Latest studies
- Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Adolescent and Adult Subjects with Moderate to Severe Atopic Dermatitis
This study is testing a new medicine, upadacitinib, for people aged 18 and over with moderate to severe eczema (atopic dermatitis). They want to see how well it clears up skin, reduces itching, and improves quality of life over 16 weeks compared to a dummy pill.
Moderate and Severe Atopic DermatitisCroatia - RecruitingPHASE3
Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
This study looks at a new medicine, abelacimab, for people with an irregular heartbeat (atrial fibrillation) who can't take usual blood thinners. It compares abelacimab to a dummy medicine to see if it can prevent strokes.
Atrial Fibrillation (AF)Croatia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Open-Label, Long-Term Safety Extension Study Evaluating the Safety and Tolerability of the Fixed-Dose Combination of Obeticholic Acid and Bezafibrate in Subjects with Primary Biliary Cholangitis
This study looks at a new drug combination for Primary Biliary Cholangitis (PBC). It checks if mixing two existing medicines, Obeticholic Acid and Bezafibrate, helps liver health over a long time. Researchers want to see how safe and effective this combination is for patients.
Primary Biliary Cholangitis (PBC)Croatia - Active not recruitingPHASE3
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
This study is looking at a new drug, quizartinib, combined with standard chemotherapy for adults recently diagnosed with a specific type of leukaemia called AML. We want to see if this combination improves treatment outcomes compared to chemotherapy alone.
LeukemiaCroatia - Recruiting
Lysosomal Acid Lipase (LAL) Deficiency Registry
This study is gathering information on a rare genetic condition called LAL Deficiency. It aims to understand the disease better and improve care for affected individuals, from babies to adults. It's a worldwide effort to collect health data over time.
Lysosomal Acid Lipase DeficiencyCholesterol Ester Storage DiseaseWolman DiseaseAcid Cholesteryl Ester Hydrolase Deficiency, Type 2Croatia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 Study to Evaluate the Efficacy and Safety of ARO-APOC3 in Adults with Familial Chylomicronemia Syndrome
This study is looking into a new medication called ARO-APOC3 for adults with a rare genetic condition called Familial Chylomicronemia Syndrome (FCS). Researchers want to see if this new medicine can help lower high levels of fats in the blood and if it's safe to use.
Familial Chylomicronemia Syndrome (FCS)Croatia - RecruitingPHASE3
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
This study, called REMAP-CAP, looks at different treatments for serious lung infections like pneumonia, flu, and COVID-19 in adults needing intensive care. It aims to find out which treatments work best to help patients recover.
Community-acquired Pneumonia, Influenza, COVID-19Croatia - RecruitingPHASE2
WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)
This study, called WISPer, is testing a new medicine called MTX-463 for Idiopathic Pulmonary Fibrosis (IPF). It's comparing MTX-463 to a dummy medicine (placebo) to see if it's safe and effective for people with this lung condition.
Idiopathic Pulmonary FibrosisCroatia - RecruitingPHASE3
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
This study looks at a new combination of drugs, adagrasib, pembrolizumab, and chemotherapy, for people with a specific type of advanced non-small cell lung cancer (NSCLC) that hasn't been treated before and has a KRAS G12C gene change.
Carcinoma, Non-Small-Cell LungCroatia - Active not recruitingPHASE3
A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)
This study is testing a new medicine, tulisokibart, for people with moderate to severe ulcerative colitis. It aims to see if the medicine can help people feel better and stay in remission, compared to a dummy medicine, both in the short and long term.
Ulcerative ColitisCroatia - Active not recruitingPHASE3
Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis
This study is looking at a new medicine called frexalimab for people aged 18-55 with certain types of Multiple Sclerosis (MS). It compares frexalimab to an existing MS medicine, teriflunomide, to see how well it stops MS relapses and if it's safe.
Multiple SclerosisCroatia - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
This study is looking into a new medication called remibrutinib for people with a type of multiple sclerosis (MS) called Secondary Progressive MS (SPMS). It will check if the medicine is safe and helps slow down the disease.
Secondary Progressive Multiple Sclerosis (SPMS)Croatia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Study Evaluating INCB099280 in Participants With Advanced Cutaneous Squamous Cell Carcinoma
This study is looking at a new medicine called INCB099280 for people with a type of skin cancer called advanced cutaneous squamous cell carcinoma. It's for patients whose cancer hasn't been treated with immunotherapy before and can't be cured by surgery or radiotherapy.
Treatment of immunotherapy-naive patients with previously untreated or recurrent locally advanced or metastatic cSCC not amenable to curative surgery and/or radiotherapyCroatia - RecruitingPHASE3
Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)
This study is an extension of a previous trial for people with a condition called hereditary angioedema (HAE). It's looking at the long-term safety and how well a medicine, ADX-324, works for HAE types 1 and 2. Participants would have already taken part in the earlier study.
