- RecruitingPHASE1
A Study of LY4213663 in Healthy Participants and Participants With Rheumatoid Arthritis
This study is testing a new medicine, LY4213663, for rheumatoid arthritis. We want to see if it's safe, what side effects it might cause, and how it works in the body. It includes healthy people and those with rheumatoid arthritis.
For: Rheumatoid Arthritis (RA)United States · Germany - Active not recruitingPHASE3
A Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or Overweight
This study looks into a new medication called orforglipron for people with sleep apnoea and who are overweight or obese. It checks how well it works and if it's safe, especially for those who can't or don't want to use CPAP, or for those already using continuous positive airway pressure (CPAP).
For: OSA · Overweight or ObesityUnited States · Argentina · Brazil - Active not recruitingPHASE3
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
This study is looking into a new medication called tozorakimab for people with severe COPD who have frequent flare-ups. It aims to see if this treatment can reduce these flare-ups and improve symptoms. Patients will receive either the new medicine or a dummy treatment.
For: Chronic Obstructive Pulmonary Disease (COPD)United States · Argentina · Belgium - Active not recruitingPHASE3
Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)
This study is for people who have had surgery for bile duct cancer. It's testing a new medicine called rilvegostomig with chemotherapy, to see if it stops the cancer from coming back. It compares the new medicine to a dummy pill.
For: Biliary Tract CancerUnited States · Australia · Belgium - RecruitingPHASE3
Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects
This study is testing a new immunotherapy, GLSI-100, for people with a specific type of HER2-positive breast cancer to see if it can stop the cancer from coming back. It involves injections given over time.
For: Breast CancerUnited States · Belgium · France - RecruitingPHASE1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL628 in Participants With Early Alzheimer's Disease
This study is testing a new drug, DNL628, for people with early Alzheimer's disease. Researchers want to see if it's safe, how the body handles it, and if it has any effects. Participants will receive either the drug or a placebo.
For: Alzheimer Disease, Early OnsetNetherlands · United Kingdom - Active not recruitingPHASE1
A Study to See the Effect of NNC0194-0499 Alone or in Combination With Semaglutide on Blood Sugar Control in People Living With Type 1 Diabetes
This study is testing a new medicine, NNC0194-0499, for people with type 1 diabetes. Researchers want to see how it affects blood sugar when taken alone or with semaglutide, alongside your usual insulin.
For: Diabetes Mellitus, Type 1Germany - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of JNJ-77242113 (Icotrokinra) in Biologic-naïve Participants With Active Psoriatic Arthritis
This study is testing a new medicine called icotrokinra for people with active psoriatic arthritis who haven't tried biological treatments before. We want to see if it helps reduce symptoms and if it's safe to use, compared to a dummy treatment or an existing one.
For: Arthritis, PsoriaticUnited States · Argentina · Australia - Active not recruitingPHASE3
Autologous Muscle Derived Cells Compared to Placebo for Urinary Sphincter Repair in Post-surgical Female Stress Incontinence
This study looks at a new treatment for women with stress urinary incontinence, especially after surgery. It compares injecting a patient's own muscle cells into the bladder area with a dummy treatment (placebo) to see if it reduces leaks.
For: Stress Urinary IncontinenceUnited States · United Kingdom - Active not recruitingPHASE2
Study to Assess Safety and Efficacy of PRI-002 in Patients With MCI to Mild Dementia Due to Alzheimer's Disease (AD)
This study is testing a new drug, PRI-002, for people with early Alzheimer's disease or mild memory problems caused by Alzheimer's. Scientists hope PRI-002 can break down sticky substances in the brain thought to cause the disease, potentially slowing its effects.
For: Mild Cognitive Impairment Due to Alzheimer's Disease · Alzheimer's Disease, Early OnsetCzechia · Germany · Italy - Active not recruitingPHASE1
Intranasal Insulin and Olanzapine Study in Healthy Volunteers
This study looks at how a common medicine called olanzapine affects sugar levels and brain function, and if a nasal spray insulin can help. It's for healthy volunteers and aims to better understand medicine side effects.
For: Healthy ControlsCanada - RecruitingPHASE2
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants
This study is looking at a new medicine called obinutuzumab for teenagers and children aged 5 to 17 with a kidney condition called lupus nephritis. We want to see if it's safe, how well it works, and how the body uses it.
For: Lupus NephritisUnited States · Brazil · Canada - Active not recruitingPHASE2
Frexalimab in Preservation of Endogenous Insulin Secretion Compared to Placebo in Adults, Adolescents and Children on Top of Insulin Therapy (FABULINUS)
This study looks at a new drug called frexalimab for people aged 12-35 newly diagnosed with Type 1 Diabetes. It aims to see if frexalimab, taken alongside insulin, can help the body keep making its own insulin. Half the participants will get frexalimab, and half a dummy medicine.
