Parkinson Disease research hub

TUS to Disrupt Pathological Oscillations

This study explores a new, gentle sound wave method to correct faulty brain signals in Parkinson's. We're testing if this non-invasive technique can improve symptoms, offering a safer alternative to current brain surgery. It could also help treat other brain conditions in the future.

To Evaluate the Efficacy of CVN424 in Parkinson's Disease Participants With Motor Complications

This study is testing a new medicine, CVN424, for people with Parkinson's disease who experience 'OFF' times (when their medication isn't working as well). It aims to see if CVN424 can help reduce these 'OFF' periods. Participants will take the medicine or a dummy pill for 12 weeks.

An open-label, single-center study to evaluate the safety and test-retest characteristics of [11C]MODAG-005 as PET radioligand for imaging pathological alpha-synuclein deposition in the brains of patients with Parkinson’s disease (PD) or Multiple System Atrophy (MSA) compared to age-matched healthy controls (AMHC)

This study looks at a new way to see unusual protein build-up in the brains of people with Parkinson's and Multiple System Atrophy. It uses a special scan to help doctors understand these conditions better and work towards new treatments.

Bioequivalence study 1 to compare pharmacokinetics of Parkinson´s disease drugs in healthy volunteers

This study is looking at how two different versions of a Parkinson's disease medicine are handled by the body in healthy adult volunteers. It's a first step to make sure new medicines work in the same way as existing ones.

Serotonin Release in Premotor and Motor PD

This study aims to better understand Parkinson's disease by using special brain scans. Researchers hope to find a 'biomarker' – a sign of the disease – which could help develop new medicines to slow down Parkinson's symptoms.

ExAblate Pallidotomy for Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Parkinson's Disease

This study is looking at a new way to treat symptoms of advanced Parkinson's disease, like uncontrolled movements or 'on-off' periods, when medicines aren't working well. It uses focused sound waves to target a small area of the brain.

Longitudinal Investigation of I2BS in PD

This study aims to find ways to measure Parkinson's disease progression using special brain scans and spinal fluid tests. Researchers hope to understand the disease better and help develop new treatments to slow down its effects. It involves multiple visits over a year in London.

AI-PROGNOSIS - Digital Biomarkers Development Study (dBM-DEV)

This study looks at whether smartwatches can help spot early signs of Parkinson's disease. Researchers are testing if these watches can pick up sleep problems linked to brain conditions. They hope to find an easier way to check for these issues than current complex tests.

A Study to Evaluate the Effects of ACI-7104.056 in Patients With Early Stages of Parkinson's Disease

This study is looking for people with early Parkinson's disease to test a new treatment called ACI-7104.056. We want to see if it's safe, how the body reacts to it, and if it could help. Participants will receive either the study medicine or a dummy treatment (placebo) by injection.

Patient Engagement Investigation of NMS Assist

This study looks at a new digital helper called NMS Assist for people with Parkinson's. It aims to help manage common non-motor symptoms like pain and sleep problems, which can really affect daily life. We want to see if it helps people feel more confident and knowledgeable about their symptoms.

A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

This study is looking into a new medication called NEU-411 for people aged 40-80 with early Parkinson's disease. It focuses on those with a specific genetic marker. The aim is to see if the drug is safe and effective in slowing the disease's progress.

Validation of a Novel Functional Food Designed to Meet the Nutritional Needs of People Living With Parkinson's Disease

This study looks at a special drink for people with Parkinson's disease who have constipation. The drink contains helpful fibres and vitamins. Researchers want to see if it improves gut health and overall well-being over 12 weeks.

Ambroxol to Slow Progression in Parkinson Disease

This UK study is testing if a drug called ambroxol, already used for colds, can slow the progression of Parkinson's disease. Participants will take either ambroxol or a dummy pill, then all take ambroxol. We want to see if it's safe and effective.

Radiofrequency (RF) Ablation Prospective Outcomes Study for Central Nervous System - RAPID for CNS

This study looks at how well a treatment called radiofrequency ablation works for certain brain conditions, like Parkinson's. Researchers are collecting information from people who are already having this treatment in real life to see how it helps them.

Molecular and Functional Imaging in Monogenic PD.

This study uses special brain scans to understand Parkinson's disease better, especially in people with a genetic link. The goal is to find ways to measure the disease and help develop new medicines to slow down symptoms.

