Latest studies
- Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1 Study of BMS-986406 as Monotherapy and in Combination in Advanced Tumors
This early-stage study is looking at a new medicine called BMS-986406 for people with advanced cancers. Researchers want to see if it's safe and how it works, both by itself and with other treatments. It's an important first step in developing new cancer therapies.
Advanced Malignant TumorsBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized Study of Andexanet Alfa Compared to Usual Care in Patients Receiving a Factor Xa Inhibitor who Require Urgent Surgery or Procedure (ANNEXA-RS)
This study is comparing a new medication called Andexanet Alfa to usual care. It's for patients who are taking blood thinners (like apixaban, rivaroxaban, or edoxaban) and need urgent surgery. The aim is to see if Andexanet Alfa helps stop bleeding during their operation.
Reversal of anticoagulation effect in patients on a FXa inhibitor (apixabanrivaroxabanor edoxaban) who require urgent surgery or procedureand who have a major risk of bleeding.Belgium - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Phase 1 Study of PYX-106 in Solid Tumors
Researchers are looking into a new medicine called PYX-106 for people with solid tumours (growths in the body). This is a very early study to see if it's safe and how it works in humans for the first time. It's a key first step in developing new treatments.
Solid TumorsBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
I6T-MC-AMBA - A Multicenter, Phase 3, Open-Label Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mirikizumab in Participants 2 Years to Less Than 18 Years of Age with Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine, Mirikizumab (also called Omvoh), for children and teenagers aged 2 to under 18 who have moderate to severe ulcerative colitis. We want to see how well it works and if it's safe to help them feel better.
Moderately to Severely Active Ulcerative ColitisBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity without type 2 diabetes
This study is testing a new medicine, BI 456906, for people who are overweight or have obesity. It wants to see if the medicine helps with weight loss and if it's safe. Participants will get either the real medicine or a dummy injection.
ObesityBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomised, double-blind, parallel-group, 76-week, efficacy and safety study of BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity and type 2 diabetes mellitus
This study is testing a new medicine, BI 456906, for people who are overweight or have obesity and type 2 diabetes. We want to see if it helps with weight loss and is safe to use over about 1.5 years, compared to a dummy medicine.
ObesityDiabetes mellitus type IIBelgium - Ongoing, recruitingTherapeutic use (Phase IV)
I4V-MC-JAJA (RA-BRIDGE): A Randomized, Active-Controlled, Parallel-Group, Phase 3b/4 Study of Baricitinib in Patients with Rheumatoid Arthritis
This study looks at how safe and effective a medicine called baricitinib is for people with rheumatoid arthritis, compared to other common treatments. It will see how long it takes for a blood clot to happen. This is a long-term study that will last over five years.
Rheumatoid ArthritisBelgium - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Evaluation of the effect of CHF6795 on the pharmacokinetics of midazolam, repaglinide and rosuvastatin in healthy subjects
This study looks at how a new medicine, CHF6795, affects how common drugs like midazolam, repaglinide, and rosuvastatin work in the body. It involves healthy adults to understand these interactions before testing the medicine in people with chronic cough.
Chronic coughBelgium - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b, Open-Label, Multiple Ascending Dose, Multicenter Study of VRG50635 in Participants With Sporadic and Familial Amyotrophic Lateral Sclerosis Followed by Long-Term Treatment
This study is testing a new medicine called VRG50635 for people with Amyotrophic Lateral Sclerosis (ALS). It's an early-stage study to see how the medicine works, how much to give, and if it's safe. Both common and inherited forms of ALS are included.
Amyotrophic Lateral SclerosisBelgium - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Evaluate Safety, Pharmacokinetics and Pharmacodynamics of Selnoflast in Participants with Moderate to Severe Asthma
This study is testing a new medicine, Selnoflast, for people with moderate to severe asthma. Researchers want to see if it's safe, how it moves through the body, and what effects it has. It's an early-stage study, open to adults aged 18 and over.
Moderate to Severe AsthmaBelgium - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
Phase 1/2 Open-label Study of BMS-986466 in Combination with Adagrasib with or without Cetuximab in Participants with KRAS G12C-mutant Advanced Solid Tumors
This study is testing new combinations of medicines for advanced cancers that have a specific genetic change called KRAS G12C. It's looking at how safe the new medicines are and if they can shrink tumours in people with lung or bowel cancer.
OncologyNSCLC and CRCBelgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
A pilot single center, open label trial to assess the impact of doxycycline postexposure prophylaxis on antimicrobial resistance
This study is looking at whether taking an antibiotic called doxycycline after sex might change how common bacteria in the body react to antibiotics. It focuses on men and aims to understand if this approach could lead to antibiotic resistance.
