Latest studies
- RecruitingPhase I/II
Testing a novel home-based approach for strengthening motor pathways
This study is looking for people with hand weakness from a spinal cord injury. We're testing a new home device that uses small electrical pulses and hand movements to help strengthen the brain-hand connection. We hope this will improve hand function.
Individuals who have had a cervical spinal cord injury which resulted in hand weaknessEngland - Recruiting
Fatigue and brain function in young people after brain injury
This study looks at why young people who have had a brain injury often feel very tired and have trouble thinking clearly. We want to understand what causes this fatigue and how it affects their daily lives, as well as explore links to sleep, brain activity, and memory.
Cognitive fatigue in children and young people (CYP) with acquired brain injury (ABI)England - Recruiting
Understanding why cancer immunotherapy helps some people but causes side effects in others
This study looks at why immunotherapy for cancer works for some people but causes side effects in others. By studying samples from patients, researchers hope to improve treatment and reduce side effects for future patients. It's an observational study, meaning your treatment won't change.
Psychosocial oncology and survivorshipEngland - Recruiting
Intimate lives matter: sex, relationships and the Care Act
This study aims to improve how social workers support autistic people and those with learning disabilities in their relationships. It will create tools and training for social workers, helping them discuss sex and relationships during care assessments to reduce loneliness and improve well-being.
Support for autistic people and people with learning disabilities around sex and relationshipsEngland - Recruiting
Use of forum theatre in service design and patient decision aids
This study looks at using a special type of theatre to help design better maternity services. It aims to improve how pregnant people make important decisions about their birth, especially for things like larger babies. We want to make sure everyone gets the right support.
Decision-making in maternity care, specifically informed choice for birth planning (e.g. large-for-gestational-age pregnancies), and optimisation of healthcare service design using forum theatreEngland - Not yet recruiting
The SAFE study: Exploring a new support package for autistic children and their families
This study, called SAFE, explores a new support programme for autistic children aged 3-16 and their families. It aims to see if SAFE improves family mental health and coping compared to usual care, and if it's suitable and affordable for the NHS.
Diagnosis of autism; if other diagnoses are present (e.g., ADHD, OCD, ED), autism must be the primary diagnosisEngland - Recruiting
The Imperial College comprehensive study of people with chronic damage to small blood vessels in the brain to define underlying mechanisms
This study from Imperial College London looks at people with small vessel disease in the brain. It aims to understand why this condition happens and how it affects people, hoping to find new ways to treat it. It involves reviewing medical records, interviews, and some simple tests.
Cerebral small vessel diseaseEngland - Recruiting
Respiratory-swallow training in head and neck cancer
This study aims to develop and test a new breathing and swallowing exercise programme for head and neck cancer patients in the UK. Many people find swallowing difficult after treatment, and this programme hopes to offer a simpler, more accessible way to help improve it.
Swallow training in head and neck cancerEngland - Recruiting
A study testing if a new support package used in medication reviews helps patients take their medicines as prescribed
This study tests a new support package to help people with high blood pressure take their medicines. It helps doctors understand why patients might struggle with their medication and offers helpful solutions. It aims to improve care for people with high blood pressure in the future.
Cardiovascular, medication non-adherence, hypertensionEngland - RecruitingNot Applicable
Vagus nerve stimulation for epilepsy in children and adults: assessment of longer term clinical and cost effectiveness in a randomised controlled trial
This study looks at how well a treatment called Vagus Nerve Stimulation (VNS) works for children and adults with epilepsy that hasn't responded to other medicines. We want to understand its long-term benefits and if it helps people with learning difficulties.
EpilepsyEngland - RecruitingPhase II
Restoring intestinal symbiosis for efficacy in IBS
This study is looking into a new oral capsule treatment called EBX-102 for Irritable Bowel Syndrome with Constipation (IBS-C). It aims to restore gut bacteria in people aged 18-70 to help improve symptoms like pain and bowel habits.
Irritable Bowel Syndrome - constipation predominant (IBS-C)England - Recruiting
A-PATH: A path towards healing and support for older women
This study, A-PATH, aims to create better support for women aged 60-74 in England and Wales who have experienced domestic abuse. It will adapt an existing programme to suit their unique needs, helping them on their path to healing and recovery.
Domestic abuseEngland - Recruiting
Feasibility of brief training to support pulmonary rehabilitation referral and attendance in chronic obstructive pulmonary disease
This study looks at new ways to help people with a lung condition called COPD access a helpful exercise programme (pulmonary rehab). We're testing a short training program for healthcare staff to improve how they talk about and refer patients to this rehab.
