Latest studies
- Completed
A feasibility study of electron radiotherapy delivered during a surgical operation for rectal cancer
This study looks at giving targeted radiotherapy directly into the pelvis during surgery for rectal cancer. Doctors want to see if treating the area during the operation helps destroy any leftover cancer cells, lowering the chance of the cancer returning while keeping the treatment safe for patients.
Colorectal CancerEngland - Completed
Remote rehabilitation after intensive care
Leaving intensive care can be tough, leaving people physically weak and emotionally drained. This UK study tests a six-week online rehabilitation programme designed to help people recover at home. Researchers want to see if regular remote support, gentle exercises, and recovery advice improve quality of life compared to standard NHS care.
Any condition requiring admission to intensive care and 48 hours of invasive mechanical ventilationEngland - Recruiting
Can screening programmes for abdominal aortic aneurysm safely be made more efficient by targeting them at people at the highest risk of disease?
Currently, the NHS offers abdominal aortic aneurysm (AAA) scans to all 65-year-old men. This computer-based study looks at health records to see if scans could instead be offered only to men at higher risk. The goal is to make screening more efficient while still finding life-threatening swellings early.
Abdominal aortic aneurysmEngland - RecruitingPhase II
Carbogen for status epilepticus in children trial
When a child has a prolonged epileptic seizure, it is a medical emergency. This UK study looks at whether breathing Carbogen—a safe mix of oxygen and a tiny amount of carbon dioxide—can stop severe seizures faster than pure oxygen, alongside the usual emergency medications.
Severe epileptic seizures in children that are not stopping by themselves and require emergency medication to stop themEngland - Completed
Adaptation and implementation of health Qigong and Tai Chi exercises on quality of life and physical functioning in patients with atrial fibrillation: a feasibility study
This study looks at whether gentle online Tai Chi and Qigong classes can help people with atrial fibrillation (an irregular heartbeat). Researchers want to see if patients enjoy these slow, home-based exercises, find them easy to do, and feel benefits to their everyday wellbeing and physical health.
Tai Chi and Qigong for patients with atrial fibrillation.England - CompletedNot Applicable
Investigating the use of lenzilumab for acute graft versus host disease (when transplanted stem cells attack the body’s cells)
This UK clinical trial is testing a new drug called lenzilumab for acute graft versus host disease (GvHD). GvHD happens when transplanted donor cells attack the patient's body. Researchers want to see if adding lenzilumab to standard steroid treatment is safe and helps patients who have a higher risk of severe illness.
Graft versus host disease following allogeneic stem cell transplantationEngland - Completed
AFTER – Ankle fracture treatment: enhancing rehabilitation trial
The AFTER study explores the best way to help people aged 50 and over recover from a broken ankle. It compares doing exercises at home using a guide and website against having four to six one-to-one sessions with an NHS physiotherapist, to see which approach works best.
Ankle fractureEngland - Completed
MWIQ - AI-powered decision support tool for diabetes clinicians
This study tests a new computer tool called MyWay IQ. It uses artificial intelligence (AI) to help GPs in Greater Manchester choose the best treatments for adults with diabetes. Researchers want to see if the tool is safe, helpful, and easy to use during normal clinic appointments.
DiabetesEngland - CompletedPhase II
A comparison of response to treatment in patients with Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap Syndromes taking ASTX727 versus best supportive care
This UK clinical trial is testing a new tablet called ASTX727 for adults with rare bone marrow cancers called MDS/MPN overlap syndromes. Researchers want to find out if taking this tablet at home works better at managing the condition and improving quality of life than standard supportive hospital care.
Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap SyndromesEngland - Completed
Urine HPV testing in women over 65 years of age
This UK study explores whether a simple urine test can screen for cervical cancer risk in people aged 65 to 79. Routine screening stops at 65, but risks remain. Researchers want to see if checking for HPV in urine during routine lung health checks is easy, helpful, and acceptable.
Identification of cervical cancer risk in women over 65 years of age using urine HPV testingEngland - CompletedPhase II
Pausing post-COVID fatigue
This UK clinical trial investigates whether a gentle, battery-powered ear stimulation device can reduce ongoing tiredness in adults with Long COVID. Researchers want to see if stimulating a major nerve through the skin of the ear can calm the nervous system and help ease long-term fatigue.
