- AuthorisedTherapeutic exploratory (Phase II)
A phase II efficacy and safety study of cell-free circulating tumor DNA-guided commencement of second-line treatment in patients with DLBCL/HGBCL relapse
This study looks at new ways to decide when to start a second treatment for certain types of lymphoma, using a blood test. It aims to see if this approach is safe and effective in helping patients.
For: Diffuse large B-cell lymphomas (DLBCL · Diffuse large B-cell lymphoma) and aggressive B-cell lymphomas (HGBCL · High-grade B-cell lymphoma) originate from mature B-cells at various stages of terminal differentiationPoland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Prospective, Open-Label, Multicenter Randomized Phase III Study to Compare the Efficacy and Safety of a Combined Regimen of Venetoclax and Obinutuzumab Versus Fludarabine, Cyclophosphamide, and Rituximab (FCR)/ Bendamustine and Rituximab (BR) in FIT Patients with previously untreated Chronic Lymphocytic Leukemia (CLL) without DEL(17P) or TP53 Mutation
This study compares two treatments for newly diagnosed Chronic Lymphocytic Leukemia (CLL). It looks at how well a combination of venetoclax and obinutuzumab works against standard treatments (FCR/BR) to reduce tiny amounts of cancer cells and improve overall health.
For: Chronic Lymphocytic Leukemia (CLL)Spain · France · Italy - Ongoing, recruitingTherapeutic use (Phase IV)
Selän alueen poikkeava aktiivisuus servikaalisessa dystoniassa
This study looks at how abnormal muscle activity in the back is linked to cervical dystonia, a condition causing twisted neck positions. It compares different botulinum toxin injections (like Botox) to see how well they reduce muscle overactivity and improve symptoms.
For: Servikaalinen dystonia · jossa poikkeavaa lihasaktiivisuutta esiintyy kaulan alueen lihaksissa aiheuttaen tyypillisiä virheasentoja kuten pään kiertymistä · kallistumista ja vapinaa. Servikaalista dystoniaa hoidetaan ensisijaisesti paikallisesti botuliinitoksiinipistoksillaFinland - AuthorisedTherapeutic use (Phase IV)
Systemic Neoadjuvant and adjuvant Control by Precision medicine in rectal cancer (SYNCOPE) – approach on high-risk group to reduce metastases
This study, called SYNCOPE, looks at new ways to treat advanced bowel cancer (rectal cancer) to stop it from coming back. It uses special medicine combinations for people at high risk to improve their chances of staying cancer-free.
For: Rectal cancerFinland - AuthorisedTherapeutic use (Phase IV)
Treatment of Warthin's tumor: schlerotherapy and its natural course
This study looks at how a treatment called sclerotherapy works for a salivary gland lump called Warthin's tumour. Researchers are checking if it shrinks the lump and helps with symptoms like pain or swelling. They're comparing it to what usually happens with this type of lump.
For: Warthin's tumorFinland - AuthorisedTherapeutic exploratory (Phase II)
Chemoimmunotherapy in conjunction with blood-brain-barrier opening in patients with newly diagnosed or relapsed primary central nervous system lymphoma
This study looks at new ways to treat a rare type of brain lymphoma in adults. It combines chemotherapy with newer immune-boosting drugs. Doctors want to see if this treatment helps patients live longer, whether they are newly diagnosed or if their cancer has returned.
For: Primaari aivolymfomaa · ensilinjan hoito tai hoito relapoituneessa tai refraktaarissa taudissaFinland - AuthorisedPhase III and phase IV (Integrated)
Antibiotic Treatment Trial in Acute Coronary Syndrome
This study is looking at whether common antibiotics could help people who have had a heart attack. It will check if these medicines can reduce serious heart and brain problems over time. Both men and women over 18 can take part.
For: non-ST-elevation myocardial infarction (NSTEMI) · ST-elevation myocardial infarction (STEMI) · coronary artery diseaseFinland - AuthorisedTherapeutic confirmatory (Phase III)
Continuous antibiotic infusion in children
This study looks at how giving antibiotics continuously through a drip affects children with infections. It compares common antibiotics to see if this method can help children get better faster, spend less time in hospital, and avoid infections coming back. It's a key step before this treatment could be widely used.
For: Infection diseaseFinland - AuthorisedTherapeutic confirmatory (Phase III)
Double blind, multicenter, randomized, controlled trial of dexmedetomidine vs placebo in premature neonates receiving invasive ventilation
This study is looking at a new medicine called dexmedetomidine for premature babies who need help breathing. It aims to see if this medicine can reduce the amount of strong pain relief (opioids) these tiny babies need while still keeping them comfortable.
For: Neonatal respiratory distress. Pain and discomfortFrance