- completed
Clinical trial to evaluate Reducose® mulberry leaf extract as a functional food ingredient to improve metabolic health
Researchers in Oxford are testing whether a natural mulberry leaf extract called Reducose® can help control blood sugar and support gut health. This 12-week study is for healthy adults aged 18 to 60 who are overweight. Participants take either the extract or a dummy capsule and attend three clinic visits.
United Kingdom · England - active not recruitingPHASE2
A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight
This study is testing a new medicine, BI 3034701, to see if it helps adults with obesity or overweight lose weight. Participants will get either the medicine or dummy medicine, plus advice on diet and exercise.
United States · Australia · Canada - recruitingPHASE3
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
This study is looking into a new medication called Eloralintide for people who are overweight or have obesity but don't have type 2 diabetes. It aims to see how well it works and if it's safe to help with weight management.
United States · Argentina · Australia - recruitingPHASE3
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
This study is for children and teenagers aged 6-17 who are overweight or have obesity. It's testing a new medication called Orforglipron to see if it's safe and helps with weight management, compared to a dummy medicine. It aims to find better ways to help young people manage their weight.
United States · Belgium · Brazil - active not recruitingPHASE3
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
This study is looking at how a medication called Tirzepatide might help people living with obesity. Researchers want to see if it can reduce serious health problems and improve overall health in adults.
United States · Argentina · Australia - recruitingTherapeutic confirmatory (Phase III)
I8F-MC-GPHJ: A Phase 3b, Randomized Controlled Study to Evaluate the Efficacy and Safety of Tirzepatide Compared to Semaglutide 2.4 mg in Adults Who Have Obesity or Overweight with Weight-Related Comorbidities
This study is comparing two medicines, Tirzepatide and Semaglutide, to see which is more effective and safer for helping adults with obesity or overweight, who also have other health issues, to lose weight. It's looking at how much weight people lose and other health changes.
Germany · Belgium · Poland - active not recruitingPHASE3
Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes
This study is looking at a new medicine called KAI-9531. It aims to see if weekly injections of this medicine can help people who are overweight or obese, and have other health issues related to their weight, lose weight. We want to know if it's safe and effective.
United States · Argentina · Australia - not yet recruitingNA
Glycaemic Response of Arabic Bread
This study is looking at how different types of Arabic bread, made with chickpea, pea, or lentil flour, affect blood sugar levels. They want to see if these breads can help keep blood sugar more steady compared to regular wheat bread in people who are overweight or have obesity.
United Kingdom - active not recruiting
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
This study looks at lots of past research to see if swapping animal protein for plant protein makes a difference to health conditions like diabetes, heart problems, and kidney issues. They want to understand if eating more plant-based protein, like from beans or nuts, can be better for our health.
Canada - recruitingPHASE3
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
This study looks at a new medicine, NNC0487-0111, for people who are overweight and have knee pain from arthritis. It wants to see if this medicine helps with losing weight and reducing pain compared to a dummy medicine.
United States · Australia · Bulgaria - recruitingPHASE3
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
This study looks at a new medicine called retatrutide for people who are overweight or have obesity and suffer from long-term lower back pain. It aims to see if the medicine helps ease their pain and if it's safe to use.
United States · Argentina · Canada - active not recruitingPHASE1
A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity
This study looks at a new drug, RO7204239, for people with type 2 diabetes who are overweight or have obesity. It aims to see if the drug can improve how the body uses insulin and affects muscle health. This is an early stage study.
Germany - recruitingPHASE3
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities
This study looks at a new daily tablet, ASC30, for adults who are overweight or have obesity and related health problems like high blood pressure. It compares ASC30 with a dummy pill (placebo) to see if it helps with weight loss and is safe over a long period. We want to find out how well it works.
United States · Canada · Czechia - recruitingPHASE3
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes
This study is looking at a new tablet, ASC30, for adults who have obesity or are overweight and also have type 2 diabetes. It's a large study that compares the new tablet to a dummy pill (placebo) to see how well it works for managing weight and its safety over time.
United States · Czechia · Germany - active not recruitingPHASE3
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
This study looks at a new medicine for adults with overweight or obesity and type 2 diabetes. It aims to see if the medicine helps with weight loss and is safe. The medicine is given as a weekly injection under the skin.
United States · Argentina · Bulgaria - recruitingNA
PROTeIn-rich Meals to Control Glucose
This study looks at how different eating patterns might help people with prediabetes or type 2 diabetes manage their blood sugar. Researchers are comparing two diets to see which is better for controlling sugar levels and body inflammation.
Germany - recruitingPHASE3
AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
This study looks at a new medicine, NNC0487-0111, for people who are overweight or obese and have sleep apnoea. We want to see if it helps with weight loss and improves sleep apnoea. Participants will take weekly injections, either the new medicine or a dummy medicine.
United States · Australia · China - active not recruitingPHASE3
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
This study is looking at a new medicine called orforglipron for people with obesity or who are overweight and have type 2 diabetes. It wants to see how well it helps control blood sugar compared to a dummy medicine, called a placebo.