Bacterial sexually transmittable diseases (chlamydiagonorrheasyphilis)Belgium - Ongoing, recruitingPhase III and phase IV (Integrated)
A phase 3b, interventional, adaptive, clinical trial to evaluate the efficacy and safety of tralokinumab 300 mg every second week monotherapy compared with placebo in subjects with moderate-to-severe atopic hand eczema who are candidates for systemic therapy (ADHAND)
This study is looking into a new treatment called tralokinumab for adults with moderate to severe eczema on their hands. It wants to see how well it works and if it's safe compared to a dummy treatment. The goal is to see if the medicine can clear up or significantly improve hand eczema in a few months.
Atopic dermatitis and moderate-to severe atopic hand eczemaBelgium - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Learn If the Study Medicine Called Vepdegestrant Changes How the Body Processes the Other Study Medicine Called Midazolam
This study is looking at a new medicine for ER+/HER2 positive breast cancer. Researchers want to see if this new medicine, called vepdegestrant, affects how your body handles another medicine, midazolam, which is often used during medical procedures.
ER+/HER2 positive breast cancerBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized controlled trial to compare the immunogenicity and skin imprinting of intradermal and intramuscular rabies vaccination < RABISKIMM >
This study compares two ways of giving the rabies vaccine – into the skin or into the muscle. We want to see which method is better at training your body's immune system to fight off the rabies virus, especially looking at how the immune cells remember the vaccine.
RabiesBelgium - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3, Multicenter, Randomized, Double-blind Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Oral Ozanimod (RPC1063) in Pediatric Participants with Moderately to Severely Active Crohn’s Disease with an Inadequate Response to Conventional Therapy
This study is looking at a new medicine called Zeposia for children and young people with Crohn's disease that hasn't responded well to other treatments. Researchers want to see if Zeposia can help improve symptoms and how safe it is over time.
Moderately to Severely Active Crohn's DiseaseBelgium - Ongoing, recruitingTherapeutic use (Phase IV)
RCT part: CareRA2020: Effectiveness of a combination of Methotrexate and a step down glucocorticoid regimen (COBRA-Slim) for remission induction in patients with early Rheumatoid Arthritis (RA), with or without fast access to 24 weeks of Tumor Necrosis Factor (TNF) blockade in insufficient responders, a randomized, multicenter, pragmatic trial. LTE part: CareRA2020 LTE: a 3 year longitudinal observational, multicenter, follow-up of early RA patients after participation in the CareRA2020 RCT.
This study looks at how well a treatment for early rheumatoid arthritis (RA) works over a long time. It compares a standard approach with one that offers quicker access to a stronger medicine for those who aren't improving enough.
Rheumatoid ArthritisBelgium - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
MK-7480 Multiple Ascending Dose Study in Healthy Participants
This study is testing a new medicine, MK-7480, in healthy men. It aims to see how safe the medicine is and how the body handles different doses. This is a very early stage of research, paving the way for potential future treatments for liver disease.
Non-alcoholic steatohepatitisBelgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, single arm, multicenter open label trial to determine the efficacy and safety of tisagenlecleucel (CTL019) in adult patients with refractory or relapsed follicular lymphoma
This study is for adults in the UK with a type of cancer called follicular lymphoma that has come back or not responded to previous treatments. It investigates a new cell therapy called tisagenlecleucel to see how well it works and if it's safe.
Adult patients with refractory or relapsed follicular lymphomaBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (MIRANDA)
This study is testing a new medicine, tozorakimab, for people with lung disease called COPD. It wants to see if this medicine can help reduce flare-ups of COPD. Some people will get the new medicine, and others will get a dummy medicine, alongside their usual care.
Chronic Obstructive Pulmonary Disease (COPD)Belgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 1/2 Multicenter, Open-label Study to Assess the Safety, Pharmacokinetics and Efficacy of CC-92480 Monotherapy and in Combination with Dexamethasone in Subjects with Relapsed and Refractory Multiple Myeloma
This study is looking at a new drug, CC-92480, for people with multiple myeloma that has come back or not responded to previous treatments. It aims to see how safe the drug is, how it moves through the body, and how well it works, both on its own and with another medicine called dexamethasone.
Relapsed and refractory multiple myeloma (RRMM)Belgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Brensocatib in Participants with Chronic Rhinosinusitis Without Nasal Polyps – The BiRCh Study
This study is looking into a new tablet called brensocatib for adults with long-term sinus problems that don't involve growths (nasal polyps). It wants to see if this new medicine can help reduce symptoms like stuffy nose and improve how people feel, compared to a dummy pill.
