Latest studies
- Completed
How common is intraoperative pain occur during caesarean delivery surgery when the patient is awake and what is the impact on mothers?
This study looks at how often pain happens during C-sections when mums are awake, and how this pain affects them. It aims to improve care for future C-section mothers.
Reproductive health and childbirthNorthern Ireland - Completed
Feasibility of conducting a randomised controlled trial (RCT) comparing invasive (catheter or needle) and non-invasive (clean catch/urine caught in a pot) urine sampling techniques in children under 16 years old with a suspected urinary tract infection
This study looks at the best way to collect urine samples from children under 16 with a suspected urine infection. We want to find out if it's possible to run a larger study comparing different methods, like catching urine in a pot or using a thin tube, to help doctors decide the safest and most effective way.
Urinary tract infectionNorthern Ireland - CompletedPhase I
Phase I trial: CA47303
This early-stage study, called CA47303, is looking for healthy women aged 18 to 45. It's designed to understand how a new investigational treatment works in the body and if it's safe. Details about the treatment will be made public later.
Healthy volunteersNorthern Ireland - Recruiting
Pelvic floor muscle exercises plus pessary for treatment of prolapse versus pelvic floor muscle exercises alone
This study looks at combining pelvic floor exercises with a vaginal pessary for women with pelvic organ prolapse. It wants to see if this combined approach works better at reducing symptoms than just doing the exercises alone, helping to improve women's daily lives.
Pelvic organ prolapseNorthern Ireland - RecruitingPhase III
Through knee amputation compared to above knee amputation
This study compares two types of leg amputation: through-knee and above-knee. It aims to find out which one leads to a better quality of life and easier recovery for patients who need this surgery, helping doctors make the best choices in the future.
Major lower limb amputationNorthern Ireland - Completed
Effects of exercise and quercetin on DNA integrity
This study looks at how exercise and a natural supplement called quercetin affect our DNA as we get older. We hope to learn more about how to keep our bodies healthy and prevent common diseases in middle-aged men.
Prevention of genome instability in healthy middle-aged menNorthern Ireland - Recruiting
Fix or replace enhancing distal humerus fracture outcomes
This study compares two common surgeries for broken elbows in people over 60: elbow replacement or fixing the break with plates and screws. It aims to find which treatment works best to help people recover and use their arm normally again.
Intra-articular fracture of the distal humerus AO type B or CNorthern Ireland - RecruitingNot Specified
Developing genetic tests to diagnose, monitor and guide treatment decisions for children and young people whose cancer has returned
This study looks at the genes in children and young people whose cancer has come back or not responded to treatment. We compare genes in healthy cells with cancer cells to find changes. This helps doctors personalise treatments and find new ways to fight cancer based on genetic information.
Relapsed/refractory solid tumours (including lymphomas) or leukaemiaNorthern Ireland - Recruiting
Treatment of retinal detachment in people who have not had cataract surgery and are not very short-sighted with either vitrectomy surgery alone or with vitrectomy and removal of the cataract at the same time
This study looks at the best way to fix a detached retina, a problem at the back of your eye. It compares having a single eye surgery called vitrectomy to having vitrectomy and cataract surgery at the same time. The goal is to see which option works better for your vision and overall eye health.
Rhegmatogenous retinal detachmentNorthern Ireland - Completed
Understanding the role of community pharmacy in the support of people with long COVID
This study looks at how local chemists (community pharmacies) can better support people in the UK living with "long COVID." Researchers will talk to people with long COVID and pharmacy staff to create a useful online training course for pharmacists to help them understand and assist those with ongoing symptoms.
Long COVIDNorthern Ireland - Completed
An evaluation of a cognitive-behavioural intervention for medical students
This study looks at a special support program called Thumos for UK medical students. It aims to help them cope with stress, feel more confident, and reduce burnout and depression during their clinical placements. We want to see if Thumos works better than usual support.
