Latest studies
- Enrolling by invitationPHASE1
A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring
This study helps us understand the long-term safety of new treatments for certain cancers like leukemia and lymphoma. People who have already been in an earlier drug trial for these conditions will continue to be monitored to see how they respond over time.
Leukemia, Myeloid, AcuteLeukemia, Lymphocytic, Chronic, B-CellLymphoma, Non-HodgkinMyelodysplastic SyndromesMoldova - Active not recruitingPHASE2
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer
This study looks at a new drug, erdafitinib, for people with a type of bladder cancer called urothelial cancer that has spread or can't be removed by surgery. It aims to see how well it works and if it's safe, specifically for those with certain genetic changes in their cancer.
Urothelial CancerMoldova - RecruitingPHASE2
AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2
This study is looking at a new medicine called AZD0901 for people with certain advanced cancers like stomach or pancreatic cancer. We want to see how safe it is, if it works, and how the body handles it, sometimes on its own and sometimes with other cancer drugs.
Gastric CancerGastroesophageal Junction CancerBiliary Tract CancerPancreatic Ductal AdenocarcinomaMoldova - Active not recruitingPHASE1
A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone
This study is for adults with head and neck cancer that has spread or returned. It tests if combining new medicines like BI 770371, pembrolizumab, and cetuximab can shrink tumors better than pembrolizumab alone. It aims to see if these combinations help the immune system fight cancer.
Head and Neck Squamous Cell CarcinomaMoldova - RecruitingPHASE3
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine called Duvakitug for people with Crohn's disease that isn't well controlled. It compares Duvakitug to a dummy medicine to see if it's safe and effective in improving symptoms for those with moderately to severely active Crohn's.
Crohn's DiseaseMoldova - Active not recruitingPHASE2
A Study Evaluating the Efficacy and Safety of ALG-000184 Compared With Tenofovir Disoproxil Fumarate in Untreated HBeAg-Positive and HBeAg- Negative Adult Subjects With Chronic Hepatitis B (B-SUPREME)
This study looks at a new drug, ALG-000184, for chronic hepatitis B. It compares it with an existing treatment, tenofovir, to see how safe and effective it is over 48 weeks. It's for adults who haven't been treated for hepatitis B before.
Chronic Hepatitis B InfectionMoldova - Active not recruitingPHASE1, PHASE2
GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors
This study is testing a new cancer medicine, GEN1042, both by itself and with other treatments. It's for people with certain advanced solid tumours where standard treatments haven't worked or aren't available. The main goals are to check its safety and see how well it fights cancer.
Malignant Solid TumorNon-Small Cell Lung Cancer (NSCLC)Colorectal Cancer (CRC)MelanomaMoldova - RecruitingPHASE3
DAREON ® -Lung-1: A Study in People With Advanced Small Cell Lung Cancer to Compare Obrixtamig Plus Atezolizumab, Carboplatin, and Etoposide Treatment With Standard Chemoimmunotherapy
This study looks at a new medicine called obrixtamig for advanced small cell lung cancer. It compares obrixtamig plus standard treatment against standard treatment alone to see if it helps people live longer. It also tests a device to measure a cancer marker.
Small Cell Lung Cancer (SCLC)Extensive-stage Small Cell Lung Cancer (ES-SCLC)Moldova - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaMoldova - RecruitingPHASE3
A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
This study is testing a new treatment called Duvakitug for people with moderate to severe Ulcerative Colitis. We want to see if it helps keep the condition under control and if it's safe to use over a long time. Half the participants will get the new medicine, and half will get a dummy treatment to compare.
Ulcerative ColitisMoldova - RecruitingPHASE1, PHASE2
A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer
This study is testing two new treatments, BNT323 and BNT327, for advanced breast cancer. It aims to find the safest and most effective dose when used together, and to see if this combination helps patients with different types of breast cancer.
Locally Advanced Breast CancerUnresectable Breast CarcinomaMetastatic Breast CancerMoldova - RecruitingPHASE3
A Study to Assess the Efficacy and Safety of Empasiprubart in Adults With CIDP
This study is testing a new medicine called empasiprubart for adults with a nerve condition called CIDP. It wants to see if the medicine is safe and helps people feel better. Participants will get the study medicine or a dummy medicine first, then everyone will get the study medicine.
