Latest studies
- Completed
Can patients with residual cancer after chemotherapy for early breast cancer be identified with multiple ultrasound-guided biopsies?
This study looks at whether ultrasound-guided needle biopsies can reliably check for remaining breast cancer after chemotherapy. For some people, chemotherapy clears the cancer completely. Researchers want to see if precise biopsies can confirm this, which could help doctors discover if surgery might safely be avoided in the future.
Breast cancerNorthern Ireland - Completed
SMART Spaces - spaced learning revision programme: an education endowment foundation efficacy trial
This UK educational trial looks at a revision technique called SMART Spaces. It tests whether Year 11 pupils taking GCSE double award science can improve their chemistry exam results by breaking revision into short sessions, taking active breaks like juggling, and allowing a night of sleep between lessons.
15 – 16 year old pupils in Year 11 studying AQA double award GCSE scienceNorthern Ireland - CompletedNot Applicable
Investigating local or regional anaesthesia during surgery to create a connection between an artery and a vein
This UK study looks at two ways to numb the arm during surgery to create a dialysis fistula. Doctors want to see if using a nerve block, which numbs the whole arm, helps the fistula work better and last longer than numbing just the small surgical area.
Patients undergoing primary (Radiocephalic fistula) RCF or (Brachiocephalic fistula) creationNorthern Ireland - Completed
VITDALIZE UK: Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency
This study looks at whether giving high-dose vitamin D to very sick adults in intensive care helps them recover better. Around seven in ten critically ill patients have low vitamin D levels. Researchers want to see if replacing this vitamin improves survival rates and shortens time spent in hospital.
Vitamin D deficiencyNorthern Ireland - CompletedPhase IV
Can people with cystic fibrosis safely stop taking some of their nebulised treatments if they are established on the new modulator therapy, Kaftrio?
The CF STORM trial is looking at whether people with cystic fibrosis who take the medicine Kaftrio can safely stop their daily mucus-clearing nebulisers. Researchers want to see if reducing these time-consuming treatments keeps lung function steady and makes day-to-day life easier without harming overall health.
Cystic fibrosisNorthern Ireland - Completed
A trial comparing the effectiveness of an online sleep behavioural intervention versus standard care in children with rolandic epilepsy
This UK study tests whether an online sleep programme can help children with epilepsy sleep better. Children aged 4 to 12 who have sleep issues take part completely from home. Half use an online sleep programme alongside standard care, while half continue with their usual NHS care alone.
Sleep quality in children with rolandic epilepsyNorthern Ireland - Completed
Remote rehabilitation after intensive care
Leaving intensive care can be tough, leaving people physically weak and emotionally drained. This UK study tests a six-week online rehabilitation programme designed to help people recover at home. Researchers want to see if regular remote support, gentle exercises, and recovery advice improve quality of life compared to standard NHS care.
Any condition requiring admission to intensive care and 48 hours of invasive mechanical ventilationNorthern Ireland - Completed
AFTER – Ankle fracture treatment: enhancing rehabilitation trial
The AFTER study explores the best way to help people aged 50 and over recover from a broken ankle. It compares doing exercises at home using a guide and website against having four to six one-to-one sessions with an NHS physiotherapist, to see which approach works best.
Ankle fractureNorthern Ireland - CompletedPhase II
A comparison of response to treatment in patients with Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap Syndromes taking ASTX727 versus best supportive care
This UK clinical trial is testing a new tablet called ASTX727 for adults with rare bone marrow cancers called MDS/MPN overlap syndromes. Researchers want to find out if taking this tablet at home works better at managing the condition and improving quality of life than standard supportive hospital care.
Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap SyndromesNorthern Ireland - Completed
To determine if critically ill patients with acute respiratory failure treated with carbocisteine, hypertonic saline, or both, experience increased hydration of airway mucus.
This study looks at whether medicines called carbocisteine and hypertonic saline help clear thick phlegm from the lungs of critically ill patients on breathing machines. By testing small mucus samples, researchers hope to see how these treatments work to help patients recover and breathe on their own sooner.
