Study of Novel Treatment Combinations in Patients With Lung Cancer

To join this study, you must have lung cancer that is not a specific type called 'small-cell lung cancer'. Your general health and how well you can do daily tasks will be checked; you’ll usually need to be fairly active. Your body's organs, like your liver and kidneys, also need to be working well. People who could have children will need to use effective birth control throughout the study.

Each substudy has additional requirements. For example, if your cancer has certain genetic changes, you might not be eligible for some parts, especially if there are already specific treatments for those changes. If you have advanced cancer, you will need to have some visible cancer that doctors can measure. If you have an active autoimmune disease (where your body attacks itself), a serious infection, or have had recent lung problems like pneumonia, you probably won't be able to take part.

If you join this study, you will receive one of the new drug combinations or a standard treatment. These drugs are given in different ways, some might be infusions (drips) and others might be pills. You will have regular hospital visits for check-ups, blood tests, and scans (like CT scans) to see how the treatment is working and monitor your health. The number of visits and tests will depend on which part of the study you are in and which treatment you receive.

Usually, you'll continue treatment for a period determined by the study doctors, as long as it's helping and not causing too many side effects. After treatment, there will be follow-up appointments to track your health over time. The total length of your participation, including follow-up, could be several months to a couple of years.