Post-COVID fatigueEngland - Completed
To determine if critically ill patients with acute respiratory failure treated with carbocisteine, hypertonic saline, or both, experience increased hydration of airway mucus.
This study looks at whether medicines called carbocisteine and hypertonic saline help clear thick phlegm from the lungs of critically ill patients on breathing machines. By testing small mucus samples, researchers hope to see how these treatments work to help patients recover and breathe on their own sooner.
Critically ill patients with acute respiratory failure (ARF)England - Completed
Surveillance towards preventing RSV respiratory infection in paediatrics
This UK study looks at how common Respiratory Syncytial Virus (RSV) is in children under three years old. RSV often causes winter chest infections like bronchiolitis. By testing simple nose swabs and surveying parents, researchers want to measure the impact on families and the NHS to help design future vaccines.
Respiratory syncytial virus (RSV)England - CompletedPhase III
Symptoms, trajectory, inequalities and management: understanding Long COVID to address and transform existing integrated care pathways
This UK study tests different ways to treat Long COVID. Researchers want to see if existing medicines, specialised body scans, and a recovery app can help reduce ongoing symptoms. The goal is to discover which treatments work best so the NHS can provide clearer, more equal care for everyone.
COVID-19 (SARS-CoV-2 infection)England - Completed
Early rehabilitation promoting motor recovery from spinal cord injury
This study tests whether using an arm-pedal bike soon after a spinal cord injury can help people regain better torso control and sitting balance. Researchers want to see if exercising working arm muscles can stimulate nerve repair to the chest and stomach muscles, helping people become more independent.
Traumatic and non-traumatic cervical and thoracic spinal cord injury.England - Recruiting
CAMELOT - Continuous rectus sheath Analgesia in eMErgency LaparOTomy
The CAMELOT study tests a new pain relief method for people having emergency tummy surgery. It looks at whether placing two tiny numbing tubes into the stomach wall during surgery helps control pain better, reduces the need for strong morphine painkillers, and helps patients recover more quickly.
Use of rectus sheath catheters (RSCs) in patients undergoing emergency bowel surgery.England - Completed
A parenting course to reduce behavioural difficulties and improve the quality of life for families of those diagnosed with fetal alcohol spectrum disorders
This UK study tests 'SPECIFIC', a new seven-week online parenting course designed for families raising children with foetal alcohol spectrum disorder (FASD). Researchers want to see if the course helps boost parental confidence, reduces stress, and improves day-to-day family life before running a much larger national trial.
Stress reduction in families diagnosed with fetal alcohol spectrum disorderEngland - Completed
Specialist pre-hospital redirection for ischaemic stroke thrombectomy (SPEEDY)
The SPEEDY study tests whether paramedics can take stroke patients straight to specialist hospitals for an emergency clot-removal procedure called a thrombectomy. By phoning hospital specialists from the ambulance, paramedics hope to cut out transfer delays, helping patients receive life-saving care faster and recover with fewer long-term disabilities.
Suspected and confirmed acute strokeEngland - RecruitingPhase I
The first-in-human trial of MDX-124 in patients with advanced cancer
This clinical trial is testing a new drug called MDX-124 for adults with advanced solid cancers. It is the first time this medicine is being given to humans. Doctors want to find out what dose is safe, how well the body copes with it, and what side effects it causes.
Locally advanced, unresectable or metastatic solid malignanciesEngland - Completed
Retrospective analysis of vital signs data from patients with COVID-19 using the 'virtual high dependency unit' monitoring system
This study looks back at anonymised health data from hospital patients with COVID-19. Researchers want to see how wearable sensors, which continuously tracked heart rate, breathing, and blood pressure, helped monitor patient health. The goal is to discover how these devices can help doctors spot early warning signs of illness.
COVID-19 (SARS-CoV-2 infection)England - Completed
Does nocturnal haemodialysis improve heart disease for patients on dialysis?
This study looks at whether having dialysis overnight for 6 to 8 hours is gentler on the heart than standard daytime dialysis. Standard dialysis can cause heart scarring. Researchers want to see if slower, longer overnight treatment protects the heart and improves health for people with kidney failure.
