning some get the new drug combo and some get the standard one.

In-Depth Characterisation of Biliary Strictures and Hepato-Pancreato-Biliary Focal Lesions for Development of New Technologies to Tackle Hepato-Pancreato-Biliary Cancers

This study aims to better understand cancers in the liver, bile ducts, and pancreas to find new ways to diagnose and treat them. Researchers are collecting samples to develop new technologies for earlier detection and more effective treatments for these challenging cancers.

A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours

This study is testing a new drug, HMBD-001, for advanced cancers where a protein called HER3 is active. We want to find the best dose, understand side effects, and see if it helps stop cancer growth, sometimes with another drug called enzalutamide.

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

This study is looking at a new medicine called PF-08046876 for people with advanced cancers like bladder, lung, head & neck, oesophageal, or pancreatic cancer. It checks how safe the medicine is and how well it works. The medicine is given through a drip.

Volatile Organic Compound Assessment in Pancreatic Ductal Adenocarcinoma (VAPOR2)

We're testing a new breath test to find pancreatic cancer earlier. This is important because pancreatic cancer can be hard to spot early. The test looks for special smells on your breath that might be linked to the cancer. Finding it sooner could mean more treatment choices and better health outcomes.

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.

Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)

This study looks at adding special radiation to standard care for rare cancers that have spread a little. It wants to see if this addition helps people live longer compared to standard care alone.

American Hepato-Pancreato-Biliary Association (AHPBA) Pancreatic Irreversible Electroporation (IRE) Registry

This study is gathering information on a treatment called IRE for pancreatic cancer. It aims to help doctors understand the treatment better, improve care, and learn about any problems or benefits patients experience.

Phase I Trial of Defactinib and VS-6766.

This study is testing two new drugs, Defactinib and VS-6766, for patients with advanced cancers like certain lung, ovarian, womb, and pancreatic cancers. It aims to find the safest dose and see how well the combination works.

REVOLUTION Surgery (REVOLUTION Surgery)

This study looks into why some cancer patients lose weight and muscle, a condition called cachexia. It aims to understand this problem better by gathering information from patients undergoing surgery for certain cancers and comparing it with people having surgery for non-cancer conditions.

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.

A Phase 1 Study of PRT3789 in Participants with Advanced or Metastatic Solid Tumors with a SMARCA4 Mutation

A Study of ZW171 in Participants with Advanced or Metastatic Mesothelin Expressing Cancers

Diagnostic yield of Endoscopic aspiration of duodenopancreatic juice after secretin stimulation (ADPJ-secr-) vs endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for molecular analysis of intraductal papillary mucinous intraductal neoplasia (IPMN)

68Ga-FAPI-46 PET for imaging of gastrointestinal cancers: A prospective interventional single-arm clinical trial (FAPI-PET-GI)

Exercise to Boost Immunity in Advanced Cancer

This study in Sheffield looks at how exercise might help advanced mesothelioma or pancreatic cancer patients undergoing treatment. It wants to see if weekly exercise can boost their immune system and improve how well treatments work.

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

This study looks at a drug called entrectinib for different types of advanced cancer. It focuses on cancers with specific genetic changes (NTRK, ROS1, or ALK gene fusions). Researchers want to see if entrectinib can help treat these cancers.

Cancer Loyalty Card Study 2 (CLOCS-2)

Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies

This study is looking into a new drug, AZD5305, by itself or with other cancer treatments, for advanced solid cancers like ovarian, breast, and lung cancer. It aims to see if it's safe, tolerable, and effective.

Pembrolizumab With Olaparib as Combined Therapy in Metastatic Pancreatic Cancer

This study is testing a new combination of two drugs, pembrolizumab and olaparib, for people with pancreatic cancer that has spread. It focuses on patients whose cancer has specific genetic changes, hoping to find a more effective treatment.