Latest studies
- Completed
The SENSE-Cog Randomised Controlled Trial (RCT): Comparing individualised sensory intervention to standard care to improve quality of life in people with dementia and their companions
This trial looks at whether personalised support for hearing and sight loss improves daily life for people with dementia and their carers. Half of participants receive free hearing aids or glasses with home visits from a therapist, while the other half receive standard care and advice.
DementiaCyprus - RecruitingPhase II and Phase III (Integrated)
A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group, 2-Arm, Multicenter, Operationally Seamless Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of Efgartigimod PH20 SC in Participants Aged 18 Years and Older With Active Idiopathic Inflammatory Myopathy
This clinical trial is testing a new injection called efgartigimod for adults with inflammatory muscle disease (myositis). Researchers want to see if the medicine can safely reduce muscle inflammation, improve strength, and help people lower their daily steroid dose compared to a dummy treatment over 52 weeks.
Active Idiopathic Inflammatory Myopathy (IIM)Cyprus - RecruitingTherapeutic confirmatory (Phase III)
HELIOS-A: A Phase 3 Global, Randomized, Open-label Study to Evaluate the Efficacy and Safety of ALN-TTRSC02 in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)
This study is testing a new medicine, Amvuttra, for a rare inherited condition called hereditary transthyretin amyloidosis (hATTR amyloidosis). It aims to see if Amvuttra is safe and helps improve symptoms compared to standard treatments.
Hereditary Transthyretin AmyloidosisCyprus - RecruitingTherapeutic exploratory (Phase II)
Lutetium-177-PSMA in Oligo-metastatic Hormone Sensitive Prostate Cancer.
This study is looking at a new treatment called Lutetium-177-PSMA for men with prostate cancer that hasn't spread widely and is sensitive to hormone therapy. It aims to see if this treatment can slow down the cancer's growth.
prostate cancerCyprus - AuthorisedTherapeutic exploratory (Phase II)
Efficacy of Ketamine for the Prevention of Relapse in Patients with Opioid-Use Disorders (OUD)
This study is looking into whether a medicine called ketamine can help people with opioid use disorder (addiction to strong painkillers or drugs like heroin) stay off opioids and reduce their cravings. It's an early-stage study to see how well it works.
Opioid Use DisorderCyprus - Recruiting
BPH Global Registry
This study is gathering information on men who are treated for an enlarged prostate (BPH) and related bladder symptoms. We want to understand what treatments are being used globally and how successful they are, to help improve care in the future.
Benign Prostatic HyperplasiaLower Urinary Tract SymptomsCyprus - Recruiting
Sex differences in interoception and mental health: an investigation across the menstrual cycle
This study looks at how we sense internal body signals, like our heartbeat or breathing. Researchers want to discover whether these signals affect mental health differently in men and women, and how monthly hormonal cycles play a part. Participants aged 18 to 40 will track daily symptoms on an iPhone app for seven months.
Identifying sex differences in interoception (i.e. the perception of the internal state of the body), common mental health disorders (i.e. anxiety, depression) and mood, and somatic complaints (i.e. physical symptoms), and identifying whether the menstrual cycle may contribute to these differences.Cyprus - RecruitingTherapeutic confirmatory (Phase III)
A Multicenter, Adaptive, Randomized, Controlled Trial Platform to Evaluate Safety and Efficacy of Strategies and Treatments for Hospitalized Patients with Respiratory Infections: Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE) - Immune Modulation Strategy Trial
This study is looking at new ways to treat adults in hospital with COVID-19. We're testing a medicine called Orencia against a dummy treatment to see if it helps people recover faster and has fewer side effects. It's a big study to find the best care.
COVID-19Cyprus - RecruitingTherapeutic exploratory (Phase II)
A Phase II, Single-Arm, Open-Label Study Evaluating the Safety and Pharmacokinetics of the Intravenous Fixed‑Dose Combination (IV FDC) of Tiragolumab and Atezolizumab in Participants with Locally Advanced, Recurrent or Metastatic Solid Tumors
This study is testing a new combination of two drugs, tiragolumab and atezolizumab, for people with advanced solid tumours. It aims to see how safe the combination is and how the body handles these medicines.
Solid TumorsCyprus - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaCyprus - Recruiting
Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
This study looks into Charcot-Marie-Tooth (CMT) disease. It aims to find new genes that cause CMT and other genes that change how severe the symptoms are. Researchers want to understand CMT better to help people living with the condition.
Charcot-Marie-Tooth Disease, Type Ia (Disorder)HMSNCyprus - Recruiting
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
This study looks at how Charcot-Marie-Tooth disease (CMT) changes over time in different types. Researchers want to understand the disease better and test new ways to measure its effects, which could help in finding treatments later on.
Charcot Marie Tooth DiseaseCyprus - RecruitingPHASE3
TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy
This study is testing a new medicine called Nucresiran for people with hereditary transthyretin amyloidosis (hATTR) that affects their nerves. It aims to see how well the medicine works compared to current treatments to improve nerve problems, quality of life, and reduce the level of a harmful protein in the blood.