For: Type 1 Diabetes MellitusUnited States · Austria · Belgium - Active not recruitingPHASE3
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
This study is looking at a medicine called semaglutide for a liver condition called non-alcoholic steatohepatitis (NASH). Participants will receive either semaglutide or a dummy medicine. It's a long study, lasting about 5 years, with regular clinic visits.
For: Non-alcoholic SteatohepatitisUnited States · Argentina · Australia - Active not recruitingPHASE2, PHASE3
A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer
This study is looking at a new combination of medicines, abemaciclib, abiraterone acetate, and prednisone, for men with advanced prostate cancer that has spread. It aims to see if adding abemaciclib is safe and effective in treating their cancer.
For: Prostate CancerUnited States · Australia · China - RecruitingPHASE3
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
This study is testing a new injection, Xeomin, for people with frequent migraines. We want to see if it reduces the number of migraine days compared to a dummy injection (placebo). It involves head and neck injections and lasts about a year.
For: Chronic MigraineUnited States · Austria · Canada - RecruitingPHASE4
Effect of infLuenza vaccInation After Myocardial INfArction on Cardiac inflammaTory responsE
This study looks at how the flu vaccine affects heart inflammation in people who recently had a heart attack. Researchers want to see if the vaccine helps reduce inflammation in the arteries and throughout the body, compared to a dummy shot.
For: Acute Myocardial Infarction · Cardiovascular Diseases · Inflammatory ResponseDenmark · Sweden · United Kingdom - RecruitingPHASE2
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
This study is testing a new medication called GlyphAllo for adults with depression, with or without anxiety. It's a key step to see if it's safe and helps improve mood and reduce symptoms. Half the participants will receive the new medication and half will receive a dummy pill.
For: Major Depressive Disorder (MDD) · Major Depressive Disorder With Anxious DistressUnited States · Bulgaria · Czechia - Active not recruitingPHASE3
Study of ALXN2220 Versus Placebo in Adults With ATTR-CM
This study is testing a new medicine, ALXN2220, for a heart condition called ATTR-CM. It aims to see if ALXN2220 can help prevent serious heart problems and reduce the risk of death compared to a dummy treatment. We hope to find a new way to help people with this condition.
For: Transthyretin Amyloid CardiomyopathyUnited States · Argentina · Australia - RecruitingPHASE2
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
This study is looking into a new medication called MK-2214 for people with early Alzheimer's disease. Researchers want to see if it can slow down changes in the brain that cause memory and thinking problems. They will also check if it's safe for people to take.
For: Early Alzheimer's DiseaseUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study of Apalutamide (JNJ-56021927, ARN-509) Plus Androgen Deprivation Therapy (ADT) Versus ADT in Participants With mHSPC
This study looks at adding a new drug, Apalutamide, to standard hormone therapy for men with prostate cancer that has spread. We want to see if this combination helps patients live longer or keeps their cancer from getting worse.
For: Prostate CancerUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
This study is looking at a new medicine called orforglipron for people with obesity or who are overweight and have type 2 diabetes. It wants to see how well it helps control blood sugar compared to a dummy medicine, called a placebo.
For: Obesity · Overweight · Type 2 DiabetesUnited States · Argentina · China - Active not recruitingPHASE2
Assess the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of RXC007 in Idiopathic Pulmonary Fibrosis
This study is looking into a new medication called RXC007 for Idiopathic Pulmonary Fibrosis (IPF). Researchers want to see if it's safe, how it works in the body, and if it helps patients with IPF. It involves taking the medication or a placebo for 12 weeks.
For: IPF · FibrosisAustria · Belgium · Czechia - RecruitingPHASE1
Study of KM-023 in Healthy Volunteers and Patients With Olmsted Syndrome.
This study is testing a new medicine, KM-023, for Olmsted Syndrome. It first checks safety in healthy people, then looks at effects and safety in patients. It also studies how the body handles the medicine and how it affects the skin.
For: Olmsted SyndromeUnited States · France · United Kingdom - RecruitingPHASE2
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
This study is looking into a new medication called Afimkibart for adults with moderate to severe rheumatoid arthritis. It's for those who haven't found enough relief from or can't take other common treatments. The aim is to see how well it works and if it's safe.