Chronic Inflammatory Demyelinating PolyneuropathyCIDPChronic Inflammatory Demyelinating PolyradiculoneuropathyMoldova - Active not recruitingPHASE3
A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)
This study looks at the long-term effects and safety of a drug called mirikizumab for people with moderate to severe ulcerative colitis. It can last up to three years, with a chance to continue treatment afterward.
Ulcerative ColitisMoldova - Active not recruitingPHASE2
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study
This study is for men with prostate cancer who are already taking enzalutamide as part of another research study. It aims to gather more information on the long-term safety of enzalutamide when it's helping them. Participants will continue their current treatment and have regular check-ups.
Prostate CancerMoldova - RecruitingPHASE1, PHASE2
A Platform Study in Non-Small Cell Lung Cancer (NSCLC)
This study looks at new and existing treatments for advanced lung cancer (non-small cell type). Researchers are testing different drug combinations to see how safe and effective they are. It aims to find better ways to treat this condition.
Advanced or Metastatic Non-small Cell Lung CancerMoldova - RecruitingPHASE3
C-Forward: Efficacy and Safety of BEM/RZR vs SOF/VEL in Subjects With Chronic HCV
This study compares two treatments, BEM/RZR and SOF/VEL, for chronic hepatitis C in adults. It's looking to see how well they work and if they are safe. It’s for people who haven't had these types of treatments before and usually have mild or no liver damage.
HEPATITIS C VIRUS CHRONIC INFECTIONHepatitis C, ChronicHepatitis C Virus InfectionHepatitis CMoldova - RecruitingPHASE2
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
The APEX study is looking at a new medicine called TX000045 for people with high blood pressure in their lungs caused by a certain type of heart failure. It will compare two doses of the medicine against a dummy treatment to see if it helps.
Pulmonary HypertensionHeart Failure With Preserved Ejection FractionMoldova - Active not recruitingPHASE2
A Study to Evaluate Tobevibart+Elebsiran Versus Bulevirtide in Chronic HDV Infection
This study is testing new medicines, Tobevibart and Elebsiran, against an existing treatment, Bulevirtide. It's for people in the UK who have long-lasting hepatitis delta virus (HDV) infection to see which treatment works best to control the virus and improve liver health.
Viral HepatitisMoldova - Recruiting
Clinical Epidemiology in Contemporary Patients With Myelofibrosis.
This study is looking at people living with myelofibrosis, a rare bone marrow condition, across Europe. We're gathering information on how the disease affects them and how it's treated in real life. This helps us understand the condition better and improve care for future patients.
MyelofibrosisMoldova - Recruiting
Long-Term Follow-up Study for Subjects With CHB Previously Treated With Imdusiran (AB729)
This study is for adults in the UK who have previously taken part in a trial for a liver condition called chronic hepatitis B, and who were treated with a medicine called imdusiran. It looks at their health over the long term after stopping treatment, without giving them new medicines.
Long Term Follow-upMoldova - Active not recruitingPHASE3
A Study to Evaluate Tobevibart + Elebsiran in Chronic HDV Infection
This study is testing new medicines, tobevibart and elebsiran, for people with chronic hepatitis D. It's a large study looking at how well they work and if they are safe, compared to starting treatment later.
Viral HepatitisMoldova - Not yet recruitingPHASE2
A Study to Assess the Safety, Pharmacokinetics, and Efficacy of ABI-6250 in Participants With Chronic Hepatitis D Virus Infection
This study is looking at a new medicine called ABI-6250 for people with chronic hepatitis D (HDV) infection. Researchers want to see if it's safe, how it works in the body, and if it helps treat the infection. It's a Phase 2 trial, meaning it's still in the earlier stages of testing.
