- Recruiting
A Study Measuring Markers of Airway Inflammation in Breath Samples From People With Respiratory Diseases and Healthy Volunteers.
This study looks for early signs of lung cancer and other lung problems by testing breath. We're trying to find a simple, quick way to help doctors decide who needs more tests, especially for people with ongoing breathing issues.
For: Lung Cancer (Diagnosis) · Lung Cancer (Suspected or Confirmed) · HealthyUnited Kingdom - Recruiting
Reproductive Endocrinology Oxford Study (RepOx)
This study is looking at how Polycystic Ovary Syndrome (PCOS) develops and causes problems like difficulty getting pregnant or complications during pregnancy. Researchers will study different biological information to understand PCOS better.
For: Polycystic Ovary SyndromeUnited Kingdom - Not yet recruiting
Sepsis in Oncology Patients
This study looks at how the body's defence system (immune system) works in cancer patients who get a serious infection called sepsis. Researchers want to understand why some cancer patients get sepsis and how their bodies react.
For: Sepsis in Cancer PatientsUnited Kingdom - Recruiting
A Pilot Study to Assess Body Mass Composition Measurement Using BIA and Muscle Ultrasound in IPF and PPF Patients on Anti-fibrotic Medications
This study looks at how anti-fibrotic medicines for lung scarring might affect your body shape, specifically your muscle and fat. It uses simple tests like body scanners and muscle scans to see if these medicines cause changes not picked up by just weighing yourself.
For: Idiopathic Pulmonary Fibrosis (IPF) · Progressive Pulmonary FibrosisUnited Kingdom - Active not recruiting
Long Term Follow Up to Evaluate DTX301 in Adults With Late-Onset OTC Deficiency
This study is checking on the long-term safety of a treatment called DTX301 for adults with a condition called OTC deficiency. It's for people who've already taken part in an earlier study of DTX301. Researchers want to see how participants are doing over time.
For: Ornithine Transcarbamylase (OTC) DeficiencyUnited States · Canada · France - Enrolling by invitation
A Study to Evaluate Safety of Exposure to Wegovy During Pregnancy
This study looks at how babies and mothers are doing when the mother has taken Wegovy for obesity or being overweight during pregnancy. It compares their health outcomes with mothers who didn't take Wegovy but had similar health conditions.
For: Pregnancy · Obesity · OverweightUnited States · Spain · United Kingdom - Active not recruiting
A Study of Lanadelumab in Teenagers and Adults With Hereditary Angioedema (HAE)
This study looks at how a medicine called lanadelumab helps teenagers and adults in the UK with a swelling condition called Hereditary Angioedema (HAE). We're comparing their HAE attacks before and after starting this treatment to see how well it works.
For: Hereditary Angioedema (HAE)United Kingdom - Recruiting
A Study to Learn How Nusinersen (Spinraza) Affects Participants With Spinal Muscular Atrophy (SMA) Who Took it Before or During Pregnancy And About The Health of Their Babies
This study looks at pregnant women with Spinal Muscular Atrophy (SMA) who have taken the drug nusinersen (Spinraza). Researchers want to understand how the drug affects their pregnancy and the health of their babies, as there's not enough information yet.
For: Muscular Atrophy, SpinalUnited States · United Kingdom - Recruiting
Long-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)
This study is checking on the long-term well-being and health progress of children who previously took part in a study for a rare liver condition called Ornithine Transcarbamylase Deficiency (OTCD). It also looks at how the condition naturally develops in those who didn't receive the study treatment.
For: Ornithine Transcarbamylase Deficiency · Ornithine Transcarbamylase Deficiency Disease · Urea Cycle Disorders, InbornUnited States · United Kingdom - Recruiting
An International Observational Study of Adults With Acute Infection
This study looks at adults admitted to hospital with infections. Researchers will collect information and samples to better understand different types of infections, how they affect people, and how best to treat them. This helps plan future studies and improve care.
For: Infectious DiseaseUnited States · Argentina · Australia - Not yet recruiting
A Postmarketing Study of LEQEMBI in United Kingdom (UK) Participants With Alzheimer's Disease (AD)
This study is gathering real-world information on a new Alzheimer's drug called LEQEMBI. It's looking at how safe the drug is and if there are any side effects, especially brain swelling or bleeding, in people using it as part of their regular care.
For: Alzheimers DiseaseUnited Kingdom - RecruitingPHASE3
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
This study looks at the long-term safety of a medicine called vedolizumab for children and young people with Crohn's disease or ulcerative colitis. It's for those who have already taken part in a previous study with vedolizumab.