Haemodialysis, kidney failureEngland - Completed
SMART Schools Study: An evaluation of the impact of school policies restricting daytime use of smartphones and social media on adolescent mental wellbeing
This UK study looks at how school smartphone rules affect teenagers' mental wellbeing. Researchers are comparing schools that ban phones during the school day with those that allow them at break times. The goal is to see how these rules influence pupils' mood, sleep, physical activity, and learning.
Smartphones, social media and adolescent mental wellbeingEngland - Completed
IGLOo: Sickness absence and sustainable return to work pilot study
Taking long-term sick leave can be stressful and isolating. The IGLOo study tests whether an online support toolkit can help employees on sick leave feel better supported by their managers, return to work smoothly when ready, and stay well in their jobs. It is taking place across large UK workplaces.
Mental healthEngland - CompletedPhase IV
The New Horizons Study
After giving birth, women have an increased risk of blood clots. Current blood thinners require daily injections or frequent blood tests. This study looks at whether newer, easier tablet medicines pass into breast milk, helping doctors learn if they could be safe for breastfeeding mothers in the future.
Treatment and prevention of blood clots following the birth of a babyEngland - Completed
Text messaging and training to support the taking of statins
This UK study tests whether text message reminders help people take their cholesterol-lowering statins regularly. It also offers extra training for GP surgery staff. Researchers want to see if this combination helps patients keep their cholesterol at safer levels and lowers their risk of heart disease and strokes.
HypercholesterolaemiaEngland - CompletedPhase II
A clinical trial adding Sativex (a cannabis-based medicine) to standard treatment, temozolomide, to find out if it is beneficial for patients whose glioblastoma brain tumour has returned after treatment
The ARISTOCRAT trial is testing whether adding a cannabis-based mouth spray called Sativex to standard chemotherapy (temozolomide) helps people whose glioblastoma brain tumour has returned. Researchers want to see if combining these treatments slows tumour growth, helps patients live longer, and improves day-to-day quality of life.
Glioblastoma multiformeEngland - CompletedPhase III
Ayurveda for promoting recovery in long COVID
This UK study tests whether a traditional Indian herb called Ashwagandha can help people recover from long COVID. Adults diagnosed with long COVID take study capsules daily for three months. Researchers want to see if this natural remedy safely eases symptoms like fatigue, restores energy, and improves daily quality of life.
Long COVIDEngland - CompletedNot Applicable
Testing the ability to reduce immunosuppression in older renal transplant recipients
This study looks at whether older adults having a kidney transplant can safely take lower doses of anti-rejection medicines. Lower doses may help reduce the risk of serious infections while still keeping the new kidney safe. Researchers will closely monitor patients using new, gentle blood tests.
Kidney transplant recipientsEngland - RecruitingPhase IV
Aspirin after hospitalisation with pneumonia to prevent heart attacks and stroke
Pneumonia can temporarily raise your risk of suffering a heart attack or stroke. The ASPECT clinical trial is testing whether taking a low dose of daily aspirin for three months after being hospitalised with pneumonia can help protect patients from these serious heart and blood circulation problems.
Pneumonia - lung infectionEngland - Completed
Passport to Success: can teaching children social and emotional skills improve their mental health?
Around one in six children struggles with mental health challenges like worry and sadness. This UK study tests a school programme called 'Passport'. It uses comic books and fun classroom activities to teach 8 to 11-year-olds emotional skills, aiming to boost their wellbeing and help them cope with difficult feelings.
Prevention of internalizing symptoms in children aged 8-9 (at baseline)England - CompletedNot Applicable
Risks of preventative antibiotics for surgery
Before surgery, patients often receive antibiotics to stop wound infections. However, these drugs can sometimes cause side effects. This UK observational study looks at adults having common operations to see how well preventative antibiotics work today, how often side effects happen, and how antibiotic allergy labels affect patient recovery.
Use of antimicrobials as prophylaxis in surgical patientsEngland - Completed
Audit-based education to implement NICE clinical recommendations of things 'not to do' in people with cardiometabolic diseases: a two-round cluster randomised trial
This UK study tests whether a training and tracking tool helps GP practices follow official 'Do-Not-Do' health guidance. The goal is to reduce unnecessary prescriptions and treatments for adults with two or more long-term heart or metabolic conditions, helping improve patient safety and care.
