Semaglutide 2.4 mg in Patients With Poor Weight-loss

To join this study, you generally need to be an adult between 18 and 65 years old. You must have had either a gastric bypass or sleeve gastrectomy at least one year ago, and not have lost as much weight as hoped (less than 20% of your starting weight). It's important that this slower weight loss isn't due to another surgery problem or a psychological issue.

There are also some important things that would prevent you from taking part. For example, if you've had a different type of weight-loss surgery, or if you have type 1 diabetes or type 2 diabetes treated with insulin, you wouldn't be able to join. You can't be pregnant, breastfeeding, or planning to get pregnant. People with certain serious health conditions, including severe uncontrolled high blood pressure, significant kidney problems, or a history of recent suicidal thoughts, would also not be eligible.

If you join this study, you'll be assigned by chance (like flipping a coin) to either receive the study medicine (semaglutide) or a dummy treatment (placebo). You'll receive this as an injection under the skin for 68 weeks, which is about 15 months. Neither you nor your study doctor will know which treatment you are receiving until the study is over.

Throughout these 68 weeks, you'll have regular visits to the clinic where you'll have assessments. These will include checking your weight, blood pressure, and having blood tests to look at various health markers. You'll also be asked to fill out questionnaires about your health and how you're feeling, to help understand your quality of life. The study will monitor your progress and health closely. After the 68 weeks of treatment, there will likely be some follow-up visits to see how you are doing.