For: Ulcerative Colitis · Crohn's DiseaseUnited States · Australia · Belgium - RecruitingNA
Balloon Inflation in Biofeedback
This study looks at a new way to treat ongoing constipation, especially when muscles don't work together properly. We're testing if inflating a small balloon during special exercises helps people learn to poo more easily compared to the usual method without a balloon. This could improve how we treat constipation.
For: Constipation · Chronic Constipation · DyssynergiaUnited Kingdom - Recruiting
Prodromal Alpha-Synuclein Screening in Parkinson's Disease Study
This study is looking for people aged 50-99 to understand who might be at higher risk of developing Parkinson's disease in the future. Researchers will follow these individuals for five years to learn more about early signs and how the condition develops. There are no treatments involved, only observation and investigation.
For: Parkinson DiseaseGermany - Active not recruitingNA
Evaluation of an Educational Intervention on Antibiotics in Dental Care
This study in British Columbia, Canada, looks at how different information given to dentists affects their antibiotic prescribing habits, especially for a drug called clindamycin. The aim is to reduce unnecessary antibiotic use and improve patient safety by exploring new ways to support dentists in making prescribing decisions.
For: Dental Infection · Clindamycin · AntibioticsCanada - Not yet recruitingPHASE1, PHASE2
FMT in Triple Negative Breast Cancer Guided by ctDNA
This study looks at whether changing gut bacteria (FMT) can help standard treatments work better for an aggressive type of breast cancer (TNBC). It aims to check if FMT is safe and possible to use alongside usual chemotherapy and immunotherapy.
For: Breast CancerCanada - Recruiting
The ASSESS National Multi-center Prospective Cohort
This study, called ASSESS, follows people in France with Primary Sjögren's Syndrome over 20 years to understand how the condition develops and if they get other health problems, especially a type of cancer called lymphoma. It helps doctors learn more about this long-term condition.
For: Primary Sjögren's SyndromeFrance - Recruiting
Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement
This study looks at how people with knee arthritis walk and move, both before and after knee replacement surgery, compared to healthy people. We want to understand why some people still struggle with activity after surgery, hoping to find better ways to help them.
For: Knee Osteoarthritis · Total Knee ReplacementUnited Kingdom - Not yet recruiting
Mapping Diabetes in Quebec: Validating Medico-administrative Algorithms for Type 1 Diabetes, Type 2 Diabetes and LADA
This study looks at health records in Quebec, Canada, for people aged 1 to 40 with diabetes until 2024. It aims to improve how we identify different types of diabetes (Type 1, Type 2, and LADA) using existing healthcare data. This helps us better understand diabetes in the community.
For: Diabetes Mellitus, Type 1 · Diabete Type 2 · Diabetes;Adult OnsetCanada - Recruiting
The DefiPace Study
This study looks at how a common heart rhythm problem called atrial fibrillation is treated after heart surgery. It aims to understand current care and then see how a new system, DefiPace, works to help prevent and treat this condition, using gentle electrical pulses.
For: Post-operative Atrial Fibrillation POAFAustria · Germany - Recruiting
Danon Disease Natural History Study
This study aims to understand Danon disease better by looking at health information from people living with it. Researchers want to learn how the condition progresses over time in males and females. There are no new treatments given; it's purely about observing the disease.
For: Danon DiseaseUnited States · Germany · Israel - Active not recruiting
Development of Novel Clinical Endpoints in Intermediate AMD
This study looks at how to best measure changes in intermediate Age-related Macular Degeneration (AMD). It aims to find new ways to track the condition's progression, understand how it affects vision, and identify risks for it getting worse. There are no treatments involved.
For: Age Related Macular Degeneration (AMD)Denmark · France · Germany - Recruiting
Molecular Tumor Board at the Center for Personalized Medicine Tübingen
This study looks at how a 'Molecular Tumour Board' helps doctors make treatment choices for people with advanced cancer. They check patient details, see how well treatments work, and how patients feel, aiming to improve future care.
For: Advanced CancerGermany - RecruitingPHASE2
A Safety and Efficacy Study of GTX-102 in Subjects With Deletion- or Nondeletion-type Angelman Syndrome (AS)
This study is looking at a new treatment called GTX-102 for Angelman Syndrome. It aims to see if the treatment is safe and if it helps improve the condition in people of different ages and genetic types. Some people will get the treatment, and some won't at first.
