- RecruitingPHASE2, PHASE3
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
This study looks at a new medicine called ponsegromab for advanced pancreatic cancer that has spread, especially when patients have lost a lot of weight and feel very tired. It aims to see if adding ponsegromab to standard chemotherapy helps more than chemotherapy alone.
For: Cachexia · Metastatic Pancreatic Ductal AdenocarcinomaUnited States · Australia · Belgium - RecruitingPHASE3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes
This study looks at a new medicine called enicepatide for people who are overweight or have obesity and also have type 2 diabetes. We want to see if it helps with weight loss and if it's safe to use.
For: Obesity or Overweight · Type 2 Diabetes MellitusUnited States · Argentina · Australia - RecruitingPHASE3
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
This study is testing a new medicine, Elecoglipron, for adults with type 2 diabetes and kidney problems. It compares Elecoglipron to a dummy pill (placebo) to see if it's safe and effective when taken with other usual diabetes medicines, including dapagliflozin.
For: Type 2 Diabetes Mellitus · Type 2 Diabetes With Chronic Kidney DiseaseUnited States · Bulgaria · China - RecruitingPHASE3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
This study is testing a new medicine, enicepatide, for people who are overweight or have obesity but do not have type 2 diabetes. It aims to see if the medicine helps with weight loss and if it's safe compared to a dummy medicine.
For: Obesity or OverweightUnited States · Argentina · Australia - RecruitingPHASE3
Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis
This study is testing a new medicine, plozasiran, for people with very high triglycerides who have had pancreatitis. It will check if the medicine is safe and helps reduce the risk of future pancreatitis attacks. Participants will get either the study medicine or a dummy medicine.
For: Severe HypertriglyceridemiaUnited States · Argentina · Austria - RecruitingPHASE3
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
This study looks at a new drug, elritercept, for people with myelofibrosis and anaemia who are already taking ruxolitinib. It compares elritercept to a dummy drug (placebo) to see if it improves anaemia and other symptoms, and how safe it is.
For: Myelofibrosis · AnemiaUnited States · Argentina · Australia - RecruitingPHASE3
An Evaluation of Treatments for Sustained Clinical Response (18 Months) in Symptomatic Alzheimer's Disease
This study is testing different treatments for Alzheimer's disease in people aged 55 and over. It aims to see if new medications can help improve memory, thinking, and daily activities over 18 months, compared to a dummy pill.
For: Alzheimer's Disease (AD) · Mild Cognitive Impairment Due to Alzheimer's Disease · Alzheimer Disease DementiaUnited Kingdom - RecruitingNA
Nutritional Supplementation on Physiological and Metabolic Markers in Females
This study looks at whether a 12-week nutritional supplement can help women aged 38-55 going through changes around menopause. We want to see if it affects body shape, weight, and general well-being compared to a dummy pill.
For: Perimenopausal Women · Body Composition ChangesUnited Kingdom - RecruitingPHASE3
INTREPID: A Study of Sapablursen Evaluating the Safety and Efficacy in Participants With Polycythemia Vera (PV)
This study is testing a new medicine called sapablursen for people with Polycythemia Vera (PV). It aims to see if adding sapablursen to usual treatment is safe and helps control the condition better. Participants will be involved for up to three years, comparing the new medicine to a dummy treatment.
For: Polycythemia VeraUnited States · Australia · Brazil - RecruitingPHASE2
Bexmarilimab + Azacitidine Versus Placebo + Azacitidine in Participants With Treatment-naïve Higher-risk Myelodysplastic Syndromes
This study tests a new drug called bexmarilimab alongside a standard treatment (azacitidine) for adults newly diagnosed with higher-risk myelodysplastic syndromes (MDS). Researchers want to find the safest and most effective dose, and see if combining these treatments helps manage this blood condition better than standard treatment alone.
For: Higher Risk Myelodysplastic SyndromesUnited States · Czechia · Finland - RecruitingPHASE1, PHASE2
A Study of RO7830698 in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease
This study tests a new potential medicine called RO7830698. Researchers want to find out how safe it is and how it behaves in the body. The trial involves both healthy volunteers and people with chronic obstructive pulmonary disease (COPD). It compares the new medicine against a dummy treatment called a placebo.
