Latest studies
- Recruiting
Balancing "bad" and "good" immune cells: testing a novel method for monitoring an immunosuppression strategy in people with Type 1 diabetes
This study is testing a new way to quickly check if treatments for Type 1 diabetes are working. It involves two medicines to help balance immune cells and aims to find better ways to stop the body from attacking insulin-producing cells.
Type 1 diabetesEngland - RecruitingPhase II
Preventing new infections while patients are sick in hospital with omega-3 fatty acids
This study looks at whether fish oil (omega-3) can stop seriously ill hospital patients from getting new infections. It's a Phase II trial to find the best dose and understand if it helps patients stay healthy and leave hospital sooner.
Prevention of hospital-acquired infection in adult, critically ill patientsEngland - RecruitingPhase II
DAPA-PD: a trial to test the use of dapansutrile, an anti-inflammatory medication, in people with Parkinson’s disease
This study is testing a new anti-inflammatory drug, dapansutrile, for people with early Parkinson's disease. We want to see if it can reduce brain inflammation and slow down Parkinson's progression. It's for people aged 50-80 in Cambridge, UK.
Parkinson's diseaseEngland - Completed
A study evaluating Your Local Pantry membership
This study looks at how joining a local food pantry might help people struggling to afford enough food. Researchers want to see if it improves their diet, health, and feelings of well-being compared to those who haven't joined yet.
Food insecurityEngland - Completed
Investigating an environmental intervention for office workers with poor sleep
This study looks at how changing the environment of office workers could improve their sleep. If you're an Oxford-based office worker aged 23-65 with sleep problems, you might be able to help. It involves wearing sensors and attending sessions over six weeks.
Modifying the behaviour of office workers to improve sleepEngland - Recruiting
A realist evaluation of ‘paste’ and ‘dry’ compression bandages
This study looks at two types of bandages – 'paste' and 'dry' – used for leg ulcers or to prevent them. Researchers want to know which kind works best for different people and why, focusing on nurses' views on applying them and patients' comfort.
Patients with/without leg ulceration who require compression bandagesEngland - Completed
An online consensus-building study to agree on key policy measures for assessing whether the England Rare Diseases Action Plans (developed by the Department of Health and Social Care) are effective
This study asks people with rare diseases and healthcare experts in England to agree on the best ways to check if new plans to improve rare disease care are working well. It's an online survey aiming to make care better for everyone.
Any rare diseaseEngland - Completed
How common is intraoperative pain occur during caesarean delivery surgery when the patient is awake and what is the impact on mothers?
This study looks at how often pain happens during C-sections when mums are awake, and how this pain affects them. It aims to improve care for future C-section mothers.
Reproductive health and childbirthEngland - CompletedPhase II
A study to test the effectiveness of a vaccine targeting a protein that hides cancer cells from the body's immune system in operable colorectal cancer that has defective mismatch repair
This study tests a new vaccine for a certain type of bowel cancer before surgery. It aims to see if the vaccine can help your body's immune system fight the cancer and how well it works in people whose cancer has specific genetic changes.
Operable microsatellite instability-high (MSI-high) colorectal cancerEngland - CompletedPhase I
A study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of BCX10013 in healthy participants
This study is testing a new medicine, BCX10013, for the very first time in healthy people. It aims to see if it's safe, how the body handles it, and how it affects a part of the immune system. This could help treat future patients.
Healthy participantsEngland - CompletedPhase IV
Benefits of fitting non contact lens wearers with astigmatism with MyDay® 1-day toric contact lenses
This study looks at how comfortable new contact lens wearers with astigmatism find daily disposable contact lenses. It compares a special lens for astigmatism to a standard lens to see which is more comfortable and helps vision better.
AstigmatismEngland - Completed
Feasibility of conducting a randomised controlled trial (RCT) comparing invasive (catheter or needle) and non-invasive (clean catch/urine caught in a pot) urine sampling techniques in children under 16 years old with a suspected urinary tract infection
This study looks at the best way to collect urine samples from children under 16 with a suspected urine infection. We want to find out if it's possible to run a larger study comparing different methods, like catching urine in a pot or using a thin tube, to help doctors decide the safest and most effective way.
Urinary tract infectionEngland - Completed
Smart technology for diabetic foot monitoring
This study looks at smart socks to help people with Type 2 diabetes. It aims to measure pressure on the feet during walking to prevent serious foot problems like ulcers. Researchers want to see if these socks can spot early signs of nerve damage in the feet. Join if you have Type 2 diabetes and can walk.