For: Rheumatoid ArthritisUnited States · Argentina · Belgium - Active not recruitingPHASE3
A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma
This study looks at a new medicine called benralizumab for children aged 6 to 18 with severe asthma. It wants to see if the medicine can stop asthma attacks and if it's safe. Half the children get the medicine, and half get a dummy medicine.
For: AsthmaUnited States · Argentina · France - RecruitingPHASE3
A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.
This study is testing a new medicine, Fosmanogepix, for serious fungal infections called candidemia or invasive candidiasis. It compares the new medicine to standard treatments to see if it's safe and works just as well. We're looking for adults diagnosed with these infections.
For: Candidemia · Candidiasis, InvasiveUnited States · Argentina · Australia - Active not recruitingPHASE3
Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome
This study looks at a new drug, venetoclax, combined with existing treatment, azacitidine, for adults with a type of blood disorder called higher-risk Myelodysplastic Syndrome (MDS). It aims to see if this combination is safe and effective compared to azacitidine alone.
For: Myelodysplastic Syndrome (MDS)United States · Australia · Austria - RecruitingPHASE2
Study of ALXN1920 in Adult Participants With Primary Membranous Nephropathy (PMN)
This study is looking at a new medicine called ALXN1920 to see if it can help adults with a kidney disease called Primary Membranous Nephropathy (PMN). Researchers want to find out if this medicine works better than a dummy treatment (placebo) for people at higher risk of their kidney disease getting worse.
For: Primary Membranous NephropathyUnited States · Argentina · Australia - RecruitingPHASE1
Phase 1 Single Ascending Doses (SAD) of M5542 in Healthy Participants
This study is testing a new medicine called M5542 in healthy volunteers. It checks how safe it is, whether people can tolerate it, and how the body handles it after a single dose. This is an early stage of testing new medications.
For: HealthyGermany - Not yet recruitingPHASE4
Study to Evaluate the Effect of a Single Oral Dose of Zoliflodacin 3 g on Testicular Function in Healthy Adult Men
This study looks at how a single dose of a medicine called zoliflodacin affects male fertility. Healthy men aged 18-45 will take either zoliflodacin or a dummy pill. Researchers will check their sperm and hormones over several weeks to see if the medicine changes how their testicles work.
For: Testicular AbnominaliesGermany · United Kingdom - RecruitingPHASE2
Study of Remibrutinib (LOU064) Efficacy and Safety and Exploration of Its Mechanism of Action in Participants With Chronic Urticaria
This study is testing a new medicine, remibrutinib, for chronic urticaria, also known as chronic hives. We want to see how well it works and how safe it is for people whose hives haven't improved with other treatments.
For: Chronic Urticaria (CU): Chronic Inducible Urticaria (CINDU) and Chronic Spontaneous Urticaria (CSU)United States · France · Germany - Active not recruitingPHASE3
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension
This study looks at a new, higher dose of macitentan (75mg) for people with pulmonary arterial hypertension (PAH). Researchers want to see if this dose is better than the current 10mg dose at preventing serious health problems or death related to PAH.
For: Pulmonary Arterial HypertensionUnited States · Argentina · Australia - RecruitingPHASE2
ACOU085 for Hearing Loss Prevention in Testicular Cancer Patients Receiving Cisplatin
This study is testing a new treatment, ACOU085, to prevent hearing loss in men with testicular cancer who are having chemotherapy with cisplatin. Scientists want to see if giving this treatment into the ear can protect hearing.
For: Cisplatin-induced Hearing LossGermany - RecruitingPHASE2
Blockade of the Renin-angiotensin-aldosterone System in Patients With ARVD
This study looks at whether a medicine called spironolactone can help people with a rare heart condition called ARVD. It aims to see if it can slow down the changes in the heart and reduce irregular heart rhythms, potentially improving quality of life.
For: Arrhythmogenic Right Ventricular DysplasiaFrance - Active not recruitingPHASE3
A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer
This study looks into a new drug called elinzanetant to see if it can help women with hot flashes caused by breast cancer treatment. It compares the drug to a dummy pill to check how well it works and if it's safe.
For: Vasomotor Symptoms Caused by Adjuvant Endocrine Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer · Hot FlashesAustria · Belgium · Canada - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Rozanolixizumab in Adult Participants With Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Disease (MOGAD)
This study is looking at a new medicine called rozanolixizumab for adults with a rare condition called MOGAD. We want to see if it's safe and helps improve symptoms or stop flare-ups of the condition.
For: Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD)United States · Australia · Belgium - RecruitingNA
Investigating the Neuropsychological Effects of 5-HT2a Antagonism
This study looks at how a specific brain chemical, serotonin, affects memory, emotions, and decisions. Researchers are using a drug called pimavanserin to understand more about a particular 'lock' (receptor) for serotonin. This could help develop new treatments for depression.
