Ongoing, recruitingHuman Pharmacology (Phase I)- OtherInterventional

A Study to Understand What the Body Does to the Study Medicine Called PF-07976016 When Taken by Healthy Adults

This early-stage study, called a Phase I trial, is investigating a new medicine named PF-07976016. The medicine is being developed to help people who are overweight or have obesity. However, for this first study, researchers are looking for healthy adult men to take part. The main goal is to find out what happens to the medicine inside the body – how it's absorbed, distributed, used, and finally removed. This helps scientists understand how the medicine behaves and if it's safe enough to test in people with obesity or who are overweight in later studies. It's a key step in developing new treatments.

At a glance

Status

Ongoing, recruiting

Phase

Human Pharmacology (Phase I)- Other

Sponsor

Pfizer Inc.

Enrolment target

Start

26 May 2025

Obesity Overweight

What is this study about?

Imagine your body as a complex machine. When you take a new medicine, scientists need to understand exactly how that medicine travels through your system, what it does along the way, and how your body eventually gets rid of it. That's what this particular study, about a medicine called PF-07976016, aims to find out.

This medicine is being developed as a potential new treatment for people who are overweight or have obesity. Knowing how it acts inside the body is really important. It helps researchers work out the right dose, understand potential side effects, and make sure it's working as expected. Because this is a very early study, it helps doctors decide if the medicine is safe and promising enough to move on to larger studies involving people who are actually overweight or have obesity.

So, even though this study is for healthy adult men right now, the information gathered will be incredibly valuable for developing future treatments that could help many people. It’s a vital first step in the journey of any new medicine.

Key takeaways

This is an early study for a new medicine for obesity.
It's about understanding how the medicine works in the body.
Only healthy adult men can take part at this stage.
Participation involves clinic visits and health checks.
It helps science, but offers no direct health benefit to participants.
You can stop participating at any time.

Who may be eligible?

To be able to take part in this study, there are some specific requirements. One important point is that this study is only open to men.

Also, you need to be an adult, aged at least 18 years old. There isn't an upper age limit mentioned, but you would still need to meet all other health criteria.

For this particular study, all participants must be in good general health. This is because the study wants to understand how the new medicine behaves in a typical, healthy body before it's given to people with specific health conditions like obesity.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you male?
Are you 18 years old or older?
Are you generally healthy?
Are you comfortable with regular clinic visits and health checks?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would be asked to attend a number of visits at the study clinic. During these visits, the research team would closely monitor your health to see how your body responds to the study medicine, PF-07976016. You would take the medicine as directed by the study team.

Assessments might include having blood samples taken, checking your heart rate and blood pressure, and providing urine samples. These tests help the researchers understand how the medicine is working and whether there are any changes to your body. There would also be follow-up appointments after you've finished taking the medicine to make sure you remain well. The total duration of your participation, including all visits and follow-ups, would be explained to you in detail by the study team.

Potential risks and benefits

Taking part in a study like this might offer some potential benefits by helping advance medical science, but you would not directly benefit from the medicine itself as you are healthy. There are always potential risks with any new medicine, such as unexpected side effects, and these would be fully explained to you before you agree to participate. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Netherlands

Common questions

What is PF-07976016?

It's a new medicine being studied to see how it works in the body, with the aim of helping people who are overweight or have obesity in the future.

Why are only healthy men being asked to take part?

This is an early-stage study to first understand how the medicine behaves in a healthy body before testing it in people with the condition it's designed to treat.

Will I become healthier by taking part?

Since you need to be healthy to join, this study is about understanding the medicine, not directly improving your health. You won't get a personal health benefit from it.

What kind of tests will I have?

You'll likely have blood tests, blood pressure checks, and maybe other routine checks to see how your body handles the medicine.

How long will I need to be involved?

The study team will tell you the exact duration, which includes taking the medicine and follow-up checks, ensuring your safety throughout the process.