Critically ill patients with acute respiratory failure (ARF)Northern Ireland - CompletedPhase II
A clinical trial adding Sativex (a cannabis-based medicine) to standard treatment, temozolomide, to find out if it is beneficial for patients whose glioblastoma brain tumour has returned after treatment
The ARISTOCRAT trial is testing whether adding a cannabis-based mouth spray called Sativex to standard chemotherapy (temozolomide) helps people whose glioblastoma brain tumour has returned. Researchers want to see if combining these treatments slows tumour growth, helps patients live longer, and improves day-to-day quality of life.
Glioblastoma multiformeNorthern Ireland - Completed
The neoGASTRIC trial: Avoiding routine gastric residual volume measurement in neonatal critical care
Premature babies fed through a tube often have their stomach contents checked regularly to see how they digest milk. The neoGASTRIC study looks at whether stopping these routine checks helps premature babies reach full milk feeds more quickly and safely. It compares two standard care approaches already used in hospitals.
Preterm birthNorthern Ireland - Completed
No routine measurement of gastric residual volume in paediatric critical care
Children in intensive care need good nutrition through a feeding tube to help them heal. Doctors usually use a syringe to check fluid in the stomach every six hours, which can pause feeding. This study looks at whether stopping these routine checks safely allows children to get more of their required food.
Oral and GastrointestinalNorthern Ireland - Completed
Investigating methods of measuring visual field sensitivity in glaucoma
Glaucoma causes gradual loss of side vision. Current clinic tests for this were designed over 40 years ago. This study explores new and better ways to test peripheral vision. Researchers in Cardiff, London, and Northern Ireland are welcoming both people with glaucoma and healthy volunteers aged 40 and older.
Investigating peripheral visual sensitivity in people with glaucoma and normally-sighted individualsNorthern Ireland - Completed
Changing habits to prevent child caries
The CHOICE study looks at whether a friendly, supportive chat with a dental nurse can help families build better tooth-brushing and eating habits. Researchers want to see if setting simple home goals reduces future tooth decay in children aged 3 to 7 compared to standard dental care alone.
Tooth decayNorthern Ireland - Completed
Effectiveness of a maternity improvement programme to reduce excess bleeding and need for transfusion after childbirth: the Obstetric Bleeding Study UK (OBS UK)
Heavy bleeding is a common complication after giving birth. The OBS UK study tests a new maternity care package across 36 NHS hospitals to help staff spot and treat heavy bleeding faster. By measuring blood loss accurately and acting early, researchers hope to reduce blood transfusions and improve safety.
Obstetric bleedingNorthern Ireland - RecruitingPhase III
Investigating the clinical and cost-effectiveness of two different drugs (amiodarone and beta blockers) to treat patients with new-onset atrial fibrillation whilst in the intensive care unit
This UK study looks at two standard NHS medicines for an irregular heartbeat that can start during a stay in intensive care. Researchers want to find out whether drugs called beta-blockers or a drug called amiodarone work best to return the heart to a normal rhythm safely.
New onset atrial fibrillation (NOAF)Northern Ireland - Recruiting
Pressurised IntraPeritoneal Aerosolised Chemotherapy (PIPAC) in the management of cancers of the bowel, ovary and stomach: a randomised controlled trial of efficacy in peritoneal metastases
This UK clinical trial is testing a new way to deliver chemotherapy called PIPAC for people whose bowel, ovarian, or stomach cancer has spread to the lining of the abdomen. It aims to see if spraying chemotherapy directly into the tummy during keyhole surgery works better than standard chemotherapy alone.
Colorectal, ovarian and stomach cancer with peritoneal metastasisNorthern Ireland - RecruitingPhase II
Can a drug with the potential to boost the immune system (interferon gamma) prevent infection in patients who are critically ill and at particularly high risk of developing new infections during their stay in an intensive care unit?
Patients in intensive care often develop weakened immune systems, leaving them vulnerable to hospital-acquired infections. This UK trial investigates whether an immune-boosting medicine called interferon gamma can help protect critically ill patients. By helping the body fight off bugs naturally, the treatment may also reduce the need for antibiotics.
Critically ill patients in intensive care units who are at particularly high risk of secondary (hospital-acquired) infectionNorthern Ireland - Completed
Is a lifestyle intervention designed to support muscle mass in people with advanced bowel cancer during their chemotherapy feasible?
