- RecruitingPHASE3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
This study looks at a new medicine, Maridebart cafraglutide, for people with heart failure and obesity. It aims to see if the medicine can reduce heart-related problems like hospital stays, improve symptoms, and help people live longer, alongside their usual heart failure care.
For: Heart Failure With Preserved Ejection Fraction · Heart Failure With Mildly Reduced Ejection Fraction · ObesityUnited States · Argentina · Australia - Active not recruitingPHASE4
OM-85 in Paediatric Recurrent Respiratory Tract Infections With Wheezing Lower Respiratory Illness
This study looks at a medicine called OM-85 to see if it can help young children, aged 6 months to 5 years, who get lots of chest infections and wheezing. We want to know if it's safe and effective at reducing how often they get ill.
For: Respiratory Tract Infections · Wheezing Lower Respiratory IllnessGermany · Hungary · Italy - RecruitingPHASE3
Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
This study looks at a new medicine, abelacimab, for people with an irregular heartbeat (atrial fibrillation) who can't take usual blood thinners. It compares abelacimab to a dummy medicine to see if it can prevent strokes.
For: Atrial Fibrillation (AF)United States · Argentina · Brazil - RecruitingPHASE2
A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease
This study is testing a new medicine, GSK4532990, for people aged 18-70 with liver damage caused by alcohol. We want to see if it's safe and if it helps the liver. Some people will get the medicine, others a dummy pill.
For: Liver Diseases, AlcoholicUnited States · Argentina · Australia - Active not recruitingPHASE3
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
This study is looking at a new drug, quizartinib, combined with standard chemotherapy for adults recently diagnosed with a specific type of leukaemia called AML. We want to see if this combination improves treatment outcomes compared to chemotherapy alone.
For: LeukemiaUnited States · Australia · Austria - RecruitingPHASE2
Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
This study is testing a new medicine, Imeroprubart, for adults with a nerve condition called Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Researchers want to see if it's safe and helps improve symptoms compared to a dummy treatment.
For: Chronic Inflammatory Demyelinating PolyneuropathyUnited States · Argentina · Australia - Active not recruitingPHASE2
Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With Systemic Sclerosis Associated With Interstitial Lung Disease (SSc-ILD) (MK-7240-007)
This study looks at a new drug, tulisokibart, for people with a lung condition called interstitial lung disease (ILD) linked to scleroderma. We want to see if it's safe and helps improve the condition.
For: Diffuse Cutaneous Systemic Sclerosis · Interstitial Lung DiseaseUnited States · Argentina · Australia - Active not recruitingPHASE3
Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas
This study is testing a new medicine, selumetinib, for adults with a condition called Neurofibromatosis Type 1 (NF1). It focuses on people who have painful, non-removable growths called plexiform neurofibromas. We want to see if this medicine can help reduce symptoms and safely shrink these growths.
For: Neurofibromatosis 1 · Plexiform Neurofibroma (PN)United States · Australia · Brazil - Active not recruitingPHASE3
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy
This study looks at a medicine called atezolizumab for people with a type of bladder cancer that has spread into the muscle. It checks if this medicine, given after surgery, can stop the cancer from coming back in those who show signs of tiny cancer cells in their blood.
For: Muscle-invasive Bladder CancerUnited States · Argentina · Belgium - RecruitingNA
Probiotic Intake and Perimenopausal Psychological Assessments
This study looks at how a special probiotic might help women in perimenopause with their emotions and thinking skills, like memory and focus. Researchers will check changes in mood, memory, and gut bacteria.
For: Emotional Processing and Cognitive Function in Perimenopausal Women Experiencing Cognitive Perturbations · Perimenopause · Perimenopause-Related DepressionUnited Kingdom - RecruitingNA
Training Health Recovery and Improvement Via Levagen+® Evaluation
This study looks at how a supplement called Levagen+® might help active cyclists recover during tough training. We want to see if it helps with soreness, sleep, and overall well-being compared to a dummy pill.
For: Exercise RecoveryUnited Kingdom - Active not recruitingPHASE3
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions
This study looks at a new drug, Luspatercept, for people with myelofibrosis and anaemia who need regular blood transfusions and are already taking a JAK2 inhibitor. We want to see if it helps reduce the need for transfusions.
For: Myeloproliferative Disorders · Myelofibrosis · Primary MyelofibrosisUnited States · Argentina · Australia - RecruitingPHASE1
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
This study looks at a new medicine called LY3954068 for people with early Alzheimer's disease. Researchers want to see if it's safe, how it moves through the body, and if it affects signs of the disease. Participants will receive the medicine or a dummy treatment through an injection into the spinal fluid.