Chronic Rhinosinusitis without Nasal Polyps (CRSsNP)Belgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Open-label, Phase 3 Trial of A+AVD Versus ABVD as Frontline Therapy in Patients With Advanced Classical Hodgkin Lymphoma
This study looks at a new combination of medicines (A+AVD) compared to a standard treatment (ABVD) for advanced Hodgkin Lymphoma. It aims to see if the new combination can better control the cancer and help people live longer.
Advanced Classical Hodgkin LymphomaBelgium - Ongoing, recruitingPhase III and phase IV (Integrated)
MEMENTO-A Phase 3b/4 Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate Mavacamten in Adults with Symptomatic Obstructive Hypertrophic Cardiomyopathy to assess the impact on Myocardial Structure with Cardiac Magnetic Resonance Imaging (CMR)
This study is looking at a new medicine called mavacamten for adults with a heart condition called obstructive hypertrophic cardiomyopathy (HCM). It aims to see if the medicine can reduce the thickness of the heart walls and the size of the heart's upper chambers.
Symptomatic Obstructive Hypertrophic CardiomyopathyBelgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Patient- and Investigator-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Bepranemab (UCB0107) in Study Participants With Prodromal to Mild Alzheimer’s Disease (AD), Followed by an Open-Label Extension Period
This study is testing a new medicine called Bepranemab for people with early Alzheimer's disease. Researchers want to see if it's safe and helps with memory and thinking, compared to a dummy drug. It's a key step in understanding if this treatment could work.
Alzheimer’s DiseaseBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind Study of Adjuvant Immunotherapy with Nivolumab + Relatlimab Fixed-dose Combination versus Nivolumab Monotherapy after Complete Resection of Stage III-IV Melanoma
This study looks at a new combination treatment for advanced melanoma that has been removed by surgery. It compares two drugs given together (nivolumab and relatlimab) against nivolumab alone, to see if the combination can help prevent the cancer from coming back.
Participants with completely resected Stage III or Stage IV melanomaBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE)
This study is testing a new medicine called semaglutide for people with early Alzheimer's disease. Researchers want to see if it can help improve memory and thinking, and how safe it is to use.
Mild cognitive impairment (MCI) or mild dementiaboth of the Alzheimer’s typeBelgium - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study to Evaluate Safety, Pharmacokinetics, and Preliminary Clinical Activity of RO7276389 Alone and in Combination with Cobimetinib in Participants with BRAF-V600 Mutation-Positive Advanced Solid Tumor or BRAF-V600 Mutation-Positive Melanoma with Central Nervous System Metastases
This study is looking at a new drug, RO7276389, by itself and with another medicine, cobimetinib. It's for adults with advanced cancers that have a specific change (BRAF-V600 mutation), especially melanoma that has spread to the brain. We want to see if it's safe and how it works.
BRAF-V600 Mutation-Positive Advanced Solid Tumor or BRAF-V600 Mutation-Positive Melanoma with or without Central Nervous System MetastasesBelgium - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
B3461114- A Phase 1, Open-Label, Randomized, Three-Treatment, Three-Period, Crossover, Single Dose Study to Estimate the Relative Bioavailability of 61 mg and 70 mg Tafamidis Free Acid Tablets to Commercial 61 mg Tafamidis Free Acid Capsule Administered Under Fasted Conditions in Healthy Adult Participants
This study is testing new forms of a medicine called tafamidis. It aims to see how well these new forms are absorbed into the body compared to the version already available. This research helps us understand if the new versions might work just as well.
aransthyretin amyloid cardiomyopathyBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants Whose Disease has Remained Stable or Responded to First-Line Platinum Based Chemotherapy with Pembrolizumab for Stage IIIB/IIIC or IV Non-Small Cell Lung Cancer (ZEAL 1L)
This study looks at a new combination treatment for advanced lung cancer (non-small cell lung cancer). It compares two medicines, Niraparib and Pembrolizumab, with Pembrolizumab alone, to see if the combination helps people live longer or keeps their cancer from growing for longer.
Lung CancerNon-Small CellBelgium - AuthorisedTherapeutic use (Phase IV)
High versus low dose serratus anterior plane block after minimally invasive valve surgery: a double-blinded randomized controlled trial
This study looks at different doses of a pain-numbing injection given after heart valve surgery. It aims to see which dose best helps control pain and reduces the need for strong pain medicines, helping patients recover more comfortably.
