Latest studies
- Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Adolescent and Adult Subjects with Moderate to Severe Atopic Dermatitis
This study is testing a new medicine, upadacitinib, for people aged 18 and over with moderate to severe eczema (atopic dermatitis). They want to see how well it clears up skin, reduces itching, and improves quality of life over 16 weeks compared to a dummy pill.
Moderate and Severe Atopic DermatitisFinland - RecruitingPHASE3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
This study looks at a new medicine, Maridebart cafraglutide, for people with heart failure and obesity. It aims to see if the medicine can reduce heart-related problems like hospital stays, improve symptoms, and help people live longer, alongside their usual heart failure care.
Heart Failure With Preserved Ejection FractionHeart Failure With Mildly Reduced Ejection FractionObesityFinland - RecruitingPHASE3
Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
This study looks at a new medicine, abelacimab, for people with an irregular heartbeat (atrial fibrillation) who can't take usual blood thinners. It compares abelacimab to a dummy medicine to see if it can prevent strokes.
Atrial Fibrillation (AF)Finland - Enrolling by invitationNA
Optical Coherence Tomography in Acute Vessel Evaluation
This study compares two ways to help people having a heart attack: one uses standard X-rays, the other uses a special camera called OCT. We want to see if the OCT camera leads to better results for patients.
Ischemic Heart DiseaseIschemic Coronary Artery DiseaseACS (Acute Coronary Syndrome)Finland - Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3, Randomized, Double-blind, Parallel-group, Placebo-controlled, Flexible-dose, Multicenter Study to Evaluate the Efficacy and Safety of SEP 363856 in the Treatment of Adults with Generalized Anxiety Disorder
This study is looking at a new medicine called Ulotaront for adults with generalised anxiety disorder. We want to see if it helps reduce anxiety and if it's safe to use. Some people will get the new medicine, and others will get a dummy pill.
generalised anxiety disorderFinland - RecruitingPHASE2
Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
This study is testing a new medicine, Imeroprubart, for adults with a nerve condition called Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Researchers want to see if it's safe and helps improve symptoms compared to a dummy treatment.
Chronic Inflammatory Demyelinating PolyneuropathyFinland - Active not recruitingPHASE3
A Study to Compare Chemotherapy Alone Versus Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Therapy After Surgery With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle Invasive Bladder Cancer
This study looks at treating muscle-invasive bladder cancer. It compares standard chemotherapy with chemotherapy plus a new immunotherapy drug called nivolumab, given before and after surgery. The aim is to see if adding nivolumab helps more people.
Urinary Bladder NeoplasmsMuscle-Invasive Bladder CancerFinland - AuthorisedPhase II and Phase III (Integrated)
An International Prospective Study in Children Older than 3 to 5 Years with Clinically Standard-Risk Medulloblastoma with Low-Risk Biological Profile (PNET 5 MB – LR and PNET 5 MB – WNT-HR), average-risk biological profile (PNET 5 MB -SR), or TP53 mutation, and registry for MB ocurring in the context of genetic predisposition
This study is for children aged 3-18 with a type of brain tumour called medulloblastoma. It looks at different ways to treat the tumour, including various chemotherapy drugs, to find the most effective and safest options for different types of medulloblastoma, aiming to improve chances of recovery and quality of life.
MedulloblastomaFinland - RecruitingPHASE3
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
This study, called REMAP-CAP, looks at different treatments for serious lung infections like pneumonia, flu, and COVID-19 in adults needing intensive care. It aims to find out which treatments work best to help patients recover.
Community-acquired Pneumonia, Influenza, COVID-19Finland - Not yet recruitingPHASE3
Stratification and Treatment in Early Psychosis Study - PROMOTE
This study looks at whether a cannabis-based medicine (CBD) can help young people (aged 12-35) who are at high risk of developing psychosis. It also checks if CBD is safe and helps us understand how the brain works in these conditions.
