- RecruitingPHASE3
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
The BEATRIX study is looking at a vaccine for Group B Streptococcus (GBS) in pregnant women and their babies. It aims to understand if the vaccine is safe and how well it works to protect against GBS, a common bacteria that can sometimes cause serious infections.
For: HealthyUnited States · Argentina · Brazil - RecruitingPHASE2
A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy
This study is testing a new medicine, CDR132L, for people with heart failure. It aims to see how the medicine affects the heart's structure and function. Some people will get the new medicine, others a dummy pill, to compare the results over about 60 weeks.
For: Heart FailureAustralia · Czechia · Germany - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity and type 2 diabetes mellitus
This study is testing a new medicine, BI 456906, for people who are overweight or have obesity and type 2 diabetes. We want to see if it helps with weight loss and is safe to use over about 1.5 years, compared to a dummy medicine.
For: Obesity · Diabetes mellitus type IINetherlands · Czechia · Denmark - Active not recruiting
Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)
This study looks at the long-term safety of a treatment called teplizumab for young people with recent Type 1 diabetes. It follows participants from a previous study, PROTECT, for an extra 42 months to see how they're doing without giving new medication.
For: Diabetes Mellitus, Type 1United States · Belgium · Canada - Active not recruitingPHASE3
Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)
This study is testing a new drug, elafibranor, for people with a liver condition called Primary Biliary Cholangitis (PBC). It aims to see if the drug can improve liver health and reduce symptoms like itching and tiredness compared to a dummy treatment.
For: Primary Biliary CirrhosisUnited States · Argentina · Belgium - RecruitingPHASE3
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
This study is testing a new injection, Xeomin, for people with frequent migraines. We want to see if it reduces the number of migraine days compared to a dummy injection (placebo). It involves head and neck injections and lasts about a year.
For: Chronic MigraineUnited States · Austria · Canada - RecruitingPHASE1
Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Male and Female Subjects and Safety, Tolerability, Pharmacokinetics, and Pilot Efficacy Biomarkers in Subjects With Cold Agglutinin Disease
This study is looking at a new medicine called GL-0719. It will check how safe it is and how the body handles it in healthy people. It will also see if it helps people with a rare blood condition called cold agglutinin disease (CAD).
For: First in Man Study to Evaluate Initial SafetyUnited Kingdom - Not yet recruitingPHASE2
A Trial to Compare Treatment With Surlorian (ARM210, S48168) to Placebo in Effects on Muscle Strength and Safety in Adults With Autosomal Dominant RYR1-related Myopathy
This study is testing a new medicine, Surlorian, for adults with a genetic muscle condition called RYR1-related myopathy. We want to see if it helps improve muscle strength and if it's safe to use. Half the time participants get the real medicine, half the time a dummy medicine.
For: Autosomal Dominant RYR1-Related MyopathyFrance · Germany · Netherlands - RecruitingNA
Mapping the Impact of Gut Microbiota on Brain and Behavior Through the Lens of GABA
This study explores how gut bacteria, specifically those making GABA, might affect our brains and behavior. We're looking to see if taking a special probiotic can change GABA levels in the brain and improve how people perform on certain tasks.
For: HealthyUnited Kingdom - Active not recruitingPHASE2
Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease
This study is looking into a new medication called BMS-986446 for people in the early stages of Alzheimer's disease. Researchers want to see if it helps with memory and thinking, if it's safe to use, and if people can take it without too many problems. It's a new treatment being tested.
For: Alzheimer Disease, Early OnsetUnited States · Australia · Belgium - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Disease (MOGAD)
This study is looking at a new medicine called rozanolixizumab for adults with a rare condition called MOGAD. We want to see if it's safe and helps improve symptoms or stop flare-ups of the condition.
For: Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD)United States · Australia · Belgium - Enrolling by invitationPHASE3
An Extension Study to Investigate the Long-term Safety and Tolerability of Itepekimab in Adult Participants With Inadequately Controlled Chronic Rhinosinusitis With Nasal Polyps
This study looks at the long-term safety and effects of a medicine called itepekimab for adults with a condition called chronic rhinosinusitis with nasal polyps, which causes stuffy nose and other symptoms. This is an extension study for people who were already in an earlier trial.
For: Chronic Rhinosinusitis With Nasal PolypsUnited States · Australia · Canada - Active not recruitingPHASE3
Study of Bitopertin in Participants With EPP or XLP (APOLLO)
This study is looking into a new medication called bitopertin for people with EPP or XLP. Researchers want to see if it's safe and helps people spend more time in the sun without pain, and how it affects certain blood chemicals.
