A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight

To be considered for this study, you would generally need to be an adult (18 years or older) and meet certain criteria related to your weight. This often means having a Body Mass Index (BMI) of 30 or higher, which is generally considered obesity. Alternatively, if your BMI is 27 or higher (which is considered overweight), you might still be eligible if you also have at least one weight-related health condition, such as high blood pressure, unhealthy cholesterol levels, sleep apnea, or heart disease. You also need to have tried to lose weight through dieting in the past without success.

There are also some reasons why you wouldn't be able to join the study. For example, if your weight has changed by more than 5 kg (about 11 pounds) in the last 3 months, or if you've had surgery for weight loss or plan to have one. People with certain health conditions, like Type 1 or Type 2 diabetes, certain thyroid cancers (called MTC or MEN-2), or serious heart problems like a recent heart attack or stroke, wouldn't be able to take part. Also, if you've had problems with your pancreas (like pancreatitis) or have taken other weight loss medications (even over-the-counter ones) in the last 3 months, you wouldn't be eligible.

If you decide to take part in this study, you will be involved for about 65 weeks, which is roughly 15 months. Over this time, you would attend about 18 appointments at the study clinic. During these visits, the study team would monitor your health, take various measurements, and you would receive either the study medication (retatrutide) or the placebo. You wouldn't know which one you are receiving. The study team will provide all the necessary medication and instructions. Throughout the study, your health and progress will be carefully checked. There will also be a follow-up period to ensure your safety and monitor your health after the main treatment phase.