standard of care clinical trials

Effectiveness of a Visual Telerehabilitation Program on Visual Perception in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour

This study is looking at whether specially designed computer games, using virtual reality, can help young people aged 10-40 who have lost some of their vision (hemianopsia) due to a brain tumour. It aims to improve their sight and daily life.

Long-term Safety and Efficacy Extension Trial of Bimatoprost SR

This study looks at the long-term effects of a special eye implant, Bimatoprost SR, for people with glaucoma or high eye pressure. It checks how safe and effective it is over a longer period, continuing from previous studies.

Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC)

This study looks at how new patients with severe ulcerative colitis are treated in hospitals across the UK. It aims to understand why some patients get better with standard treatments and why others might need surgery or different medicines.

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

This study is looking at a new treatment called AAA817, combined with standard prostate cancer drugs, for men with advanced prostate cancer. It compares this new combination to existing treatments to see which works best at slowing the cancer's growth.

Safety of AI-Powered Virtual Assistant in Outpatient Management of Heart Failure

This study looks at whether a special computer program called SIRIO-HF, which is like a virtual assistant, can help people with a new diagnosis of heart failure manage their condition at home after leaving the hospital. We want to see if it's safe and helps reduce clinic visits.

Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1

This study is looking at a new medicine called encaleret for a condition called Autosomal Dominant Hypocalcemia Type 1 (ADH1). It compares encaleret to the usual treatment to see if it's safe and works better for patients.

Trans-coronary Cooling and Dilution for Cardioprotection During Revascularisation for ST-elevation Myocardial Infarction

This study is looking at a new way to protect the heart during a heart attack. We're testing if gently cooling the heart directly through a small tube, instead of the whole body, can reduce damage. This might make the current treatment even better.

Additional Treatments to the Local Tumour for Metastatic Prostate Cancer: Assessment of Novel Treatment Algorithms

This study looks at new ways to treat prostate cancer that has spread. It compares adding treatments directly to the prostate and other affected areas with standard care, to see if it improves outcomes for men who have recently been diagnosed.

The LIFT-ECHO Last Mile Project

This study aims to improve care for people with intestinal failure. It involves a learning program called LIFT-ECHO for doctors, helping them learn from specialists. The goal is to see if better doctor knowledge leads to better health and quality of life for patients.

The PERSEVERE Study

The PERSEVERE Study is looking at a new device, the FlowTriever System, to treat severe lung blood clots (pulmonary embolism). It compares this new approach to standard NHS care for people with high-risk clots, aiming to see which is more effective.

Hospitalised COVID-19 Patients Cohort Study in the EuCARE Project

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

This study is looking into a new medication called rimegepant. It's for women who get migraines around their period. We want to see if this medicine can help prevent these 'menstrual migraines' and if it's safe to use.

Global Patient Registry of Inherited Retinal Diseases

A Study on Hemolytic Disease of the Fetus and Newborn (HDFN) Through Global Registry

This study looks at a blood condition called HDFN, which can affect babies during pregnancy or soon after birth. Researchers want to understand the risk of babies getting anaemia (low red blood cells) when their mothers have HDFN, using information collected from medical records.

A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer

This study compares new drug combinations (dostarlimab and niraparib) with standard care for women newly diagnosed with advanced ovarian cancer. It aims to see if these new treatments can stop the cancer from growing for longer.

Speech Performance and Clinic Efficiency With Remote Care Compared With Standard of Care in Adults With a Cochlear Implant in the First 12 Months Post-activation

This study compares remote and in-clinic care for people with cochlear implants in their first year. It checks if remote care works well for hearing and saves time/money, offering a convenient alternative to traditional hospital visits.

A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)

This study looks at a new medicine called tirzepatide for adults with obesity but not diabetes. It compares it to standard care to see how well it helps with weight loss and if it can prevent type 2 diabetes over about five years.

International Registry for Men With Advanced Prostate Cancer (IRONMAN)

This study, called IRONMAN, is collecting information from men with advanced prostate cancer across many countries, including the UK. It aims to understand treatments, how they vary, and what helps men live longer and have a better quality of life.

Seal, Stopping Eczema and Allergy Study

This study is for babies under 12 weeks old with early eczema. It compares special skin creams and treatments to standard care to see if they can reduce eczema and prevent food allergies. We want to find the best ways to keep young skin healthy.

Paediatric Sjögren Syndrome Cohort Study and Repository (PaedSSCoRe)

This study looks at Sjögren's syndrome (SS) in children and teenagers in the UK. Researchers want to understand how SS affects young people, gather information on their health, and create better ways to identify the condition. It's hoped this will lead to improved care.