For: Erythropoietic Protoporphyria (EPP) · X-Linked Protoporphyria (XLP)United States · Australia · Belgium - Ongoing, recruitingTherapeutic use (Phase IV)
A parallel-group low-intervention, phase IV, randomized, double-blind, placebo-controlled, single-center, national, two-arm trial to investigate efficacy and safety of Cardiodoron® in patients with functional cardiovascular disorders (FCD)
This study is looking at a medicine called Cardiodoron to see if it helps people with heart-related symptoms, often called functional cardiovascular disorders. It compares Cardiodoron to a dummy pill (placebo) to check its effects and safety in adults in the UK.
For: functional cardiovascular disordersGermany - Not yet recruitingPHASE1
A Study to Investigate the Safety and Pharmacokinetics of Single- and Multiple-ascending Doses of AZD4916 in Healthy Volunteers
This study is looking at a new medicine called AZD4916 in healthy adults. Researchers want to check if it's safe and how it moves through the body after taking different doses, both once and multiple times.
For: Healthy ParticipantsUnited Kingdom - Active not recruitingPHASE3
Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia
This study is testing a new injection, Plozasiran, for adults with very high triglycerides. It will check if the treatment is safe and effective compared to a dummy injection over 12 months. Afterwards, participants might continue in an optional extension.
For: Severe HypertriglyceridemiaUnited States · Argentina · Australia - Active not recruitingPHASE3
A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer
This study is for people with a type of lung cancer that can't be removed by surgery. It tests new drug combinations (Durvalumab with Oleclumab, or Durvalumab with Monalizumab) after standard treatment to see if they can help stop the cancer from coming back or getting worse.
For: Non-Small Cell Lung CancerUnited States · Australia · Brazil - Active not recruitingPHASE3
A Randomized, Double-blind 2-arm, Followed by an Open-label 1-arm, NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.
This study looks at the long-term safety and effectiveness of a new medicine, ianalumab, for people with Sjögren's Syndrome. It's for those who have already completed an earlier study and aims to see how well the treatment works and if it has any long-term side effects.
For: Sjogrens SyndromeUnited States · Argentina · Australia - RecruitingPHASE2
Sotagliflozin in Patients With Heart Failure Symptoms and Type 1 Diabetes
This study looks at whether a tablet called sotagliflozin can help people with type 1 diabetes and heart failure feel better. We're testing if it improves their quality of life and is safe, compared to a dummy pill.
For: Type 1 Diabetes · Heart FailureUnited Kingdom - RecruitingPHASE2, PHASE3
A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)
This study is looking at a new oral medicine, enlicitide decanoate, for children and teenagers aged 6-17 with a condition called Heterozygous Familial Hypercholesterolemia (HeFH). We want to see if it's safe and helps lower high cholesterol levels.
For: Heterozygous Familial Hypercholesterolemia (HeFH)United States · Australia · Belgium - RecruitingPHASE2
Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial
This study looks at restoring healthy gut bacteria in people with blood cancers before a stem cell transplant. We're testing special capsules (IMT) against a dummy capsule to see if they improve gut health and reduce common problems like infections after transplant.
For: Acute Lymphoblastic Leukaemia · Acute Leukemia of Ambiguous Lineage · Chronic Myeloid LeukemiaUnited Kingdom - RecruitingPHASE1, PHASE2
A Two-part Study to Investigate the Effects in Adults of Two Doses of Golexanolone in Patients With Primary Biliary Cholangitis (PBC) With Fatigue and Cognitive Dysfunction
This study is testing a new medicine, golexanolone, for people with Primary Biliary Cholangitis (PBC) who feel very tired and have problems with their thinking. It aims to see if the medicine is safe and helps with these symptoms.
For: Primary Biliary Cholangitis (PBC)Germany · Greece · Hungary - Active not recruitingPHASE3
A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD
This study looks at the long-term safety of a new medicine, itepekimab, for people with severe lung disease (COPD). It will also check if the medicine continues to help over time. Participants will have already been part of a previous study on this medicine.
For: Chronic Obstructive Pulmonary DiseaseUnited States · Argentina · Brazil - RecruitingPHASE1
A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma
This study is testing a new medicine, AMG 691, for safety in healthy people and those with mild-to-moderate asthma. Researchers want to see how the body reacts to single and multiple doses and check for side effects.
For: AsthmaUnited States · Australia · Belgium - Active not recruitingPHASE3
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)
This study looks at a new drug, lepodisiran, to help people with high lipoprotein(a) reduce their risk of heart attacks and strokes. It's for adults with existing heart disease or those at high risk. The drug is given as an injection under the skin.