For: Chronic Obstructive Pulmonary Disease (COPD) · Healthy ParticipantsUnited Kingdom - Active not recruitingPHASE3
Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes
This study is looking at a new medicine called Ribupatide for people living with obesity. It compares Ribupatide with another medicine, Semaglutide, and a dummy treatment, to see how well it helps with weight loss. We want to find out if Ribupatide is more effective and safe.
For: ObesityUnited States · Australia · Bulgaria - Not yet recruitingPHASE4
Study of the Effects of Atomoxetine on Motivation
This study looks at how a medicine called atomoxetine affects motivation in people with apathy, which is when you feel very low on drive and energy. We want to see if increasing a brain chemical called noradrenaline can help people feel more motivated and focus better.
For: ApathyUnited Kingdom - RecruitingPHASE3
A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes Mellitus
This study is testing a new medicine called AZD6234 for adults who are overweight or have obesity and other health issues, including some with type 2 diabetes. It aims to see if adding AZD6234 to their current weight management medicines helps them lose more weight safely.
For: Obesity or Overweight · Weight-Related Comorbidity · With/Without Diabetes Mellitus, Type 2United States · Argentina · Brazil - RecruitingPHASE3
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
This study is looking at a new medication called Brenipatide for adults with major depression. It aims to see if this new treatment, when added to usual care, can help prevent depression symptoms from coming back compared to a dummy treatment (placebo) plus usual care.
For: Depressive Disorder, MajorUnited States · Australia · Brazil - Not yet recruitingNA
MRI Parameters as Biomarkers in Cystic Fibrosis (FEMPTO)
This study uses special MRI scans to understand how a medication called linaclotide affects digestion in adults with Cystic Fibrosis (CF). Many people with CF experience gut problems like bloating and constipation. Linaclotide helps the gut release more fluid, making things move easier. This research will check if MRI scans can reliably measure these changes.
For: Cystic Fibrosis (CF)United Kingdom - RecruitingPHASE1
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of DNL921 in Healthy Participants and Participants With Alzheimer's Disease
This study is looking at a new potential medicine, DNL921, for Alzheimer's disease. Researchers want to see if it's safe, how the body handles it, and how it affects the body. They're testing it in healthy people and those with early Alzheimer's.
For: Alzheimer's Disease · Healthy ParticipantsUnited Kingdom - RecruitingPHASE3
A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma
This study is testing a new medicine called Depemokimab for people aged 12 and over with a type of asthma that often causes flare-ups. It aims to see if this new medicine can help reduce these flare-ups better than usual treatments or a dummy medicine.
For: AsthmaUnited States · United Kingdom - Not yet recruitingPHASE1, PHASE2
Study to Test Effects and Safety of RO7568282 in Early Parkinson's Disease
This clinical trial is testing a new experimental medicine, called RO7568282, for people with early-stage Parkinson’s disease. Researchers want to see if the medicine is safe and if it helps improve movement and daily symptoms better than a dummy pill (placebo) when taken alongside usual levodopa treatment.
For: Parkinson's DiseaseUnited Kingdom - RecruitingTherapeutic exploratory (Phase II)
A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose-Escalation, Proof-of-Concept Study Evaluating the Safety, Tolerability, Efficacy and Pharmacokinetics of INT-787 in Subjects with Severe Alcohol-Associated Hepatitis
This study looks into a new medication called INT-787 for people with severe liver damage caused by alcohol. Doctors want to see if it's safe, if patients tolerate it well, and if it helps improve their condition more than a dummy treatment.
For: Severe Alcohol-Associated HepatitisFrance - Active not recruitingPHASE3
A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
This study is testing a new medicine, BLU-5937, for adults in the UK with a long-lasting cough that hasn't responded to other treatments. It aims to see if the medicine can reduce how often people cough over 24 weeks, compared to a dummy pill.
For: Cough · Refractory Chronic CoughUnited States · Australia · Canada - Active not recruitingPHASE3
A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event
This study looks at a new drug, AZD0780, for people with heart disease or who are at risk of it, and who have high 'bad' cholesterol (LDL-C). We want to see if AZD0780 safely lowers this cholesterol.
For: Cardiovascular DiseaseUnited States · Argentina · Australia - Active not recruitingPHASE2
A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease
This study is looking at a new combination treatment, JNJ-78934804, for people aged 18-65 with Crohn's disease that is moderate to severe. It compares this new treatment to existing medicines, guselkumab and golimumab, to see how well it works over 48 weeks.