Clinical High Risk for Psychosis (CHR)Clinical High Risk for PsychosisClinical High Risk for Developing PsychosisFinland - Active not recruiting
Continuum Ceramic on Ceramic Bearing Post Market Clinical Follow-Up Study
This study looks at how well a specific type of ceramic hip replacement works. Doctors will check pain, movement, and how long the new hip lasts in people having a hip replacement for conditions like arthritis. The aim is to see if it's safe and effective.
OsteoarthritisAvascular NecrosisInflammatory ArthritisPost-traumatic ArthritisFinland - Active not recruitingPHASE3
Study Comparing Blinatumomab Alternating With Low-intensity Chemotherapy Versus Standard of Care Chemotherapy for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia
This study looks at a new way to treat a type of leukaemia (blood cancer) called B-cell precursor acute lymphoblastic leukaemia (ALL) in older adults. It compares a drug called Blinatumomab combined with gentler chemotherapy against the usual chemotherapy treatment to see which works best.
Newly Diagnosed Philadelphia (Ph)-Negative B-cell Precursor Acute Lymphoblastic Leukemia (ALL)Finland - RecruitingPHASE3
A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)
This study looks at a new treatment called Pumitamig for advanced non-small cell lung cancer that hasn't been treated before. It compares Pumitamig to an existing treatment, Pembrolizumab, in people whose cancer cells have a high level of a specific marker called PD-L1.
Non-Small Cell Lung Cancer (NSCLC)Finland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
C4601003 - A PHASE 3, MULTICENTER, PLACEBO-CONTROLLED, RANDOMIZED, OBSERVER-BLINDED TRIAL TO EVALUATE THE EFFICACY, SAFETY, TOLERABILITY, IMMUNOGENICITY, AND LOT CONSISTENCY OF A 6-VALENT OSPA-BASED LYME DISEASE VACCINE IN HEALTHY PARTICIPANTS ≥5 YEARS OF AGE
This study is testing a new vaccine to see if it can prevent Lyme disease. Researchers want to find out how well it works, if it's safe for people aged 5 and older, and if it causes any side effects. They are also checking how the body reacts to the vaccine.
Active immunization against Lyme diseaseFinland - Active not recruitingPHASE3
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
This study, KRYSTAL-10, is for people with advanced bowel cancer that has a specific genetic change (KRAS G12C). It compares a combination of new drugs, MRTX849 and cetuximab, against standard chemotherapy to see which works better for those who have already had initial treatment.
Advanced Colorectal CancerMetastatic Colorectal CancerFinland - Active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis
This study is looking into a new medication called BMS-986278 for people with progressive pulmonary fibrosis. It aims to see if the medication is safe and effective in slowing down this lung condition.
Progressive Pulmonary FibrosisFinland - Active not recruiting
The SPECTRUM Study: An Observational Study to Learn More About How Well Aflibercept 8 mg Works in Treating Visual Impairment Due to Neovascular Age-related Macular Degeneration or Diabetic Macula Edema
The SPECTRUM Study is looking at how well a new eye medicine called aflibercept 8 mg works for vision problems caused by wet AMD or diabetic macular oedema. Researchers will collect information from patients who are already prescribed this medicine by their doctor.
Visual ImpairmentNeovascular Age-related Macular Degeneration (nAMD)Diabetic Macula Edema (DME)Finland - Active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis
This study is looking at a new medicine called BMS-986278 for a lung condition called Idiopathic Pulmonary Fibrosis (IPF). It aims to see how well it works, if it's safe, and if people can tolerate it.
Idiopathic Pulmonary FibrosisFinland - Active not recruitingPHASE3
A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)
This study is testing a new medicine, tulisokibart, for people with moderate to severe ulcerative colitis. It aims to see if the medicine can help people feel better and stay in remission, compared to a dummy medicine, both in the short and long term.