Exploring the effect of an ABE intervention tool to assist general practices on the implementation of NICE ‘Do-Not-Do' recommendations in people with cardiometabolic multimorbidity.England - CompletedPhase I
Assessing the safety of atezolizumab being directly administered to the bladder in bladder cancer patients undergoing radical cystectomy
This study tests whether giving an immunotherapy drug called atezolizumab directly into the bladder is safe. It is for adults with bladder cancer who are scheduled to have their bladder removed. Doctors want to see if treating the tumour directly causes fewer side effects than giving the medicine into a vein.
Urothelial cell carcinoma of the bladderEngland - Completed
A phase III trial of intensity-modulated proton beam therapy versus intensity-modulated radiotherapy for multi-toxicity reduction in oropharyngeal cancer
This UK clinical trial compares two forms of radiotherapy for throat cancer: standard radiotherapy and proton beam therapy. Researchers want to find out if proton therapy causes fewer long-term side effects, such as speech and swallowing problems, while working just as well to treat the cancer alongside chemotherapy.
Oropharyngeal cancerEngland - RecruitingPhase IV
Stimulant medication for ADHD and tics - understanding response versus non-stimulants
About 1 in 5 young people with ADHD also experience tics. Doctors often worry that standard ADHD stimulant medicines might worsen tics. The UK SATURN study compares two approved medicines—methylphenidate and guanfacine—to discover which one best manages ADHD symptoms and tics safely, helping families make clearer treatment choices.
Attention Deficit Hyperactivity Disorder (ADHD) and ticsEngland - Completed
A study to evaluate operation of flexor tendon injury under local anaesthesia compared to general or regional anaesthesia
This UK study looks at whether repairing cut hand tendons while patients are fully awake using numbing injections works as well as standard surgery under general or regional anaesthetic. Researchers want to see if running a larger trial comparing both approaches is practical and acceptable to NHS patients.
Surgery for flexor tendon injuriesEngland - CompletedPhase I/II
Platform study Kaleidoscope: A Phase 1/2 Open-label Platform Study to Evaluate the Safety and Efficacy of Multiple Amivantamab-based Therapeutic Combinations in Participants with Advanced, Unresectable Lung Cancer (LC) ISA1 METalmark (now closed in UK): A phase I/II open-label platform study to evaluate the safety and efficacy of multiple amivantamab-based therapeutic combinations in participants with advanced, unresectable lung cancer ISA2 Polydamas: A Phase 1/2 Study Evaluating the Safety and Efficacy of Amivantamab and Cetrelimab Combination Therapy in Metastatic Non-small Cell Lung Cancer ISA3 SwalloWTail: A Phase 1/2 Study Evaluating the Safety and Efficacy of Amivantamab and Docetaxel Combination Therapy in Metastatic Non-small Cell Lung Cancer
This clinical trial tests new combination treatments for advanced non-small cell lung cancer that has spread. Researchers are checking whether combining a targeted drug called amivantamab with other cancer medicines is safe and helps slow cancer growth. Two study branches are currently open for adults at specialist UK cancer hospitals.
Unresectable metastatic non-small cell lung cancerEngland - Completed
Evaluating a mastery approach to teaching English in Key Stage 3
This UK study tests whether a programme called English Mastery helps Key Stage 3 pupils improve their reading and writing. Whole secondary schools join the programme. Teachers receive extra training, lesson plans, and coaching, while pupils take part during their regular school English lessons without needing extra classes.
English teaching in schoolsEngland - Completed
A study investigating the possibility and practicality of assessing and treating dizziness after traumatic brain injury
Many people feel dizzy after a head injury. This UK study explores whether hospital ward staff can easily check for and treat a common inner-ear cause of dizziness, called BPPV, while patients are still on the ward. The goal is to improve care and recovery times for future patients.
Benign paroxysmal positional vertigoEngland - CompletedPhase IV
Dequalinium versus usual care antibiotics for the treatment of bacterial vaginosis
Bacterial vaginosis (BV) is a common vaginal condition usually treated with antibiotics. This UK study compares standard antibiotics with dequalinium chloride, an antiseptic tablet placed in the vagina. Researchers want to find out if this alternative works just as well, without harming healthy bacteria or causing antibiotic resistance.