This study looks at whether a 12-week gentle exercise and healthy eating programme can help people with advanced bowel cancer keep their muscle strength. Adults starting chemotherapy in Belfast work one-to-one with a specialist coach in a hospital gym to stay active, eat well, and cope better with treatment side effects.
Advanced (unresectable and/or metastatic) colorectal cancer undergoing chemotherapyNorthern Ireland - RecruitingPhase I/II
A trial looking at different treatments for neuroblastoma which has come back after initial therapy
The BEACON2 trial is testing new combinations of cancer medicines for children and young people whose neuroblastoma has returned or worsened after initial treatment. The goal is to find out which drug combinations are safest and work best to control the disease and improve future care.
Relapsed NeuroblastomaNorthern Ireland - RecruitingPhase II
AIR-NET- Testing anti-inflammatories for the treatment of bronchiectasis
The AIR-NET study tests whether three existing medicines can calm lung inflammation in adults with bronchiectasis. Researchers want to find out if repurposing these safe, well-known drugs can help ease daily symptoms, reduce chest damage, and offer better treatment options alongside usual care for people living with this lung condition.
BronchiectasisNorthern Ireland - Recruiting
Co-development of a web-app for young people with attention deficit hyperactivity disorder
Researchers in the UK are developing a new web app to support young people aged 16 to 30 who have ADHD or are waiting for an assessment. By testing the app in friendly workshops, participants help design useful tools and trusted information to improve everyday life and future NHS care.
Attention deficit hyperactivity disorder (ADHD)Northern Ireland - Completed
Investigating the clinical and cost-effectiveness of children’s early self-care support in children with neurodisability
This UK study tests a programme called CHESS, which helps young children with disabilities learn everyday skills like eating, dressing, and washing. Researchers want to find out if CHESS works better and provides better value for money than the usual care NHS therapists currently provide.
Investigating the clinical and cost-effectiveness of self-care support in children with neurodisabilityNorthern Ireland - Recruiting
Can a digital self-help tool, created together with autistic people, support them in managing headaches?
Headaches are common in autistic people, but most health apps are not built with their needs in mind. This UK study works alongside autistic people to adapt a headache self-help app. Researchers want to see if the new app is easy, practical, and helpful to use in daily life.
Self reported persistent or chronic headache in autistic individualsNorthern Ireland - RecruitingPhase III
Better outcomes in babies with bacterial meningitis
This study looks at whether giving a steroid medicine called dexamethasone helps babies under three months recover from bacterial meningitis. Bacterial meningitis is a serious infection around the brain. Steroids help older children, but we do not know if they help young babies. The trial aims to improve survival and prevent disabilities.
Bacterial meningitis (BM)Northern Ireland - RecruitingPhase II
Finding the best treatment for lung disease from infection with Mycobacterium abscessus
This clinical trial is testing different combinations of antibiotics to find the best way to treat lung infections caused by Mycobacterium abscessus. The goal is to discover which medicines work best to clear the bacteria while causing the fewest and least severe side effects for patients.
Mycobacterium abscessus pulmonary diseaseNorthern Ireland - Completed
R&R: A trial for moral injury related mental health difficulties
This study tests a new talking therapy called Restore & Rebuild (R&R) for UK military veterans. It aims to help veterans who are struggling with difficult feelings or mental health issues caused by moral injury from their service, comparing R&R to standard care provided by Combat Stress.
Moral injury related mental health difficulties in UK military veterans.Northern Ireland - CompletedNot Applicable
Does an infusion of alpha-melanocyte stimulating hormone reduce blood sugar after a sugary drink in healthy people and those with type 1 diabetes mellitus?
This UK clinical study tests whether a natural brain hormone called alpha-MSH helps control blood sugar after drinking a sugary drink. Researchers are testing this in healthy adults and people with type 1 diabetes to see if it makes the body more sensitive to insulin.
Glucose clearance from the bloodNorthern Ireland - CompletedPhase III
Remote ischaemic Conditioning After Stroke Trial - 3
This UK study tests whether gently squeezing both arms with blood pressure cuffs can help protect the brain after a stroke. Known as remote ischaemic conditioning, it aims to reduce long-term disability. Around 1,300 patients will receive either this cuff treatment or a dummy version alongside their standard NHS care.