Hereditary Angioedema (HAE)Hereditary Angioedema - Type 1Hereditary Angioedema - Type 2HAECroatia - Active not recruitingPHASE2, PHASE3
A Study to Evaluate the Efficacy and Safety of 2 Doses of EYE103 Compared With Ranibizumab (0.5 mg) in Participants With DME
This study is looking at a new medicine, EYE103, for people with a common eye condition called diabetic macular oedema (DME). It compares EYE103 with a standard treatment, ranibizumab, to see if it's safe and helps improve vision.
Diabetic Macular Edema (DME)Croatia - RecruitingNA
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
This study looks at two types of heart bypass surgery for women: using one or multiple healthy arteries. Researchers want to see if using more arteries leads to better long-term health, quality of life, and fewer future heart problems for women.
Heart DiseasesCoronary Artery DiseaseCoronary Artery Bypass GraftingCroatia - Recruiting
Diagnostic and Therapeutic Applications in Microarrays in Organ Transplantation
This study is looking at a new way to understand what's happening in kidney transplants. It combines different tests, like looking at cells and using new technology, to give doctors a clearer picture. The aim is to help doctors make better decisions about treatment for patients.
Validation Study of Molecular Diagnostic SystemDevelopment of Reporting System for Molecular DiagnosisIncorporate Molecular Diagnosis Into Diagnostic StandardsCroatia - Active not recruiting
Development and Validation of a New Paediatric Inflammatory Bowel Disease NUTrition Risk Score (PIBD-NUTS)
This study aims to find the best way to identify children with inflammatory bowel disease (IBD) who are at risk of malnutrition. We're testing an existing tool called PYMS, and if it's not effective, we'll create a new tool specifically for IBD children.
Inflammatory Bowel Diseases (IBD)Crohns DiseaseUlcerative Colitis (UC)Croatia - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, multicenter, open-label extension study to evaluate the long-term safety, tolerability, and efficacy of subcutaneous sonelokimab in participants with psoriatic arthritis (PsA)
This study looks at a new medicine called sonelokimab for psoriatic arthritis. It checks how safe and helpful the medicine is over a long time for people who have already tried it in another study. Doctors will monitor side effects and overall health.
psoriatic arthritis (PsA)Croatia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
An Open-label Extension Study of ARGX-113-2009 to Evaluate the Long-term Safety, Tolerability, and Efficacy of Efgartigimod PH20 SC in Adult Participants With Bullous Pemphigoid
This study looks at a new medicine called efgartigimod for adults with Bullous Pemphigoid. It's an ongoing study to see how safe and effective the medicine is long-term, and how well it helps manage symptoms and improve quality of life.
Bullous PemphigoidCroatia - RecruitingPHASE3
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
This study looks at new treatments, CagriSema and cagrilintide, for children and teenagers aged 8-18 who are overweight. It compares these new drugs to an existing medicine (semaglutide) or a dummy drug (placebo) to see how well they help with weight loss.
OverweightObesityCroatia - RecruitingPHASE3
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
This study is for people who have already taken part in other studies for a medicine called sotatercept, used to treat Pulmonary Arterial Hypertension (PAH). It aims to check the long-term safety and how well people tolerate sotatercept when taken with their usual PAH treatments.
Pulmonary Arterial HypertensionCroatia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4/2.4 mg and 1.0/1.0 mg once weekly versus semaglutide 2.4 mg and 1.0 mg, cagrilintide 2.4 mg and placebo in participants with type 2 diabetes inadequately controlled on metformin with or without an SGLT2 inhibitor
This study is testing a new combination medicine, CagriSema, for people with type 2 diabetes. It's looking at whether this combined medicine is better at controlling blood sugar and helping with weight loss than existing treatments, including its individual components, semaglutide and cagrilintide.
Type 2 diabetesCroatia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Adolescent and Adult Subjects with Moderate to Severe Atopic Dermatitis
This study is looking at a new medicine called Upadacitinib for teenagers and adults with moderate to severe eczema. It wants to see if the drug helps clear up skin and reduce itching better than a dummy pill.
Moderate and Severe Atopic DermatitisCroatia - AuthorisedTherapeutic confirmatory (Phase III)
CN012-0025: A Phase 3, Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of KarXT + KarX-EC for the Treatment of Agitation Associated with Alzheimer’s Disease (ADAGIO-3)
This study looks at a new drug, KarXT, for people with Alzheimer's disease who experience agitation. It's an extension of previous studies, checking the long-term safety and how well people tolerate the medication. Researchers want to see if it causes any unwanted side effects over time.
