Latest studies
- CompletedPhase II
Testing new medicine for adults with Cystic Fibrosis who do not have access to the currently available CFTR-modulating drugs due to genetic mutations
This clinical trial tests a new three-in-one medicine for adults with cystic fibrosis who have rare genetic mutations. These patients cannot access currently approved treatments. Researchers are checking whether this daily combination of capsules can safely improve lung health after promising results in laboratory tests using patient cell samples.
Treatment of Cystic Fibrosis (CF) in patients with CFTR mutations who are responders in the organoid assayCzech Republic - Completed
Evaluation of a dermocosmetic regimen for acne-prone skin in volunteers with mild, moderate or severe skin conditions
Acne is a common skin condition that affects confidence and well-being. This study tests whether a daily skincare routine using Eucerin products helps clear mild to severe spots. Researchers want to see how well these creams work over a year in people aged 12 to 50 across the UK and worldwide.
Subjects with acne-prone skin aged 12-50 years with Investigator's Global Assessment (IGA) grades 2-4, evaluating treatment of mild to severe acne vulgaris.Czech Republic - RecruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active Crohn's disease
This clinical trial is testing a new combination medicine, JNJ-78934804, for moderate to severe Crohn’s disease. It combines two drugs into one injection to target gut inflammation. Researchers want to see if this two-in-one approach works better than a single medicine for people whose previous treatments have stopped working.
Crohn’s diseaseCzech Republic - Recruiting
Atrial fibrillation ablation versus heart rate control using conduction system pacing with ablation of the atrioventricular node
This study compares two standard treatments for people living with both persistent atrial fibrillation and heart failure. Researchers are testing catheter ablation against a special pacemaker system to find out which procedure is better at preventing hospital stays, improving heart function, and helping people enjoy a better quality of life.
Persistent atrial fibrillation and heart failureCzech Republic - Completed
Corticosteroids plus standard of care treatment versus standard of care treatment alone to prevent heart complications in Kawasaki disease
Kawasaki disease causes swollen blood vessels that can damage a child's heart. Standard treatment helps, but some children still develop complications. This clinical trial is testing whether adding a steroid medicine to standard treatment works better to protect the heart in children and teenagers aged 30 days to 15 years.
Coronary artery aneurysms in Kawasaki diseaseCzech Republic - CompletedPhase II
The assessment of D5 Ethanol as a marker in exhaled breath to distinguish between people with and without lung cancer
Researchers in the UK are testing whether a simple breath test can help spot lung cancer early. Participants receive a safe, non-radioactive marker through a vein and then breathe into a mask. Scientists measure the breath to see if it can clearly distinguish between people with and without lung cancer.
Lung cancerCzech Republic - RecruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active ulcerative colitis (DUET ENCORE-UC)
This clinical trial is testing a new combined injection called JNJ-78934804 for adults with moderate to severe ulcerative colitis. Researchers want to see if combining two different medicines into one injection works better and is safer at reducing gut inflammation than using a single medicine on its own.
Moderately to Severely Active Ulcerative ColitisCzech Republic - CompletedNot Applicable
Finding out the genetic cause of Juvenile Myoclonic Epilepsy
This study aims to find the genetic causes of Juvenile Myoclonic Epilepsy (JME). Researchers are comparing DNA and brainwave tests (EEGs) from people with JME to people without epilepsy. The goal is to better understand JME, potentially helping scientists develop more targeted and personalised treatments in the future.
People with a diagnosis of Juvenile Myoclonic EpilepsyCzech Republic - Completed
Integrated short-term palliative rehabilitation in incurable cancer
This clinical trial investigates whether a short rehabilitation programme can help people with advanced, incurable cancer stay independent and improve their quality of life. Participants receive either standard care alone or standard care with up to three specialist rehabilitation sessions, along with answering questionnaires about their daily wellbeing over 16 weeks.
Advanced incurable solid cancer: lung, colorectal, breast, prostate, etc.Czech Republic - Recruiting
Sex differences in interoception and mental health: an investigation across the menstrual cycle
This study looks at how we sense internal body signals, like our heartbeat or breathing. Researchers want to discover whether these signals affect mental health differently in men and women, and how monthly hormonal cycles play a part. Participants aged 18 to 40 will track daily symptoms on an iPhone app for seven months.
Identifying sex differences in interoception (i.e. the perception of the internal state of the body), common mental health disorders (i.e. anxiety, depression) and mood, and somatic complaints (i.e. physical symptoms), and identifying whether the menstrual cycle may contribute to these differences.Czech Republic - CompletedPhase III
A study comparing talquetamab in combination with daratumumab or in combination with daratumumab and pomalidomide versus daratumumab in combination with pomalidomide and dexamethasone in participants with multiple myeloma that returns after treatment or is resistant to treatment
This study tests whether a new medicine called talquetamab, given alongside other cancer drugs, helps people with multiple myeloma that has returned or stopped responding to past treatments. Researchers want to see if these new combinations keep the cancer under control for longer than the current standard treatment.