Adults with acute ischaemic stroke presenting in Emergency Departments and Stroke Units in the UKNorthern Ireland - RecruitingPhase III
Metoclopramide for avoiding pneumonia after stroke
Pneumonia is a serious risk for people who struggle to swallow after a stroke. This UK trial investigates whether an everyday anti-sickness medicine, metoclopramide, can prevent chest infections. By helping to empty the stomach, researchers hope to stop fluids entering the lungs, protecting patients and aiding recovery.
Prevention of pneumonia caused by dysphagia after an acute strokeNorthern Ireland - Completed
Personalised treatment packages for adults with a learning disability
The PETAL study tests a personalised support programme for adults with learning disabilities who show aggressive behaviour. By tailoring care to each person's unique needs, researchers hope to help individuals and their carers better manage distress, improve everyday quality of life, and reduce the need for strong medications or hospital stays.
Intellectual disabilityNorthern Ireland - CompletedPhase II
A two-part study to assess the effectiveness, safety, and blood levels of repeat doses of inhaled ETD001 in people with cystic fibrosis
This study looks at a new inhaled medicine called ETD001 for adults with cystic fibrosis. The treatment aims to loosen sticky lung mucus to help make breathing easier. Researchers want to see if the medicine is safe, well tolerated, and improves lung function when taken alongside usual daily care.
Cystic fibrosisNorthern Ireland - RecruitingPhase II/III
Optimising therapy in FLT3-mutated acute myeloid leukaemia
This clinical trial looks at the best chemotherapy combinations for people newly diagnosed with acute myeloid leukaemia (AML) who have a specific gene change called FLT3. It compares current standard treatment with two new drug mixtures to see which clears the cancer best and prevents it from returning.
Acute myeloid leukemiaNorthern Ireland - CompletedNot Applicable
A 2x2 factorial randomised open label trial to determine the CLinical and cost-Effectiveness of hypertonic saline (HTS 6%) and carbocisteine for Airway cleaRance versus usual care over 52 weeks in bronchiectasis
This UK clinical trial investigates whether two mucus-clearing treatments—a salty water mist (hypertonic saline) and a capsule called carbocisteine—help people with bronchiectasis. Researchers want to find out if using these treatments on their own or together helps reduce chest infections and improves daily quality of life compared with usual care.
BronchiectasisNorthern Ireland - Completed
A study working with healthcare professionals and parents/carers to explore whether giving information resources about medicines helps parents take their baby home from a neonatal unit
Taking a baby home from a neonatal unit can feel daunting, especially if they need medicine. The PADDINGToN-2 study looks at whether clear, parent-friendly information resources help parents feel more confident, less anxious, and better prepared to give their baby medicines safely at home after leaving the hospital.
Whether giving information resources about medicines helps parents/carers take their baby home from a neonatal unitNorthern Ireland - RecruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active Crohn's disease
This clinical trial is testing a new combination medicine, JNJ-78934804, for moderate to severe Crohn’s disease. It combines two drugs into one injection to target gut inflammation. Researchers want to see if this two-in-one approach works better than a single medicine for people whose previous treatments have stopped working.
Crohn’s diseaseNorthern Ireland - CompletedPhase II
A study on the safety and effectiveness of fedratinib with ropeginterferon alfa-2b in patients with myelofibrosis
This study is looking at a new combination of two medicines, fedratinib and ropeginterferon alfa-2b, for people with myelofibrosis. Researchers want to find out if taking these treatments together is safe and whether they can help control the disease better than single treatments.
MyelofibrosisNorthern Ireland - Completed
Project HIIT: determining the feasibility of a school-based intervention to promote increased physical activity for adolescents with intellectual disabilities
Project HIIT is a UK study testing a new school exercise programme for teenagers with learning disabilities. It aims to see if regular, fun physical activity sessions during the school day can help pupils stay healthy and active. The study checks whether running this programme in schools works well.
Physical activity as a modifiable risk factor for overweight and obesityNorthern Ireland - Not yet recruiting
Developing stratified pathways to advance readiness in children for school
This UK study looks at how to support children who spent time in a neonatal unit as babies. Researchers want to know what help families need before school begins. Parents can fill in a quick 5-minute online survey, and some may take part in an online video interview.
