Latest studies
- Recruiting
Care of people at the end of their lives in the rural and coastal communities of the South West Peninsula of England
This study aims to improve end-of-life care in rural and coastal areas of Devon, Cornwall, and Somerset. It involves talking to patients, families, and professionals to understand current care and find ways to make it better for everyone involved.
People at the end of life, family members and professionalsEngland - RecruitingPhase I
Phase I Trial: Quotient Code QSC303820
This early-stage study, called QSC303820, is testing a new treatment or medicine for the first time in people. The aim is to check if it's safe and how the body handles it. More details about what the study is for will be shared later, within 30 months after it finishes.
The sponsor has confirmed that the trial meets the criteria for deferral of publication of the full details of the trial. The full details will be added to the study record within 30 months after the trial has ended.England - Not yet recruiting
Myoinositol in adolescent polycystic ovary syndrome
This study looks at whether a natural supplement, myoinositol, could help teenage girls with PCOS. It's a first step to see if a bigger study is possible, exploring if myoinositol is a good alternative to current treatments for symptoms like irregular periods and acne.
Polycystic ovary syndromeEngland - Recruiting
Economic evaluation of the BabblePlay app intervention to support early vocalising in infants with Down syndrome
This study looks at whether the BabblePlay app, designed to help babies with Down syndrome make sounds, is good value for money for the NHS. It's for families already in a related app study, to see if the app's costs are worth the benefits.
Down syndromeEngland - RecruitingNot Applicable
Evaluating an artificial intelligence tool for measuring the aorta from computed tomography (CT) scans
This study is testing an AI tool called Aorta AIM to see how well it measures the main blood vessel (aorta) from CT scans. It aims to make these measurements quicker and more consistent for doctors, potentially helping patients with heart and blood vessel conditions.
Aortic pathology, including aneurysm and dissectionEngland - RecruitingPhase II
Restoring intestinal symbiosis for efficacy in IBS
This study is looking into a new oral capsule treatment called EBX-102 for Irritable Bowel Syndrome with Constipation (IBS-C). It aims to restore gut bacteria in people aged 18-70 to help improve symptoms like pain and bowel habits.
Irritable Bowel Syndrome - constipation predominant (IBS-C)England - Recruiting
Understanding why cancer immunotherapy helps some people but causes side effects in others
This study looks at why immunotherapy for cancer works for some people but causes side effects in others. By studying samples from patients, researchers hope to improve treatment and reduce side effects for future patients. It's an observational study, meaning your treatment won't change.
Psychosocial oncology and survivorshipEngland - Recruiting
Intimate lives matter: sex, relationships and the Care Act
This study aims to improve how social workers support autistic people and those with learning disabilities in their relationships. It will create tools and training for social workers, helping them discuss sex and relationships during care assessments to reduce loneliness and improve well-being.
Support for autistic people and people with learning disabilities around sex and relationshipsEngland - RecruitingNot Applicable
Vagus nerve stimulation for epilepsy in children and adults: assessment of longer term clinical and cost effectiveness in a randomised controlled trial
This study looks at how well a treatment called Vagus Nerve Stimulation (VNS) works for children and adults with epilepsy that hasn't responded to other medicines. We want to understand its long-term benefits and if it helps people with learning difficulties.
EpilepsyEngland - Recruiting
A study testing if a new support package used in medication reviews helps patients take their medicines as prescribed
This study tests a new support package to help people with high blood pressure take their medicines. It helps doctors understand why patients might struggle with their medication and offers helpful solutions. It aims to improve care for people with high blood pressure in the future.
Cardiovascular, medication non-adherence, hypertensionEngland - Completed
Exploring the experiences of transgender patients and their healthcare professionals at Milton Keynes University Hospital
Researchers at Milton Keynes University Hospital want to understand how transgender patients and hospital staff feel during hospital visits. They will interview transgender patients and their nominated healthcare professionals to improve future care.
Transgender patient experienceEngland - RecruitingPhase II
Repair effects of leramistat in participants with rheumatoid arthritis
This study is looking at a new medicine called leramistat for people with rheumatoid arthritis. It wants to see what effects leramistat has on muscles. It's an early-stage study, meaning we're still learning if the medicine works and is safe.
Rheumatoid arthritisEngland - Recruiting
Creating Active Schools (CAS): Investigating sustained implementation and long-term (cost)-effectiveness on children’s physical activity in multi-ethnic and socioeconomically challenged communities in Bradford
This study looks at how a programme called 'Creating Active Schools' helps primary school children in Bradford get more active. It's especially for children in diverse and less wealthy areas. Researchers want to see if the programme works over a long time to improve kids' health and well-being.