Type 2 Diabetes MellitusEngland - Completed
Acceptability of radiofrequency assessment of breast density
This study looks at a new, simple way to check breast density, a risk factor for breast cancer, in younger women (30-49). It uses a device called Mi~Scan® to help identify women who might need earlier check-ups, potentially saving lives.
Early detection of breast cancer risk in younger womenEngland - RecruitingPhase III
A study to assess the safety and effectiveness of inavolisib plus a cdk4/6 inhibitor and letrozole versus placebo plus a CDK4/6 inhibitor and letrozole in participants with advanced breast cancer
This study looks at a new drug, inavolisib, for advanced breast cancer that has a specific genetic change (PIK3CA mutation). It compares inavolisib combined with standard treatments (palbociclib and letrozole) to a dummy drug plus the standard treatments. The goal is to see if inavolisib is safe and works better.
Endocrine-sensitive phosphatidylinositol 3-kinase (PIK3CA)-mutated, hormone receptor-positive, human epidermal growth factor receptor 2- (HER2-) negative advanced breast cancerEngland - Recruiting
Automatic high flow oxygen support for tiny babies during breathing tube placement – a research study
This study looks at how best to help tiny premature babies breathe during a procedure to place a breathing tube. We're comparing two ways of giving breathing support to see which prevents low oxygen levels more effectively, aiming to make this vital procedure safer for these vulnerable infants.
Preterm intubationsEngland - CompletedNot Applicable
Strength gel with Kaempferia Parviflora Extract for improving the appearance of cellulite.
This study is testing a new body gel designed to improve the look of cellulite. We want to see if the gel can really make cellulite less noticeable and if it's safe to use. Women aged 25-75 with cellulite can take part.
CelluliteEngland - Recruiting
gameChange VR: automated virtual therapy to help patients with psychosis reduce anxious avoidance of everyday situations
This study looks at a new virtual reality (VR) therapy called gameChange for people with psychosis who struggle to leave their homes due to severe fears. It aims to see if gameChange works well in the NHS to help people face everyday situations, improving their lives and independence.
Agoraphobic avoidance (severe) in patients with a diagnosis of psychosisEngland - RecruitingNot Specified
Does use of a new pre-eclampsia screening test reduce pre-eclampsia and preterm birth in the NHS?
This study looks at a new test to help prevent pre-eclampsia, a pregnancy condition with high blood pressure. It compares a new test to the current one used in the NHS to see if it reduces pre-eclampsia and premature births, aiming for better health outcomes for mums and babies.
Pre-eclampsiaEngland - Recruiting
Duramesh versus suture for prevention of port-site hernia after keyhole surgery
This study compares a new product, Duramesh, with standard stitches to see which is better at preventing hernias after keyhole surgery. It involves adults having keyhole surgery at Croydon University Hospital and aims to reduce the common problem of hernias at the operation site.
Duramesh versus conventional suture closure for laparoscopic periumbilical trocar sitesEngland - RecruitingPhase III
HIVEC® HEAT - the drug mitomycin medac will be warmed to 43°C and administered through a catheter into the bladder via HIVEC® device for patients with nonmuscle-invasive bladder cancer that have previously had no response to BCG treatment
This study looks at a new way to treat bladder cancer that hasn't responded to usual treatment. It uses a warmed drug, mitomycin medac, delivered directly into the bladder to help people avoid bladder removal surgery.
Non-Muscle-Invasive Bladder Cancer (NMIBC)England - Recruiting
Enhancing care for delirium in palliative care units
This study aims to improve care for acute confusion (delirium) in hospices across the UK. We're testing new ways to help hospices follow guidelines better, hoping to reduce delirium and improve life quality for patients and their families.
DeliriumEngland - Completed
A pilot study investigating a probiotic strain for health and well-being
This study is looking at whether a special type of good gut bacteria (a probiotic) can help people with slightly high blood sugar. It involves taking a daily supplement for 6 weeks and monitoring your health from home.
Individuals with HbA1c levels between 39.0 mmol/mol and 51.9 mmol/mol (5.7% to 6.9%)England - Recruiting
Phase-locked brain stimulation for people with Parkinson's disease
This study is testing a new way to use deep brain stimulation (DBS) for Parkinson's disease. Researchers are trying to make DBS work better by timing its electrical pulses with brain waves. They want to see if this `phase-locked` stimulation can improve movement more effectively.
People undergoing deep brain stimulation (DBS) surgeryEngland - Recruiting
Pelvic floor muscle exercises plus pessary for treatment of prolapse versus pelvic floor muscle exercises alone
This study looks at combining pelvic floor exercises with a vaginal pessary for women with pelvic organ prolapse. It wants to see if this combined approach works better at reducing symptoms than just doing the exercises alone, helping to improve women's daily lives.