For: Atherosclerotic Cardiovascular Disease (ASCVD) · Elevated Lp(a)United States · Argentina · Australia - RecruitingPHASE3
Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
This study looks at a new medicine called muvalaplin to see if it can lower the risk of heart attacks and strokes in people with high levels of a specific fat in their blood called Lp(a).
For: Elevated Lp(a) · Atherosclerotic Cardiovascular Disease (ASCVD)United States · Argentina · Australia - RecruitingPHASE3
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
This study looks at a new drug, dordaviprone (ONC201), for a type of brain tumour called H3 K27M-mutant diffuse glioma. It aims to see if the drug, given after radiotherapy, can help people live longer and slow down the tumour's growth.
For: H3 K27M · GliomaUnited States · Argentina · Australia - RecruitingNA
The Effects of Postbiotic Supplementation in Female Athletes
This study looks at whether a special supplement called a postbiotic can help active women with tummy and gut problems, especially around their periods. It compares the supplement to a dummy pill to see if it makes a difference.
For: Gastrointestinal Symptoms · Menstrual CycleUnited Kingdom - RecruitingPHASE3
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-2)
This study is looking into a new treatment called KarXT + KarX-EC for agitation (feeling restless or upset) in people with Alzheimer's disease. It wants to see if the treatment is safe and if it helps reduce agitation.
For: Alzheimer DiseaseUnited States · Argentina · Chile - Active not recruitingPHASE2, PHASE3
A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Participants With PIK3CA-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer
This study looks at a new drug, Inavolisib, combined with standard treatments (Palbociclib and Fulvestrant) for a specific type of advanced breast cancer. It compares this new combination to the standard treatments alone, checking how well it works and if it's safe.
For: Breast CancerUnited States · Argentina · Australia - Active not recruitingPHASE2
CM-101 in PSC Patients -The SPRING Study
This study, called The SPRING Study, is looking into a new medication called CM-101 for adults with a liver condition called Primary Sclerosing Cholangitis (PSC). It aims to see if CM-101 is safe, well-tolerated, and helpful in treating PSC.
For: Primary Sclerosing CholangitisUnited States · Germany · Israel - RecruitingPHASE3
Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma
This study is looking at a new drug, casdatifan, combined with an existing one, cabozantinib, for advanced clear cell kidney cancer. It compares this combination to cabozantinib with a dummy drug (placebo) to see if it stops cancer growth for longer in patients who've already had immunotherapy.
For: Metastatic Clear Cell Renal Cell Carcinoma · Advanced Clear Cell Renal Cell CarcinomaUnited States · Australia · Canada - Active not recruitingPHASE3
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
This study is testing a new medicine called olpasiran to see if it can help people with heart disease and high levels of a specific fat in their blood, called Lp(a). We want to find out if olpasiran can lower the risk of heart attacks and other heart problems.
For: Atherosclerotic Cardiovascular DiseaseUnited States · Argentina · Australia - RecruitingPHASE2
ALTO-207 in Adults With Treatment-resistant Depression (TRD)
This study is testing a new medicine called ALTO-207 for people with depression that hasn't improved with other treatments. Researchers want to see if ALTO-207 helps reduce symptoms more than a dummy pill.
For: Treatment-resistant Depression (TRD)United States · United Kingdom - Active not recruitingPHASE3
Study of AG-120 (Ivosidenib) vs. Placebo in Combination With Azacitidine in Participants With Previously Untreated Acute Myeloid Leukemia With an IDH1 Mutation
This study looks at a new drug (AG-120) combined with a standard treatment (azacitidine) for adults newly diagnosed with a specific type of acute myeloid leukaemia (AML) that has a particular gene change (IDH1 mutation). It compares this combination to azacitidine alone to see if it works better.
For: Newly Diagnosed Acute Myeloid Leukemia (AML) · Untreated AML · AML Arising From Myelodysplastic Syndrome (MDS)United States · Australia · Austria - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome
This study is testing a new medicine, Deucravacitinib, for adults with an active form of Sjögren's Syndrome. Researchers want to see if it's safe and effective compared to a dummy pill. It's a key step to finding better treatments for this autoimmune condition.
For: Sjögren's SyndromeUnited States · Argentina · Australia - Active not recruitingPHASE1
A Safety, Tolerability, and Immunogenicity Study of mRNA-1345 and mRNA-1365 in Participants Aged 5 Months to <24 Months
This study is testing new mRNA vaccines against common winter viruses, RSV and hMPV, in babies and toddlers aged 5 to 24 months. Researchers want to see if the vaccines are safe and good at triggering the body's immune response.