Improvement of psychological resilience in UK medical studentsNorthern Ireland - Completed
Digestibility of broad bean (faba bean) protein compared to whey protein
This study looks at how well broad bean protein is digested compared to whey protein. Researchers want to see how these proteins affect appetite and blood sugar when eaten alone or with sugar. They hope to understand how broad beans can be a healthy protein source.
This is an acute feeding study in healthy adultsNorthern Ireland - Completed
Development of guidelines for treating patients with cancer-related blockages in the upper urinary tract
This study aims to create clear guidelines for doctors treating cancer patients who have blockages in their urinary tubes. These blockages can cause serious problems, and currently, there aren't agreed-upon ways to treat them. Experts will share their knowledge to help improve patient care.
Clinical guidelines for the management of malignant upper urinary tract obstruction (MUUTO), in cancer patients.Northern Ireland - RecruitingPhase III
A phase 3 randomized double-blinded, placebo-controlled study of JNJ-78278343, T-Cell redirecting agent targeting Human Kallikrein 2 with best supportive care (BSC) versus placebo with BSC for metastatic castration-resistant prostate cancer_KLK2 comPAS_78278343PCR3001
This study is testing a new drug called pasritamig for men with advanced prostate cancer that has spread and isn't responding to hormone therapy. It aims to see if pasritamig, along with usual care, helps men live longer compared to a dummy drug.
Metastatic Castration-resistant Prostate CancerNorthern Ireland - Recruiting
Diet-driven gut microbiome and outcome in patients with early-stage triple-negative breast cancer undergoing neoadjuvant chemotherapy and immunotherapy
This study looks at how the 'good' bacteria in our gut might affect treatment for a type of breast cancer called triple-negative breast cancer. Researchers want to see if changes in diet could help improve how well chemotherapy and immunotherapy work.
Stage I-III Triple Negative Breast CancerNorthern Ireland - Recruiting
How treatments affect people recently diagnosed with follicular lymphoma. A study over time
This study looks at how treatments affect people newly diagnosed with follicular lymphoma. It will collect information during your usual hospital visits, helping us understand the illness better and hopefully improve future care for patients in the UK and worldwide. You won't have extra tests or treatments.
Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissueNorthern Ireland - Recruiting
Supermarket voluntary price promotion ban: a public health study
This study looks at what happens when two UK supermarkets stop using special offers on unhealthy foods. Researchers want to see how this affects what people buy, their health, and the businesses involved. It aims to understand if stopping these deals helps people eat better.
The main focus of this work is the prevention of obesity and risk of chronic non-communicable diseases through reduction of consumption of high fat salt sugar foods.Northern Ireland - Completed
A study to assess nicotine uptake to the bloodstream after use of six different oral nicotine products in adult smokers
This study looks at how much nicotine gets into the blood when adult smokers use different nicotine products. It also checks how people feel about these products, their flavour, and how they affect the urge to smoke and mood. Participants will stay at a research site for 8 days.
Nicotine uptakeNorthern Ireland - Completed
Understanding corridor care in UK emergency departments
This study looks at how many patients are cared for in places like hospital corridors when emergency departments are busy. It wants to understand who these patients are and why they're there, to help improve emergency care across the UK.
UK Emergency Department use of escalation areasNorthern Ireland - RecruitingPhase III
IIH-Advance: A randomised clinical trial to determine the effects of weight loss, induced by a weight loss drug (Tirzepatide), in adults with active idiopathic intracranial hypertension
This study looks at whether a weight loss drug, Tirzepatide, can help adults with a condition called Idiopathic Intracranial Hypertension (IIH). IIH causes high pressure in the head, leading to headaches and eye problems. We want to see if losing weight with this drug can improve these symptoms.
Idiopathic intracranial hypertensionNorthern Ireland - RecruitingPhase III
Investigating whether prolonged antibiotics can prevent permanent Pseudomonas infection in bronchiectasis
This study looks at whether early, strong antibiotic treatment can stop a lung infection called Pseudomonas from becoming permanent in people with bronchiectasis. We hope to reduce flare-ups and improve health.