Ulcerative ColitisFinland - AuthorisedTherapeutic use (Phase IV)
Fecal microbiota transplantation in patients receiving infliximab and vedolizumab for ulcerative colitis: A randomized controlled trial
This study looks at how well a treatment called faecal microbiota transplant (FMT) works with other medicines (infliximab and vedolizumab) for people with ulcerative colitis. The aim is to see if this combination helps people feel better and stay in remission without needing steroids.
Ulcerative Colitis, Crohn´s diseaseFinland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Study Evaluating INCB099280 in Participants With Advanced Cutaneous Squamous Cell Carcinoma
This study is looking at a new medicine called INCB099280 for people with a type of skin cancer called advanced cutaneous squamous cell carcinoma. It's for patients whose cancer hasn't been treated with immunotherapy before and can't be cured by surgery or radiotherapy.
Treatment of immunotherapy-naive patients with previously untreated or recurrent locally advanced or metastatic cSCC not amenable to curative surgery and/or radiotherapyFinland - Active not recruitingPHASE3
A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)
This study compares a new treatment called Sacituzumab Tirumotecan with standard care for recurrent or metastatic cervical cancer. It aims to see if the new treatment improves how long people live when current treatments aren't enough.
Cervical CancerFinland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-0616 in Adults With Heterozygous Familial Hypercholesterolemia
This study is testing a new tablet, MK-0616, for adults with a condition called Heterozygous Familial Hypercholesterolemia (HeFH). We want to see if it lowers 'bad' cholesterol (LDL-C) and if it's safe to use. Half the people will get the new tablet, and half will get a dummy tablet.
Heterozygous Familial Hypercholesterolemia (HeFH)Finland - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY STUDY FOR SAFETY, TOLERABILITY, BIODISTRIBUTION AND PERFORMANCE OF [68Ga]Ga-DOTA-SIGLEC-9 FOLLOWING A SINGLE INTRAVENOUS ADMINISTRATION IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS, VASCULITIS OR PULMONARY SARCOIDOSIS AS WELL AS RADIATION DOSIMETRY, PLASMA PHARMACOKINETICS, BIODISTRIBUTION OF THE TRACER IN HEALTHY VOLUNTEERS
This study is looking at a new way to see what's happening inside the bodies of people with certain inflammatory conditions like arthritis, vasculitis, or sarcoidosis. It's an early-stage study using a special scan, and it's also looking at healthy volunteers to understand how it works.
active arthritis, vasculitis, pulmonary sarcoidosisFinland - AuthorisedTherapeutic exploratory (Phase II)
Influence of Dexmedetomidine on the Human Glymphatic Cerebrospinal Fluid Flow, Neural Activity and Cerebral Blood Flow in Functional Magnetic Resonance Imaging (GlymphDex)
This study looks at how a medicine called Dexdor affects brain activity, blood flow, and how fluid moves in the brain, especially when people are more or less conscious. We want to understand how this medicine works in different brain conditions like dementia.
Neurodegenerative diseaseDeliriumAcute neurological diseaseFinland - AuthorisedTherapeutic confirmatory (Phase III)
Tranexamic Acid in Hind and Midfoot Arthrodesis Surgery: A Multicentre, Randomized, Placebo-Controlled Trial (TRASH Trial)
This study looks at whether a medicine called tranexamic acid can help prevent infections after foot and ankle surgery. We want to see if it reduces the number of wound infections and other problems over one year, compared to a dummy treatment.
Deformity, OsteoarthritisFinland - RecruitingPHASE1, PHASE2
Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)
This study is testing new treatments for advanced prostate cancer that has spread and no longer responds to hormone therapy. It aims to see how safe and effective a new drug, Opevesostat, is when given alone or with other medicines to men with this condition.
Prostatic Neoplasms, Castration-ResistantFinland - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Accelerator-based BNCT for head and neck carcinoma
This early-stage study is looking at a new way to treat head and neck cancers using a special type of radiation. Researchers want to see if this treatment is safe and how the body reacts to it. It's for adults with head and neck cancer.