Agitation Associated with Alzheimer’s DiseaseCroatia - RecruitingPHASE3
Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)
This study looks at a new gene therapy, Surabgene Lomparvovec, for 'wet' age-related macular degeneration (nAMD). It aims to see if it's safe and effective in reducing the need for frequent eye injections and protecting vision in adults.
Neovascular Age-related Macular DegenerationCroatia - RecruitingPHASE4
A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
This study looks at the long-term safety of a medicine called pirtobrutinib for people with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). It's for those already taking part in a previous pirtobrutinib study, to continue treatment and monitoring.
Chronic Lymphocytic LeukemiaLymphoma, Small LymphocyticCroatia - Active not recruitingPHASE3
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)
This study is looking at a medicine called semaglutide for a liver condition called non-alcoholic steatohepatitis (NASH). Participants will receive either semaglutide or a dummy medicine. It's a long study, lasting about 5 years, with regular clinic visits.
Non-alcoholic SteatohepatitisCroatia - Active not recruitingPHASE3
A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.
This study is testing a new medicine, inclisiran, to see if it can prevent serious heart problems like heart attacks and strokes in people who are at high risk but haven't had one before. They are comparing it to a dummy medicine.
Primary Prevention of Atherosclerotic Cardiovascular DiseaseCroatia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, 52-week, Placebo-controlled, Double-blind Study With Rerandomization to Assess the Efficacy, Safety, and Tolerability of Rocatinlimab (AMG 451) in Adolescent Subjects With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-ASTRO)
This study is testing a new medicine, rocatinlimab, for teenagers with moderate to severe eczema (atopic dermatitis). Researchers want to see if it's safe and helps improve their skin and reduce itching over 52 weeks, compared to a dummy treatment.
Atopic DermatitisCroatia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized, double-blind, placebo-controlled, multi-center study to evaluate the efficacy, safety, tolerability, pharmacokinetics, and pharmacodynamics of orally administered GLPG3667 once daily for 24 weeks in adult subjects with dermatomyositis
This study is testing a new medicine called GLPG3667 for adults with dermatomyositis. We want to see if it helps improve their condition, if it's safe to use, and how the body handles it. Participants will take either the medicine or a dummy pill for 24 weeks.
dermatomyositisCroatia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, double-blind, placebo-controlled, multicenter phase III study to evaluate the efficacy and safety of ABX464 once daily for induction treatment in subjects with moderately to severely active ulcerative colitis
This study is testing a new medicine, ABX464, for people with moderate to severe ulcerative colitis. Researchers want to see if it helps improve the gut lining and reduces symptoms after 8 weeks, and if it's safe to use.
Moderately to severely active ulcerative colitisCroatia - Active not recruitingPHASE1
A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm
This study looks at a new drug, navitoclax, alone or with an existing drug, ruxolitinib, for a group of blood cancers called myeloproliferative neoplasms. Researchers want to see if it's safe, how the body handles it, and if it affects other drugs.
Myeloproliferative NeoplasmCroatia - Active not recruitingPHASE3
An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis
This study is an extension for people in the UK with moderately to severely active ulcerative colitis who have already taken part in a specific etrasimod trial. It aims to gather more information on the long-term safety and effectiveness of etrasimod for this condition.
Ulcerative ColitisCroatia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Single Arm, Open Label Multicentre Extension Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Patients with Multiple Sclerosis Previously Enrolled in A F. Hoffmann-La Roche Sponsored Ocrelizumab Phase IIIb/IV Clinical Trial
This study looks at how well a medicine called ocrelizumab works and if it's safe for people with multiple sclerosis (MS). It's for patients who have already been in similar studies with the same medicine.
Multiple sclerosis (MS)Croatia - Active not recruiting
The OPBC-07/microNAC Study
This study looks at whether it's safe to skip a full lymph node removal surgery in breast cancer patients who have only tiny traces of cancer left in their armpit lymph nodes after chemotherapy. It checks how these patients have fared over time.
Breast CancerCroatia - Active not recruitingPHASE3
Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis
This study looks at a new drug, navitoclax, combined with ruxolitinib, or navitoclax alone, for adults with myelofibrosis whose previous treatment didn't work. It compares these to standard care to see how they affect spleen size and safety.
Myelofibrosis (MF)Croatia - Active not recruitingPHASE3
A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW).
This study looks at a new drug, zolbetuximab, combined with chemotherapy for advanced stomach or food pipe cancer. It aims to see if this combination works better than chemotherapy alone for people with a specific protein in their cancer.
Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or CancerLocally Advanced Unresectable Gastric Adenocarcinoma or CancerMetastatic Gastric Adenocarcinoma or CancerMetastatic Gastroesophageal Junction (GEJ) AdenocarcinomaCroatia - Active not recruitingPHASE3
HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
This study is looking at a new medicine called vutrisiran for people with a heart condition called transthyretin amyloidosis (ATTR) cardiomyopathy. It aims to see if the medicine can help improve the condition and if it's safe compared to a dummy treatment.