Pelvic organ prolapseEngland - Recruiting
Increasing informed participation in lung cancer screening using pathway navigation
This study looks at how a special phone call service called 'pathway navigation' can help more people attend important lung cancer screening appointments. It's for people aged 55-74 who've missed a screening appointment and aims to improve early detection of lung cancer.
Lung cancer screeningEngland - CompletedPhase II
The purpose of the trial is to test the safety, tolerability and efficacy of the drug tildacerfont, that is being developed for the treatment of major depressive disorder
This study is testing a new drug called tildacerfont for moderate to severe depression. It aims to see if it's safe and helps people who haven't found enough relief from current treatments. Participants will take either the drug or a dummy pill for 15 weeks.
Major depressive disorder (MDD)England - Recruiting
Keep Control of Eczema Study
This study looks at the best ways to use steroid creams for eczema. It checks if specific advice on how long to use these creams helps keep eczema under control for longer. Anyone aged 1 and over in the UK who uses steroid creams for eczema can take part from home.
EczemaEngland - RecruitingPhase I
Safety and tolerability of APL-3007 administered as a single dose in addition to background therapy with a C5 inhibitor in adults with paroxysmal nocturnal hemoglobinuria
This study is testing a new medicine, APL-3007, for adults with a rare blood condition called PNH. We want to see how safe it is and if people can take it well alongside their usual PNH treatment. It's an early-stage study to gather important safety information.
Paroxysmal Nocturnal Hemoglobinuria (PNH)England - Completed
An observational study to understand markers indicating disease progression in dry age-related macular degeneration
This study looks at dry age-related macular degeneration (AMD), specifically intermediate AMD and geographic atrophy (GA). We want to find early signs of these eye conditions getting worse. Participants will have eye checks and scans over one year to help us understand how these conditions progress.
Age-related macular degeneration - intermediate AMD and geographic atrophyEngland - Recruiting
Sodium effect on aldosterone in real time
This study looks at how much salt you eat affects a hormone called aldosterone in healthy people. We want to see how this hormone changes over 24 hours, which could help diagnose high blood pressure better in the future.
Assessing whether altering dietary sodium intake affects the aldosterone pattern of a healthy individual over 24 hours.England - Recruiting
PRISM Follow-up: Child health review following progesterone in pregnancy
This study checks the health of children whose mothers took progesterone in early pregnancy during the PRISM trial. We want to understand if progesterone had any long-term effects on their health. This helps us ensure it's safe for future mothers.
A prospective observational study to follow up children born to women following first-trimester progesterone treatment who participated in the PRISM trial.England - Completed
A school-based study, co-designed with teachers and families to help improve children's oral health behaviours
This study looks at new ways to help 7-8 year old children in Greater Manchester have healthier teeth. It compares extra tooth-brushing support and school lessons with usual teaching to see which works best for preventing tooth decay.
Oral health behaviours (plaque control, toothbrushing habits, and sugar intake)England - Recruiting
Use of contactless sleep technology for measuring sleep in people living with dementia and mild cognitive impairment
This study looks at using a special bedside device to track sleep in people with dementia or memory problems. We want to see if it's easy to use and if the information helps doctors and carers improve sleep. Poor sleep can affect health and wellbeing for those living with dementia and MCI, and their families.
Dementia or mild cognitive impairmentEngland - Recruiting
Understanding the health, caring activities, and experiences of informal carers of patients in hospital at home services
This study looks into the experiences of unpaid carers for patients using 'Hospital at Home' services. It aims to understand carers' health, daily activities, and how caring affects them. The goal is to improve support for these crucial carers.
The health, caring activities, and experiences of informal carers of patients in hospital at home servicesEngland - Recruiting
Falls in stroke survivors
This study looks at a new programme, called SAF, to help stroke survivors avoid falls after leaving hospital. It compares SAF with usual care to see if it reduces falls over 12 months. SAF involves a checklist and action plan to manage fall risks.
StrokeEngland - CompletedNot Applicable
Clinical investigation of soft contact lenses in children
This study looks at new soft contact lenses for children aged 8-15 who are short-sighted and already wear contact lenses. Researchers want to see if these special lenses can help slow down the worsening of short-sightedness and reduce future eye problems.