Chronic obstructive pulmonary disease (COPD)England - Recruiting
Randomised controlled trial of dialysate cooling for preservation of cognitive function in haemodialysis
This study is looking at how to help preserve thinking and memory in people having dialysis. It will test if slightly cooling the fluid used in dialysis makes a difference. No treatments currently exist for these memory problems in dialysis patients. This study will run from October 2026 to October 2027.
Cognitive function in haemodialysis patientsEngland - Recruiting
Serotonin effects on brain function and their relationship to relapse when stopping antidepressants
This study looks at why depression sometimes comes back when people stop taking antidepressants. Researchers will study brain activity in people who have recovered from depression and plan to stop their medication. The aim is to understand how changes in brain chemicals contribute to relapse.
DepressionEngland - Completed
Exploring the experiences of transgender patients and their healthcare professionals at Milton Keynes University Hospital
Researchers at Milton Keynes University Hospital want to understand how transgender patients and hospital staff feel during hospital visits. They will interview transgender patients and their nominated healthcare professionals to improve future care.
Transgender patient experienceEngland - Recruiting
Early identification of patients with palliative care needs
This study looks at a new computer tool called HOMR Now! It aims to help doctors quickly spot hospital patients who might need extra supportive care sooner. The goal is to make sure people get the right care and comfort when they need it most.
Identification of patients who may need palliative care assessment or intervention following admission to an acute hospital.England - Not yet recruiting
Myoinositol in adolescent polycystic ovary syndrome
This study looks at whether a natural supplement, myoinositol, could help teenage girls with PCOS. It's a first step to see if a bigger study is possible, exploring if myoinositol is a good alternative to current treatments for symptoms like irregular periods and acne.
Polycystic ovary syndromeEngland - Recruiting
Surgery or rehabilitation for traumatic shoulder dislocations
This study looks at the best way to treat young adults (16-30) after their first shoulder dislocation. We're comparing keyhole surgery plus physiotherapy versus physiotherapy alone. The goal is to stop the shoulder from dislocating again, aiming for the most effective and affordable treatment.
Shoulder dislocationEngland - Recruiting
A staged dose-finding and challenge/rechallenge study of Staphylococcus aureus nasal colonisation in healthy adults
This study looks at how a common bacterium called Staphylococcus aureus lives in people's noses. Researchers will put a small amount of the bacteria into healthy adult volunteers' noses to see how it settles and if it can protect them from future infections. It aims to help develop new ways to prevent infections.
Staphylococcus aureus nasal colonisationEngland - Recruiting
Discovering new methods of analysing pleural fluid samples to reach a diagnosis earlier in pleural effusions with an unclear cause
This study aims to find new ways to identify the cause of fluid build-up around the lungs (pleural effusion) more quickly and accurately, especially when current tests aren't clear. By looking for special markers in fluid samples, researchers hope to develop better diagnostic tools for future patients.
Diagnosis of patients with exudative pleural effusionEngland - Recruiting
Looking for nerve problems caused by chemotherapy: determining the effectiveness of an early identification screening programme
This study looks at how well a screening programme can spot nerve problems early in children having chemotherapy. They want to see if finding these problems sooner can lead to better health outcomes in the long run. It's a small study first, to make sure everything works well.
Chemotherapy induced peripheral neuropathyEngland - RecruitingNot Applicable
Evaluating a new test for blood disorders
This study is testing a new, easy finger-prick blood test, called MySELF, for people with monoclonal gammopathy. It aims to see if it's as accurate as current lab tests and how practical it is for patients and staff. This condition sometimes needs regular monitoring as it can be an early sign of blood cancers like myeloma.
Monoclonal gammopathiesEngland - Not yet recruitingPhase II
A study to investigate whether novel vaccines can improve Crohn's disease by targeting a bacterium thought to contribute to the condition
This study is testing two new vaccines for Crohn's disease. Researchers believe these vaccines could help by targeting a specific common bacterium. It's a Phase II trial looking at how well they work, their safety, and how the body reacts in adults with active Crohn's.
Crohn's diseaseEngland - Recruiting
A digital parent support programme for parents
This study looks at an online program called Stepping Stones Online to help parents of children with learning disabilities. It aims to see if the program can support families and improve children's behaviour, making it easier for parents to get help.
Parenting practices and parental well-beingEngland - Recruiting
From womb to world: creating womb-like environments for preterm language development
This study looks at whether recreating sounds heard in the womb can help premature babies' language development. It compares premature babies hearing these sounds with those receiving standard care, and full-term babies. Researchers hope it helps understanding how early sounds shape language skills.