Transthyretin Amyloidosis (ATTR) With CardiomyopathyCroatia - RecruitingPHASE3
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
This study is testing a new drug called finerenone for people hospitalised with heart failure. We want to see if it's safe and effective for patients whose hearts can still pump blood fairly well, to improve their health and quality of life.
Heart FailureAcute Heart FailureCroatia - Recruiting
SCAD : a Registry of Spontaneous Coronary Artery Dissection
This study is gathering information on a heart condition called Spontaneous Coronary Artery Dissection (SCAD). It's looking at how doctors currently diagnose and treat SCAD across Europe to learn more about it and improve care for patients.
Spontaneous Coronary Artery DissectionCroatia - Ongoing, recruitingPhase III and phase IV (Integrated)
Open-label Phase 3 Study of MK-7684A (Coformulation of Vibostolimab with Pembrolizumab) in Combination with Concurrent Chemoradiotherapy followed by MK7684A Versus Concurrent Chemoradiotherapy followed by Durvalumab in Participants with Unresectable, Locally Advanced, Stage III NSCLC (KEYVIBE-006)
This study is looking at new ways to treat advanced lung cancer that can't be removed by surgery. It compares a new combination of medicines with a standard treatment, both given with chemotherapy and radiotherapy, to see which works best.
Non-small cell lung cancerCroatia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE plus)
This study is looking at a new tablet, semaglutide, to see if it can help people with early Alzheimer's disease. Researchers want to know if it's safe and if it can slow down changes in memory and thinking over about two years.
Mild cognitive impairment (MCI) or mild dementia, both of the Alzheimer’s typeCroatia - RecruitingPHASE3
STOP-HAE: A Phase 3 Study of ADX-324 in HAE
This study is looking at a new medicine called ADX-324 for people with Hereditary Angioedema (HAE) Type 1 or 2. It will check if the medicine helps prevent HAE attacks and if it is safe. Researchers will also look at how it affects quality of life.
Hereditary AngioedemaHAEHereditary Angioedema - Type 1Hereditary Angioedema - Type 2Croatia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, Single-Arm, Open-Label Study Evaluating the Safety and Pharmacokinetics of the Intravenous Fixed‑Dose Combination (IV FDC) of Tiragolumab and Atezolizumab in Participants with Locally Advanced, Recurrent or Metastatic Solid Tumors
This study is testing a new combination of two drugs, tiragolumab and atezolizumab, for people with advanced solid tumours. It aims to see how safe the combination is and how the body handles these medicines.
Solid TumorsCroatia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, double-blind, placebo-controlled, parallel-group study to assess the efficacy, safety, and tolerability of dexpramipexole administered orally for 52 weeks in participants with severe eosinophilic asthma (EXHALE-3)
This study looks at a new medicine called dexpramipexole for severe asthma. It wants to see if the medicine can reduce asthma flare-ups and improve breathing over 52 weeks. Researchers will compare it to a dummy medicine to see if it works and is safe.
Severe eosinophilic asthmaCroatia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 1b/2a Three-Part Open-Label Multicenter Study to Evaluate the Safety and Efficacy of LY2880070 as Monotherapy and in Combination with Gemcitabine in Patients with Advanced or Metastatic Cancer with a Focus on Ovarian Cancer
This study is testing a new medicine, LY2880070, alone or with another cancer drug, gemcitabine. It's for women with advanced or metastatic cancer, especially ovarian cancer. We want to see how safe the new medicine is and if it helps control the cancer.
Advanced or Metastatic CancerCroatia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A double-blind, randomized, placebo-controlled study to evaluate the efficacy, safety, and tolerability of intravenous ganaxolone added to standard of care in refractory status epilepticus
This study is testing a new medicine, ganaxolone, for a severe type of epilepsy called refractory status epilepticus. It's a late-stage trial comparing ganaxolone to a dummy medicine to see if it can stop seizures quickly and safely when other treatments haven't worked.
Refractory Status Epilepticus (RSE)Croatia - RecruitingPHASE3
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)
This study looks at a medicine called vedolizumab for children and teenagers with moderate to severe Crohn's disease. It aims to see if the medicine can make their symptoms better and heal inflammation in their gut.
Crohn's Disease (CD)Croatia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Ulcerative Colitis
This study is testing a new medicine called Rosnilimab for people with moderate to severe Ulcerative Colitis. Researchers want to see if it helps reduce symptoms and improve gut health compared to a dummy treatment, and if it's safe to use.
Ulcerative ColitisCroatia