Unmet needs and school readiness in children who received neonatal care, and their familiesNorthern Ireland - Recruiting
Blood cancer clinical trials long-term follow-up using integrated Healthcare Systems Data
The BLISS study looks at long-term health records of people with multiple myeloma who previously took part in Leeds-run clinical trials in England. Researchers are safely linking past trial details with routine NHS records. This helps doctors learn how treatments work over many years without asking patients to attend extra hospital appointments.
Multiple myelomaNorthern Ireland - Recruiting
Low Grade Glioma in Children (LOGGIC) Core BioClinical Data Bank
The LOGGIC Core study is building a secure database of tumour and blood samples from young people with low-grade glioma, a type of slow-growing brain tumour. By studying their genes, researchers hope to design more personalised treatments and discover tests that show how the tumour might behave in the future.
Low-grade gliomaNorthern Ireland - Completed
RECOVERY Respiratory Support: Respiratory Strategies in patients with coronavirus COVID-19 – CPAP, high-flow nasal oxygen, and standard care
This UK study tests whether two common breathing supports—CPAP masks or high-flow nasal oxygen—work better than standard oxygen masks for people in hospital with COVID-19. The aim is to help people recover safely and reduce the need for invasive mechanical ventilators in intensive care.
Respiratory failure in patients with known or suspected COVID-19 (SARS-CoV-2 infection)Northern Ireland - Completed
Does NIGHT-time dialysis improve quality of LIFE?
This UK clinical study looks at whether having haemodialysis overnight in a clinic can improve quality of life for people with kidney failure. Researchers want to see if longer, gentler dialysis sessions while you sleep help you feel better and give you more free time during the day.
Haemodialysis, renal failureNorthern Ireland - CompletedPhase IV
Real world health outcomes in people with cystic fibrosis after initiation of a new combination treatment
This study looks at how new combination medicines help people with cystic fibrosis in everyday life. Researchers across the UK and Ireland are following children and adults aged six and older for up to seven years to see how these treatments improve health and daily living over time.
Cystic fibrosisNorthern Ireland - Not yet recruiting
Protocol for a pilot study of an online (eHealth) intervention to reduce heart disease risk in male taxi drivers
This study tests 'ManGuard', a new smartphone programme designed to help male taxi drivers in Northern Ireland improve their heart health. Because driving involves long hours of sitting and irregular meals, this trial investigates whether an easy-to-use digital tool can help drivers become more active and reduce heart disease risk.
Prevention of cardiovascular disease in male taxi driversNorthern Ireland - RecruitingNot Applicable
Does the timing and order of breast surgery and hormone treatment affect the quality of life and the amount of surgery required in post-menopausal women with breast cancer? The EndoNET study
The EndoNET study looks at whether taking hormone tablets before breast cancer surgery can shrink the tumour. Usually, women have surgery first, then take hormone therapy. Researchers want to see if taking the tablets first allows surgeons to remove less breast tissue, improving comfort, healing, and quality of life.
Newly diagnosed strongly ER-positive negative breast cancerNorthern Ireland - Completed
Supermarket voluntary price promotion ban: a public health study
This study looks at what happens when two UK supermarkets stop using special offers on unhealthy foods. Researchers want to see how this affects what people buy, their health, and the businesses involved. It aims to understand if stopping these deals helps people eat better.
The main focus of this work is the prevention of obesity and risk of chronic non-communicable diseases through reduction of consumption of high fat salt sugar foods.Northern Ireland - RecruitingPhase III
Testing and comparing multiple drugs at once against the standard treatment for progressive multiple sclerosis treatment
The OCTOPUS trial tests whether medications already used for other health conditions can slow down or stop disability in people with progressive multiple sclerosis (MS). By testing several drugs at the same time against a dummy pill, researchers hope to find effective new NHS treatments much faster than traditional trials allow.
Primary progressive multiple sclerosis and secondary progressive multiple sclerosisNorthern Ireland - Completed
A trial of manual versus instrumental rotation of malpositioned babies at birth
Some babies get stuck facing sideways or back-to-back during birth. Doctors can gently turn them using their hands or instruments like forceps or a suction cup. This study compares both standard NHS methods to find out which is safer, causes fewer tears, and gives mothers and babies the best recovery.
Fetal head in malposition at birthNorthern Ireland