A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities

To be considered for this study, you would typically be between 12 and 17 years old. You should have previously tried to lose weight for at least three months through a structured diet and exercise plan without enough success.

Your weight would need to meet certain criteria related to obesity or being overweight. If you are overweight, you would also need to have at least one weight-related health condition, such as high blood pressure, prediabetes, or obstructive sleep apnea (where breathing stops and starts during sleep). It's important that your obesity isn't due to another medical condition, like a hormone imbalance.

There are also reasons why you might not be able to join. For example, if you've recently lost a lot of weight (more than 5 kg or 11 pounds) in the last three months, or if you're planning to have weight-loss surgery during the study. If you have Type 1 diabetes, a history of certain thyroid cancers, or very high blood sugar levels, you would also not be able to take part.

If you take part in this study, you'll be involved for about 18 months in the main phase. During this time, you will regularly attend clinic visits (the exact number will be explained by the study team) where various assessments will be done. These might include blood tests, physical examinations, and having your vital signs checked. You will be given either the study medicine (orforglipron) or a placebo to take once daily as a tablet, and you'll receive guidance on healthy eating and exercise.

After completing the main 18-month part, there might be an option to continue treatment with orforglipron for another 156 weeks (about three years), still receiving lifestyle advice. Throughout your participation, the study team will monitor your health closely. You are always free to withdraw from the study at any time, for any reason, without it affecting your medical care.