BronchiectasisNorthern Ireland - CompletedPhase I
A Phase I trial of LY3143921 hydrate in solid tumours
This study looks at a new drug, LY3143921 hydrate, for advanced solid cancers. It aims to find a safe dose and understand its effects, especially in cancers where usual treatments haven't worked or aren't suitable. This is the first time it’s being tested in people.
Colorectal Cancer (CRC), High Grade Serous Ovarian Cancer (HGSOC), Non-Small Cell Lung Cancer (NSCLC; Squamous Cell Variant), Squamous Carcinoma of the Oesophagus, Squamous Carcinoma of the Head and Neck (Human Papillomavirus Negative), Urothelial Cancer, Breast Cancer (Triple Negative Type), Pancreatic CancerNorthern Ireland - RecruitingPhase I/II
A two-part study to investigate the effects in adults of two doses of golexanolone in patients with primary biliary cholangitis with fatigue and cognitive dysfunction
This study looks at a new drug, golexanolone, for people with a liver condition called Primary Biliary Cholangitis (PBC) who also feel very tired and have trouble thinking clearly. Researchers want to see if it's safe, how it works in the body, and if it helps these symptoms.
Patients with primary biliary cholangitis with fatigue and cognitive dysfunctionNorthern Ireland - Recruiting
A study to find out if a new blood test (microRNA) can be used to monitor people after surgery for seminoma or dysgerminoma cancer
This study looks at a new blood test to see if cancer has come back in people treated for specific early-stage cancers like seminoma or dysgerminoma. It aims to reduce the need for scans by seeing if a simple blood test can do the job and help find cancer recurrence earlier.
Seminoma and dysgerminomaNorthern Ireland - Recruiting
Comparing large chest drains with small chest drains to explore the best treatments for chest injury
This study compares two types of tubes, small and large, used to drain air or blood from the chest after an injury. It aims to find out which one works best and is safer for patients, and if it could save the NHS money.
Specialty: Trauma and Emergency Care, Primary sub-specialty: Emergency Medicine; Health Category: Injuries and accidents, Respiratory; Disease/Condition: Injuries to the thoraxNorthern Ireland - Recruiting
Pharmacogenetics to avoid loss of hearing UK
This study uses a quick genetic test to protect newborn babies from hearing loss. Some babies given a common antibiotic, gentamicin, can become deaf if they have a certain gene. This test identifies those babies quickly so they can receive a safer treatment. It's being tested across the UK.
Use of a genetic test to detect the m.1555A>G variant associated with aminoglycoside-induced hearing loss in neonatal care unitsNorthern Ireland - RecruitingNot Specified
Study of whether radiotherapy after surgery to treat a weakened or broken bone caused by cancer helps to reduce pain and improve quality of life
This study looks at whether radiation treatment after surgery for cancer-related broken bones helps with pain and quality of life. Some people will get radiation, others won't immediately, to see if it makes a difference and if it's truly needed after surgery.
Bone metastasesNorthern Ireland - Completed
Testing how well a new online platform can support people living with overweight or obesity to lose weight
This study tested a new online tool called the STOP portal to help adults who are overweight or obese manage their weight. Participants used the portal to track their food, activity, and weight for three months, to see if it helped with weight loss.
Individuals living with overweight or obesityNorthern Ireland - Completed
Performance evaluation of type 1 diabetes genetic risk test
This study looks at a new genetic test for Type 1 Diabetes. It aims to help doctors tell the difference between Type 1 and other types of diabetes more easily. This is important for ensuring people get the right treatment early.
Discrimination of Type 1 Diabetes from other non-autoimmune diabetes such as type 2 diabetes, monogenic diabetes or secondary diabetes.Northern Ireland - Recruiting
A study evaluating whether immobilisation or no immobilisation affects pain scores in toddlers fractures
This study looks at how best to treat toddlers' shin bone breaks. It compares using a cast or boot with no cast, to see which helps children with pain, convenience, and recovery. It aims to find the safest and most practical approach for families and the NHS.