For: Crohn's DiseaseUnited States · Australia · Austria - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
This study is testing a new drug (INCA33890) alongside standard chemotherapy and another medicine (bevacizumab) for advanced bowel cancer that has spread. It aims to see if adding INCA33890 is safe and helps people live longer and feel better.
For: CRC (Colorectal Cancer)United States · Argentina · Australia - RecruitingPHASE3
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
This study is looking into a new medication called Eloralintide for people who are overweight or have obesity but don't have type 2 diabetes. It aims to see how well it works and if it's safe to help with weight management.
For: Obesity · OverweightUnited States · Argentina · Australia - Active not recruitingPHASE2
A Phase 2 Trial to Investigate Efficacy and Safety of Vipoglanstat in Women With Endometriosis
This study is testing a new medicine, Vipoglanstat, for women with endometriosis. We want to see if it helps reduce ongoing pelvic pain that isn't related to periods and if it's safe to use. Half the women will get the new medicine, and half will get a dummy pill.
For: EndometriosisBulgaria · Czechia · Hungary - Active not recruitingPHASE3
Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)
This study is looking at a new medicine called ravulizumab for adults with a kidney condition called IgAN. We want to see if it helps reduce kidney damage and improve kidney function compared to a dummy medicine.
For: Immunoglobulin A Nephropathy · IgANUnited States · Argentina · Australia - Active not recruitingPHASE3
A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)
This study looks at a new personalised treatment, Intismeran Autogene, combined with Pembrolizumab for high-risk melanoma. It aims to see if this combination can stop cancer from coming back better than Pembrolizumab alone after surgery, focusing on safety and effectiveness.
For: MelanomaUnited States · Argentina · Australia - Active not recruitingPHASE3
Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL
This study is for people in the UK with a type of blood cancer called Diffuse Large B-cell Lymphoma (DLBCL) that has returned or not responded to previous treatments. It aims to see if adding an experimental drug, brentuximab vedotin, to two existing treatments (rituximab and lenalidomide) works better than the two existing treatments alone.
For: Diffuse Large B-cell LymphomaUnited States · Australia · Belgium - RecruitingPHASE2, PHASE3
A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion
This study looks at a new drug, Navlimetostat, combined with standard treatments for advanced lung cancer. It compares this combination to standard treatments alone in patients whose cancer has a specific genetic change called an MTAP deletion. The aim is to see if the new combination works better.
For: Metastatic Non-small Cell Lung Cancer With MTAP DeletionUnited States · Argentina · Australia - Enrolling by invitationPHASE3
Selatogrel Outcome Study in Suspected Acute Myocardial Infarction
This study looks at a new treatment called Selatogrel for people who have recently had a heart attack and are at risk of another. It checks if taking Selatogrel when symptoms start can help prevent a second heart attack.
For: Acute Myocardial InfarctionUnited States · Australia · Austria - RecruitingPHASE3
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
This study is looking at a new drug, Saruparib, for men with high-risk prostate cancer and a faulty BRCA gene. It aims to see if adding Saruparib to standard treatments can help prevent the cancer from spreading.
For: Prostate CancerUnited States · Argentina · Australia - RecruitingPHASE3
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
This study investigates if a new drug, vicadrostat, combined with empagliflozin, can help adults with heart failure and a weakened heart pump. Participants will take study medications for up to 3.5 years, alongside their usual care.
For: Heart FailureUnited States · Argentina · Belgium - Active not recruitingPHASE3
Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome
This study is testing a new medicine, ianalumab, for people with active Sjögren's syndrome. Researchers want to see if it's safe and helps improve symptoms. Participants will receive either the new medicine or a dummy medicine called a placebo.
For: Sjogren SyndromeUnited States · Argentina · Australia - Active not recruitingPHASE2
A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD
This study is testing a new medicine, Verekitug, for people with moderate to severe COPD. It will check how well the medicine works and if it's safe. Participants will take Verekitug or a dummy pill alongside their usual COPD treatments.
For: Chronic Obstructive Pulmonary DiseaseUnited States · Argentina · Bulgaria - Active not recruitingPHASE2
A Study of Sequential Therapy With Daplusiran/Tomligisiran (DAP/TOM) Followed by Bepirovirsen in Participants Living With Chronic Hepatitis B (CHB)
This study is testing new medicines, daplusiran/tomligisiran (DAP/TOM) and bepirovirsen, for people with long-term Hepatitis B. It aims to find the best dose of DAP/TOM to use with bepirovirsen to improve treatment.