Babies born pretermEngland - CompletedPhase I
Phase I Trial: Quotient Code QSC303299
This early-stage study, called Phase I: Quotient Code QSC303299, is testing a new treatment. We don't have many details yet, as they will be shared within 30 months after the study finishes. It's for men aged 30 to 65 years old. More information will become available later.
The sponsor has confirmed that the trial meets the criteria for deferral of publication of the full details of the trial. Full details will be added to the study record within 30 months after the trial has ended.England - RecruitingPhase I
An early-stage study to see if U8:ranibizumab eye drops are safe, well-tolerated, and effective for patients with a specific eye condition called choroidal neovascularisation
This study tests new eye drops for wet AMD, a condition causing central vision loss. It checks if the drops are safe, work well, and are better than injections. We're looking for adults aged 60+ with wet AMD to join.
Wet age-related macular degenerationEngland - RecruitingPhase I
A new device to examine raised level of proteins during inflammation
This study is testing a new, quick device to check for high protein levels in the blood, which can happen with infections like lung infections. It aims to help doctors diagnose and treat these conditions faster.
Respiratory infection/inflammationEngland - Recruiting
The More Life with CF co-design study
This study aims to create a new weight management program for adults with cystic fibrosis (CF) who are overweight or obese. It will be designed with CF patients and healthcare workers to help them eat healthily and be more active, especially after new CF treatments.
Adults with cystic fibrosis who are living with overweight or obesityEngland - Recruiting
Moves Different: Boxing to reduce youth offending
This study looks at whether a six-month boxing programme can help young people, aged 13-18, at risk of crime or violence in England and Wales. It compares boxing to a gym membership to see if it improves behaviour and reduces offending.
Involvement in youth violence and crime (youth offending risk). The study targets adolescents who have one or more recognised risk factors for involvement in violence, offending, or related antisocial behaviour, and evaluates whether a structured boxing programme reduces offending and improves socio-emotional and behavioural outcomes.England - RecruitingPhase I
A novel collagen-based dressing to use in bleeding wounds
This study is testing a new dressing called CLOTTA™ that helps stop bleeding from wounds. It's for adults with a single bleeding wound who come to the emergency department. We want to see if it's safe and works well to help people who've had an accident.
Patients with a single actively bleeding woundEngland - Recruiting
Improving outcomes in panic disorder in NHS talking therapies
This study looks at improving NHS talking therapies for panic disorder. It tests a focused type of CBT to see if it works better than usual care for patients aged 18 and over, aiming to help more people recover from panic attacks and related fears.
Panic disorder with or without agoraphobiaEngland - Not yet recruitingPhase II
A study testing two targeted medicines, bomedemstat, which helps normalise blood cell development, and momelotinib, which reduces symptoms and anaemia, to see whether the combination is safe and effective for people with myelofibrosis
This study looks at combining two medicines, bomedemstat and momelotinib, for people with myelofibrosis. It aims to see if this combination is safe and helps more than momelotinib alone, especially for those whose first treatment isn't working well.
MyelofibrosisEngland - Recruiting
Testing online, self-help single session interventions for UK young people with low mood: the Unlock Wellbeing trial
This study, called 'Unlock Wellbeing', is for UK young people aged 13-18 who feel low. It tests online activities to help manage thoughts and feelings. Participate from home to help research better support for young people's mental health.
Elevated depressive symptomsEngland - CompletedNot Specified
Developing an intervention to help pregnant women decide whether to vaccinate or not
This study aims to create better information about vaccines for pregnant women. We want to understand what information pregnant women need and how they want to receive it, so they can make informed choices about vaccines like flu, COVID-19, and whooping cough during pregnancy.
Vaccine in pregnancyEngland - CompletedPhase I
Phase 1 Trial: EMP-012-1
This early-stage study, called EMP-012-1, is looking into a new treatment. Because it's very early research, the full details of who can join and what it involves aren't public yet. This information will be shared later, once the study is further along.
The Health Research Authority (HRA) has approved deferral of publication of the full details of the trial. The full details will be added to the study record within 30 months after the trial has ended.England - Recruiting
Evaluation of self-initiated humour protocol
This study explores a new digital humour program called SIHP to boost your emotional well-being. It involves daily exercises and weekly lessons over eight weeks, using a virtual coach to help you laugh more and feel better.
