A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)

To join this study, you need to be an adult aged 18 or over. You must be overweight or have obesity (your Body Mass Index, or BMI, needs to be 27 or higher). You also need to have type 2 diabetes that was diagnosed at least six months ago, with your blood sugar levels (HbA1c) in a specific range. Your diabetes treatment should have been stable for at least 90 days, meaning you can't be taking certain diabetes medicines like GLP-1 agonists or insulin.

It's important that you are willing and able to give yourself injections under the skin once a week (or have a caregiver help you) and check your blood sugar with finger-prick tests if needed. You also need to have tried to lose weight through diet at least once before.

You cannot join if you are pregnant or breastfeeding, or if you have type 1 diabetes or another type of diabetes not including type 2. If you've had severe low blood sugar recently, have uncontrolled high blood pressure, or have had weight loss surgery, you also won't be able to take part. Also, if you've recently taken other weight loss medications or received steroid treatment, you would not be eligible.

If you decide to take part, you'll be in the study for about 21 months, which is just under two years. The main part of the treatment will involve giving yourself a weekly injection of the study medicine (or placebo) under the skin, usually in your belly. You'll be trained on how to do this safely at home. Throughout the study, you'll have about 14 visits to the study site for check-ups and assessments. You'll also have about 5 check-ups over the phone. These visits allow the study team to monitor your health, see how you're responding to the medicine, and check for any side effects.