For: Chronic Hepatitis B Virus Infection · Hepatitis BUnited States · Australia · Belgium - Active not recruitingPHASE3
Atrasentan in Patients With IgA Nephropathy
This study is testing a new medicine, atrasentan, for people with a kidney disease called IgA nephropathy. It compares atrasentan to a dummy pill (placebo) to see if it can slow down kidney damage and improve kidney function.
For: IgA Nephropathy · Immunoglobulin A NephropathyUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study of Zigakibart in Adults With IgA Nephropathy
This study is testing a new medicine, BION-1301, for adults with IgA Nephropathy to see if it can help their kidneys. It compares the new medicine to a dummy medicine (placebo).
For: IgA Nephropathy · Immunoglobulin A NephropathyUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study to Determine the Efficacy and Safety of Deucravacitinib Compared With Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease-modifying Anti-rheumatic Drugs
This study is looking at a new medicine called deucravacitinib for people with active psoriatic arthritis who haven't tried certain other strong medicines for their condition before. It aims to see how well it works and if it's safe.
For: Psoriatic ArthritisUnited States · Argentina · Australia - RecruitingPHASE3
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
This study looks at a new treatment called intismeran autogene, given with pembrolizumab, after surgery for non-small cell lung cancer. We want to see if this combination stops the cancer from coming back compared to pembrolizumab alone.
For: Carcinoma, Non-Small-Cell LungUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
This study is looking at two new drug combinations, amivantamab and lazertinib, compared to a standard drug, osimertinib, for people in the UK with advanced non-small cell lung cancer that has a specific genetic change (EGFR mutation).
For: Carcinoma, Non-Small-Cell LungUnited States · Argentina · Australia - RecruitingPHASE3
A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease
This study is looking into a new medication, rilzabrutinib, for adults with a condition called IgG4-related disease. It compares the medication to a dummy pill to see if it's safe and helps control the disease over 52 weeks.
For: Immunoglobulin G4 Related DiseaseUnited States · Argentina · Belgium - Active not recruitingPHASE3
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
This study is testing a new medication called donanemab for people in the early stages of Alzheimer's disease. Researchers want to see if it's safe and helps improve or slow memory and thinking problems. It's a key step in understanding potential new treatments for this condition.
For: Alzheimer Disease · Dementia · Brain DiseasesArgentina · Australia · China - RecruitingPHASE3
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
This study is looking at a new combination of medicines for a certain type of advanced breast cancer. It compares a new drug, inavolisib, with existing treatments to see if it's more effective and safe for people whose cancer has a specific genetic change (PIK3CA mutation).
For: Breast CancerUnited States · Argentina · Australia - RecruitingPHASE3
Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis
This study is looking into a new medicine called Seladelpar for people with a liver condition called Primary Biliary Cholangitis (PBC) and mild liver scarring (cirrhosis). It aims to see how well Seladelpar works compared to a dummy pill to improve health outcomes.
For: Primary Biliary CholangitisUnited States · Argentina · Australia - Active not recruitingPHASE3
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
This study looks at whether a new medicine, retatrutide, can help adults with obesity who also have heart disease or kidney problems. It aims to see if the medicine can reduce serious heart issues or stop kidney problems from getting worse.
For: Atherosclerotic Cardiovascular Disease (ASCVD) · Chronic Kidney Disease (CKD)United States · Argentina · Australia - Active not recruitingPHASE3
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
This study is looking at a new drug, quizartinib, combined with standard chemotherapy for adults recently diagnosed with a specific type of leukaemia called AML. We want to see if this combination improves treatment outcomes compared to chemotherapy alone.
For: LeukemiaUnited States · Australia · Austria - RecruitingPHASE3
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)
This study is looking into a new treatment called GB-0895 for teenagers and adults with severe asthma that isn't well-controlled by usual medicines. Participants will receive either GB-0895 or a dummy treatment over about a year to see if it improves their health.
For: Severe AsthmaUnited States · Argentina · Australia - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis
This study is looking at a new medicine called icotrokinra for people with psoriatic arthritis. We want to see if it helps reduce joint pain and swelling, and if it's safe. Some people will get the new medicine, others a dummy medicine.
For: Arthritis, PsoriaticUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer
This study looks at a new combination of medicines for postmenopausal women with a certain type of breast cancer. It tests if abemaciclib with standard hormone therapy works better than hormone therapy alone.
For: Breast CancerUnited States · Australia · Austria