Clinical trials in United Arab Emirates

An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice

This study looks at how a medicine called upadacitinib works for adults with moderate to severe Ulcerative Colitis in everyday life. Researchers will check its safety and how well it helps manage the condition, following about 1000 people over three years.

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

This study is testing a new drug, iza-bren, for advanced triple-negative breast cancer or ER-low, HER2-negative breast cancer. It compares iza-bren with standard chemotherapy in patients who haven't had previous treatment for advanced disease and can't receive certain immunotherapy drugs.

A Study Observing Everyday Effectiveness and Safety of the Drug Elafibranor in Participants With Primary Biliary Cholangitis Who Are Receiving Ongoing Treatment

This study looks at how a drug called elafibranor works for people with a rare liver disease called Primary Biliary Cholangitis (PBC) in everyday life. Researchers will check its effects, how safe it is, and how well people tolerate it over about five years.

Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma

This study is looking at whether a medicine called dupilumab can help adults with moderate to severe asthma keep their lungs working better over time. It compares dupilumab to standard asthma care to see if it can prevent lung function from getting worse. It's a long-term study.

An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)

This study is looking at a new drug, camizestrant, for people with a common type of early breast cancer. It aims to see if camizestrant, compared to usual hormone therapy, can better prevent the cancer from coming back.

A Study of EP0031 in Patients With Advanced RET-altered Malignancies

This study is testing a new medicine called EP0031 for advanced cancers caused by problems with a gene called RET. It aims to see if EP0031 is safe, what side effects it causes, and how well it works, especially for a type of lung cancer called NSCLC.

A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice

This study looks at how a cancer drug called atezolizumab works in real patients. Researchers want to see its effects and safety under normal hospital care, for different types of cancer it's approved for.

Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis

This study is looking at a new medicine called frexalimab for people aged 18-55 with certain types of Multiple Sclerosis (MS). It compares frexalimab to an existing MS medicine, teriflunomide, to see how well it stops MS relapses and if it's safe.

eUltra 10k - Biofreedom Ultra

This study is gathering real-world information on the BioFreedom Ultra stent, a small tube used to keep blood vessels open. It's for people aged 18 and over who have this stent, helping researchers understand how it works in everyday medical care.

Neurovascular Product Surveillance Registry

This study looks at how well Medtronic treatments work for brain aneurysms and strokes. It's a way to keep track of these medical devices after they're used to help patients. Doctors watch how people recover over time to make sure the treatments are safe and effective.

A Study to Assess Adverse Events and Change in Disease Activity of Risankizumab Subcutaneous Induction Treatment for Moderately to Severely Active Crohn's Disease.

This study is looking at a new way to give risankizumab, a medicine for Crohn's disease, as an injection under the skin. It aims to see how well it works and if it's safe for adults with moderate to severe Crohn's disease.

Real World Observational Study of Poteligeo in Adult Patients With MF and SS (PROSPER)

This study looks at how people with Mycosis Fungoides (MF) and Sézary Syndrome (SS) are doing on a treatment called Poteligeo. It collects real-world experiences from patients and their carers, helping us understand the treatment's impact on their daily lives.

A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)

This study looks at a new drug, golcadomide, combined with rituximab, for people with follicular lymphoma that has come back or not responded to previous treatments. It compares this new combination to standard treatments chosen by doctors.

The Oxford Risk Factors And Non-Invasive Imaging Study

This study looks at heart and blood vessel problems using CT scans. It collects health information and blood samples to find better ways to spot and predict these conditions, helping doctors understand who is at risk and how best to help them.

A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab

This study compares two approved medicines, risankizumab and vedolizumab, for adults with moderate to severe ulcerative colitis who haven't tried similar treatments before. It looks at how safe and effective they are. Around 530 people will take part worldwide.

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)

This study looks at a new medicine called mitapivat for people with severe types of thalassemia who need regular blood transfusions. It aims to see if mitapivat can reduce how often they need transfusions compared to a dummy treatment.

Brivekimig for the Treatment of Moderate to Severe Hidradenitis Suppurativa

This study is testing a new medicine called brivekimig for moderate to severe hidradenitis suppurativa (HS). It compares brivekimig to a dummy medicine (placebo) to see if it's safe and helps reduce HS symptoms.

A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor

This study looks at a new medicine called amlitelimab for people aged 12 and over with moderate-to-severe eczema. These individuals haven't responded well to other common eczema treatments. Researchers want to see if amlitelimab is safe and helps improve their skin when used with their usual steroid creams.

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

This study looks at new ways to treat advanced squamous non-small cell lung cancer. It combines standard treatment (Pembrolizumab, Carboplatin, Paclitaxel/Nab-paclitaxel) with a new drug, sac-TMT, to see if it helps people live longer.

A Prospective, Non-interventional, Multinational, Observational Study With Isatuximab in Patients With Relapsed and/or Refractory Multiple Myeloma (RRMM)

This study looks at how a medicine called isatuximab works for people in the UK with a type of blood cancer called multiple myeloma that has come back or not responded to previous treatments. It checks how well it works and if it's safe in real-world settings.

The ENERGY 3 Study: Evaluation of Efficacy and Safety of INZ-701 in Children With ENPP1 Deficiency

The ENERGY 3 Study is looking at a new treatment called INZ-701 for children aged 1-12 with a rare genetic condition called ENPP1 Deficiency. This study wants to see how well INZ-701 works and if it's safe compared to usual care.