Prevention of physical inactivity and promotion of health and wellbeing in primary school children living in multi-ethnic and socioeconomically disadvantaged communities.England - RecruitingPhase II
A research study testing whether a single dose of [18F]AldoView can produce useful images of adrenal glands allowing identification of participants with and without primary aldosteronism
This study tests a new scan called AldoView for people with high blood pressure caused by primary aldosteronism (PA). PA is when adrenal glands make too much a hormone. AldoView helps doctors find which gland is causing the problem, which can help with treatment.
Primary aldosteronismEngland - Recruiting
Is it possible to assess sleep interventions aimed at improving sleep quality and daytime function in people with mild dementia?
This study looks at ways to improve sleep and daily living for people with mild Alzheimer's. It tests short daytime naps and a special device for better breathing during sleep. The aim is to see if these simple home-based ideas can genuinely help improve how people feel and function.
Adults (aged 50 - 90 years) with a confirmed diagnosis of prodromal or mild-to-moderate Alzheimer’s diseaseEngland - RecruitingPhase I
A study to test the safety, tolerability and effect of ZI-MA4-1 for patients with locally advanced or metastatic solid malignancies
This study is testing a new cell therapy called ZI-MA4-1 for certain advanced cancers. It's the first time humans will receive it, so doctors are checking its safety and the right dose. It's hoped to offer a new treatment option where current ones are limited.
Ovarian cancer, squamous non-small-cell lung cancer, synovial sarcoma, head and neck cancer.England - Recruiting
A UK study of minimally invasive emergency treatment of sudden bleeding from the lower bowel
This study looks back at records of patients in the UK and other countries who had a special X-ray guided procedure called embolisation to stop sudden bleeding from their bowel. It aims to understand how well this treatment works and to improve care for similar cases in the future.
Patients who have undergone angiography +/- embolisation for acute non-variceal lower GI haemorrhage.England - Recruiting
The Imperial College comprehensive study of people with chronic damage to small blood vessels in the brain to define underlying mechanisms
This study from Imperial College London looks at people with small vessel disease in the brain. It aims to understand why this condition happens and how it affects people, hoping to find new ways to treat it. It involves reviewing medical records, interviews, and some simple tests.
Cerebral small vessel diseaseEngland - Recruiting
ABC-UK: Single session self-help
This study looks at whether a quick online activity can help young adults (19-25) in the UK who are feeling down. It compares this activity to usual support, aiming to find an accessible way to improve mood.
Treatment of depressive symptoms in young adultsEngland - Not yet recruiting
A digital parent support programme for parents
This study looks at an online program called Stepping Stones Online to help parents of children with learning disabilities. It aims to see if the program can support families and improve children's behaviour, making it easier for parents to get help.
Parenting practices and parental well-beingEngland - Recruiting
A staged dose-finding and challenge/rechallenge study of Staphylococcus aureus nasal colonisation in healthy adults
This study looks at how a common bacterium called Staphylococcus aureus lives in people's noses. Researchers will put a small amount of the bacteria into healthy adult volunteers' noses to see how it settles and if it can protect them from future infections. It aims to help develop new ways to prevent infections.
Staphylococcus aureus nasal colonisationEngland - RecruitingNot Applicable
Evaluating the efficacy of an AI-delivered, neurosymbolic, human-supervised digital intervention for depression and anxiety versus standard cognitive-behavioural therapy in young persons and adults
This study compares a new AI-powered app, Nook, to regular online talking therapy (CBT) for young people and adults with depression and anxiety. It aims to see if Nook works just as well to help people feel better.
Depression and anxiety (Generalised Anxiety Disorder and/or Major Depressive Disorder)England - Recruiting
Trying out a virtual reality café for young people with eating disorders
This study explores a virtual reality (VR) café to help young people with eating disorders practice social eating in a safe space. It aims to see if this new treatment is helpful and how people feel about it.
Eating disordersEngland - Recruiting
Serotonin effects on brain function and their relationship to relapse when stopping antidepressants
This study looks at why depression sometimes comes back when people stop taking antidepressants. Researchers will study brain activity in people who have recovered from depression and plan to stop their medication. The aim is to understand how changes in brain chemicals contribute to relapse.