For: Angelman SyndromeUnited States · Argentina · Brazil - Recruiting
Wear and Tear on Military Personnel Post Caledonian Crisis
This study looks at how stress from the New Caledonia crisis affects military personnel. It aims to understand 'wear and tear' – how tough conditions impact mental well-being and might cause fatigue. Researchers are hoping to find ways to better support soldiers in future crises.
For: Chronic Stress DisorderFrance - Recruiting
Registry to Assess the Safety and Feasibility of the Subpulmonary Support with the Novel Venous Cannula in Patients with Failing/Absence of the Right Heart
This study looks at how well a special device, called an EXCOR Venous Cannula, works in supporting hearts that are struggling. It aims to make sure the device is safe and helps patients get better, both in the short and long term.
For: Heart Failure · Univentricular Heart · Ventricular DysfunctionGermany - Recruiting
A Study of Real-Life Current Standards of Care in Participants With Relapsed and/or Refractory Multiple Myeloma
This study looks at how treatments for multiple myeloma, a type of blood cancer, work in real life when the disease comes back or doesn't respond to previous treatments. It tracks patient experiences for two years to see how standard care affects them.
For: Relapsed/Refractory Multiple MyelomaAustria · Belgium · France - Not yet recruitingNA
Remote Ischemic Postconditioning in Septic Shock
This study is testing a new, simple treatment called remote ischemic postconditioning (RIPOST) for adults who are very ill with septic shock. We want to see if this treatment, which involves briefly squeezing and releasing a blood pressure cuff on the arm, can help improve survival for these patients.
For: Adult Patients With Septic Shock Admitted in Intensive Care UnitFrance - Not yet recruiting
Barriers and Enablers to Accessing Medical Care for Urinary Incontinence and Prolapse in GLobal Majority Women
This study wants to find out why women from certain ethnic backgrounds might find it hard to get help for bladder leakage (urinary incontinence) and pelvic organ prolapse. We want to understand what stops them and what helps them get the care they need.
For: Pelvic Prolapse ConditionsUnited Kingdom - Active not recruiting
Endometriosis and Health Care System Utilization in British Columbia
This study in British Columbia is looking at how women with endometriosis use healthcare services. It aims to understand the costs involved, how well different treatments work, what predicts surgical outcomes, and the impact of the COVID-19 pandemic on their care.
For: EndometriosisCanada - Active not recruiting
COVID-19 Symptom Tracker
This study uses a free app to track COVID-19 symptoms and how the illness progresses. It also looks at how isolation impacts people's well-being. The goal is to learn more about the virus and help tell it apart from common colds.
For: COVID-19United States · United Kingdom - Enrolling by invitation
Retrospective WGS Study
This study looks back at records of children and young people with cancer who had a special genetic test called whole genome sequencing. The aim is to see if this test helped doctors choose better treatments for them, to understand its benefits.
For: Cancer · Pediatric Cancer · NeoplasmUnited Kingdom - Recruiting
A Study to Check Liver Health in Boys With XLMTM, a Serious Genetic Muscle Condition
This study looks at liver health in boys under 18 with X-linked myotubular myopathy (XLMTM). It's an observational study, meaning researchers will collect information over about a year to understand liver, gallbladder, and bile duct issues in XLMTM.
For: X-Linked Myotubular MyopathyUnited States · Canada · United Kingdom - Recruiting
A Study Investigating the Effectiveness and Safety of Garadacimab for Treating Patients With Hereditary Angioedema (HAE)
This study looks at how a new medicine, garadacimab, works for people in the UK with a rare swelling condition called Hereditary Angioedema (HAE). We want to see how well it prevents swelling attacks and if it is safe to use in everyday life.
For: Hereditary AngioedemasUnited States · Austria · Canada - Active not recruiting
A Registry for Participants With Chronic Hypoparathyroidism
This study looks at the long-term safety and how well a treatment called rhPTH(1-84) works for chronic hypoparathyroidism. It's for people of all ages who have had the condition for at least six months and are already receiving a treatment.
For: HypoparathyroidismUnited States · Austria · Canada - Not yet recruiting
User Experience of a Gait Training Treadmill for Home Rehabilitation of Children With Chronic Conditions
This study is looking at how children, parents, and therapists like a special treadmill and games designed to help children with long-term health problems get better at home. It aims to make it easier for families to do their physiotherapy.
For: Chronic Diseases in ChildrenFrance - Active not recruitingNA
A Study About Antibody Levels and Biomarkers in the Blood in People With Late-onset Pompe Disease
This study looks at blood markers and antibody levels in people with late-onset Pompe disease. It helps researchers understand the disease better and how bodies react to treatments, even without new medicines given during the study.