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

This study is comparing a new medication called remibrutinib with an existing treatment, teriflunomide, for people with relapsing multiple sclerosis (RMS). It aims to see how well remibrutinib works and if it's safe to use in managing RMS symptoms.

PROSpect: Prone and Oscillation Pediatric Clinical Trial

This study looks at the best ways to help children with severe breathing problems (PARDS). It compares lying on the back or front, and two types of breathing machines, to see which helps children recover faster and spend less time on a ventilator.

Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials

This study looks at a medicine called amlitelimab for moderate to severe eczema in people who've already tried it in other studies. We want to see how safe and effective it is over a long time, and if it continues to help.

Pompe Disease Registry Protocol

This registry tracks people with Pompe disease globally. It helps us understand the condition better, how it changes over time, and the effects of treatments. The goal is to improve care for everyone with Pompe disease.

Safety and Tolerability of Difelikefalin in Adolescents on Haemodialysis With Moderate-to-Severe Pruritus

This study looks at a medicine called difelikefalin for teenagers (12-17) on dialysis who have very itchy skin from kidney disease. It checks if the medicine is safe and how much gets into their blood. We hope to find a new way to help young people with this problem.

A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

This study is testing a new medicine called Afimkibart for people with moderately to severely active Crohn's disease. It's a Phase 3 study, which means it's a big step before the medicine might become widely available, looking at how well it works and if it's safe.

Observational Study of Oral Atogepant to Evaluate Real-World Effectiveness in Adult Participants With Migraine

This study looks at how well a medication called atogepant works for adults with migraine in everyday life. If you're prescribed atogepant, you might be asked to join. It simply involves attending your usual doctor's appointments and won't add extra hassle.

The SPECTRUM Study: An Observational Study to Learn More About How Well Aflibercept 8 mg Works in Treating Visual Impairment Due to Neovascular Age-related Macular Degeneration or Diabetic Macula Edema

The SPECTRUM Study is looking at how well a new eye medicine called aflibercept 8 mg works for vision problems caused by wet AMD or diabetic macular oedema. Researchers will collect information from patients who are already prescribed this medicine by their doctor.

International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry

This study tracks the health of people with Gaucher disease over time, whether or not they are receiving treatment. There's also a sub-study for pregnant women with Gaucher disease to see how their pregnancies and babies' health progress. It helps doctors learn more about the condition.

A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.

A Platform Study of Novel Immunotherapy Combinations in Participants With Previously Untreated, Advanced/Metastatic Non-Small-Cell Lung Cancer

This study is looking at new combinations of medicines for advanced lung cancer that hasn't been treated before. We want to see how safe these new treatments are and how well they work together. It's for people whose cancer shows high levels of a specific marker called PD-L1.

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT)

This study looked at a new drug, mitapivat, for people aged 18 and over with a type of blood disorder called thalassemia that doesn't need regular blood transfusions. It aimed to see if mitapivat could help reduce anaemia compared to a dummy pill.

A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)

This study looks at a new drug, Giredestrant, combined with an existing treatment called Phesgo, for advanced breast cancer. It aims to see if this new combination is safe and works better than Phesgo alone for people with specific types of breast cancer.

Study Evaluating LDL-C Change and Adherence to Inclisiran Lipid-lowering Therapy in ASCVD

This study looks at how well a medicine called inclisiran works for people with high cholesterol and helps prevent heart problems. We want to see if it lowers bad cholesterol and if people stick to taking it as part of their usual care.

A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products

This study looks at how well certain eye medicines from Roche work for conditions like wet macular degeneration and diabetic eye disease in real patients. It's about understanding long-term results and why doctors choose specific treatments, without changing how patients are usually cared for.

European TIF2.0 Registry

This study looks at a keyhole procedure called TIF to treat reflux (heartburn and sickness). Doctors want to see how safe and effective it is for people experiencing symptoms like stomach acid coming up and a sore throat, sometimes combined with a small hernia repair.

A Study to Investigate Tolerability and Efficacy of Asciminib (Oral) Versus Nilotinib (Oral) in Adult Participants (≥18 Years of Age) With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+ CML-CP)

This study compared two oral medications, asciminib and nilotinib, for adults newly diagnosed with a type of blood cancer called Philadelphia chromosome-positive chronic myeloid leukemia (CML). It looked at how well people tolerated each drug.

An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)

This study tests a special cream (AC-203) for a skin condition called Epidermolysis Bullosa Simplex (EBS). It looks at how well the cream works to reduce blistering and how safe it is for people with widespread EBS, including children.

A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases

This study looks at new treatments (inebilizumab and blinatumomab) for people with Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). It mainly checks how safe these medicines are and if they help reduce symptoms of these conditions.

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

This study looks at a new drug, Dostarlimab, for adults with a certain type of head and neck cancer. It compares Dostarlimab to a dummy drug (placebo) after standard chemo and radiation, to see if it's safe and effective.

A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC in Adults With Ocular Myasthenia Gravis

This study looks at a new medicine for adults with a type of muscle weakness affecting the eyes called ocular myasthenia gravis. Researchers want to see if the medicine, Efgartigimod, is safe and helps improve eye symptoms. Some people will get the active medicine, and others will get a dummy treatment.

Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD

This study is testing a new medicine, DCR-PHXC, for people with a rare kidney disease called Primary Hyperoxaluria Type 1 (PH1) who also have severe kidney problems. It aims to see how safe and effective the medicine is.