Hereditary Transthyretin-Mediated Amyloidosis With PolyneuropathyhATTR-PNCyprus - AuthorisedTherapeutic confirmatory (Phase III)
A Randomized, Multicenter, Double-Blind, Parallel-Group, Placebo and Active-Controlled Phase III Therapeutic Superiority Trial Comparing the Efficacy and Tolerability of a Fixed-Dose Combination of Diclofenac potassium + Thiocolchicoside to Diclofenac potassium (Cataflam®) in Patients with Acute Severe Low Back Pain.
This study is looking at a new combination of two common pain medications, diclofenac potassium and thiocolchicoside, to see if it's better than diclofenac alone for severe back pain. Researchers are also checking for side effects.
LOW BACK PAINCyprus - Recruiting
Further Evaluation of Safety and Performance of the NEXUS Aortic Arch Stent Graft System and the Custom-Made NEXUS Multibranch™ Aortic Arch Stent Graft System
This study looks at how well a special device, called a stent graft, works to fix problems in a major blood vessel (the aorta) in the chest. It's collecting information on patients who have already had this treatment to see how safe and effective it is over time.
AAT9Cyprus - Recruiting
SPECTA: Screening Cancer Patients for Efficient Clinical Trial Access
This study, called SPECTA, collects information and samples from cancer patients to help scientists better understand cancer. It aims to improve how we diagnose and treat different types of cancer in the future by looking at many different aspects of the disease.
All Tumor TypesCyprus - Recruiting
The Oxford Risk Factors And Non-Invasive Imaging Study
This study looks at heart and blood vessel problems using CT scans. It collects health information and blood samples to find better ways to spot and predict these conditions, helping doctors understand who is at risk and how best to help them.
Cardiovascular DiseasesCardiovascular Risk FactorsCyprus - Not yet recruiting
Validation of the European Oncology Quality of Life Toolkit
This study is testing a new set of online surveys called the EUonQoL-Kit. These surveys help understand the quality of life for people with cancer at different stages – during treatment, after treatment, and in palliative care. The goal is to make sure the surveys are accurate and helpful across Europe.
CancerSurvivorshipPalliative CareCyprus - Active not recruitingPHASE2, PHASE3
A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy.
This study looks at a new drug, efgartigimod PH20 SC, for adults with active idiopathic inflammatory myopathy (IIM), a condition causing muscle weakness and inflammation. It compares the drug to a dummy treatment to see if it helps improve muscle strength and overall well-being.
Active Idiopathic Inflammatory MyopathyMyositisDermatomyositisPolymyositisCyprus - Active not recruitingPHASE3
A Phase 3 Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Patients With Acetylcholine Receptor Binding Antibody Seronegative Generalized Myasthenia Gravis
This study is testing a new medicine called efgartigimod for people with a type of Myasthenia Gravis (MG). It checks how well it works and if it's safe compared to a dummy medicine. Some people will then get the new medicine openly.
Generalized Myasthenia GravisgMGMyasthenia Gravis, GeneralizedMyasthenia GravisCyprus - RecruitingPHASE3
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
This study looks at whether adding chemotherapy before surgery helps people with certain types of retroperitoneal sarcoma live longer without their cancer coming back. It compares surgery alone to chemotherapy followed by surgery.
Retroperitoneal SarcomaLiposarcomaLeiomyosarcomaCyprus - Active not recruitingNA
The CROCO Study: CROhn's Disease COhort Study
The CROCO Study looks at how Crohn's disease changes over time in people getting the latest treatments. We hope to understand the disease better and find ways to predict its impact, ultimately improving care for patients.
Crohn DiseaseCyprus - Active not recruitingNA
IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
This study compares two ways to guide heart stent procedures: standard X-rays or a more detailed ultrasound method. It aims to see if the detailed ultrasound improves results for people with complex heart blockages and is good value for money.
AtherosclerosisCyprus - Recruiting
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International Registry
This international study is gathering information on a very rare blood cancer called Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN). It aims to understand the disease better, look at different treatments, and improve care by collecting data from patients worldwide.
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)Cyprus - Enrolling by invitationPHASE3
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy
This study looks at a new medicine called efgartigimod for people with certain muscle conditions like myositis. It's for adults who were in a previous study, to see if the medicine is safe and helpful over a long time.
MyositisActive Idiopathic Inflammatory MyopathyDermatomyositisPolymyositisCyprus - Recruiting
SCAD : a Registry of Spontaneous Coronary Artery Dissection
This study is gathering information on a heart condition called Spontaneous Coronary Artery Dissection (SCAD). It's looking at how doctors currently diagnose and treat SCAD across Europe to learn more about it and improve care for patients.
Spontaneous Coronary Artery DissectionCyprus - RecruitingNA
The Next Step Towards the Elimination of Iodine Deficiency and Preventable Iodine-related Disorders in Europe
This study aims to teach young people in the UK and other countries about iodine deficiency and its health risks. It's an educational project in schools to help prevent problems caused by not getting enough iodine.
Iodine DeficiencyCyprus - Active not recruitingPHASE3
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC in Adults With Ocular Myasthenia Gravis
This study looks at a new medicine for adults with a type of muscle weakness affecting the eyes called ocular myasthenia gravis. Researchers want to see if the medicine, Efgartigimod, is safe and helps improve eye symptoms. Some people will get the active medicine, and others will get a dummy treatment.
Myasthenia Gravis, OcularCyprus