For: Pompe Disease (Late-onset)United States · Australia · Brazil - Recruiting
Chemotherapy Induced Cognitive Impairment
This study looks into 'chemo fog' (memory/thinking problems after chemotherapy for breast cancer). Researchers want to understand why it happens, possibly due to brain inflammation, so they can find ways to help patients in the future.
For: Breast CancerUnited Kingdom - RecruitingNA
Evaluation of a PREHABilitation Protocol Using Adapted Physical Activity (APA) for Multiple Myeloma Patients Eligible for Intensive Autologous Stem Cell Transplantation Treatment
This study looks at how special exercise programmes, called 'adapted physical activity' (APA), can help people with multiple myeloma preparing for a stem cell transplant. It hopes to find the most helpful and enjoyable exercise plan to improve their quality of life, energy levels, and overall physical health.
For: Multiple MyelomaFrance - RecruitingNA
Predictive Factors of Autonomy Loss in Real-life Cohort
This study looks at people with memory problems to understand what might cause them to lose their ability to do everyday tasks. Researchers are collecting health information over time to find ways to predict and hopefully help slow down these changes in the future.
For: Memory DisordersFrance - RecruitingPHASE3
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
This study helps find people who might be suitable for future Alzheimer's disease research. It's like a first step to see if your memory concerns mean you could join other studies looking for new ways to treat Alzheimer's. You won't receive new treatments in this initial check.
For: Alzheimers DiseaseUnited States · Argentina · Australia - Recruiting
Molecular Landscape of Microvascular Inflammation in Kidney Allografts
This study looks closely at changes in tiny blood vessels in transplanted kidneys to understand why some kidneys get inflamed and rejected. It aims to find better ways to diagnose and treat these problems, which are a major cause of transplant failure.
For: Kidney Rejection TransplantFrance - Recruiting
PIBD-SETQuality: the Inception Cohort and Safety Registry
This study looks at how well current treatments work and their safety for children and teenagers with Inflammatory Bowel Disease (IBD). It wants to understand how individual factors might affect treatment outcomes and serious complications.
For: Inflammatory Bowel Diseases · Crohn Disease · Ulcerative ColitisNetherlands · United Kingdom - Recruiting
OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR Amyloidosis
This study looks at how ATTR amyloidosis affects people in real life. Researchers will collect information from existing medical records to understand how the condition progresses, how it's treated, and its impact on daily life and healthcare use.
For: ATTR AmyloidosisUnited States · Canada · China - Recruiting
Detecting EARLY Heart Failure in Greater Manchester
This study aims to improve early detection of heart failure in Greater Manchester. Researchers are testing a new tool that identifies people at high risk before they show symptoms. The goal is to help doctors spot heart problems sooner, potentially allowing for earlier treatment and better health outcomes.
For: Heart FailureUnited Kingdom - Recruiting
Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy
This study looks at children and young people under 22 who have had radiation therapy for cancer. It aims to understand the long-term benefits and side effects of different radiation types, especially newer proton beam therapy, by collecting information that hospitals already gather as part of routine care.
For: Pediatric Patients Treated With Radiation TherapyUnited States · Australia · Canada - RecruitingNA
Spatial Memory Training and Cognitive Function
This study looks into how special memory training might help people with mild memory problems. It focuses on improving a part of the brain important for memory, called the hippocampus, with the hope of slowing down memory decline.
For: Mild Cognitive ImpairmentCanada - Recruiting
ChemoINTEL Assay Algorithm Development Study: In-Vitro Cytotoxic Drug Induced Apoptosis Correlation with Patient Clinical Response to Administered Chemotherapy in Patients
This study aims to create a tool to predict how well ovarian cancer patients will respond to chemotherapy. It uses samples from surgery and tracks their treatment to help doctors choose the best personal treatment plan.
For: Ovarian CancerUnited Kingdom - Recruiting
Predicting Readmissions Using Omics, Biostatistical Evaluate and Artificial Intelligence
This study aims to better predict when people with heart failure might need to go back to hospital. Researchers are using new technologies like AI and information from patients themselves to find patterns that could help doctors provide more precise care.
For: Heart FailureCanada - Enrolling by invitation
Resting-state Connectivity and Individual Differences in Affective Placebo Responsiveness
This study looks at how people's natural brain activity when resting might affect how well they respond to placebos for mood. We're using information from around 50 healthy volunteers to understand if certain brain connections are linked to feeling better after a placebo.
For: Condition: HealthyGermany