United States · Argentina · China - recruitingPHASE1
A Study Looking at How Weekly Injections of Two Hormones - GIP and Amylin - Affect Stomach-related Side Effects in People Who Are Overweight or Obese
This study investigates if combining two hormones, GIP and Amylin, given weekly by injection, can reduce stomach side effects in adults who are overweight or obese. It's comparing a new combination to one of the hormones alone.
United Kingdom - active not recruitingPHASE2
A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity
This study looks at a new medicine, RO7204239, combined with an existing medicine, tirzepatide, for adults who are overweight or have obesity. It aims to see if this combination helps with weight loss and is safe for people without diabetes.
United States · Poland · Spain - active not recruitingPHASE3
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity
This study is looking at a new medicine called orforglipron to help people who are overweight or have obesity lose weight. It's for adults with at least one other health condition linked to their weight, but not diabetes. It will last about 18 months.
United States · Argentina · China - recruitingPHASE3
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Researchers are studying a new drug called Maridebart Cafraglutide to see if it can help people with heart disease and who are overweight or obese. The goal is to find out if this drug can lower the risk of heart attacks, strokes, and other serious heart problems.
United States · Argentina · Australia - active not recruitingPHASE3
Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide
This study looks at a new medicine called cagrilintide for people with overweight or obesity and type 2 diabetes. It aims to see how well cagrilintide helps people lose weight. Participants will receive either the new medicine or a dummy medicine.
United States · Argentina · Canada - recruitingPHASE3
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
This study is looking at a new once-a-day tablet, orforglipron, for teenagers (12-17 years old) with obesity or who are overweight with other health issues. It will check if the medicine helps with weight and if it's safe to use.
United States · Israel · Italy - active not recruitingPHASE2
A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
This study is looking into a new medicine called tirzepatide. It aims to see if tirzepatide can help people with kidney disease who are also overweight or living with obesity, whether or not they have type 2 diabetes.
United States · Austria · Canada - enrolling by invitationNA
Combined Bariatric Surgery and Pancreas After Kidney Transplantation for Type II Diabetics
This study looks at combining stomach reduction surgery (sleeve gastrectomy) with a new pancreas and kidney for people with Type 2 diabetes. The goal is to help them stop insulin, control blood sugar, and protect their new kidney from diabetes-related damage.
Canada - recruitingNA
The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.
This study explores if losing weight can improve the heart's health and quality of life for people with a specific type of heart failure. Participants will follow a supervised diet plan or continue their usual care.
Jersey · United Kingdom - recruitingPHASE3
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)
This study is looking into the long-term effects of a new medicine, Maridebart Cafraglutide, for people living with obesity and type 2 diabetes. It's an extension of an earlier study and aims to check how well the medicine works and if it's safe over a longer time.
United States · Canada · Japan - active not recruitingPHASE1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
This study is looking at how two different forms of a new medicine, survodutide, are taken up by the body in healthy people who are overweight or have obesity. It aims to see if both forms work in a similar way.
United Kingdom - authorisedHuman Pharmacology (Phase I)- Other
A Study of Eloralintide (LY3841136) in Participants With Overweight or Obesity
This study is looking into a new medication called Eloralintide (LY3841136) for adults who are overweight or obese. It's an early-stage study to understand how the medicine works in the body and if it's safe.
Germany - recruitingPHASE3
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
This study looks at new treatments, CagriSema and cagrilintide, for children and teenagers aged 8-18 who are overweight. It compares these new drugs to an existing medicine (semaglutide) or a dummy drug (placebo) to see how well they help with weight loss.
United States · Australia · Austria - recruiting
Weight Loss in Adults Using Semaglutide (Real-world Study)
This study looks at how a medicine called semaglutide helps adults lose weight in real-life settings. Doctors decide who receives the treatment. It aims to see how effective semaglutide is for people who are overweight or obese, following their usual healthcare.
United States · United Kingdom - enrolling by invitation
A Study to Evaluate Safety of Exposure to Wegovy During Pregnancy
This study looks at how babies and mothers are doing when the mother has taken Wegovy for obesity or being overweight during pregnancy. It compares their health outcomes with mothers who didn't take Wegovy but had similar health conditions.
United States · Spain · United Kingdom - active not recruitingPHASE3
A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
This study is looking into a new medication called retatrutide for people who are overweight or have obesity. It aims to see how well it helps with weight loss and if it's safe, compared to a dummy treatment.
United States · United Kingdom - active not recruitingPHASE3
Weight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide
This study is testing a new medicine called Cagrilintide to see if it helps people living with overweight or obesity to lose weight. Some people will get the new medicine, and others will get a dummy treatment. The study will last about 18 months for each person.
United States · Argentina · Australia - recruitingNA
Weight and Metabolic Management Study
This study is testing if a nutritional supplement, elénzia CONTROL®, can help adults manage their weight. It looks at people who haven't used certain weight-loss medications (GLP-1s) or who recently stopped them. Researchers want to see if it helps reduce weight or stops weight regain.
United Kingdom