For: Alzheimer DiseaseUnited States · Japan · United Kingdom - Active not recruitingPHASE3
Interventional Study of Vosoritide for the Treatment of Children With Hypochondroplasia
This study is testing a new medicine, vosoritide, for children aged 3 to 17 with hypochondroplasia (a type of short stature). It will compare vosoritide to a dummy medicine (placebo) to see if it helps children grow taller over 52 weeks.
For: HypochondroplasiaUnited States · Australia · Canada - RecruitingPHASE2
WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)
This study, called WISPer, is testing a new medicine called MTX-463 for Idiopathic Pulmonary Fibrosis (IPF). It's comparing MTX-463 to a dummy medicine (placebo) to see if it's safe and effective for people with this lung condition.
For: Idiopathic Pulmonary FibrosisUnited States · Argentina · Australia - RecruitingPHASE2
A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)
This study is looking for a new way to treat a type of arthritis called radiographic axial spondyloarthritis (r-axSpA). Researchers want to see if an experimental medicine, tulisokibart, can help reduce pain, stiffness, and swelling in the spine and hips for people with this condition.
For: Radiographic Axial SpondyloarthritisUnited States · Brazil · Canada - Active not recruitingPHASE2
A Study to Evaluate the Efficacy and Safety of Concomitant Use of Eplontersen and ALXN2220 Compared With Eplontersen and Placebo for Adults Participants With ATTR-CM
This study is testing two medicines, eplontersen and ALXN2220, to see if they are safe and help adults with a heart condition called ATTR-CM. Participants will take eplontersen along with either ALXN2220 or an inactive substance (placebo).
For: Transthyretin Amyloid Cardiomyopathy (ATTR-CM)United States · Canada · China - Not yet recruitingPHASE3
Stratification and Treatment in Early Psychosis Study - PROMOTE
This study looks at whether a cannabis-based medicine (CBD) can help young people (aged 12-35) who are at high risk of developing psychosis. It also checks if CBD is safe and helps us understand how the brain works in these conditions.
For: Clinical High Risk for Psychosis (CHR) · Clinical High Risk for Psychosis · Clinical High Risk for Developing PsychosisAustria · Canada · Finland - Active not recruitingPHASE3
A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer
This study looks at a new combination of medicines for postmenopausal women with a certain type of breast cancer. It tests if abemaciclib with standard hormone therapy works better than hormone therapy alone.
For: Breast CancerUnited States · Australia · Austria - RecruitingPHASE3
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
This study is looking into a new medication called AZD0780. It aims to see if this medicine can lower the risk of serious heart problems like heart attacks or strokes in people who have already had them, or in those at high risk of having one for the first time.
For: Cardiovascular DiseaseUnited States · Argentina · Brazil - RecruitingPHASE2
A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema
This study tests a new medicine, BI 1815368, for people with diabetic macular edema (DME), an eye condition linked to diabetes. It aims to see if the medicine improves sight and to find the best dose. Participants take tablets for about 11 months.
For: Macular EdemaUnited States · China · Czechia - RecruitingPHASE2
Dose-Ranging Safety, Tolerability, and Efficacy Study of AZD2373 in Participants With APOL1-Mediated Kidney Disease
This study is testing a new drug, AZD2373, for a specific type of kidney disease called APOL1-Mediated Kidney Disease. It's looking at how well the drug works and if it's safe in people aged 18-65 with this condition.
For: APOL1-Mediated Kidney DiseaseUnited States · United Kingdom - RecruitingPHASE1
A Single Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CITY-FXI in Healthy Adults and Adults With FV Leiden or Prothrombin G20210A Mutation
This study is testing a new medicine, CITY-FXI, for safety in healthy adults and those with specific blood clotting conditions. It's the first time this medicine is being given to people to see how their bodies react.
For: Factor V Leiden · Prothrombin G20210AUnited Kingdom - RecruitingPHASE3
A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
This study is looking into a new medication called efruxifermin for people with a kind of liver disease called NASH/MASH and scarring (fibrosis). It's a large study where some people get the medication, and others get a dummy treatment, to see if it's safe and helps improve the liver condition.
For: NASH With Fibrosis · MASH With FibrosisUnited States · Argentina · Australia - RecruitingPHASE2, PHASE3
(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis
This study is testing a new medicine, elenestinib, for a rare blood condition called indolent systemic mastocytosis. It compares the new medicine to a dummy pill (placebo) to see if it helps reduce symptoms that current treatments aren't fully controlling.