Serratus anterior plane block after an aortic valve replacementBelgium - AuthorisedPhase I and Phase II (Integrated)- Other
ABT-199 (Venetoclax) and Purine analogues as Novel Oral Drug Combination for Treatment of Relapsed/Refractory Acute Myeloid Leukemia (ApoAML)
This study looks at new drug combinations for adults with Acute Myeloid Leukaemia (AML) that has come back or not responded to previous treatment. It tests venetoclax and mercaptopurine together to see how well they work and if they are safe.
Acute myeloid leukemiaBelgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
An Exploratory, Multi-Centre, Interventional, Prospective, Randomised, Double-Blind, Placebo-Controlled Clinical Trial to Assess the Safety and Efficacy of AON-D21 in Patients with Severe Community-Acquired Pneumonia.
This study is testing a new medicine, AON-D21, for people with severe pneumonia. Researchers want to see if it's safe and effective, and to understand any side effects. Half the patients will get the medicine, and half will get a dummy treatment, to compare results.
Severe Community-Acquired PneumoniaBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multicentre, Randomised, Double-Blind, Parallel-Group, Placebo- Controlled Phase 3 Efficacy and Safety Study of Benralizumab in Patients with Eosinophilic Chronic Rhinosinusitis with Nasal Polyps (ORCHID)
This study looks at a new medicine called benralizumab for adults with severe nose polyps and asthma. It aims to see if it can shrink polyps and reduce stuffy noses better than a dummy treatment, using standard nasal sprays alongside.
Severe CRSwNP patients with asthma.Belgium - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Study of PIT565 in relapsed and/or refractory B-cell malignancies
This study is testing a new medicine called PIT565 for people with certain types of B-cell cancers that have come back or not responded to previous treatments. It's the very first time this medicine is being given to people, to check its safety and how it works.
Relapsed and/or refractory B-cell Non-Hodgkin lymphoma (R/R B-NHL) and relapsed and/or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL)Belgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A phase 3, prospective, open-label, multisite, extension of phase 3 studies to assess the long-term safety and tolerability of soticlestat as adjunctive therapy in subjects with Dravet Syndrome or Lennox-Gastaut Syndrome (ENDYMION 2)
This study looks at the long-term safety and how well a medicine called soticlestat works for people with Dravet Syndrome or Lennox-Gastaut Syndrome. It's for those already in a previous study and focuses on side effects and overall health.
Dravet and Lennox-Gastaut SyndromesBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Efficacy and Safety of Baxdrostat in Participants with Uncontrolled Hypertension on Two or More Medications including Participants with Resistant Hypertension
This study is testing a new drug called Baxdrostat for people whose high blood pressure isn't controlled by their current medicines. It aims to see if Baxdrostat helps lower blood pressure and if it's safe to use, compared to a dummy pill.
Uncontrolled hypertension (uTHN) defined as blood pressure that remains higher than goal levels despite patients being treated with 2 anti-hypertensive agentsincluding a diuretic. Resistant hypertension (rHTN) defined as blood pressure that remains higher than goal levels despite the use of at least 3 anti hypertensive drugs of different classes at maximum tolerated doseincluding a diuretic.Belgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE plus)
This study is looking at a new tablet, semaglutide, to see if it can help people with early Alzheimer's disease. Researchers want to know if it's safe and if it can slow down changes in memory and thinking over about two years.
Mild cognitive impairment (MCI) or mild dementiaboth of the Alzheimer’s typeBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Observer-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age
This study is testing a new vaccine (mRNA-1647) to see if it can prevent cytomegalovirus (CMV) infection in healthy people. We want to know how well it works, if it's safe, and how a person's body reacts to it. The vaccine is given to adults aged 16 to 40.
Cytomegalovirus Infection (CMV)Belgium - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple-Ascending Doses of RO7303509 in Patients with Systemic Sclerosis
This study is looking at a new medicine called RO7303509 for people with Systemic Sclerosis. It wants to see if the medicine is safe, how the body handles different doses, and if there are any side effects. This is one of the first studies in humans.
Systemic SclerosisBelgium - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Study to Evaluate the Pharmacokinetics of Afamelanotide in Patients with Erythropoietic Protoporphyria (EPP).
This study is looking at a medicine called SCENESSE to see how it moves through the body of adults with a rare skin condition called EPP. It aims to understand how much of the medicine stays in the body and for how long after treatment.