Chronic Hepatitis D InfectionMoldova - RecruitingPHASE2
Safety and Efficacy of OD-07656 and of Subsequent Vedolizumab Therapy in Moderately to Severely Active Ulcerative Colitis
This study is testing a new medicine, OD-07656, for people with moderate to severe ulcerative colitis. It also looks at whether OD-07656 can improve the effects of another medicine called vedolizumab when used afterwards. The main goal is to check how well the medicines work and if they are safe.
Ulcerative Colitis (UC)UC - Ulcerative ColitisMoldova - Active not recruitingPHASE1
A Study of Comparative Formulations of Niraparib and Abiraterone Acetate (AA) in Men With Prostate Cancer
This study is testing new ways to give medicines called niraparib and abiraterone acetate for men with advanced prostate cancer. Researchers want to see how well different forms of these drugs are absorbed by the body to help patients get the best treatment.
Prostatic NeoplasmsMoldova - Active not recruitingPHASE1, PHASE2
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Participants With Advanced Cancers
This study is looking at a new drug called JNJ-63723283 for people with advanced cancers. It aims to find the right dose and see how well it works. This drug is designed to help the body's immune system fight cancer.
NeoplasmsMoldova - Enrolling by invitationPHASE3
Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency
This study is looking into the long-term safety of a treatment called Alpha-1 MP for people with a lung condition called Alpha-1 Antitrypsin Deficiency (AATD). It's for those who have already been part of a previous study and involves weekly drips of the medication.
Pulmonary Emphysema in Alpha-1 Antitrypsin DeficiencyMoldova - RecruitingPHASE1
Study of SGR-1505 in Mature B-Cell Neoplasms
This study is testing a new medicine called SGR-1505 for certain types of B-cell lymphoma. We want to find out if it's safe, what dose works best, and if it can help slow down the disease. It's for people whose treatment hasn't worked or stopped working.
Mature B-Cell NeoplasmNon Hodgkin LymphomaDLBCLWaldenstrom MacroglobulinemiaMoldova - RecruitingPHASE1, PHASE2
A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)
This study is testing new combination medicines, BNT326 and BNT327, for people with advanced non-small cell lung cancer. It aims to find a safe dose and see how well they work, both for those who've had previous treatments and those who haven't.
Non-small Cell Lung CancerMoldova - Active not recruitingPHASE3
Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)
This study is looking into a new way to treat lung damage (emphysema) caused by a rare condition called Alpha-1 Antitrypsin Deficiency (AATD). It compares two different doses of a medicine (Alpha-1 MP) to a dummy treatment over three years to see if it helps protect the lungs.
Pulmonary Emphysema in Alpha-1 PI DeficiencyMoldova - Active not recruitingPHASE2, PHASE3
A Trial Evaluating BJT-778 vs Delayed Treatment for the Treatment of Chronic Hepatitis Delta Infection
This study is looking at a new medicine called Brelovitug (BJT-778) for chronic Hepatitis Delta. It compares different doses of the medicine and also looks at starting treatment now versus starting it later to see how well it works and if it's safe.
Chronic Hepatitis D InfectionMoldova - Not yet recruiting
Validation of the European Oncology Quality of Life Toolkit
This study is testing a new set of online surveys called the EUonQoL-Kit. These surveys help understand the quality of life for people with cancer at different stages – during treatment, after treatment, and in palliative care. The goal is to make sure the surveys are accurate and helpful across Europe.
CancerSurvivorshipPalliative CareMoldova - Active not recruitingPHASE2
A Study to Investigate the Efficacy and Safety of Brivekimig in Adult Participants With Ulcerative Colitis
This study is testing a new drug, SAR442970, for adults with moderate to severe Ulcerative Colitis. It compares different doses of the drug to a dummy pill to see if it helps reduce symptoms and is safe.
Ulcerative ColitisMoldova - Active not recruitingPHASE1
A PK Study to Compare GME751 (Proposed Pembrolizumab Biosimilar) and US-licensed and EU-authorized Keytruda® in Participants With Stage II and III Melanoma
This study compares a new medicine called GME751 to an existing treatment, Keytruda, for people with melanoma that has been removed by surgery. It checks if GME751 works similarly and is safe.