DepressionEngland - RecruitingPhase I/II
Testing a novel home-based approach for strengthening motor pathways
This study is looking for people with hand weakness from a spinal cord injury. We're testing a new home device that uses small electrical pulses and hand movements to help strengthen the brain-hand connection. We hope this will improve hand function.
Individuals who have had a cervical spinal cord injury which resulted in hand weaknessEngland - Recruiting
Psychodynamic Interpersonal Therapy for psychosis (PITp): a feasibility randomised controlled trial
This study looks into a talking therapy called PITp for people experiencing psychosis. It wants to see if this therapy, alongside usual NHS care, is a good idea for a larger study. Adults in Greater Manchester with psychosis can take part.
PsychosisEngland - Recruiting
A new intelligent eye imaging method to detect diabetic nerve damage early
This study is testing a new, gentle eye scan for people with and without diabetes. It aims to find early signs of nerve damage caused by diabetes, without touching the eye. This could help doctors start treatment sooner and prevent future problems.
Diabetes mellitus, polyneuropathies and other disorders of the peripheral nervous systemEngland - CompletedNot Applicable
TinnSpire: Personalised vagus nerve & sound stimulation for the treatment of tinnitus
This study is testing a new treatment called TinnSpire for long-lasting tinnitus. It combines gentle electrical ear stimulation, sound therapy, and breathing exercises. We want to see if it's safe and helpful for people with ringing or buzzing in their ears.
Chronic tinnitusEngland - Recruiting
Use of forum theatre in service design and patient decision aids
This study looks at using a special type of theatre to help design better maternity services. It aims to improve how pregnant people make important decisions about their birth, especially for things like larger babies. We want to make sure everyone gets the right support.
Decision-making in maternity care, specifically informed choice for birth planning (e.g. large-for-gestational-age pregnancies), and optimisation of healthcare service design using forum theatreEngland - Recruiting
Long Covid and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) study
This study, called HERITAGE, wants to understand Long Covid and ME/CFS better. It looks at people's symptoms, experiences with NHS services, and how care can improve. It involves questionnaires and interviews, but no treatments.
Long Covid and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)England - Completed
Secondary analysis of paediatric chronic pain team service data
This study looks at information from children in West Sussex who have long-lasting muscle, joint, or bone pain. It uses existing, anonymous records to understand how many children are affected and their characteristics, helping to improve future care.
Chronic musculoskeletal pain is defined as pain lasting three months or more, affecting muscles, joints, or bones.England - Recruiting
Improving chronic kidney disease identification and assessing its association with health inequalities in coding practices
This study aims to improve how a long-term kidney condition (CKD) is found and recorded in GP notes. It uses a new computer tool to make sure nearly everyone with CKD gets the right care and no one is wrongly coded.
Chronic Kidney DiseaseEngland - Not yet recruiting
The SAFE study: Exploring a new support package for autistic children and their families
This study, called SAFE, explores a new support programme for autistic children aged 3-16 and their families. It aims to see if SAFE improves family mental health and coping compared to usual care, and if it's suitable and affordable for the NHS.
Diagnosis of autism; if other diagnoses are present (e.g., ADHD, OCD, ED), autism must be the primary diagnosisEngland - Recruiting
A-PATH: A path towards healing and support for older women
This study, A-PATH, aims to create better support for women aged 60-74 in England and Wales who have experienced domestic abuse. It will adapt an existing programme to suit their unique needs, helping them on their path to healing and recovery.
Domestic abuseEngland - Recruiting
A study evaluating the Steps programme, a school-based programme for boys in Key Stage 3 to prevent gender-based violence
This study looks at a school programme called Steps for boys aged 11-14 in Greater Manchester. It aims to teach them about healthy relationships and challenge harmful ideas about gender, helping to prevent violence.
Reduce gender-based violence in boys in Year 7, 8 and 9.England - RecruitingPhase I
Phase I trial, HS-25-802
This early-stage study is looking for healthy adults aged 18 to 55. Not much information is available about it yet, as the details will be shared later once the study finishes, as approved by the Health Research Authority.
Healthy volunteersEngland - RecruitingPhase IV
Initiation and management of DExcom continuous glucose monitoring in primary care in people living with type 2 diabetes on insulin
This study looks at how a glucose monitoring system (Dexcom ONE+) works in UK GP practices for people with type 2 diabetes on insulin. It aims to see if it helps manage blood sugar and fits into routine care.