Erythropoietic Protoporphyria (EPP)Belgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 1b/3 Study of Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab Alone in Subjects With Previously Untreated Advanced Gastric and Gastroesophageal Junction Cancer With FGFR2b Overexpression (FORTITUDE-102)
This study is for people with advanced stomach or gut cancer that has a specific genetic marker called FGFR2b. It tests a new drug, bemarituzumab, combined with usual treatments (chemotherapy and nivolumab) to see if it works better than usual treatments alone.
Gastric and Gastroesophageal Junction Cancer With FGFR2b OverexpressionBelgium - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
C4891024 - TACTIVE-U: AN INTERVENTIONAL SAFETY AND EFFICACY PHASE 1B/2, OPEN-LABEL UMBRELLA STUDY TO INVESTIGATE TOLERABILITY, PK, AND ANTITUMOR ACTIVITY OF VEPDEGESTRANT (ARV-471/PF-07850327), AN ORAL PROTEOLYSIS TARGETING CHIMERA, IN COMBINATION WITH OTHER ANTICANCER TREATMENTS IN PARTICIPANTS AGED 18 AND OLDER WITH ER+ ADVANCED OR METASTATIC BREAST CANCER, SUB-STUDY C (ARV-471 IN COMBINATION WITH SAMURACICLIB)
This study is testing a new combination treatment for advanced or metastatic breast cancer. It combines a drug called vepdegestrant (ARV-471) with samuraciclib. Researchers are looking at how safe and effective this new combination is for people aged 18 and over.
Advanced or Metastatic Breast CancerBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Multi-center, Double-blind, Placebo-controlled Phase 3 Study of Bemarituzumab plus Chemotherapy versus Placebo plus Chemotherapy in Subjects with Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer with FGFR2b Overexpression FORTITUDE-101)
This study looks at a new drug, bemarituzumab, for advanced stomach or gullet cancer that hasn't been treated before. It aims to see if adding bemarituzumab to standard chemotherapy helps people live longer and improves their quality of life compared to chemotherapy alone.
Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer with FGFR2b overexpressionBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, double-blind, placebo-controlled, 2-arm Phase III study to assess efficacy and safety of xevinapant and radiotherapy compared to placebo and radiotherapy for demonstrating improvement of disease-free survival in participants with resected squamous cell carcinoma of the head and neck, who are at high-risk for relapse and are ineligible for high-dose cisplatin
This study looks at a new medicine called xevinapant, given with radiotherapy, for people who have had surgery for head and neck cancer. It compares this treatment to radiotherapy with a dummy medicine, to see if xevinapant helps prevent the cancer from coming back.
Resected squamous cell carcinoma of the head and neckBelgium - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to test how well multiple doses of BI 765423 are tolerated by healthy men
This study is looking for healthy men aged 18 and over to test a new medicine called BI 765423. It's a very early-stage trial to see if the medicine is safe and how well people tolerate different doses. It's not for treating any illness.
Healthy volunteer trialBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Effects of Plasma Exchange with Human Serum Albumin 5% (PE-A 5%) on Short-term Survival in Subjects with Acute-On-Chronic Liver Failure" (ACLF) at High Risk of Hospital Mortality
This study looks at a treatment called plasma exchange with human albumin for people with serious liver problems. We want to see if this treatment helps people live longer and get better, compared to standard care alone.
Subjects with cirrhosis with ACLF-1bACLF-2or ACLF-3a detected either at admission or during hospitalizationBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (Oberon)
This study is looking at a new medicine called Tozorakimab for people with COPD. It aims to see if it can reduce severe flare-ups and if it's safe. Participants will be compared to those taking a dummy medicine.
Chronic Obstructive Pulmonary Disease (COPD)Belgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized Study of Nivolumab plus Ipilimumab in Combination with Chemotherapy vs Chemotherapy alone as First Line Therapy in Stage IV Non-Small Cell Lung Cancer (NSCLC)
This study is testing if adding two new drugs, nivolumab and ipilimumab, to standard chemotherapy works better than chemotherapy alone for advanced lung cancer. It seeks to understand if this new combination helps people live longer.
Stage IV Non-Small Cell Lung Cancer (NSCLC)Belgium - Ongoing, recruitingPhase II and Phase III (Integrated)
A randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of PLN-74809 (bexotegrast) for the treatment of idiopathic pulmonary fibrosis (BEACON-IPF)
This study is looking at a new medicine called bexotegrast for idiopathic pulmonary fibrosis (IPF). It aims to see if the medicine can help improve lung function and slow down the disease, and if it's safe to use. Some participants will receive the medicine, and others a dummy pill.
Idiopathic pulmonary fibrosis (IPF)Belgium