For: Indolent Systemic Mastocytosis · Smoldering Systemic MastocytosisUnited States · Argentina · Australia - RecruitingPHASE3
Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma
This study is looking at a new drug, casdatifan, combined with an existing one, cabozantinib, for advanced clear cell kidney cancer. It compares this combination to cabozantinib with a dummy drug (placebo) to see if it stops cancer growth for longer in patients who've already had immunotherapy.
For: Metastatic Clear Cell Renal Cell Carcinoma · Advanced Clear Cell Renal Cell CarcinomaUnited States · Argentina · Australia - Active not recruitingPHASE2
Phase 2 Study of EDG-5506 in Becker Muscular Dystrophy (GRAND CANYON)
This study is testing a new medicine called sevasemten (also known as EDG-5506) for adults with Becker muscular dystrophy. It wants to see if the medicine is safe and if it helps people. Early parts of the study are now full, but one large part, GRAND CANYON, has also finished taking new participants.
For: Becker Muscular DystrophyUnited States · Australia · Belgium - RecruitingPHASE3
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
This study looks at a new combination of drugs, adagrasib, pembrolizumab, and chemotherapy, for people with a specific type of advanced non-small cell lung cancer (NSCLC) that hasn't been treated before and has a KRAS G12C gene change.
For: Carcinoma, Non-Small-Cell LungUnited States · Argentina · Australia - Active not recruitingPHASE3
Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC
This study is looking into a new combination treatment for a type of breast cancer called triple-negative breast cancer (TNBC) that has spread or is advanced. It combines a new drug, Capivasertib, with a common chemotherapy, Paclitaxel, to see if it works better than just Paclitaxel alone.
For: Triple Negative Breast NeoplasmsUnited States · Argentina · Brazil - Active not recruitingPHASE3
Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC)
This study is testing a new drug, elafibranor, for people with a liver condition called Primary Biliary Cholangitis (PBC). It aims to see if the drug can improve liver health and reduce symptoms like itching and tiredness compared to a dummy treatment.
For: Primary Biliary CirrhosisUnited States · Argentina · Belgium - RecruitingPHASE3
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
This study is testing a new medicine, vepugratinib, for advanced or spread bladder cancer. It will be given with two other drugs, enfortumab vedotin and pembrolizumab, to see if it's safe and helps. It’s compared to a dummy medicine (placebo).
For: Carcinoma, Transitional Cell · Urinary Bladder Neoplasms · Neoplasm MetastasisUnited States · Australia · Brazil - Active not recruitingPHASE3
REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels
This study, called REDEFINE 3, investigates a new medicine, CagriSema, for people with heart and blood vessel diseases. It aims to see if CagriSema can reduce the risk of serious events like heart attacks and strokes.
For: Cardiovascular DiseaseUnited States · Argentina · Australia - RecruitingPHASE3
Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD
This study looks at a new medicine, pelacarsen, for people with heart and circulation problems and high levels of a specific fat called Lp(a). It aims to see if it's safe and effective when used alongside another medicine, inclisiran.
For: Atherosclerotic Cardiovascular Disease (ASCVD)United States · China · France - Active not recruitingPHASE3
A Study to Evaluate the Treatment Response and Safety of Two Dose Regimens of Subcutaneous Amlitelimab Compared With Treatment Withdrawal in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis
This study is testing a new medicine, Amlitelimab, for moderate-to-severe eczema in people aged 12 and over. It's looking at how well different doses work and if they're safe, compared to stopping treatment.
For: Dermatitis AtopicUnited States · Argentina · Australia - Active not recruitingPHASE3
Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)
This study aims to see if adding the drug pembrolizumab to standard chemotherapy before and after surgery helps people with early-stage non-small cell lung cancer live longer and prevent the cancer from returning. It's a large study comparing this new approach with chemotherapy alone.
For: Non-small Cell Lung CancerUnited States · Argentina · Australia - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
This study is looking into a new medication called remibrutinib for people with a type of multiple sclerosis (MS) called Secondary Progressive MS (SPMS). It will check if the medicine is safe and helps slow down the disease.
For: Secondary Progressive Multiple Sclerosis (SPMS)United States · Argentina · Australia - RecruitingPHASE3
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
This study is looking into new treatments, pozelimab and cemdisiran, for Geographic Atrophy (GA), an advanced form of Age-related Macular Degeneration (AMD). It compares these new drugs, alone or together, against a placebo to see if they can slow down vision loss.
For: Age-related Macular Degeneration (AMD) · Geographic Atrophy (GA)United States · Australia · Austria - Active not recruitingPHASE3
Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants With Early Alzheimer's Disease (Polaris-AD)
This study is testing a new medicine, AR1001, for people in the early stages of Alzheimer's disease. We want to see if it's safe and helps improve or slow down symptoms compared to a dummy medicine.