For: Respiratory Syncytial Virus · Human MetapneumovirusUnited States · Australia · Canada - RecruitingPHASE3
Edmond J. Safra Accelerating Clinical Trials in Parkinson's Disease: A Multiarm Multi-stage Platform Trial
This study is testing new treatments for Parkinson's disease. It uses a clever design to test several medicines at once, including Telmisartan and Terazosin, against a dummy pill. The goal is to find effective and safe ways to manage this growing condition and improve people's lives.
For: Parkinsons Disease (PD)United Kingdom - Active not recruitingPHASE1, PHASE2
Effects of Caffeine Ingestion on Morning Cognitive and 4-km Time Trial Performance in Males
This study looks at how caffeine affects morning exercise and thinking skills in healthy men who train regularly. It compares caffeine, a fake pill, and no pill to see if caffeine can help athletes perform better when competing in the morning.
For: Caffeine · Placebo - Control · No PillUnited Kingdom - RecruitingPHASE2
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease
This study looks at a new drug, TAK-279, for people aged 18-75 with Crohn's disease that isn't well-controlled. We want to see if it reduces gut inflammation and is safe, compared to a dummy drug. It lasts about one year.
For: Crohn's DiseaseUnited States · Australia · Belgium - RecruitingPHASE3
A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines
This study looks at a new drug, zasocitinib, for adults with psoriatic arthritis. It aims to see how well it works compared to a dummy drug. We're interested in people who have or haven't tried certain other treatments before.
For: Psoriatic ArthritisUnited States · Argentina · Australia - Active not recruitingPHASE3
Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
This study is testing a new drug, quemliclustat, alongside standard chemotherapy for pancreatic cancer that has spread. Researchers want to see if adding quemliclustat helps people live longer compared to chemotherapy alone. It's a phase 3 trial, meaning it's in the final stages of testing.
For: Metastatic Pancreatic Ductal AdenocarcinomaUnited States · Australia · Austria - RecruitingPHASE2
A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease
This study is looking into a new medication called NEU-411 for people aged 40-80 with early Parkinson's disease. It focuses on those with a specific genetic marker. The aim is to see if the drug is safe and effective in slowing the disease's progress.
For: Parkinson Disease · Parkinson · Idiopathic Parkinson DiseaseUnited States · Israel · Italy - Active not recruitingPHASE3
Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
This study is looking at a new medicine called fenebrutinib for people with a type of multiple sclerosis (MS) called relapsing MS. It compares fenebrutinib to an existing medicine, teriflunomide, to see if it works better and is safe.
For: Relapsing Multiple SclerosisUnited States · Austria · Brazil - RecruitingPHASE3
STOP-HAE: A Phase 3 Study of ADX-324 in HAE
This study is looking at a new medicine called ADX-324 for people with Hereditary Angioedema (HAE) Type 1 or 2. It will check if the medicine helps prevent HAE attacks and if it is safe. Researchers will also look at how it affects quality of life.
For: Hereditary Angioedema · HAE · Hereditary Angioedema - Type 1United States · Argentina · Australia - Active not recruitingPHASE2
A Phase 2b, Randomized, Double-blind Study of Redasemtide (S-005151) in Adult Participants With Acute Ischemic Stroke
This study is looking at a new medicine called Redasemtide for people who have recently had a stroke. It wants to see if the medicine is safe and if it helps people get better after a stroke.
For: Acute Ischemic StrokeUnited States · Australia · Belgium - RecruitingPHASE3
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
This study is testing a new medicine, tezepelumab, for adults with moderate to very severe COPD. It wants to see if the medicine helps improve their breathing and overall health, and if it's safe to use.
For: Chronic Obstructive Pulmonary Disease (COPD)United States · Brazil · Canada - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis
This study is looking at a new medicine called icotrokinra for people with psoriatic arthritis. We want to see if it helps reduce joint pain and swelling, and if it's safe. Some people will get the new medicine, others a dummy medicine.
For: Arthritis, PsoriaticUnited States · Argentina · Australia - Active not recruitingPHASE3
Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)
This study looks at a new drug, Tarlatamab, for people with a type of lung cancer called limited-stage small-cell lung cancer (LS-SCLC). It aims to see if Tarlatamab can help people live longer without their cancer getting worse after chemotherapy and radiotherapy.
For: Limited Stage Small Cell Lung Cancer · Small Cell Lung CancerUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study to Evaluate Effectiveness and Safety of Deucravacitinib (BMS-986165) Compared With Placebo in Participants With Active Systemic Lupus Erythematosus
This study is looking at a new medicine called deucravacitinib to see if it's safe and helps people with a type of lupus called Systemic Lupus Erythematosus (SLE). It compares the new medicine to a dummy pill (placebo).
For: Systemic Lupus ErythematosusUnited States · Argentina · Australia