Non-invasive Detection of Volatile Metabolites in Parkinson's Disease

This study is looking for a new, simple way to diagnose Parkinson's disease earlier. Researchers are checking if a breath test can spot early signs of the condition by looking at tiny molecules in your breath, combined with changes in gut bacteria.

PD Frontline (Part of RAPSODI GD) Remote Assessment of People With Parkinson's

PD Frontline is an online study for people with Parkinson's. It helps researchers understand the disease better by looking at your genes. You'll give a saliva sample to check key genes linked to Parkinson's and get your results, letting you know about future research you might help with.

Abbott DBS Post-Market Study of Outcomes for Indications Over Time

This study looks at how well Abbott's Deep Brain Stimulation (DBS) systems work and how safe they are over time for people with movement problems like Parkinson's or essential tremor. It helps doctors understand the long-term benefits.

PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

This study aims to understand how Parkinson's disease progresses by tracking changes in people with Parkinson's, those at risk, and healthy volunteers. Scientists hope to find new ways to measure the disease's progression, which will help develop better treatments.

Brain Training to Improve Balance in Parkinson's Disease

This study looks at new ways to help people with Parkinson's improve their balance and prevent falls. It tests a special 'brain training' exercise game to see if it can change brain activity and lead to better balance.

A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)

This study is testing a new gene therapy, AAV2-GDNF, for people with moderate Parkinson's disease. We want to see if it's safe and helps improve symptoms. It involves a single surgery and comparing the gene therapy to a control surgery.

Frontosubthalamic Networks in Parkinson's Disease.

This study looks at how deep brain stimulation (DBS) for Parkinson's disease affects brain networks, especially concerning changes in impulsive behaviour. We want to see if different DBS settings can help reduce impulsivity.

Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR

This study looks into how inflammation might play a role in Parkinson's disease. Researchers will use special scans and tests to understand why inflammation happens and how it affects the disease, hoping to find new ways to help patients in the future.

An Observational Study of Patients With Moderate Parkinson's Disease

This study watches people with moderate Parkinson's disease to see how their symptoms change over time. Participants continue their usual medicine, but doctors might suggest adjustments. It helps us understand the condition better.

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study and Open-Label Extension to Evaluate the Safety and Efficacy of NEU-411 in Companion Diagnostic-Positive Participants with Early Parkinson’s Disease (NEULARK)

Observational Case Series of Patients With Parkinson's Disease (PD) Attending a Complementary Medicine Neuro-degenerative Disease (NDD) Clinic.

This study looks at how people with Parkinson's disease experience complementary therapies like homeopathy and herbalism in a London clinic. Researchers want to understand if these treatments help and how they are used alongside regular medical care.

DBS and Respiration

This study looks at how deep brain stimulation (DBS) for Parkinson's disease might affect breathing. Researchers want to see if DBS in a specific brain area causes breathing problems and understand why, using questionnaires, tests, and activity trackers.

A Trial to Determine the Safety and Tolerability of Transplanted Stem Cell Derived Dopamine Neurons to the Brains of Individuals With Parkinson's Disease

This study is testing a new stem cell treatment for Parkinson's disease. Surgeons will place special cells into the brain to see if they are safe and can help replace damaged cells. It's hoped this could improve movement for people with Parkinson's.

Digital App for Speech & Health Monitoring

This study is using a smartphone app to record and analyse speech from people with conditions like dementia, MND, MS, and Parkinson's. The goal is to see if speech changes can help diagnose and monitor these conditions, comparing them to healthy individuals, using simple digital technology.

Mobilise-D: Extension Study

This study looks at how Parkinson's disease affects movement and how our movement changes as we get older. Researchers will use a special device to track how people move, hoping to understand the condition better and improve ways to measure it in daily life.

Compassionate Use for BIA 28-6156 in Patients With Parkinson's Disease (PD) Who Have a Pathogenic Variant in the GBA1 Gene (GBA-PD) and Completed the ACTIVATE Study

This programme offers continued access to an investigational drug, BIA 28-6156, for people with a specific type of Parkinson's disease (related to the GBA1 gene) who have already completed a previous study. It provides the medicine free of charge on compassionate grounds.

Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation

A Trial to Test the Use of Dapansutrile, an Anti-inflammatory Medication, in People With Parkinson's Disease

This study is testing a new drug called dapansutrile for people with Parkinson's disease. Researchers want to see if it's safe, reduces inflammation in the brain and body, and helps with Parkinson's symptoms. Inflammation is thought to play a role in the disease.