Clinical trials in North Macedonia

Nuwiq for Perioperative Management Of Patients With Haemophilia A on Emicizumab Regular Prophylaxis Study

This study looks at how well a medicine called Nuwiq works to prevent bleeding during surgery in people with severe haemophilia A who are already taking another medicine called emicizumab. It's for males aged 12 and over undergoing major operations.

A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer

This study compares a new drug, alectinib, with standard chemotherapy for people with a certain type of lung cancer (ALK-positive non-small cell lung cancer) after surgery. We want to see if alectinib is better at stopping the cancer from coming back and if it's safe.

Open-label Berotralstat Access to HAE Patients Previously Enrolled in Berotralstat Studies

This study offers ongoing access to a medicine called berotralstat for people with Hereditary Angioedema (HAE) who have already taken part in previous berotralstat studies. It aims to check the long-term safety of the treatment.

Computerized Registry of Patients With Venous Thromboembolism (RIETE)

The RIETE study is building a large database of information from patients with blood clots (venous thromboembolism). It helps doctors better understand and treat patients, especially those with other health problems, to improve care and understand what medicine works best for different groups.

A Study of Navenibart in Participants With Hereditary Angioedema

This study is testing a new medicine, navenibart, for people with Hereditary Angioedema (HAE). Researchers want to see if it safely and effectively prevents swelling attacks in adults and teenagers with HAE.

Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry

This international study looks at how a type of medicine called SGLT2 inhibitors is used in adults with heart problems they were born with. Researchers want to see how safe these medicines are, if people tolerate them well, and if they help improve heart failure.

A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)

This study compares a new drug, Giredestrant, with standard hormone therapy for early breast cancer. It's for people with a specific type of breast cancer (ER-positive, HER2-negative) who have already had surgery.

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis

This study is comparing two medicines, fenebrutinib and ocrelizumab, to see which is safer and better at slowing down primary progressive multiple sclerosis (PPMS). It's for adults with PPMS and aims to understand how these treatments affect the disease progression.

An Open-label Extension Trial to Evaluate the Long-term Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)

This study is looking into the long-term safety of a new medication, KVD900 (Sebetralstat), for teenagers and adults with Hereditary Angioedema (HAE). It is an extension of a previous study, continuing to monitor participants who have already been taking the drug.

A Clinical Study to Evaluate DNTH103 in Adults With Multifocal Motor Neuropathy

This study is testing a new medicine, Claseprubart, for adults with Multifocal Motor Neuropathy (MMN). We want to see if it's safe, how it works in the body, and if it can help improve symptoms. Participants will receive either the new medicine or a placebo.

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies

This study is for people with cancer that has spread, who are already benefiting from a specific medicine called trastuzumab emtansine (T-DM1) or other similar treatments in an earlier study. It allows them to keep receiving these important treatments for longer to see if they continue to help.

A Long-Term Study of Navenibart in Participants With Hereditary Angioedema

This study looks at a new medicine called navenibart for people with hereditary angioedema (HAE). It checks how safe and effective it is over a long time. Only people who were in a previous study with this medicine can join.

A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

This study looks at a new medicine called guselkumab for adults with moderately to severely active Crohn's disease. Researchers want to see how well it works and if it's safe compared to other treatments or a dummy medicine.

Advancing Knowledge in Ischemic Stroke Patients on Oral Anticoagulants

This study looks at people who have a stroke while taking blood thinners for an irregular heartbeat. It aims to understand why this happens and what treatments work best afterwards to prevent another stroke. Researchers will collect information from medical records and follow some patients over time.

A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)

This study looks at a new drug, claseprubart, for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). It aims to see if the drug helps people with CIDP and if it's safe. Some participants will receive the drug, and others a dummy treatment.

A Research Study on How Well Concizumab Works for You if You Have Haemophilia A or B With or Without Inhibitors

This study is testing a new medicine, concizumab, for people with haemophilia A or B, with or without 'inhibitors'. It aims to see if concizumab can prevent bleeds and if it's safe to use. Participants will inject the medicine daily under their skin.

Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

This study looks at two types of heart bypass surgery for women: using one or multiple healthy arteries. Researchers want to see if using more arteries leads to better long-term health, quality of life, and fewer future heart problems for women.