For: Alzheimer DiseaseUnited States · Canada · China - RecruitingPHASE3
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype
This study is testing a new medicine, lunsekimig, for people with COPD who still have symptoms even with current treatments. It aims to see if lunsekimig is safe and helps improve COPD, particularly for those with a specific type called an 'eosinophilic phenotype'.
For: Chronic Obstructive Pulmonary DiseaseUnited States · Argentina · Australia - RecruitingPHASE3
A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder
This study is looking at a new medicine called brenipatide for people with moderate to severe alcohol use disorder. It compares brenipatide to a dummy medicine (placebo) to see if it's safe and effective in helping people cut down or stop drinking.
For: Alcohol Use DisorderUnited States · Belgium · China - Active not recruitingPHASE3
A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
This study looks at a new drug, astegolimab, for people with COPD who have flare-ups often. It compares the new drug to a dummy treatment (placebo) to see if it's safe and helps improve their breathing and reduce flare-ups.
For: Chronic Obstructive Pulmonary Disease (COPD)United States · Argentina · Australia - RecruitingPHASE2
Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection
This study looks at a new inhaled medicine, SNG001, for people in intensive care with severe breathing problems from a viral infection. We want to see if it's safe and helps them get better faster, compared to usual care.
For: Viral PneumoniaUnited States · Belgium · France - Active not recruitingPHASE3
A Phase 3 Study of Obexelimab in Patients With IgG4-Related Disease
This study is testing a new medicine called obexelimab for IgG4-related disease. It wants to see if this medicine can stop flare-ups of the condition and if it's safe to use. Half the participants will get the new medicine and the other half will get a dummy medicine.
For: IgG4 Related DiseaseUnited States · Argentina · Canada - Active not recruitingPHASE2
A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)
This study is looking into a new medicine called efinopegdutide for a liver condition called MASH. We want to see if it can help reduce liver fat, swelling, and scarring in people with MASH and mild scarring. It also checks how safe the medicine is.
For: Non-alcoholic Fatty Liver Disease · Nonalcoholic Steatohepatitis · NAFLDUnited States · Australia · Canada - RecruitingPHASE2
Efficacy and Safety of Vamifeport in Adult Participants With Homeostatic Iron Regulator Gene (HFE)-Related Hereditary Hemochromatosis
This study is testing a new medicine, Vamifeport, for people with a common type of iron overload called hereditary hemochromatosis. It aims to see if the medicine can reduce the amount of iron stored in the liver. Two groups will be compared: one getting the medicine and one getting a dummy pill.
For: Homeostatic Iron Regulator Gene-related Hereditary HemochromatosisUnited States · Australia · Austria - RecruitingPHASE3
Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial
This 52-week study is testing a new drug, depemokimab, for adults with uncontrolled Hypereosinophilic Syndrome (HES). It aims to see if depemokimab is effective and safe compared to a placebo, alongside their usual HES treatment.
For: Hypereosinophilic SyndromeUnited States · Argentina · Australia - RecruitingPHASE3
A Study to Investigate Efficacy and Safety of Teplizumab Compared With Placebo in Participants 1 to 25 Years of Age With Stage 3 Type 1 Diabetes
This study is looking at a new medicine called Teplizumab for people aged 1 to 25 with a recent diagnosis of Stage 3 Type 1 Diabetes. It compares Teplizumab to a dummy medicine to see if it makes managing blood sugar easier and reduces how much insulin they need.
For: Type 1 Diabetes MellitusUnited States · Argentina · Australia - RecruitingPHASE3
Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation
This study looks at adding a new medicine, revumenib, to standard chemotherapy for people with a specific type of newly diagnosed acute myeloid leukaemia (AML) with a particular gene change (NPM1 mutation). It aims to see if this combination works better and is safe.
For: Acute Myeloid LeukemiasUnited States · Australia · Austria - RecruitingPHASE2, PHASE3
Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
This study is testing a new medicine called nipocalimab for adults with a nerve condition called CIDP. It wants to see if nipocalimab is safe and effective at stopping CIDP symptoms from returning, compared to a dummy medicine, after patients have improved on nipocalimab first.
For: Polyradiculoneuropathy, Chronic Inflammatory DemyelinatingUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)
This study is testing a new medicine, CAEL-101, for people with a serious heart condition called AL amyloidosis. Researchers want to see if it helps people live longer, reduces hospital stays, and is safe when added to standard treatment.
For: AL AmyloidosisUnited States · Australia · Austria