MyopiaEngland - RecruitingNot Applicable
Evaluating the efficacy of an AI-delivered, neurosymbolic, human-supervised digital intervention for depression and anxiety versus standard cognitive-behavioural therapy in young persons and adults
This study compares a new AI-powered app, Nook, to regular online talking therapy (CBT) for young people and adults with depression and anxiety. It aims to see if Nook works just as well to help people feel better.
Depression and anxiety (Generalised Anxiety Disorder and/or Major Depressive Disorder)England - RecruitingNot Applicable
Testing whether home sensors can predict flare-ups in chronic lung disease
This study is testing a system with smartwatches and home monitors to help spot flare-ups in people with a lung condition called COPD. It aims to see if these tools can help people manage their condition better by noticing problems earlier.
Chronic obstructive pulmonary disease (COPD)England - Recruiting
Co-designing system improvement for Atypical Parkinsonian Syndromes
This study aims to improve care for people with Atypical Parkinsonian Syndromes (APS) and their carers across the UK. It will look at why care varies, how it affects daily life, and how to make services better for everyone.
Atypical Parkinsonian SyndromesEngland - RecruitingPhase II
The use of CARBALIVE in the treatment of cholestatic liver disease
This study is for people in the UK with a liver condition called primary sclerosing cholangitis and inflammatory bowel disease. It tests a new treatment called CARBALIVE to see if it's safe and helps improve health by stopping harmful gut bacteria from damaging the liver.
The study is looking at patients with primary sclerosing cholangitis and co-existant inflammatory bowel disease.England - Recruiting
BREATHE: A Realist Evaluation study to understand smoking tobacco cessation and how to support pregnant women with this
This study, BREATHE, looks at how best to help pregnant women in West Yorkshire stop smoking, especially those in poorer areas. It uses interviews with women and staff, and hospital records, to find out what works, for whom, and why. The goal is to improve support and reduce risks like premature birth.
Smoking tobacco cessation in pregnant womenEngland - Completed
Yoga therapy for functional neurological disorder
This study looks at how yoga therapy might help people with Functional Neurological Disorder (FND). It explores if gentle yoga movements, breathing, and mindfulness can improve symptoms, daily functioning, and quality of life by helping people better connect their mind and body.
Functional neurological disorder (FND)England - Recruiting
Exercise and analgesia for rehabilitation following hip fracture surgery
This study looks at how exercise and painkillers affect muscle recovery after hip fracture surgery in older adults. It compares how muscles grow and work with and without certain pain relief to help improve future recovery.
Acute fragility fracture of the hip requiring surgical managementEngland - Recruiting
Therapist-assisted internet-based cognitive therapy for prolonged grief (iCT-PG): a feasibility randomised controlled trial
This study looks into a new online therapy called iCT-PG for people struggling with prolonged grief. It aims to see if the treatment is practical, helpful, and acceptable. Participants get weekly therapist support and interactive online tools to manage their grief.
Prolonged grief disorderEngland - Recruiting
Dark adaptation and Retinal Topography in AMD (DART-AMD)
This study looks at how people with early AMD adapt to darkness and how their eye changes affect this. It aims to improve tests for new treatments that slow down AMD progression and is for people aged 55-85 with intermediate AMD.
Age-related macular degenerationEngland - RecruitingNot Applicable
Clinical performance and safety of soft contact lenses in children
This study looks at how well special daily contact lenses and glasses work for short-sighted children aged 8-12. It aims to see if these lenses can help slow down the worsening of short-sightedness and reduce future eye problems, comparing them to regular glasses.
MyopiaEngland - Recruiting
Increasing the uptake of cervical and lung cancer screening with targeting
This study aims to boost cervical and lung cancer screening rates in the UK. Researchers are testing different ways to invite people for screening, especially those who don't usually attend, to help catch cancer early and save lives.
Uptake of cervical and lung cancer screeningEngland - Recruiting
Online parent-led treatment for obsessive-compulsive disorder in preadolescent children
This study looks at a new online, parent-led therapy for children aged 5-12 with Obsessive-Compulsive Disorder (OCD). It aims to see if this online approach, which needs less therapist time, could be a good way to help more families dealing with OCD.
Specialty: Mental Health, Primary sub-specialty: Personality disorder - OCD; Health Category: Mental health; Disease/Condition: Neurotic, stress-related and somatoform disordersEngland - CompletedPhase IV
Evaluating the accuracy of remote monitoring technology in capturing how patients respond to treatments for pulmonary arterial hypertension
This study is using small, implanted devices to check how well new and existing lung treatments work for people with Pulmonary Arterial Hypertension (PAH) from their own homes. It aims to help doctors find the best treatments faster and reduce hospital visits.
Pulmonary arterial hypertension (PAH)England