MelanomaMoldova - RecruitingPHASE2
A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine called MORF-057 for adults with moderate to severe Crohn's disease. It compares different doses of the medicine to a dummy pill to see if it's safe and helps improve symptoms.
Inflammatory Bowel DiseasesCrohn's DiseaseMoldova - RecruitingPHASE2
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
This study is testing new long-acting medicines for adults with moderate to severe ulcerative colitis. It aims to see how well they work and if they are safe, both on their own and in combinations, compared to a dummy treatment.
Ulcerative ColitisInflammatory Bowel DiseasesColitisColitis, UlcerativeMoldova - RecruitingPHASE1, PHASE2
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
This study is testing a new medicine called BGB-16673 for people with certain types of B-cell cancers, like lymphoma or chronic leukaemia. It aims to find the right dose and see how well it works and if it's safe. It's an early-stage trial.
B-cell MalignancyMarginal Zone LymphomaFollicular LymphomaNon-Hodgkin LymphomaMoldova - Active not recruitingPHASE2
SOLSTICE: Combination Therapy for the Treatment of Chronic Hepatitis D Infection.
This study looks at new drug combinations (VIR-2218 and VIR-3434) to treat long-lasting Hepatitis D infection. It's a Phase 2 trial, meaning researchers are checking if these treatments are safe, handleable, and work well in people.
Hepatitis D, ChronicMoldova - Active not recruitingPHASE2
A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)
This study is looking into a new medication called Rosnilimab for people with moderate to severe rheumatoid arthritis. We want to see if it's safe, and if it helps reduce symptoms, compared to a dummy treatment.
Rheumatoid ArthritisMoldova - RecruitingPHASE1, PHASE2
A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity
This study is testing a new medicine, WVE-007, for people who are overweight or have obesity. Researchers want to see if it's safe, how the body handles it, and if it helps with weight or conditions like pre-diabetes and type 2 diabetes.
Overweight and ObesityMoldova - Active not recruitingPHASE2
A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy
This study is testing a new medicine, XEN1101, for people aged 18-75 with focal epilepsy. It aims to see if the medicine can reduce seizures, how safe it is, and if people tolerate it well, when added to their current epilepsy treatments.
Focal EpilepsyMoldova - RecruitingPHASE1
Dose Determining Study of EXS73565 in Participants With Relapsed or Refractory B-Cell Malignancies
This study is testing a new medicine called EXS73565 for people with certain types of B-cell cancers that have come back or not responded to usual treatments. We want to find a safe dose and see how it works.
Relapsed or Refractory B-cell MalignanciesChronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)Follicular Lymphoma (FL)Marginal Zone Lymphoma (MZL)Moldova - RecruitingPHASE1, PHASE2
A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors
This study is testing a new medicine, CRB-701, for people with certain advanced solid cancers. It aims to find a safe and effective dose, and see which cancers it can treat. Participants will receive the medicine and have tests to check how it works.
Solid Tumor, AdultMoldova - Active not recruitingPHASE3
An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis
This study is an extension for people in the UK with moderately to severely active ulcerative colitis who have already taken part in a specific etrasimod trial. It aims to gather more information on the long-term safety and effectiveness of etrasimod for this condition.
Ulcerative ColitisMoldova - Active not recruitingPHASE3
HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
This study is looking at a new medicine called vutrisiran for people with a heart condition called transthyretin amyloidosis (ATTR) cardiomyopathy. It aims to see if the medicine can help improve the condition and if it's safe compared to a dummy treatment.
Transthyretin Amyloidosis (ATTR) With CardiomyopathyMoldova - Active not recruitingPHASE2
Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine called emvistegrast for people with moderate to severe ulcerative colitis. It aims to see if emvistegrast can help improve their symptoms compared to a dummy medicine.
Ulcerative ColitisMoldova - Active not recruitingPHASE1
A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer
This study looks at new ways to treat head and neck cancer. It combines different medicines that help your immune system fight cancer and stop tumours from growing. It's for people whose previous treatments weren't successful or who don't have standard options.
Head and Neck Squamous Cell Carcinoma (HNSCC)Moldova