Toddler's fractures - non-displaced spiral fractures of the tibiaNorthern Ireland - Recruiting
In-Touch: person-centered palliative care to improve comfort and connection in advanced dementia
This study aims to make life better for people with advanced dementia in nursing homes. It tests new ways to keep residents comfortable and connected, and helps their families plan future care. It also supports staff caring for them.
DementiaNorthern Ireland - RecruitingPhase IV
A platform trial to identify the best treatments for critically ill children admitted to paediatric intensive care
This study is looking for better ways to care for very sick children in intensive care. We are testing common treatments to see which ones work best and are safest, hoping to improve their recovery and future well-being.
Critical illnessNorthern Ireland - Recruiting
Clinical performance evaluation of a Randox Respiratory-fleX device for respiratory infections
This study aims to check how well a new medical device, the Randox Respiratory-fleX, can find common bugs that cause chest infections. It compares the new device with one already in use to make sure it's accurate and quick. If you’re aged 18 or over and having a respiratory test, you might be able to help.
Detection and discrimination of causative pathogens of respiratory infections.Northern Ireland - Recruiting
Effect of fish and omega 3 supplements on the heart health of young adults
This study looks at how fish or omega-3 supplements affect heart health in young adults. It wants to see if eating more fish or taking supplements can improve body levels of omega-3, which is linked to a lower risk of heart disease.
Cardiovascular disease preventionNorthern Ireland - Recruiting
A population-based digital study offering people testing for cancer genes, to identify people at increased risk of cancer so they can take steps to prevent it or detect it early
This study offers a genetic test for cancer risk to people in the UK. It uses a saliva sample to check for genes linked to breast, ovarian, bowel, and womb cancers. The aim is to find people at higher risk so they can take steps to prevent cancer or detect it early.
CancerNorthern Ireland - Recruiting
A UK study of minimally invasive emergency treatment of sudden bleeding from the lower bowel
This study looks back at records of patients in the UK and other countries who had a special X-ray guided procedure called embolisation to stop sudden bleeding from their bowel. It aims to understand how well this treatment works and to improve care for similar cases in the future.
Patients who have undergone angiography +/- embolisation for acute non-variceal lower GI haemorrhage.Northern Ireland - Completed
The impact of trainer behaviour on trainee cognitive load and performance during vascular surgery simulation
This study looks at how a trainer's behaviour affects surgical trainees learning. It compares supportive trainers to rude ones in a simulated operating room. The goal is to improve training and patient safety by understanding this impact.
Surgical trainee intraoperative cognitive load, technical skills and non-technical skillsNorthern Ireland - Recruiting
Impact of having a long lie after a fall
This study looks into what happens when someone falls and can't get up for a long time. It aims to improve how we help people waiting for assistance, making things better for patients, ambulance services, and care homes.
Specialty: Trauma and Emergency Care, Primary sub-specialty: Pre-hospital; Health Category: Disputed Aetiology and OtherNorthern Ireland - Recruiting
Can we safely reduce the number of days of radiotherapy needed to treat people with breast cancer who need boost treatment?
This study looks at whether we can safely give breast cancer patients who need an extra 'boost' of radiotherapy a shorter 5-day treatment instead of the usual 15 days. It compares two different 5-day boost doses with the standard 15-day boost.
Breast cancerNorthern Ireland - Recruiting
FORENSIC-UK: Fusion versus Best Conservative Care
This study looks at whether an operation called spinal fusion helps people with ongoing severe lower back pain better than other non-surgical treatments. It also checks if the operation is good value for the NHS.
Low back painNorthern Ireland - Completed
A study exploring healthcare professionals' experiences using a ready-to-use botulinum toxin for cosmetic treatments in UK aesthetic clinics
This study looks at how UK skincare doctors and nurses use a new, ready-to-use treatment for facial lines like frown lines and crow's feet. It aims to see if this new product is easy to use and helps clinics run smoothly.