Type 2 Diabetes MellitusEngland - Recruiting
Surgery or rehabilitation for traumatic shoulder dislocations
This study looks at the best way to treat young adults (16-30) after their first shoulder dislocation. We're comparing keyhole surgery plus physiotherapy versus physiotherapy alone. The goal is to stop the shoulder from dislocating again, aiming for the most effective and affordable treatment.
Shoulder dislocationEngland - Recruiting
Randomised controlled trial of dialysate cooling for preservation of cognitive function in haemodialysis
This study is looking at how to help preserve thinking and memory in people having dialysis. It will test if slightly cooling the fluid used in dialysis makes a difference. No treatments currently exist for these memory problems in dialysis patients. This study will run from October 2026 to October 2027.
Cognitive function in haemodialysis patientsEngland - Recruiting
Feasibility of brief training to support pulmonary rehabilitation referral and attendance in chronic obstructive pulmonary disease
This study looks at new ways to help people with a lung condition called COPD access a helpful exercise programme (pulmonary rehab). We're testing a short training program for healthcare staff to improve how they talk about and refer patients to this rehab.
Chronic obstructive pulmonary disease (COPD)England - Recruiting
Early identification of patients with palliative care needs
This study looks at a new computer tool called HOMR Now! It aims to help doctors quickly spot hospital patients who might need extra supportive care sooner. The goal is to make sure people get the right care and comfort when they need it most.
Identification of patients who may need palliative care assessment or intervention following admission to an acute hospital.England - Recruiting
Gut microbial activity, lifestyle factors, and bone metabolism in premenopausal and postmenopausal women
This study looks at how gut bacteria, diet, and exercise link to bone health in women before and after menopause. We want to see if changes in these areas affect bone strength as women get older.
OsteoporosisEngland - Recruiting
Scratch Less Study
The Scratch Less study is for people aged 8 and over with eczema. It tests an online programme to help manage itching and scratching. You'll either try the programme or continue your usual care. Researchers want to see if the program helps reduce scratching and improve eczema.
Eczema in people aged 8 years and olderEngland - Recruiting
Helping local authorities to help parents: the BeST Engage Project
This study helps local councils improve how they offer parenting programs to families, especially in areas where families might have fewer opportunities. The goal is to make it easier for more parents to join and finish these helpful programs.
Low engagement (uptake and retention) in parenting programmes among socially deprived familiesEngland - RecruitingPhase I
Phase I study of PM534 to patients with advanced solid tumors
This early-stage study is looking at a new medicine called PM534 for people with advanced cancers. More details about the study will be available soon, as the Health Research Authority has given more time to provide information. It's open to adults aged 18 to 100, regardless of gender.
The Health Research Authority has approved a deferral. Full details will be added to the trial record on or before the deferral expiry date.England - Recruiting
Discovering new methods of analysing pleural fluid samples to reach a diagnosis earlier in pleural effusions with an unclear cause
This study aims to find new ways to identify the cause of fluid build-up around the lungs (pleural effusion) more quickly and accurately, especially when current tests aren't clear. By looking for special markers in fluid samples, researchers hope to develop better diagnostic tools for future patients.
Diagnosis of patients with exudative pleural effusionEngland - Recruiting
Looking for nerve problems caused by chemotherapy: determining the effectiveness of an early identification screening programme
This study looks at how well a screening programme can spot nerve problems early in children having chemotherapy. They want to see if finding these problems sooner can lead to better health outcomes in the long run. It's a small study first, to make sure everything works well.
Chemotherapy induced peripheral neuropathyEngland - Not yet recruitingPhase I
Deferred registration - Phase I trial - Quotient Sciences code: QSC303633
This early-stage study is looking for healthy volunteers aged 18-55. It's a 'Phase 1' trial, which means it's one of the first times a new treatment is tried in people. We're waiting for more details, but it's important for understanding how new medicines work safely.
Healthy volunteersEngland - Not yet recruiting
Trial investigating the effects of a brief online uncertainty tolerance training for young people
This study looks at an online training for young people aged 18-24 to help them cope better with everyday uncertainties. It compares two online programs to see if one can reduce worry and improve how young adults handle unsure situations.
Reduction of intolerance of uncertainty and anxiety symptoms in an unselected population (i.e., with or without a psychiatric condition).England - Recruiting
Exploring communication between people living with Motor Neurone Disease and their close persons with healthcare professionals
This study looks at how people with Motor Neurone Disease (MND), their families, and healthcare staff talk to each other. We want to find out what helps and what makes communication harder, to improve care for everyone with MND.
Motorneurone DiseaseEngland