Not yet recruitingOBSERVATIONAL

Ultrahypofractionated, Adaptive Radiation Therapy of Prostate Cancer

This study is exploring a new, very focused type of radiation treatment for men with early-stage prostate cancer. It uses a special machine that can adapt to changes in your body each day, ensuring the radiation is delivered precisely. Researchers want to see if this treatment is well-tolerated and how it affects a patient's quality of life. They will compare these results to patients who had older, less focused types of radiation. The study is taking place in several hospitals in Germany and uses digital questionnaires to understand patients' experiences over time.

At a glance

Status

Not yet recruiting

Sponsor

Jena University Hospital

Enrolment target

150

Start

15 Sep 2025

Estimated completion

30 Sep 2032

Prostate Cancer Adaptive Radiotherapy Quality of Life

What is this study about?

This study is looking into a modern way to treat prostate cancer using radiation. Imagine radiation treatment like shining a light on the cancer cells to destroy them. Historically, this light was shone in many small doses over a long period. More recently, doctors have started using fewer, larger doses, which is called 'hypofractionated' treatment. This study is taking it a step further with 'ultrahypofractionated' treatment – even fewer, but bigger doses.

The exciting part is the special machine used in this study. It's called an online-adaptive radiotherapy device. This means it's super smart! Every day before your treatment, it takes a look at your body. Because things inside your body can shift slightly, the machine can automatically adjust the radiation plan to make sure the treatment hits its target perfectly and avoids healthy tissue. This daily adjustment is hoped to make the treatment more precise and potentially reduce side effects.

The main goal of the study is to see how well patients get along with this new treatment (its 'tolerability') and how it affects their daily lives, often called 'quality of life'. Researchers will ask patients to fill out questionnaires on a digital device to track their feelings and experiences over time. They will then compare these results with information from patients who had the older, more traditional radiation treatments to see if this new method offers benefits in terms of comfort and well-being.

Key takeaways

Exploring a new, very precise radiation treatment for prostate cancer.
Uses a smart machine that adapts daily to your body for accurate treatment.
Aims to improve treatment tolerability and patient's quality of life.
Involves answering digital questionnaires about your experience.
Compares results to older radiation methods.
Only for men with early-stage prostate cancer meeting specific health criteria.

Who may be eligible?

This study is for men who have prostate cancer. To be considered, you generally need to be healthy enough for treatment and able to go about your daily activities without much difficulty.

There are a few important things that would mean you couldn't join. For example, if you've recently had certain hormone treatments for your prostate cancer in the last two months, you wouldn't be able to take part. Also, if you have had other types of cancer in the past (not including very common, easily treated skin cancers), this study might not be suitable for you.

Only men aged 18 to 120 can participate. Your doctor will be able to tell you if you fit all the specific requirements for this study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you a man?
Are you 18 years old or older?
Do you have early-stage prostate cancer?
Have you not had certain hormone treatments in the last two months?
Are you generally well and active?
Have you not had other types of cancer (excluding common, treated skin cancers)?

Answer every question to see your result.

What does participation involve?

If you decide to participate in this study, you would receive the new, very focused radiation treatment for your prostate cancer. This would involve regular visits to the hospital for your radiation sessions. Each day before your treatment, the special machine would check your body and adjust the treatment plan specifically for you. Throughout the study, you would be asked to fill out digital questionnaires. These questionnaires are important for telling the researchers how you feel and how the treatment is affecting your quality of life over time. The study will mainly focus on surveying your experience during and after your treatment.

Potential risks and benefits

Participating in a study like this might offer the benefit of receiving a cutting-edge treatment that aims to be more precise and could potentially lead to fewer side effects or a better quality of life. However, like all medical treatments, there can be potential risks and side effects, and because this is a newer approach, not all long-term effects are fully known. You have the right to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

Department of Radiotherapy and Radiation Oncology, Jena University Hospital
Verified postcode
Jena, Germany

Common questions

What is 'ultrahypofractionated' radiotherapy?

It's a modern way of giving radiation treatment using fewer, but larger, doses compared to traditional methods.

What does the special machine do?

The machine checks your body every day before treatment and adjusts the radiation plan to make sure it's as accurate as possible.

Will I have to take any new medicines?

The study focuses on the radiation treatment itself. It doesn't mention giving new medicines specific to the study, but your regular care might include them.

How will the study know how I'm feeling?

You'll be asked to complete digital questionnaires regularly to share your experiences and how the treatment affects your daily life.

Is this treatment available to everyone with prostate cancer?

This particular treatment is part of a research study, so it's only available to people who meet specific criteria for the study.

How to find out more

Klaus Pietschmann, MD. MBa. LLM.

strahlentherapie@med.uni-jena.de 00 - 49 03641 - 9-328401 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.