Head and neck carcinomaFinland - Active not recruitingPHASE3
A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma
This study compares two treatments, Iberdomide and Lenalidomide, after a stem cell transplant for multiple myeloma. It aims to find out which one works better at keeping the cancer under control following initial treatment.
Multiple MyelomaFinland - Active not recruitingPHASE3
A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
This study looks at a new medicine called survodutide for people who are overweight or obese. It checks if survodutide helps with heart health problems. Participants take the medicine weekly for up to 2 years, alongside diet and exercise advice.
ObesityFinland - Ongoing, recruitingTherapeutic use (Phase IV)
COVID-19 vaccine immunological studies in Finland
This study in Finland is looking at how well different COVID-19 vaccines protect people. It's especially interested in how strong our body's defence (antibodies) is six months after two vaccine doses, and how this works against current virus types.
COVID-19 infectionFinland - RecruitingPHASE2
A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS)
This study is looking at a new medicine called sarilumab for children and teenagers with a type of arthritis called systemic Juvenile Idiopathic Arthritis (sJIA). It aims to find the right dose and see how safe and effective it is.
Juvenile Idiopathic ArthritisFinland - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, multicenter, open-label extension study to evaluate the long-term safety, tolerability, and efficacy of subcutaneous sonelokimab in participants with psoriatic arthritis (PsA)
This study looks at a new medicine called sonelokimab for psoriatic arthritis. It checks how safe and helpful the medicine is over a long time for people who have already tried it in another study. Doctors will monitor side effects and overall health.
psoriatic arthritis (PsA)Finland - Ongoing, recruitingTherapeutic exploratory (Phase II)
C4801002 - A Phase 2, Randomized, Open-Label Trial to Describe the Safety and Immunogenicity of A Monovalent Pneumococcal Conjugate Candidate Administered As a 2-Dose Series in Healthy Toddlers 12 Through 15 Months of Age Who Previously Received PCV10 Primary Series in the European Union
This study is looking at a new pneumonia vaccine for toddlers aged 12 to 15 months in the EU. It checks how safe the vaccine is and how well it helps their bodies fight off infections. All toddlers in the study have already had a different pneumonia vaccine.
Pneumococcal InfectionsFinland - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b Study to Characterize the Safety and Tolerability of TEV-53408 in Adults with Celiac Disease
This study is looking into a new medication called TEV-53408 for adults with coeliac disease. It's an early-stage trial focusing on making sure the medication is safe and can be handled well by the body, rather than how well it treats the condition.
Celiac diseaseFinland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3b, open-label, multi-center study to assess the immune response and safety of the meningococcal group B vaccine rMenB+OMV NZ when administered to healthy participants aged 10 to 20 years old, who were primed during the first 2 years of life
This study is looking at how well a meningitis B vaccine, Bexsero, works and how safe it is in young people aged 10-20. Participants would have had their first meningitis B vaccinations as babies. We want to see if a booster dose helps protect them.
Invasive meningococcal disease (IMD)Finland - RecruitingPHASE3
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
This study is looking at a new medicine called INCB161734, given alongside standard chemotherapy, for advanced pancreatic cancer with a specific genetic change (KRAS G12D). It aims to see if this combination works better and is safe for people who haven't had treatment for their advanced cancer.
Solid TumorsFinland - RecruitingPHASE3
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
This study compares a new medicine, PF-08046054, with a standard lung cancer treatment, Docetaxel. It's for adults with a certain type of lung cancer that has already been treated and has a specific marker called PD-L1.
Non-small Cell CarcinomaNon-Small Cell Lung Cancer MetastaticNon-Small Cell Lung CarcinomaFinland - Recruiting
Cerebellar Mutism Syndrome Study
This study looks at why some children develop Cerebellar Mutism Syndrome (CMS) after brain surgery for a tumour. CMS causes speech problems and other issues. Researchers hope to understand its causes, how it progresses, and the best ways to treat it for better patient care.