Relapsed or refractory multiple myelomaCzech Republic - Not yet recruitingPhase III
A study of ramantamig plus daratumumab versus investigator’s choice in participants with newly diagnosed multiple myeloma
This study tests a new drug combination for adults recently diagnosed with multiple myeloma who cannot have a stem cell transplant. Researchers want to see if combining a new drug called ramantamig with daratumumab works better and is safer than standard NHS treatments.
Newly diagnosed multiple myelomaCzech Republic - RecruitingPhase III
A Phase III trial of inhaled mosliciguat in pulmonary hypertension associated with interstitial lung disease
This clinical trial is testing an inhaled medicine called mosliciguat for people with high blood pressure in the lungs caused by lung scarring. Researchers want to see if breathing in this drug helps people walk further over six minutes compared to a dummy inhaler with no active medicine.
Pulmonary hypertension associated with interstitial lung diseaseCzech Republic - CompletedPhase III
Euro Ewing 2012
Euro Ewing 2012 is a clinical trial for children, teenagers, and adults newly diagnosed with Ewing's sarcoma. The study compares different chemotherapy drug combinations to find out which treatment works best to cure the cancer while keeping side effects as low as possible.
Ewing's sarcomaCzech Republic - Recruiting
In-Touch: person-centered palliative care to improve comfort and connection in advanced dementia
This study aims to make life better for people with advanced dementia in nursing homes. It tests new ways to keep residents comfortable and connected, and helps their families plan future care. It also supports staff caring for them.
Advanced dementiaCzech Republic - Recruiting
Capillary markers to predict type 1 diabetes
This study is looking for easier, less painful ways to test children for early signs of type 1 diabetes, like using finger-prick tests instead of needles. The goal is to make these important tests possible at home, removing the need for hospital visits.
Type 1 diabetesCzech Republic - CompletedPhase II
A long-term extension study of JNJ-81201887 (AAVCAGsCD59) parent studies in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD)
This study looks at the long-term safety of a new gene therapy, JNJ-81201887, for Geographic Atrophy (GA), a severe eye condition. It involves people who previously took part in earlier studies of this treatment, to see how they are doing over several years.
Geographic Atrophy, secondary to age-related macular degenerationCzech Republic - RecruitingPhase III
JNJ-90301900 (NBTXR3) activated by radiotherapy with or without cetuximab in LA-HNSCC
This study looks at a new treatment called JNJ-90301900 with radiotherapy, sometimes with another drug called cetuximab. It's for older patients with a type of head and neck cancer who can't have standard chemotherapy.
Locally advanced head & neck squamous cell carcinomaCzech Republic - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaCzech Republic - RecruitingPhase III
A study of nipocalimab in adults with moderate to severe systemic lupus erythematosus
This study is testing a new drug called nipocalimab for adults with moderate to severe lupus (SLE). Researchers want to see if it works better than a dummy drug to reduce symptoms. It involves regular visits and monitoring over several years.
Systemic lupus erythematosusCzech Republic - RecruitingPhase III
A study of guselkumab versus risankizumab in participants with moderately to severely active Crohn's Disease
This study compares two approved medicines, guselkumab and risankizumab (Skyrizi), for adults with moderate to severe Crohn's Disease. Researchers want to see which one works better to reduce inflammation and symptoms, especially for those who haven't responded to other treatments.
Moderately to severely active Crohn's DiseaseCzech Republic - Completed
Does removing both ovaries prior to menopause reduce breast cancer risk in BRCA1 and BRCA2 mutation carriers?
This study looks at existing health records to see if removing ovaries and fallopian tubes before menopause reduces breast cancer risk for women with BRCA1 or BRCA2 gene changes. It aims to understand if these operations help prevent cancer in these women.
Breast cancerCzech Republic - RecruitingPhase I/II
A study to learn how the study medicine called PF-07868489 is tolerated and acts in people with pulmonary arterial hypertension
This study is looking into a new medicine, PF-07868489, for pulmonary arterial hypertension (PAH). Researchers want to see if it's safe and how it works in people with this lung condition. It's an early-stage study to understand the medicine better.
Pulmonary arterial hypertensionCzech Republic - Completed
Transatlantic registry of type A aortic dissection
This study looks at how people recover after surgery for a serious heart condition called Type A Aortic Dissection. Researchers are collecting information from patients across different hospitals to understand the best ways to treat it and improve outcomes.
Type A aortic dissectionCzech Republic - RecruitingPhase III
Astria STAR-0215-302 trial for Navenibart in Hereditary Angioedema
This study looks at a new medicine called navenibart for hereditary angioedema (HAE). It aims to see how safe it is and how well people tolerate it over a long time. Navenibart might help prevent HAE attacks, which can be severe and painful.
Hereditary angioedemaCzech Republic - Completed
Three gold-standard evaluations in Portugal, Czechia and the UK of an augmented social play intervention (Lina) to test its effects on belonging and costs for schools
This study looks at a new school activity called 'Lina' for 12-13 year olds in the UK, Portugal, and Czechia. It wants to see if Lina helps students feel more like they belong and improves their mental health, while also checking its cost for schools.
Sense of belonging and mental health and wellbeingCzech Republic