Emotional well-beingEngland - Recruiting
The role of the carotid chemoreflex in long-COVID
This study investigates why some people with Long COVID have ongoing breathing problems. We're looking at a small organ in the neck called the carotid body, which helps control breathing. We want to see if temporarily calming it down can improve breathing for those affected.
Long-COVIDEngland - CompletedNot Specified
Ultra-long-term EEG monitoring in people with intellectual disabilities
This study looks at a new tiny device, called SubQ, that fits under the skin on your head. It helps track brain activity in people with learning disabilities and epilepsy, aiming to better understand and manage seizures without needing hospital stays. It also checks if it's safe and improves quality of life.
Epilepsy and intellectual disabilityEngland - Recruiting
A study to see if earlier and more hormonal testing can detect problems sooner in patients who have had radiotherapy treatment for brain tumours
This study checks hormone levels more often after brain tumour radiotherapy. By testing every four months, doctors hope to spot and treat hormone problems earlier, which could improve long-term health. It's for people aged 25 or under who've had specific brain radiotherapy.
Tumour of the central nervous system where 10Gy or more radiotherapy has been received to the hypothalamus or pituitary glandEngland - CompletedNot Specified
Evaluation of N-Tidal in primary care COPD diagnosis
The CORMORANT study is testing a new device called N-Tidal to see if it can help doctors diagnose a lung condition called COPD more easily and accurately in GP practices. This could lead to quicker treatment and better care for patients.
Chronic Obstructive Pulmonary DiseaseEngland - Completed
A Phase 1 trial: Fortrea Phase 1 Leeds Clinic: SUDO-550-101
This early-stage study, called Fortrea Phase 1 Leeds Clinic: SUDO-550-101, is taking place in Leeds. The full details about what the study is looking for and who can join will be publicly shared up to 30 months after it finishes. We don't have more information yet.
The Health Research Authority (HRA) has approved deferral of publication of the full details of the trial. The full details will be added to the study record within 30 months after the trial has ended.England - Recruiting
Using exercise as a prevention tool for venous leg ulcers
This study looks at whether regular exercise can help stop painful leg ulcers from coming back once they've healed. If you live in Sheffield and have recently healed from a venous leg ulcer, you might be able to join. The study compares an exercise plan with standard care over 12 months.
Venous leg ulcersEngland - Recruiting
Tailored physiotherapy rehabilitation after revision total hip replacement
This study looks into two types of physiotherapy after hip revision surgery. It helps us understand if a larger study is possible to find the best approach: either tailored exercises and education or standard care. It checks if people are willing to take part and stick with the treatment.
Musculoskeletal and orthopaedics; elective orthopaedic surgery; arthrosisEngland - Recruiting
Genicular embolisation for knee osteoarthritis
This study explores a new treatment called genicular artery embolisation (GAE) for ongoing knee pain from osteoarthritis. It aims to see if blocking small blood vessels in the knee can reduce pain for people who haven't found relief from other treatments but aren't ready for surgery.
Knee osteoarthritisEngland - Recruiting
Evaluating artificial intelligence for detecting diseases on medical images and diagnostic tests
This study evaluates AI's ability to detect diseases on medical scans and tests using anonymised NHS data. It aims to see if AI tools are accurate and useful for doctors, without involving patients directly.
Evaluation of artificial intelligence algorithms for detecting various pathologies across multiple diagnostic modalities including medical imaging (X-ray, CT, MRI, ultrasound) and other diagnostic tools (e.g., electrocardiograms). Specific conditions will be defined at the sub-study level.England - Recruiting
Online remote behavioural intervention for tics
This study is testing an online program to help young people in the UK manage tics caused by Tourette Syndrome. It aims to see if this web-based therapy, supported by coaches, is easy to use and helpful for reducing tics and improving quality of life for 9-17 year olds.
Tic disordersEngland - Recruiting
Improving the adoption of clinical guidelines for the treatment of gum disease in primary dental care
This study aims to improve how dental practices in North East London treat gum disease. We're working with dental teams and patients to create better ways for practices to follow important guidelines, ensuring everyone gets the best possible care for healthy gums.
Periodontal diseaseEngland - Completed
Narrative exposure therapy in early intervention in psychosis: a study providing an initial assessment of safety and acceptability of this psychological therapy for individuals with a first episode of psychosis who have experienced repeated trauma
This study looks at a new talking therapy called Narrative Exposure Therapy (NET) for people experiencing psychosis who have also had difficult life experiences. It checks if NET is safe and helpful, and if therapists can be trained easily to deliver it.
History of multiple trauma, early intervention for psychosis, post-traumatic stress disorderEngland