Infratentorial NeoplasmsMutismFinland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-blind, Multicenter, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants with Major Depressive Disorder (MDD) with Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy and an Open-label Long-term Extension Treatment with Aticaprant
This study is looking into a new medication, Aticaprant, for adults with depression who feel little pleasure and whose current treatments aren't working well enough. It aims to see if Aticaprant, taken with their usual antidepressant, can improve their mood and help them feel better.
Major Depressive Disorder (MDD) with Moderate-to-severe AnhedoniaFinland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4/2.4 mg and 1.0/1.0 mg once weekly versus semaglutide 2.4 mg and 1.0 mg, cagrilintide 2.4 mg and placebo in participants with type 2 diabetes inadequately controlled on metformin with or without an SGLT2 inhibitor
This study is testing a new combination medicine, CagriSema, for people with type 2 diabetes. It's looking at whether this combined medicine is better at controlling blood sugar and helping with weight loss than existing treatments, including its individual components, semaglutide and cagrilintide.
Type 2 diabetesFinland - Ongoing, recruitingPhase III and phase IV (Integrated)
DPDIMP#1-trial: Impact of DPYD gene test on the safety and efficacy of fluoropyrimidine therapy
This study looks at how a gene test can make common cancer medicines for breast and colon cancer safer and work better. We're testing different forms of these medicines and checking how they move through the body to find the best and safest ways to treat patients.
Breast cancer, Colon cancerFinland - AuthorisedTherapeutic use (Phase IV)
Antimicrobial treatment of laryngeal leukoplakia
This study looks at treating a throat condition called laryngeal leukoplakia using common medicines. Doctors want to see if these medicines can make the white patches in the voice box disappear. It's for adults and focuses on how well the treatments work.
laryngeal leukoplakiaFinland - Active not recruitingPHASE2
Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom
This study looks at a new drug, Iopofosine I-131, for people with certain B-cell cancers like Waldenstrom, myeloma, or lymphoma, who haven't responded well to other treatments. It aims to see how safe and effective this new approach is.
Waldenstrom MacroglobulinemiaMultiple MyelomaChronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaFinland - RecruitingPHASE2, PHASE3
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
This study keeps an eye on people who have had a special treatment called gene-modified T-cell therapy for cancer. It aims to check their health and how well the treatment worked over a long time, making sure it's safe and effective.
NeoplasmsFinland - RecruitingPHASE3
A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)
This study investigates if a drug called baricitinib can protect the body's insulin-making cells in children and adults newly diagnosed with type 1 diabetes. It aims to see if preserving these cells helps manage the condition better.
Diabetes Mellitus, Type 1Finland - RecruitingPHASE3
A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
This study is looking into whether a medicine called baricitinib can delay Type 1 Diabetes in children and adults who are at a high risk of developing it. It's a key step in preventing the condition.
Diabetes Mellitus, Type 1Finland - RecruitingPHASE4
A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies
This study looks into why some breast cancers stop responding to treatment. We will examine tissue and blood samples from patients with specific types of breast cancer to understand how the cancer becomes resistant and find new ways to help them.
Breast CancerFinland - RecruitingPHASE3
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
This study looks at a new drug, golcadomide, combined with rituximab, for people with follicular lymphoma that has come back or not responded to previous treatments. It compares this new combination to standard treatments chosen by doctors.
Follicular LymphomaFinland - Ongoing, recruitingPhase II and Phase III (Integrated)
Brightline-1: A Phase II/III, randomized, open-label, multi-center study of brigimadlin (BI 907828) compared to doxorubicin as first line treatment of patients with advanced dedifferentiated liposarcoma
This study is testing a new medicine, brigimadlin, for people with advanced dedifferentiated liposarcoma. It compares brigimadlin to a standard medicine, doxorubicin, to see if it can slow down or stop the cancer from growing.
Advanced dedifferentiated liposarcomaFinland