Bacterial vaginosisEngland - Completed
Improving the quality of care for men with Abdominal Aortic Aneurysms (AAA) who undergo regular screening: reducing the psychosocial consequences of screening and developing a patient-centred Exit Strategy from surveillance
An abdominal aortic aneurysm (AAA) is a bulge in the body's main blood vessel. In the UK, men with small or medium aneurysms have regular ultrasound checks. This study explores the worry and emotional stress this monitoring can cause, aiming to design better psychological support and guidance for patients and their partners.
Abdominal aortic aneurysm screeningEngland - Completed
A clinical trial of internet-delivered acceptance and commitment therapy for family carers of people with dementia
Caring for a family member with dementia can cause worry and stress. This UK study tests an online talking therapy called iACT4CARERS. It aims to find out if this self-help course helps reduce anxiety for carers, works well across diverse communities, and could be rolled out across the NHS.
Family carers of people with dementiaEngland - Completed
Can treating sleep problems improve depression? The RESTED Trial
The RESTED study is exploring whether improving sleep can help treat depression. Adults who have depression and trouble sleeping can take part through participating GP surgeries. Half of the participants will receive six weekly sleep coaching sessions with a nurse alongside their usual care, while researchers monitor their progress over six months.
Mental healthEngland - Completed
Developing and assessing the feasibility of a psychosexual treatment for sexual difficulties in people with multiple sclerosis.
Multiple sclerosis (MS) can cause distressing sexual and intimacy problems that are rarely talked about. This UK study tests a new support programme called PIMS. Researchers want to find out if this talking-based programme is practical and helpful for adults with MS to improve their relationships, comfort, and sexual wellbeing.
Adults with multiple sclerosis experiencing sexual difficultiesEngland - Completed
Trial of food allergy IgE tests for eczema relief
The TIGER study looks at whether food allergy testing helps improve eczema in babies and young children. Researchers want to find out if removing foods like milk, egg, wheat, or soya based on allergy tests makes a real difference, or if standard eczema care works just as well.
Management of eczema in children aged between 3 months and 2 yearsEngland - RecruitingPhase IV
Are RNA signatures (biomarkers) in the tissue which surrounds the joints (synovial tissue) from patients with rheumatoid arthritis predictive of response to drug treatments?
This UK clinical study tests whether examining a small sample of joint tissue can help doctors pick the best medicine for rheumatoid arthritis. Adults with active arthritis will have a minor joint biopsy and receive one of two standard biologic medicines to see if tissue tests improve treatment success.
Rheumatoid arthritisEngland - Recruiting
Cerebrospinal fluid shunting or dural venous sinus stenting to preserve vision in idiopathic intracranial hypertension (IIH Intervention)
Idiopathic intracranial hypertension (IIH) causes high pressure around the brain that can threaten your sight. This UK study compares two standard operations: inserting a small drainage tube (shunt) or a tiny mesh tube (stent). The aim is to discover which treatment best protects your vision and helps the NHS.
Idiopathic intracranial hypertensionEngland - CompletedPhase III
A study comparing talquetamab in combination with daratumumab or in combination with daratumumab and pomalidomide versus daratumumab in combination with pomalidomide and dexamethasone in participants with multiple myeloma that returns after treatment or is resistant to treatment
This study tests whether a new medicine called talquetamab, given alongside other cancer drugs, helps people with multiple myeloma that has returned or stopped responding to past treatments. Researchers want to see if these new combinations keep the cancer under control for longer than the current standard treatment.
Relapsed or refractory multiple myelomaEngland - Completed
A trial of a new psychological intervention of cognitive behaviour therapy for young people with distressing mood swings
This UK study tests whether a specialised talking therapy, called Cognitive Behavioural Therapy (CBT), helps young people aged 16 to 25 manage distressing mood swings. Researchers want to find out if early psychological support can improve wellbeing and lower the risk of developing bipolar disorder in the future.
Bipolar disorderEngland - Completed
The neoGASTRIC trial: Avoiding routine gastric residual volume measurement in neonatal critical care
Premature babies fed through a tube often have their stomach contents checked regularly to see how they digest milk. The neoGASTRIC study looks at whether stopping these routine checks helps premature babies reach full milk feeds more quickly and safely. It compares two standard care approaches already used in hospitals.
Preterm birthEngland