Facial lines, specifically glabellar (frown) lines and lateral canthal (crow’s feet) linesNorthern Ireland - Recruiting
Introducing diabetes checks in dental settings: a study to explore whether dental settings can be used to identify new cases of prediabetes and diabetes
This study looks at whether dentists can help spot early signs of diabetes in their patients. Dentists are often seen regularly, which might make them a good place to check for diabetes early. It involves a simple questionnaire and a finger-prick test.
DiabetesNorthern Ireland - RecruitingPhase III
Implementation of Metformin theraPy to Ease DEcline of kidney function in Polycystic Kidney Disease (IMPEDE-PKD): randomised placebo-controlled trial
This study looks at metformin, a common diabetes drug, to see if it can slow kidney disease in people with ADPKD. It's for adults aged 18-70 and involves taking tablets daily for two years to understand if it helps protect kidneys.
Autosomal dominant polycystic kidney disease (ADPKD)Northern Ireland - Recruiting
A trial examining if less fluid administration is better than standard fluid administration in children undergoing kidney transplant
This study looks at how much fluid children should get during and after a kidney transplant. We want to find out if giving a bit less fluid, based on body size, is better than the usual amount for helping children recover faster and spend less time in hospital.
Fluid management in paediatric kidney transplantationNorthern Ireland - RecruitingPhase IV
Examining antibiotics for ulcerated skin cancer surgical excision
This study looks at whether antibiotics can prevent infections after surgery for ulcerated skin cancer. People will either get an antibiotic or a dummy pill to see if it reduces wound infections, helping doctors decide if antibiotics are needed for this surgery.
Antibiotic treatment for the prevention of surgical site infection in participants receiving ulcerated skin cancer excisionNorthern Ireland - Recruiting
Holistic approach for improving the care of people with multiple conditions after critical illness
This study looks at a new support program for people with multiple health issues after a stay in intensive care. It aims to help them as they return home and improve their recovery and wellbeing.
Sequalae of critical illnessNorthern Ireland - Completed
The effect of 8 weeks probiotic supplementation on sleep quality in adults aged 18 years and over
This study looks into whether taking a probiotic supplement for eight weeks can improve sleep for adults who aren't happy with their sleep. Researchers will compare those taking the probiotic to those taking a dummy pill.
Healthy adults with dissatisfaction with their current sleepNorthern Ireland - Recruiting
A UK-wide study to find out which routine top-up feeds for extremely preterm babies when there is insufficient own mother’s milk, reduce the likelihood of necrotising enterocolitis and improve survival and brain development
This study looks at the best way to feed very early babies, specifically those born before 29 weeks. It compares donor breast milk to special formula and different ways of fortifying milk to see which helps babies survive, grow, and avoid serious gut and brain problems.
Necrotising enterocolitis, mortality, and cognitive impairment in preterm babies born below 29 weeks gestationNorthern Ireland - Not yet recruitingPhase II
A trial to evaluate the safety and efficacy of treatment with azacitidine in patients with symptomatic non-obstructive hypertrophic cardiomyopathy
This study looks at a new drug, azacitidine, for non-obstructive hypertrophic cardiomyopathy (nHCM), a common heart condition. It aims to see if azacitidine is safe and effective in treating nHCM, which currently has limited direct treatments.
Symptomatic non-obstructive hypertrophic cardiomyopathy (nHCM)Northern Ireland - RecruitingPhase III
Phase III study of revumenib in combination with intensive chemotherapy in newly diagnosed NPM1-mutated AML
This study looks at adding a new drug, revumenib, to standard chemotherapy for a type of blood cancer called AML when it has a specific gene change (NPM1 mutation). It aims to see if this new combination works better to treat the cancer.
Newly diagnosed acute myeloid leukemia (AML) with an NPM1 mutationNorthern Ireland