For: HealthyUnited Kingdom - RecruitingPHASE3
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
This study is testing a new medicine, XEN1101, alongside usual treatments for a specific type of epilepsy seizure called Primary Generalized Tonic-Clonic Seizures (PGTCS). It aims to see if the new medicine helps reduce these seizures and if it's safe for people aged 12 and older.
For: Primary Generalized Tonic-Clonic SeizuresUnited States · Argentina · Australia - Not yet recruitingNA
Exploring the Cognitive Benefits of a Blackcurrant-Based Supplement in Normobaric Hypoxia
This study looks at whether a blackcurrant drink can help men think clearly at high altitudes. Participants will drink either the blackcurrant drink or a dummy drink and do thinking tests in a simulated high-altitude room.
For: Cognitive Performance · Executive Function (Cognition) · Working MemoryUnited Kingdom - RecruitingPHASE2
A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease
This study is looking at new medicines (frexalimab, brivekimig, or rilzabrutinib) for kidney conditions called Focal Segmental Glomerulosclerosis (FSGS) or Minimal Change Disease (MCD). It aims to see if these medicines are safe and can help improve kidney function compared to a dummy drug.
For: Focal Segmental Glomerulosclerosis · Glomerulonephritis Minimal LesionUnited States · Argentina · Australia - Active not recruitingPHASE1
A Study for GSK3862995B in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease
This study is testing a new medicine, GSK3862995B, for safety in healthy people and those with Chronic Obstructive Pulmonary Disease (COPD). It aims to see how well people tolerate the medicine and if it causes any side effects, starting with small doses.
For: Pulmonary Disease, Chronic ObstructiveUnited States · Germany · United Kingdom - Active not recruitingPHASE2
A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)
This study is looking into a new treatment called Rosnilimab for people in the UK with moderate to severe ulcerative colitis. It aims to see how safe and effective it is compared to a dummy treatment.
For: Ulcerative ColitisUnited States · Austria · Bulgaria - Active not recruitingPHASE3
A Study to Learn About Medicine Called Ritlecitinib in Children Aged Between 6 to 12 Years With Severe Alopecia Areata
This study is looking into a new medicine called ritlecitinib for children aged 6 to 11 with severe alopecia areata, a condition that causes hair loss. It aims to see if the medicine is safe and helps hair regrow. Participants will take a capsule daily for 6 months.
For: Severe Alopecia AreataUnited States · China · Czechia - RecruitingPHASE2, PHASE3
Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer
This study is looking into a new treatment called SBP-101 for advanced pancreatic cancer. It combines SBP-101 with standard chemotherapy (nab-paclitaxel and gemcitabine) to see if it helps people live longer and improves their quality of life.
For: Pancreatic Cancer Metastatic · Pancreatic Ductal Adenocarcinoma · Pancreatic Cancer Stage IVUnited States · Australia · Austria - Active not recruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly
This study is looking at a new medicine called paltusotine for people with acromegaly. It wants to see if this oral medicine is safe and helps control the condition in those who have already been treated with other common acromegaly medicines.
For: AcromegalyUnited States · Argentina · Belgium - RecruitingPHASE3
Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein
This study investigates if a new drug called fazirsiran can help reduce liver scarring in people with Alpha-1 Antitrypsin Deficiency. Researchers also want to see if it slows liver disease, understand how it works in the body, and check for side effects.
For: Alpha1-Antitrypsin DeficiencyUnited States · Australia · Austria - Active not recruitingPHASE3
An Efficacy and Safety Study of Apalutamide (JNJ-56021927) in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Participants With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC)
This study is looking at a new combination of medicines for men with advanced prostate cancer that has stopped responding to standard hormone therapy. It aims to see if adding a drug called apalutamide to current treatment helps men live longer without their cancer getting worse.
For: Prostatic NeoplasmsUnited States · Argentina · Australia - Active not recruitingPHASE3
Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
This study is looking at a new medicine called fenebrutinib for people with a type of multiple sclerosis (MS) called relapsing MS. It compares fenebrutinib to an existing medicine, teriflunomide, to see if it works better and is safe.
For: Relapsing Multiple SclerosisUnited States · Austria · Brazil - RecruitingPHASE3
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
This study looks at a new drug, omecamtiv mecarbil, for people with severe heart failure. It aims to see if the drug can help reduce hospital stays, the need for transplants, or the risk of death compared to a dummy pill.
For: Heart Failure · Heart Failure With Reduced Ejection FractionUnited States · Canada · China